Language models understand natural proteins. But can they generalize... beyond, to design completely new proteins from scratch? New preprint: A 🧵show more

🚨New paper! Generative models are often “miscalibrated”. We calibrate... diffusion models, LLMs, and more to meet desired distributional properties. E.g. we finetune protein models to better match the diversity of natural proteins.show more

We're excited to announce #AlphaFold 3 with Google DeepMind... in nature: our new AI model for predicting biomolecule structures with unprecedented breadth and accuracy. Expanding beyond proteins to tackle DNA, RNA, small molecules to fuel advances in biology & drug design 🧵show more

AI has two modes in drug discovery. Accelerate: moving... faster through the existing playbook. Unlock: opening frontiers that weren't possible before. Excited to announce Profluent is partnering with Eli Lilly, the global pharma powerhouse, to unlock breakthrough medicines for patients. It's a big deal beyond the numbers ($2.25B + royalties): we’ll get to use our frontier AI models and foundational datasets to design proteins focused on large gene insertion, a therapeutic moonshot. Proteins govern almost everything in biology. We've built a generalizable AI platform to design all proteins. Onward!show more

David Baker, the 2024 #NobelPrize laureate in chemistry, has... achieved the seemingly impossible feat of building entirely new kinds of proteins. In recent years, one incredible protein creation after the other has emerged from Baker’s laboratory. They range from new nanomaterials where up to 120 proteins spontaneously link together (see animation) to proteins that function as a type of molecular rotor. Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciencesshow more

What would it look like to see all ~13,000... proteins inside a single human cell at once? We share ProtiCelli — a generative model that makes this possible. Besides benchmarking, we demonstrate utility in many tasks. Preprint: A thread 🧵👇show more

2024 #NobelPrize laureate in chemistry David Baker has succeeded... with the almost impossible feat of building entirely new kinds of proteins. In recent years, one incredible protein creation after the other has emerged from Baker’s laboratory. They range from new nanomaterials where up to 120 proteins spontaneously link together… Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciences #NobelPrizeshow more

2024 #NobelPrize laureate in chemistry David Baker has succeeded... with the almost impossible feat of building entirely new kinds of proteins. In recent years, one incredible protein creation after the other has emerged from Baker’s laboratory. They range from new nanomaterials where up to 120 proteins spontaneously link together (see animation) to proteins that function as a type of molecular rotor. Who will be awarded the Nobel Prize in Chemistry this year? We will find out on 8 October. Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciencesshow more

Biggest medical discoveries of the week (🧵) #1 -... Evo: generative AI for biology From scratch, Evo could: Design a functioning CRISPR-Cas enzyme (top right figure) Predict gene essentiality at genome-wide scale (bottom left figure) Generate genome-length DNA sequences, encoding a diverse set of proteins (though not quite able to support life! - bottom right figure) Study:show more

Protein–ligand cofolding models are getting incredibly powerful… but do... they have to be so slow? 🧬🐢💊 Our new preprint introduces a new flow-map framework called DeCAF for fast few-step cofolding — up to 5× faster while preserving sample quality on the SOTA Pearl model and 20x faster than Boltz 1x. ⚡🧵 📜 Blog: 🔗arXiv: Code (coming soon):show more

A crab was seen feeding on dead skin from... a person’s foot. As natural scavengers, crabs will eat almost any organic matter they come across, including dead skin and tiny parasites. Human skin cells contain proteins and nutrients, so to a crab, dead skin can simply seem like an easy food source.show more

couldn't resist to try creating a new UI design completely🫠

Next Ghostty Tahoe PR, adding icons to menu items... as recommended by the new design guidelines. A small detail, but all the small things to help Ghostty feel right at home in the new design language when we get there.show more

🌍 Physical AI, Large Geospatial Models, and OVRMaps LLMs... understand language. But the next evolution of AI is about machines that can move, see, and operate in the physical world. This is Physical AI, and it’s already happening. 🧵👇🏼show more

How can agents understand the world from diverse language?... 🌎 Excited to introduce Dynalang, an agent that learns to understand language by 𝙢𝙖𝙠𝙞𝙣𝙜 𝙥𝙧𝙚𝙙𝙞𝙘𝙩𝙞𝙤𝙣𝙨 𝙖𝙗𝙤𝙪𝙩 𝙩𝙝𝙚 𝙛𝙪𝙩𝙪𝙧𝙚 with a multimodal world model!show more

Today Unstoppable Domains is unveiling a domainer's new best... friend. A powerful new way to search, buy, and manage domains - using natural language and our ChatGPT plugin. You can use the tool to build & deploy custom landers with your voice:show more

if you’re confused about how large language models work... this new animation from google deepmind should clear a lot of things upshow more

📐Design Systems and DESIGN.md Consistency using Design Systems and... DESIGN.md: ✨ Every new design automatically starts with a cohesive design system which GREATLY improves consistency (we heard you!) ✨ Edit the system, and all associated screens can be easily updated ✨ You can extract a design system from any URL ✨ Use DESIGN.md to export your design rules or import your design rules from other products (just ask your agent to create you a DESIGN.md file from your code or other context) ✨ You can start a new design by choosing from popular design systems ✨ Read more about DESIGN.md in the docs (link in thread)show more

A crab was seen feeding on dead skin from... a person’s foot. Crabs will eat almost any organic matter they come across, including dead skin and tiny parasites. Human skin cells contain proteins and nutrients, so to a crab, dead skin can simply seem like an easy food source.show more

Spotify reveal an all new user experience. The new... reimagined interface leverages new visuals, and a completely new and interactive design — all to drive deeper and long-lasting connections between creator and listeners. #SpotifyStreamOnshow more

New case study just dropped. We built a microsite... (3-pages) for a $41.6M Series B AI startup, from scratch in 30 days. Scope: • Copywriting • Design • Development (Webflow) Link below👇🏻show more