#keto
🚀Did your #LDL cholesterol sky-rocket on #keto? 🧈Were you told it' was because of Saturated Fat? 🚨NEW META OF 41 RCTs just busted that MYTH! 3 Main findings 👉 In studies with 'lean' BMI ( 35), LDL-C ⬇️ 💥BOOM, there's a money shot!💥 👉 Inverse association between BMI and LDL-C 👉 BMI dominates over saturated fat, which has comparatively minimal impact; thus, it's more likely having 6-pack abs is a severe risk factor for high LDL-C on #keto, not butter, beef, bacon or cream 🔗PAPER LINK 🔗 - (To share the data love, copy this link to a Quote tweet or original Tweet with your reaction. Please engage!) FULL Video Abstract (7 min): Major props to first-author Adrian Soto-Mota and senior Dr. David Ludwig. These man are humble & kind geniuses that I'm privileged to know and learn under And +100 pts for the #LEM ⚡️ Dave Feldman Of interest to More Plates More Dates Peter Attia @PlantChompers and Walter Willett (if he had a Twitter) Simon Hill MSc, BSc Thomas Dayspring William Cromwell, MD LipoFan Andrew D. Huberman, Ph.D. Dominic D'Agostino Layne Norton, PhD Metabolic Health Summit
Nick Norwitz MD PhD269,263 views • 2 years ago
Few topics are as misunderstood as LDL cholesterol. This new study highlights the fact that LDL cholesterol is a good predictor of longevity. Specifically, people with higher LDL levels tend to die less often. #cholesterol #hearthealth #asthma #lowcarb #keto #immunity #inflammation
Benjamin Bikman106,313 views • 2 years ago
You know I like to ask provocative questions 🧐… Could a NEW 💊 DRUG for Fatty Liver impact LDL cholesterol in lean metabolically healthy people on a #keto diet? If so… HOW and what could we learn!? 👉 New exciting data in NEJM on a phase III trial for a thyroid receptor beta liver-targeting drug shows impressive results for reversing fatty liver In association, there are decreases in LDL-C, along with ApoB, ApoCIII, and even Lp(a) But what happens were we to put this same drug in a VERY different metabolic context? 🔨Would said drug hammer LDL-C in #LMHR into the floor simply because their LDL levels have so far to drop? OR could the opposite happen? ⚡️Could ramping up liver metabolism increase, rather than decrease, LDL-C in LMHR. I don’t know! But point being: CONTEXT, CONTEXT, CONTEXT. Just like OREO Cookie lowered LDL-C in #LMHR, when you change the metabolic context, sometimes you get surprising results And, it’s fair game to speculate (EMPHASIS: I AM SPECULATING) and pose bold ideas, provided we are CLEAR we can’t truly know the answers until we test. For more, see video: I, for one, think the NEJM data are promising for the indicated use case, and humbly share where my scientific mind ‘wanders’ when presented with these data, framed by my own field and interests NEJM paper: P.S. I know people are going to go "off" suggesting I'm recommending X, Y or Z or saying something about "dangers" of high LDL in #LMHR. I'm not. I'm just open-mindedly and transparently providing a provocative thought puzzle... if your emotions are stimulated, I did my job I suppose... if you let them get the better of you... that's on you 😜 cc Dave Feldman Adrian Soto-Mota (my #LEM bros!) William Cromwell, MD LipoFan Simon Hill MSc, BSc Matthew A. Nehs Dominic D'Agostino STEM-Talk
Nick Norwitz MD PhD29,261 views • 2 years ago
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