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Denis Wirtz

@deniswirtz • 46,877 subscribers

VP for Research @JohnsHopkins, T.H. Smoot Professor @HopkinsEngineer & @HopkinsMedicine, Co-founder @INBT_JHU, Lab: https://t.co/9OtmgB6InU Tweets are my own.

Shorts

3D single-cell maps of embryos reveal "universal" geometry of blood vessels and nerves. More here:

3D single-cell maps of embryos reveal "universal" geometry of blood vessels and nerves. More here:

35,656 views

$Mapping nerves in a whole embryos. We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry. More here:$

Mapping nerves in a whole embryos. We find that across species and development stages, embryonic nerves display (beautiful) fractal geometry. More here:

11,904 views

CODA + sequencing = 3D genomic mapping of tumors and tissues. We use CODA to map precursor lesions in large pancreatic tissues in 3D, laser capture samples from these lesions and sequence DNA. See more here: CODA:

CODA + sequencing = 3D genomic mapping of tumors and tissues. We use CODA to map precursor lesions in large pancreatic tissues in 3D, laser capture samples from these lesions and sequence DNA. See more here: CODA:

14,662 views

Videos

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Surprisingly (to me, at least), CODA 3D mapping shows that the density of cells in a pancreatic tumor is massively lower than in healthy tissues. Tumors are first and foremost WMDs: they destroy acini and ducts.

Surprisingly (to me, at least), CODA 3D mapping shows that the density of cells in a pancreatic tumor is massively lower than in healthy tissues. Tumors are first and foremost WMDs: they destroy acini and ducts.

38,559 views • 23 days ago

For those attending AACR26 in San Diego, I will demonstrate how CODA can map whole tumors, organs, and organisms in 3D and at single-cell resolution. I will also show how CODA can integrate spatial transcriptomics, spatial proteomics, IHC, IMC, etc. April 17, 3:30 pm

For those attending AACR26 in San Diego, I will demonstrate how CODA can map whole tumors, organs, and organisms in 3D and at single-cell resolution. I will also show how CODA can integrate spatial transcriptomics, spatial proteomics, IHC, IMC, etc. April 17, 3:30 pm

27,677 views • 1 month ago

We integrate H&E and IHC sections (CODA) to generate 3D immune maps of tumors and precancerous lesions in the human pancreas. CODA allows to map very large volumes of tumors at single-cell resolution. More here:

We integrate H&E and IHC sections (CODA) to generate 3D immune maps of tumors and precancerous lesions in the human pancreas. CODA allows to map very large volumes of tumors at single-cell resolution. More here:

27,739 views • 2 months ago

Still my favorite 3D reconstruction of a pancreatic tissue. Using the CODA workflow, we mapped a billion individual cells in 3D. Red: pre-cancer lesions Navy blue: ducts Light blue: islets of Langerhans Purple: acini Green: blood vessels More here:

Still my favorite 3D reconstruction of a pancreatic tissue. Using the CODA workflow, we mapped a billion individual cells in 3D. Red: pre-cancer lesions Navy blue: ducts Light blue: islets of Langerhans Purple: acini Green: blood vessels More here:

34,864 views • 6 months ago

CODA day! The CODA team at Johns Hopkins University maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here:

CODA day! The CODA team at Johns Hopkins University maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here:

74,260 views • 2 years ago

Watch this great video that Dr. Ashley Kiemen has made. It shows how we use AI to map individual immune cells in the vicinity of precancerous lesions of the human pancreas (PanINs). More here:

Watch this great video that Dr. Ashley Kiemen has made. It shows how we use AI to map individual immune cells in the vicinity of precancerous lesions of the human pancreas (PanINs). More here:

11,733 views • 2 months ago

Our new paper on 3D single-cell mapping of immune cells near pre-cancer lesions using CODA in a video. Watch until the end. More here:

Our new paper on 3D single-cell mapping of immune cells near pre-cancer lesions using CODA in a video. Watch until the end. More here:

34,162 views • 1 year ago

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