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(1/3) insitro is excited to share our paper “EmbedGEM: A Framework to Evaluate the Utility of Embeddings for Genetic Discovery,” focusing on assessing the use of ML-derived embeddings for genetic discovery using heritability & relevance to specific diseases.

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insitro

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18,421 просмотров • 2 лет назад •via X (Twitter)

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🚨Why Greek DNA remained unchanged according to genetic science.🇬🇷 (Complete post with sources) 🔴Why Roman occupation introduced only minimal changes to Greek heritage. 🔴How Byzantine policies and resettlements helped sustain Greek identity. 🔴Why Ottoman influence left only a light genetic footprint. 🔴A rare and impressive genetic mutation found in Crete. 1. 🧬 Genetic Studies by Iosif Lazaridis Genetic Continuity to Modern Greeks The 2017 study led by Dr. Iosif Lazaridis analyzed ancient DNA from Minoan and Mycenaean remains. Findings revealed that both civilizations derived 62–86% of their ancestry from Neolithic Anatolian farmers. Additionally, 9–17% of their genetic makeup traced back to populations from the Caucasus or Iran. Notably, Mycenaeans possessed 4–16% ancestry from northern Eurasian steppe populations, a component absent in Minoans. Further research confirmed that modern Greeks share approximately 70–80% of their DNA with Mycenaeans, underscoring a strong genetic continuity from the Bronze Age to present-day populations. While subsequent historical periods introduced additional genetic influences, the primary genetic signature remains rooted in Mycenaean ancestry. A comprehensive genome-wide study of 102 ancient individuals from Crete, mainland Greece, and the Aegean Islands revealed high levels of endogamy (marriage within close kin) during the Bronze Age. This practice, unprecedented in the global ancient DNA record, suggests tightly knit communities with limited external gene flow. Source : 1. Genetic origins of the Minoans and Mycenaeans 🚨More sources according to the video : 2. Ancient DNA reveals admixture history and endogamy in the prehistoric Aegean 3. A genetic probe into the ancient and medieval history of Southern Europe and West Asia 4. Genetics of the peloponnesean populations and the theory of extinction of the medieval peloponnesean Greeks 5. The Greeks in the West: genetic signatures of the Hellenic colonisation in southern Italy and Sicily 6. A Genetic History of the Near East from an aDNA Time Course Sampling Eight Points in the Past 4,000 Years 7. The R19X mutation in the APOC3 gene has been identified in a specific population in Crete, Greece, particularly among residents of the mountainous villages of Anogia and the surrounding Mylopotamos area. This variant is associated with favorable lipid profiles, including lower triglyceride levels and higher high-density lipoprotein (HDL) cholesterol levels, which are protective against cardiovascular disease. In the general European population, the R19X variant is extremely rare, with a frequency of less than 0.05%. However, in the Cretan MANOLIS cohort, the frequency is significantly higher, around 1.9% to 4%, depending on the study. This elevated prevalence is likely due to genetic drift and the relative isolation of the population. The discovery of the R19X variant in this Cretan population underscores the value of studying isolated populations to identify rare genetic variants with significant health implications. Such findings can inform the development of targeted therapies and enhance our understanding of genetic factors contributing to disease resistance. 🚨Video belongs to Youtube Channel : "The History Hub" !!! Support his work.

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