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Lucas Farnung

@LucasFarnung • 2,692 subscribers

Assistant Professor @HarvardCellBio. Transcription & Chromatin; Biochemistry, X-ray & Cryo-EM. Views are my own.

Shorts

🧬🎉 Our new chromatin remodeling study is out: We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link:

🧬🎉 Our new chromatin remodeling study is out: We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link:

13,372 Aufrufe

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Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert

75,981 Aufrufe • vor 1 Jahr

Extremely excited to share this work by Maik Engeholm out in Molecular Cell: Chd1 engages overlapping dinucleosomes, and collaborates with FACT to restore and remodel overlapping dinucleosomes. Patrick Cramer

Extremely excited to share this work by Maik Engeholm out in Molecular Cell: Chd1 engages overlapping dinucleosomes, and collaborates with FACT to restore and remodel overlapping dinucleosomes. Patrick Cramer

23,519 Aufrufe • vor 1 Jahr

🔬 New from the Farnung Lab: We have established a fully in vitro reconstituted chromatin replication system and we report the first cryo-EM snapshots of the human replisome engaging nucleosomes. 🧬✨

🔬 New from the Farnung Lab: We have established a fully in vitro reconstituted chromatin replication system and we report the first cryo-EM snapshots of the human replisome engaging nucleosomes. 🧬✨

16,487 Aufrufe • vor 1 Jahr

Our story on the complete Rpd3S-nucleosome complex is now online on Biorxiv: We visualize the S. cerevisiae Rpd3S complex bound to a nucleosome including the "evasive" Ume1 subunit! Congrats, Jon Markert! Thank you Seychelle Vos for a great collaboration.

Our story on the complete Rpd3S-nucleosome complex is now online on Biorxiv: We visualize the S. cerevisiae Rpd3S complex bound to a nucleosome including the "evasive" Ume1 subunit! Congrats, Jon Markert! Thank you Seychelle Vos for a great collaboration.

11,761 Aufrufe • vor 3 Jahren

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