Jonathan Jarecki
@Jonathanjarecki • 3,302 subscribers
20 y/o Bio & Neuro, B.S. Student • Host of the Whole Health Podcast •
Videos
SUPPLEMENTING YOUR WORK ENVIRONMENT WITH AN INCANDESCENT LIGHT BULB IMPROVES MITOCHONDRIAL FUNCTION! - A brand new (Jan 23th, 2026) paper published by Glen Jeffery and Edward Barrett demonstrates how adding a 60 W incandescent lamp to participants work desk dramatically improves color contrast, or a proxy for color vision. The intervention here is simply placing an incandescent lightbulb on the desk without direct irradiation on participants. And this is huge: “we have obtained significant balanced improvements in both the protan and tritan range. Previously, exposure to restricted experimental 670 nm resulted in improvements biased strongly in favour of only tritan function. Hence, exposure to full spectrum lighting results in a balanced pattern of improvement in visual performance.” The mechanism seems to be mitochondrial in nature. Short wavelength light, which is dominated in standard LED lighting, reduces mitochondrial function. There’s a reduction in mitochondria ATP production, and therefore a reduced demand for glucose. This intern can increase body weight and serum cytokinin levels. Also, with short wavelength blue light, there is an increase probability of cell aging and death. “It is suggested that this is partly due to 420–450 nm light, dominant in LEDs, being absorbed by porphyrin and the subsequent production of oxygen singlets driving inflammation.” “Conversely, exposure to longer wavelengths is associated with increased mitochondrial membrane potential and increased concentration of mitochondrial complex proteins that have declined with ageing and disease. This in turn is associated with elevated ATP, reduced inflammation and extended average lifespan.“ So, for the love of mitochondria, get long-wavelength light! This can be done in many ways: -sunlight/daylight exposure (does not need to be direct sunlight) -fire light -incandescent light bulbs -LEDs that emit long-wavelength light (yes, LEDs CAN emit red and near-infrared, but most don’t)
Jonathan Jarecki63,136 Aufrufe • vor 4 Monaten
SPEAKING WITH ANDREW HUBERMAN AT EUDEMONIA SUMMIT, PART 2. Last year I had the opportunity to ask Andrew D. Huberman, Ph.D. a question regarding the conversation he had with ☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 on the Tetragrammaton podcast. This year at Eudēmonia I was able to ask Andrew a second question. Since last year, Andrew has had Roger Seheult, MD on the podcast and most recently Dr. Glen Jeffery, a physician and researcher whose work I have been following and sharing. The Andrew D. Huberman, Ph.D. podcast episode with Dr. Glen Jeffery has already been recorded so stay tuned for that. In the meantime, Huberman highlights some important studies Dr. Jeffery has done and the impacts his research has in the video below.
Jonathan Jarecki44,813 Aufrufe • vor 7 Monaten
THE SUNRISE IS THE MOST POTENT CIRCADIAN STIMULUS. A 2020 paper published in Current Biology identified a previously unknown retinal circuit explaining precisely why the spectral contrast of sunrise so powerfully entrains the circadian system. The key neuron is the M1 intrinsically photosensitive retinal ganglion cell (ipRGC), which projects directly to the suprachiasmatic nucleus (SCN), the brain’s master circadian pacemaker. In primates, M1 ipRGCs are wired to perform a spectral comparison between yellow/red and blue light via two simultaneous pathways. ***This cone-based circuit is just one of several mechanisms by which morning light entrains the circadian system. Going outside after sunrise still delivers meaningful melanopsin stimulation as overall irradiance builds, and that sustained signal remains highly beneficial. The spectral contrast mechanism described here is simply the most precisely tuned and potent stimulus the system has, one that outdoor morning light delivers far more effectively than any indoor environment. As yellow and red wavelengths increase at sunrise, L and M cones drive LM-ON bipolar cells, which directly excite the M1 ipRGC. Simultaneously, the relative decrease in short-wavelength light reduces S-cone activation, quieting S-ON bipolar cells, which reduces drive to a newly identified S-cone amacrine cell, releasing its inhibitory input onto the ipRGC. Disinhibition and excitation converge on the same cell simultaneously. Melanopsin, the ipRGC’s intrinsic photopigment peaking at ~480nm, is slower and requires sustained high irradiance, taking over as morning light intensity builds. The result is a temporal relay: the cone circuit delivers a rapid spectral signal at the horizon transition, then melanopsin sustains entrainment through the morning. No indoor lighting replicates this. The sunrise delivers the exact stimulus this circuit evolved over hundreds of millions of years to detect. #science #circadian #sunrise #neuroscience #biology
Jonathan Jarecki10,609 Aufrufe • vor 2 Monaten
THE CONTRASTING EFFECTS OF BLUE AND RED/NIR LIGHT ON THE MITOCHONDRIA. - Recent research published this year in Nature: Scientific Reports demonstrates the effects that light in the built environment has on human health. Our modern build environment is dominated by short-wavelength light from LEDs and fluorescent lighting. This can have deleterious effects on the mitochondria. Adding to this effect is the lack of long-wavelength light from sources like the sun and incandescent lighting bulbs. These long light wavelengths have a beneficial effect on mitochondria function and overall human health. The lack of them in our modern built environment, seems to be impacting public health in a delirious fashion. Two recent papers to read: 1. 2.
Jonathan Jarecki17,814 Aufrufe • vor 4 Monaten
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