Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology • 38,173 subscribers
My posts are strictly personal, not reflective of positions or policies of Insilico Medicine, which disclaims any responsibility for my individual statements.
Videos
My friends, I would like to report a true breakthrough in my life and career - the nomination of our 31st developmental candidate that is very special. Novel Mechanism, Novel Target, Novel Oral Brain-penetrant Multi-parameter Optimized Molecule for... Pain. The target is undisclosed and carries the first letter of my family name - Target Z. This is also our AI Eureka! Moment - the combination of Luck, AI, and curious human experts. I will post the press release and my blog story behind this drug separately but for this special moment, I recorded the video for you. My goal is to solve aging. But if in the process we solve pain - this life was also worth living. The beauty of Target Z is that it is also implicated in aging (and no, it is not our brain-penetrant NLRP3).
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)60,640 views • 1 month ago
Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)49,660 views • 1 month ago
For the first time in human history, we are teaching a Foundation Model to master the diverse tasks of medicinal chemists, biologists, and computational scientists all in one place. In our latest collaboration with Liquid AI, we are moving away from fragmented, specialized tools toward a single, super-intelligent model. What surprised me most? This model isn't just performing at reasonable levels—it has started outperforming specialist models across physics-based tasks, imaging, and longitudinal data. Why this changes everything: -Synergy over Specialization: Fine-tuning on specific tasks has unlocked unexpected capabilities in synergetic areas, opening a new frontier in multimodal AI research. -Zero-Shot Potential: We are building a model that can perform out-of-scope tasks, moving us closer to an "AI deity" for drug discovery. -Quality First: The goal isn't just to bypass regulations to save time; it’s about using these synergies to develop better, more effective drugs. We are no longer just looking at linear regression or simple text; we are looking at the future of how humanity fights disease. #LiquidAI #InsilicoMedicine #GenerativeAI #DrugDiscovery #DeepTech #BiotechInnovation
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)10,544 views • 5 months ago
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