Knowing that a visit to Sapporo isn’t complete without... sampling its world-famous seafood, Deputy Chief of Mission Aaron Snipe dropped by Oguma Shoten for an unforgettable “kaisendon” lunch that included Hokkaido’s spectacular scallops! 在札幌米国総領事館show more

Here's ya birthday present! The care package of the... year is dropping so don’t miss the Alliance and Fnatic booths in Sapporo! #LongLiveAlliance #ALWAYSFNATIC #ALGS札幌show more

本日の講演会にあわせて、 #大阪・関西万博 米国パビリオンのマスコット「#Spark（#スパーク）」が福岡市科学館に登場！ サプライズゲストの登場に、会場は笑顔に包まれました✨ #在福岡米国領事館 #福岡市科学館

📢北海道・札幌の水族館「AOAO SAPPORO」との コラボが決定したぞ！ 『出張ペンギン！札幌のまちと、水族館を満喫中』 開催期間：2026/4/28(火)～2026/6/30(火) 開催場所：AOAO SAPPORO #テイペンAOAOSAPPORO #テイペン... ステッカーとアクリルキーホルダーの販売や スタンプラリー、フォトスポットなど 期間限定企画が盛りだくさんだ。 さらに、札幌の街中の広告に俺たちが登場する予定だぞ。 ▼チケットはこちら▼ AOAO SAPPOROチケット窓口でも販売 住所：北海道札幌市中央区南２条西３丁目２０ moyuk SAPPORO 4階 営業時間：10:00〜22:00（最終入館 21:00） ※時期によって変更する場合があります ■お問い合わせ先 AOAO SAPPORO HPshow more

Barber dropped a masterclass, now off to the gym,... then grab some lunch & by by that time 6 of my pals will be coming to mine to watch the final #GOODEATSshow more

Canada helped found the G20 to tackle global challenges... — so an interconnected world economy can work for everyone. In a more dangerous, divided world, Canada is here to strengthen that mission for a new era of cooperation.show more

7/3(木) 18:30開演！ Zepp Sapporoで開催される 『八方不美人 サマーナイトカーニバル “ジーザス！”』 3/20(木・祝)先行発売開始です！ この機会をお見逃しなく！！... Zepp札幌 (Zepp Sapporo) STV 札幌テレビ広報show more

THE WORLD SALUTES ASIM MUNIR 🇵🇰 Bravery, Conviction, steadfastness... and Foresight that’s what embodies Field Marshal Asim Munir. World respects that, acknowledges that and displays that. An old dictum stipulates _“A man is known by the Company he keeps” and YES it’s the company of our Chief of Defence Forces that World leaders crave and want to keep.show more

The Prime Minister of Singapore posted an edit of... G-Dragon’s performance and the world leaders’ reactions on his Instagram 😭🇸🇬 Caption: “APEC isn’t all policy and trade talks. Korea put up a spectacular gala dinner for everyone, anchored by its APEC ambassador, K-pop star G-Dragon”show more

Farewell to 2025, the year Everton departed Goodison Park... for a dream stadium that enables them to be part of the world-famous Liverpool skyline by the banks of the Mersey 🌊show more

Some microbes carry a protein, called SNIPE, that "chops... up" phage DNA as it's being injected into the cell. This is a new mechanism for phage defense! CRISPR–Cas and restriction enzymes also evolved to fight against phages, but they work by recognizing sequences. SNIPE works, instead, by sensing "touch." SNIPE is a protein with about 500 amino acids. After it's made by the ribosome, it latches onto ManYZ, two proteins which sit on the cell's inner membrane. (ManYZ is an importer; it brings mannose and other sugars into the cell.) Once attached to ManYZ, SNIPE sits and waits for an invading phage. Some phages, including lambda, actually infect cells by pushing their DNA through this ManYZ channel. Lambda uses its "tail" to reach inside the protein channel, basically, and inject its DNA. When this physical touch happens, though, SNIPE is waiting. As soon as the phage DNA starts entering the cell, and passes through ManYZ and SNIPE, it gets immediately destroyed. This means that SNIPE is the first phage defense system discovered, so far, that uses spatial positioning at the injection site to destroy invaders. But there are caveats, of course. If you untether SNIPE from ManYZ, such that it can freely diffuse through the cell, it will chew up the bacterium's genome. It is not a highly discerning nuclease! Also, SNIPE is not found in most bacteria. A prior pangenome study, which sequenced lots of different microbes, found that roughly a third of well-studied bacterial lineages had at least one member with a SNIPE-like protein. (For this paper, they just ported one of those homologs into an E. coli laboratory strain.) And finally, because SNIPE's mechanism is tightly tied to ManYZ, it cannot be used to defend against phages that enter the cell through different routes. T4 phages, for example, inject their DNA straight through the cell membrane and into the cytoplasm, without interacting with ManYZ. This is a nice basic science paper. Applications TBD. (Just remember that scientists figured out that bacteria had a phage defense system, called CRISPR-Cas, many years before it was repurposed into a gene-editing tool.) P.S. The video below shows how cells with the SNIPE gene (middle row) kill invading phages, and thus continue growing and dividing. Empty vector (top row) refers to bacteria carrying a plasmid with no SNIPE gene; this is a control group. And SNIPE E414A refers to cells which received a mutated SNIPE gene, where the glutamate at position 414 has been changed to an alanine, thus destroying the protein's nuclease activity. These cells also die when they get infected with a phage.show more

Just a reminder that Tampa Bay was named The... BEST place to live in Florida by Forbes and TIME just included the City of Tampa in its list of Greatest Places in the World. 😎🌴 📸: clearwater_visuals (IG)show more

The Matrix isn’t a movie… it’s a manual. 🧠🔓... You’ve been playing the game Without knowing the rules. The world isn’t broken — It’s coded to test your awareness. 👁️✨show more

In a game that was only remembered for its... offense, an Aaron Donald strip sack on Patrick Mahomes has to be up there. It’s crazy how much Myles Garrett has us thinking about Aaron Donald.show more

洛杉磯中國領事館“習近平”治喪委員會正在抬著習近平出殯、中領事館靈堂內孝子賢孫哭的一塌糊塗。 #习近平 #洛杉矶中国领事馆 #共产党 #ENDCCP

鳥インフルエンザ対策明けで、久々に外放飼場に出た #タンチョウ。 羽を広げて飛んでいました。 #円山動物園 #動物園 #札幌 #札幌観光 #maruyamazoo #zoo #sapporo

CIRKA | Power, played quietly. A Somali MP elected... from Somaliland voices support for Hassan Sheikh’s unilateral constitutional push, declaring “the constitution will be finalized” before laughing and adding, “long live Somalia.” The laughter isn’t confusion or loyalty, it’s strategy. A knowing moment that can be read as quiet mockery of a state unraveling itself, an inside joke shared by a constituency that understands how to win by letting its opponents self-destruct. This isn’t naivety, nor betrayal. It’s political acumen: outmaneuvering rivals from within as Somalia dismantles itself in real time.show more

日中友好バカの愛知県大村知事はいつまでこんなの続けるんだろうね。 共催は中国総領事館ですよ。 大村知事は昨年も中国総領事にべったりくっついて案内してたよね。 文化交流という中国共産党の罠。

🐰 there’s that saying right? that a person is... drawn towards people who are similar to them... no but really, regardless of if they’re similar or the opposite, isn’t that a case-by-case thing for every person? 🐰 even if they’re the complete opposite of you, if you’re drawn to them you end up liking them anywaysshow more