#lungcancer

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The OncoAlert WEEKLY RoundUp 🚨 Covering the TOP of the week Sept 26-Oct 2, 2025 REGISTER at OR Discussing: 🫁 #LungCancer/ Immunotherapy ✅Dual CTLA-4 + PD-L1/PD-1 Blockade Shows No OS Advantage Overall but Boosts Outcomes in PD-L1–Low & STK11-Mutant NSCLC ✅Neoadjuvant/Perioperative Immunotherapy Outperforms Adjuvant in Resectable NSCLC, Even in PD-L1–Negative and Squamous Tumors 🩺 #BreastCancer ✅Trastuzumab Deruxtecan Outperforms T-DM1 in High-Risk HER2+ Early Breast Cancer (DESTINY-Breast05) NEWS FROM INDUSTRY ✅Adjuvant Ribociclib + Aromatase Inhibitor Maintains 4-Year iDFS Benefit in HR+/HER2– Early Breast Cancer (NATALEE Trial) ✅Sacituzumab Govitecan: Effective for Advanced TNBC & HR+/HER2– Breast Cancer With Practical AE Management Strategies ✅Higher BMI Amplifies Postmenopausal Breast Cancer Risk—Especially in Women With Cardiovascular Disease GI / #GastricCancer ✅Early-Onset Transient Gastritis Common With First-Line Zolbetuximab in CLDN18.2+ Gastric Cancer ✅CLDN18.2 Expression in Gastric Cancer Is Dynamic During Chemoimmunotherapy, Linked to Immune-Inflamed Stroma and Outcomes 🧬 GU / #ProstateCancer ✅Prostate Cancer Germline Testing: Phone or Physician Counseling Boosts Satisfaction; Asian American Men Report Lower Satisfaction (PROGRESS Registry) 🧠 Mental Health / Survivorship ✅Cancer Survivors Use Antidepressants and Anxiolytics More Than Noncancer Peers—With Persistent Racial and Insurance Disparities 🧠 Gyn / #EndometrialCancer ✅“Aggressive” Histology Predicts Prognosis in Surgically Staged, Clinically Uterine-Confined Endometrial Carcinoma Alessandro Di Federico Andrea De Giglio, MD PhD Stephen V Liu, MD Bartomeu Massuti Ke Xin Erika Hamilton, MD, FASCO Stephanie A. Haddad, DO Alexis LeVee, MD Armando Orlandi Jame Abraham, MD, FACP JAMA Oncology Dr Rishabh Jain Sergio Cifuentes Angel Lopez-Galindo, MD, MHA Elvina Almuradova ACS Journal Cancer CA: A Cancer Journal for Clinicians Heinz Freisling IARC Joel "Heart Prevention" Kahn MD, FACC Nieves Martinez Lago MD PhD Kohei shitara Faisal Scientist JAMA Network Open Dr Joseph McCollom DO Duke TORCHE Mario M. Leitao, Jr Christian Dagher Ziyi Matteo Lambertini, MD PhD Icro Meattini Hope Rugo

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The OncoAlert🚨Weekly Round Up is BACK Covering the TOP of the week March 20-27 REGISTER at OR Discussing ✅Averted #LungCancer 🫁 deaths due to reductions in cigarette smoking🚬 in the United States🇺🇸 1970–2022 ✅Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational 🧬Profiles ✅Expanding the potential of antibody–drug conjugates in💊 gastrointestinal malignancies: beyond HER2 targets ✅Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in #ProstateCancer detection (TRANSLATE) ✅Safety of Accelerated Infusion of Nivolumab and Pembrolizumab ✅PTEN inactivating mutations are associated with hormone receptor loss during #BreastCancer recurrence ✅Potential candidates for adjuvant olaparib treatment in operable breast cancer patients with germline BRCA1/2 pathogenic variants after neoadjuvant chemotherapy Matteo Lambertini, MD PhD Julia Maués Yüksel Ürün silke gillessen Ben Westphalen Allison Rosen, MS Sharlene Gill, MD, MPH, MBA, FASCO Enrique Grande American Cancer Society CA: A Cancer Journal for Clinicians Ahmedin Jemal Nigar Nargis Gonzalo Fernández Hinojal Jun Gong Manju George MVSc PhD Rectal Cancer Survivor Arndt Vogel Marcelo Wroclawski Caio Suartz Adam B. Weiner, MD Dr Akhil Santhosh #OncoAlertAF Dra. María Natalia Gandur Quiroga Alizée Camps - - Maléa Biagio Ricciuti, MD PhD Emre Yekedüz Hidehito HORINOUCHI Fadi Haddad, MD Dr. Iván R. González Al-Ola A Abdallah MD (USMIRC) Jose Fernando Moura, PhD Elisa Agostinetto Elisabetta Bonzano MD, PhD Bárbara Melão, MD, PhD Dr Joseph McCollom DO Erman Akkus Luca Arecco, MD Gaia Griguolo Kristina Jankovic, MD

OncoAlert

19,455 views • 1 year ago