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Yuri Deigin

@ydeigin • 28,377 subscribers

Developing Alzheimer’s/CNS gene therapies: https://t.co/HPgKP0rez3 | Vitalist: https://t.co/GYtWNI2YqF | DRASTIC cofounder (COVID origins): https://t.co/jpRBlDSk5z

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🧬🔬 What exactly is this rejuvenation paradigm called “partial reprogramming” or “epigenetic rejuvenation” that has taken the longevity field by storm in the past few years with billion-dollar companies like Altos Labs dedicated to it, and visionary investors like Sam Altman, Brian Armstrong, Yuri Milner investing in it? This clip provides a quick overview of partial reprogramming, Yamanaka factors, the rejuvenation they produce during cellular reprogramming, and their potential connection to germline reset of aging — the active rejuvenation process triggered upon fertilization that enables new babies to be born young despite starting out as an egg cell of the same age as their mother.
4:04
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🧬🔬 What exactly is this rejuvenation paradigm called “partial reprogramming” or “epigenetic rejuvenation” that has taken the longevity field by storm in the past few years with billion-dollar companies like Altos Labs dedicated to it, and visionary investors like Sam Altman, Brian Armstrong, Yuri Milner investing in it? This clip provides a quick overview of partial reprogramming, Yamanaka factors, the rejuvenation they produce during cellular reprogramming, and their potential connection to germline reset of aging — the active rejuvenation process triggered upon fertilization that enables new babies to be born young despite starting out as an egg cell of the same age as their mother.

Yuri Deigin

88,315 views • 1 year ago

Interesting rapamycin observation from Greg Fahy — in mice, intermittent rapamycin cuts the thymus weight in half after a month:
2:24
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Interesting rapamycin observation from Greg Fahy — in mice, intermittent rapamycin cuts the thymus weight in half after a month:

Yuri Deigin

24,027 views • 1 year ago

The case for lab leak origin of COVID: this NotebookLM podcast summarizes my articles on WIV's 2018 hunt for SARS-like viruses (10-25% spike diff), their interest in ADE, the DEFUSE proposal to insert FCSes inspired by feline CoVs (SARS2's FCS same as in a feline CoV) and more!
14:27
ydeigin's profile picture

The case for lab leak origin of COVID: this NotebookLM podcast summarizes my articles on WIV's 2018 hunt for SARS-like viruses (10-25% spike diff), their interest in ADE, the DEFUSE proposal to insert FCSes inspired by feline CoVs (SARS2's FCS same as in a feline CoV) and more!

Yuri Deigin

29,563 views • 1 year ago

IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.
2:31
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IS AGING PROGRAMMED? I recently debated this with the brilliant Aubrey de Grey, moderated by Nathan S. Cheng thinks you should work on aging. at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.

Yuri Deigin

15,038 views • 1 year ago

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