Reconstruction of a larval zebrafish brain using 2,000 individually... labeled neurons. Credit to Michael Kunst. #ZebrafishZundayshow more

Imaging the endocardium of the heart in a two-day-old... zebrafish embryo. Credit to Dr Anjalie Schlaeppi. #ZebrafishZundayshow more

Immune cell response to spinal cord injury in a... zebrafish larva. Credit to Becker Lab CRTDresden 😷. #ZebrafishZundayshow more

Tracking cardiac physiology with deep learning. Credit to Chung-Der... Hsiao. #ZebrafishZundayshow more

Happy Valentine! Check out Current Biology & find out... how sensory neurons taste bacterial metabolites in the CSF & secrete compounds to enhance host survival during brain infections. 8 years of work & paper I am the most proud of. Cheers to Yale Zebrafish Phenotyping Core!show more

A time-lapse showing neurons growing and forming new connections... as the brain learnsshow more

How neurons release neurotransmitters. Credit: Rex Twedt #neuroscience #MedTwitter

You’re looking at neurons growing and connecting in real... time 🧠. A 65-hour recording of hippocampal activity in a rat brain. The hippocampus plays a crucial role in memory and learning. In this footage, neurons extend their dendrites and axons, building and reshaping connections across days. Capturing this process live offers a rare view into how neural circuits form and reorganize. Why this matters ⬇️ 1️⃣It’s a continuous, multi-day recording of living hippocampal neurons under the microscope 2️⃣You can clearly see dendritic branching and network formation 3️⃣It reveals the dynamic processes that drive brain development and plasticity Observing growth at this resolution helps researchers understand how neurons connect—and how disruptions in these processes might contribute to neurological or psychiatric conditions. Credit to Louis Romet and Dr. Christophe Leterrier for the videoshow more

Learn how to combine a deep learning model for... pose estimation to perform a 3D reconstruction using two cameras 📸show more

Researchers grew rat neurons on a force sensor, which... allowed them to discover that neurons develop tension after forming connections with other neurons, resulting in a contractile neural network. Without this contractility, neurons fail to fire. In PNAS:show more

Michael Jackson's wink in the post credit scene of... Moonwalker does something to meshow more

E11 Bio is excited to unveil PRISM technology for... mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵show more

A microscopic view of neurons forming new connections

this is actually how your brain looks like when... you learn a new thing. every time you struggle to learn something new or work on a new skill, your neurons form strong links and weaken the ones you no longer use. so that mental pain of learning, is actually reshaping your brain.show more

Bro is using 200% of his brain 🧠

🔥🚨BREAKING: A petri dish filled with human brain cells... just learned to how to play DOOM Scientists at Cortical Labs have successfully trained a cluster of approximately 200,000 living human neurons, grown on a microelectrode array chip, to play the classic 3D video game DOOM.show more

using all of my brain power to port it... to vrc. couldn't get it 1 to 1 thoshow more

Facial reconstruction of a 2,000-year-old Maeotian man from Myskhako,... in the Northwest Caucasus. The Maeotians were direct ancestors of the modern Circassian people. They maintained close contacts with the Sauromatians, Sarmatians, and Bosporans.show more

For most of neuroscience history (until the late 1980s/early... 1990s), neurons were treated as the brain’s only decision-makers. That idea is changing. Astrocytes, once considered passive support cells, are now recognized as global regulators of brain state. They don’t encode individual thoughts or actions. Instead, they integrate activity across huge numbers of synapses and adjust how neural networks behave over time. By releasing modulatory signals and tracking slow changes in activity, astrocytes influence: -Alertness vs. fatigue -Stress vs. calm -Motivation vs. disengagement Importantly, they can shift brain function without rewiring neurons, by tuning the environment neurons operate in. The brain isn’t just wired. It’s regulated, and astrocytes play a central role in that regulation.show more