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Insilico Medicine

@InSilicoMeds • 15,757 subscribers

Insilico Medicine is a clinical-stage AI-driven biotech company dedicated to extending human productive longevity by transforming drug discovery with AI.

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Can a language model become SOTA in chemical synthesis? 🧪🔥 We put a 2.6B-parameter Liquid AI model into MMAI Gym. It now sets the state of the art in single-step retrosynthesis. 🚀 #insilicoSOTAFM

Can a language model become SOTA in chemical synthesis? 🧪🔥 We put a 2.6B-parameter Liquid AI model into MMAI Gym. It now sets the state of the art in single-step retrosynthesis. 🚀 #insilicoSOTAFM

39,706 Aufrufe

🚀 #O3DC is live: Stop scrolling 40 repos The Open #DrugDiscovery & Development Consortium just dropped its first shared resource: -115 benchmarks indexed across 10 categories and 15 consortia. -Live GitHub status checks + honest notes on the caveats papers usually hide. Open to academics, industry, and independents. Free to join. Link in the comments

🚀 #O3DC is live: Stop scrolling 40 repos The Open #DrugDiscovery & Development Consortium just dropped its first shared resource: -115 benchmarks indexed across 10 categories and 15 consortia. -Live GitHub status checks + honest notes on the caveats papers usually hide. Open to academics, industry, and independents. Free to join. Link in the comments

18,311 Aufrufe

It's out! A new Nature Biotechnology paper reveals how we used our #AI platform to find a promising target for fibrosis, TNIK, & designed a novel drug INS018_055, to treat the lung disease #IPF, bringing it all the way to PHII, w/ 300GB of data & a custom GPT.

It's out! A new Nature Biotechnology paper reveals how we used our #AI platform to find a promising target for fibrosis, TNIK, & designed a novel drug INS018_055, to treat the lung disease #IPF, bringing it all the way to PHII, w/ 300GB of data & a custom GPT.

31,904 Aufrufe

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🧬 Rentosertib just turned back biological age in people. ⏱️ 6 aging clocks. 6 independent groups. After 12 weeks, all 6 clocks read them 3 to 4 years younger. 🚀 The first AI-designed drug. The first clinical demonstration of 3–4 year biological age reversal. The first experiment is done. 🔬 Now run your own with Insilico’s SOTA models. #InsilicoSOTAFM

🧬 Rentosertib just turned back biological age in people. ⏱️ 6 aging clocks. 6 independent groups. After 12 weeks, all 6 clocks read them 3 to 4 years younger. 🚀 The first AI-designed drug. The first clinical demonstration of 3–4 year biological age reversal. The first experiment is done. 🔬 Now run your own with Insilico’s SOTA models. #InsilicoSOTAFM

Insilico Medicine

690,847 Aufrufe • vor 1 Monat

🧬 Introducing Longevity Vaccines. Building on experience from the Rentosertib program, Insilico’s new research initiative extends its strategy of tackling both disease and biological aging into preventive cell clearing. 🛡️ Combining AI and circular mRNA, the approach aims to equip the body’s own T cells to remove selected aging immune cells. 🎯 Advancing the science of longevity.

🧬 Introducing Longevity Vaccines. Building on experience from the Rentosertib program, Insilico’s new research initiative extends its strategy of tackling both disease and biological aging into preventive cell clearing. 🛡️ Combining AI and circular mRNA, the approach aims to equip the body’s own T cells to remove selected aging immune cells. 🎯 Advancing the science of longevity.

Insilico Medicine

72,986 Aufrufe • vor 1 Monat

🚀 5 new drug-discovery specialist LLMs. SOTA-level performance across 70+ benchmark tasks. Insilico Medicine has released a series of frontier Specialist Language Models for chemistry and biology, trained through MMAI Gym. They cover drug safety, potency prediction, chemical synthesis, and biology. 🧬 From general-purpose models to scientific specialists.

🚀 5 new drug-discovery specialist LLMs. SOTA-level performance across 70+ benchmark tasks. Insilico Medicine has released a series of frontier Specialist Language Models for chemistry and biology, trained through MMAI Gym. They cover drug safety, potency prediction, chemical synthesis, and biology. 🧬 From general-purpose models to scientific specialists.

Insilico Medicine

41,070 Aufrufe • vor 1 Monat

Can a language model become SOTA in chemical synthesis? 🧪🔥 We put a 2.6B-parameter Liquid AI model into MMAI Gym. It now sets the state of the art in single-step retrosynthesis. 🚀 #insilicoSOTAFM

Can a language model become SOTA in chemical synthesis? 🧪🔥 We put a 2.6B-parameter Liquid AI model into MMAI Gym. It now sets the state of the art in single-step retrosynthesis. 🚀 #insilicoSOTAFM

Insilico Medicine

39,706 Aufrufe • vor 1 Monat

📽️ Can NVIDIA help solve aging? That question became Rentosertib. Not starting from a disease. Starting from aging biology. PandaOmics identified TNIK as a target connecting aging and fibrosis. Generative chemistry designed the molecule. Target to preclinical candidate in 18 months. Phase 1, Phase 2A, now Phase 3. And this month, published in Nature Biotechnology, we asked a new question: is Rentosertib slowing aging itself? We applied six independently developed proteomic aging clocks to Phase 2A trial data. Six clocks from multiple independent groups, sharing neither features nor training data. All six agreed. Treated patients saw predicted biological age go down by up to six years. Placebo did not. This study is early and we say so plainly. But the template is clear. Find a target in aging biology. Purpose it toward a disease. Demonstrate it works. Then measure aging. Rentosertib cannot yet be called a proven human longevity drug. But it may mark the beginning of a new era. From treating diseases of aging to actively intervening in aging itself. We hope other companies and researchers repeat this template. 🧬 #Rentosertib #InSilicoMedicine #Longevity #AgingClock #NatureBiotechnology #IPF #TNIK

📽️ Can NVIDIA help solve aging? That question became Rentosertib. Not starting from a disease. Starting from aging biology. PandaOmics identified TNIK as a target connecting aging and fibrosis. Generative chemistry designed the molecule. Target to preclinical candidate in 18 months. Phase 1, Phase 2A, now Phase 3. And this month, published in Nature Biotechnology, we asked a new question: is Rentosertib slowing aging itself? We applied six independently developed proteomic aging clocks to Phase 2A trial data. Six clocks from multiple independent groups, sharing neither features nor training data. All six agreed. Treated patients saw predicted biological age go down by up to six years. Placebo did not. This study is early and we say so plainly. But the template is clear. Find a target in aging biology. Purpose it toward a disease. Demonstrate it works. Then measure aging. Rentosertib cannot yet be called a proven human longevity drug. But it may mark the beginning of a new era. From treating diseases of aging to actively intervening in aging itself. We hope other companies and researchers repeat this template. 🧬 #Rentosertib #InSilicoMedicine #Longevity #AgingClock #NatureBiotechnology #IPF #TNIK

Insilico Medicine

32,535 Aufrufe • vor 1 Monat

🧬 Rentosertib, the first AI-designed drug, is now in Phase 3 and inhibits TNIK TNIK is a kinase, a molecular switch inside the cell. The challenge with kinases is selectivity. Many of their binding pockets are remarkably similar, so a molecule designed for one kinase may also hit others. Today we’re releasing InsilicoMMAI-4B-Chem-Kinome, our 4B specialist language model with SOTA+ performance on 31 kinase targets. #insilicoSOTAFM

🧬 Rentosertib, the first AI-designed drug, is now in Phase 3 and inhibits TNIK TNIK is a kinase, a molecular switch inside the cell. The challenge with kinases is selectivity. Many of their binding pockets are remarkably similar, so a molecule designed for one kinase may also hit others. Today we’re releasing InsilicoMMAI-4B-Chem-Kinome, our 4B specialist language model with SOTA+ performance on 31 kinase targets. #insilicoSOTAFM

Insilico Medicine

23,888 Aufrufe • vor 1 Monat

Aging has a language. 🧬 We’re teaching AI to read it. On the cover of Cell: compact Longevity-LLMs, jointly trained by Insilico Medicine and Liquid AI, demonstrate SOTA performance on LongevityBench. Powered by these models, Longevity Claw nominated 328 candidate gene targets for aging research. Small model. Big questions. Open source. 🧵👇 #insilicoSOTAFM

Aging has a language. 🧬 We’re teaching AI to read it. On the cover of Cell: compact Longevity-LLMs, jointly trained by Insilico Medicine and Liquid AI, demonstrate SOTA performance on LongevityBench. Powered by these models, Longevity Claw nominated 328 candidate gene targets for aging research. Small model. Big questions. Open source. 🧵👇 #insilicoSOTAFM

Insilico Medicine

17,342 Aufrufe • vor 1 Monat

🧬 Rentosertib went from an AI-designed molecule to patients and recently showed shifts toward younger predicted biological age across 6 proteomic aging clocks. The first experiment is done. Now you can try our new SOTA+ drug discovery models yourself. InsilicoMMAI-Chem-ADMET achieves SOTA+ performance on 7 drug safety and metabolism prediction tasks. 🚀 It’s a 4B language model trained on 140K+ datapoints in our MMAI Gym for Science. #insilicoSOTAFM

🧬 Rentosertib went from an AI-designed molecule to patients and recently showed shifts toward younger predicted biological age across 6 proteomic aging clocks. The first experiment is done. Now you can try our new SOTA+ drug discovery models yourself. InsilicoMMAI-Chem-ADMET achieves SOTA+ performance on 7 drug safety and metabolism prediction tasks. 🚀 It’s a 4B language model trained on 140K+ datapoints in our MMAI Gym for Science. #insilicoSOTAFM

Insilico Medicine

18,699 Aufrufe • vor 1 Monat

🚀 #O3DC is live: Stop scrolling 40 repos The Open #DrugDiscovery & Development Consortium just dropped its first shared resource: -115 benchmarks indexed across 10 categories and 15 consortia. -Live GitHub status checks + honest notes on the caveats papers usually hide. Open to academics, industry, and independents. Free to join. Link in the comments

🚀 #O3DC is live: Stop scrolling 40 repos The Open #DrugDiscovery & Development Consortium just dropped its first shared resource: -115 benchmarks indexed across 10 categories and 15 consortia. -Live GitHub status checks + honest notes on the caveats papers usually hide. Open to academics, industry, and independents. Free to join. Link in the comments

Insilico Medicine

18,311 Aufrufe • vor 1 Monat

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