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2025 CHECKPOINT

NOTE

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111,704 次观看 • 8 个月前 •via X (Twitter)

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The IDF blew up the home of Ahmed and Muhammad Dragama in the city of Tubas last night. Ahmed Dragama a senior member of Islamic Jihad. Muhammad Dragama carried out the deadly shooting attack at the Taysir checkpoint on February 4, 2025.

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The IDF blew up the home of Ahmed and Muhammad Dragama in the city of Tubas last night. Ahmed Dragama a senior member of Islamic Jihad. Muhammad Dragama carried out the deadly shooting attack at the Taysir checkpoint on February 4, 2025.

Eli Afriat 🇮🇱🎗

13,196 次观看 • 1 年前

🇵🇱‼️Poland has reopened its border with Belarus Traffic has resumed. A stream of cars heading towards Poland has already been recorded at the Brest checkpoint. ⏯️The border was closed for almost two weeks. The Polish authorities made this decision due to the large-scale military exercises “West-2025.”

🇵🇱‼️Poland has reopened its border with Belarus Traffic has resumed. A stream of cars heading towards Poland has already been recorded at the Brest checkpoint. ⏯️The border was closed for almost two weeks. The Polish authorities made this decision due to the large-scale military exercises “West-2025.”

NEXTA

243,939 次观看 • 11 个月前

ETHEREUM JUST CLEARED $2,200. FIRST CHECKPOINT ON THE ROAD TO $10,000. Called it weeks ago. Price is at $2,244, up 50% from the $1,500 floor that held in 2024 and 2025. Three levels left: $4,000, $5,100, $10,000. Each has to break before the one above matters. I hope you didn't wait for $1,200 ETH.

ETHEREUM JUST CLEARED $2,200. FIRST CHECKPOINT ON THE ROAD TO $10,000. Called it weeks ago. Price is at $2,244, up 50% from the $1,500 floor that held in 2024 and 2025. Three levels left: $4,000, $5,100, $10,000. Each has to break before the one above matters. I hope you didn't wait for $1,200 ETH.

Merlijn The Trader

61,201 次观看 • 16 天前

Harrison narrates how police officers on a Hummer bus arrested a young man on 18th September 2025 at a checkpoint they set up at Nsugbe, Anambra State. They tagged him a cr!m!nal and said they wanted to do an investigation. The young man begged them to let him go at the station, but they later took him to Enugu State and forcefully extorted $10,000 USDT= ₦15,000,000 million from his wallet💔😳

Harrison narrates how police officers on a Hummer bus arrested a young man on 18th September 2025 at a checkpoint they set up at Nsugbe, Anambra State. They tagged him a cr!m!nal and said they wanted to do an investigation. The young man begged them to let him go at the station, but they later took him to Enugu State and forcefully extorted $10,000 USDT= ₦15,000,000 million from his wallet💔😳

CHUKS 🍥

143,452 次观看 • 11 个月前

Good to see that the story of 5 Traders and a female friend killed by Policemen at a checkpoint in Abuja in 2025 is finally out as a movie. On June 7 and 8, 2005, five young Igbo traders and one female friend were extrajudicially killed by police in Abuja, an event famously known as the "Apo Six" murders. A very tragic incident that still speaks of the atrocities of the rogue Nigeria police up till this day! Coming up in June! Produces by Linda Ikeji!

Good to see that the story of 5 Traders and a female friend killed by Policemen at a checkpoint in Abuja in 2025 is finally out as a movie. On June 7 and 8, 2005, five young Igbo traders and one female friend were extrajudicially killed by police in Abuja, an event famously known as the "Apo Six" murders. A very tragic incident that still speaks of the atrocities of the rogue Nigeria police up till this day! Coming up in June! Produces by Linda Ikeji!

Chude

34,372 次观看 • 4 个月前

NSCDC is trending because according to Nigeria Stories they’ve arrested a young man known as Abbas for dressing in full hijab as a woman to visit his girlfriend in Yobe. Sadly, as good as the story is, it is fake from Facebook. It happened in Liberia in 2025, when he was caught trying to evade Liberia’s drug enforcement agency dressed as a woman with padded bra, he refused searching at a checkpoint so they arrested him. His name is definitely not Abass Kamaludeen, and NSCDC Yobe has no records of such situation. Follow Trending Explained for dailies..

NSCDC is trending because according to Nigeria Stories they’ve arrested a young man known as Abbas for dressing in full hijab as a woman to visit his girlfriend in Yobe. Sadly, as good as the story is, it is fake from Facebook. It happened in Liberia in 2025, when he was caught trying to evade Liberia’s drug enforcement agency dressed as a woman with padded bra, he refused searching at a checkpoint so they arrested him. His name is definitely not Abass Kamaludeen, and NSCDC Yobe has no records of such situation. Follow Trending Explained for dailies..

Trending Explained

13,512 次观看 • 5 个月前

Dragging his body on a wheelchair across scorched earth, Ibrahim Abdul Dayem, a double amputee, reaches the al-Sudaniyya area where flour trucks trickle in through the Israeli occupation-controlled Zikim checkpoint. “Flour with blood,” he says. “If I don’t get food today, I’ll die of starvation.” Since March 2nd, 2025, the Israeli occupation's total blockade on Gaza has pushed the US-Israeli engineered famine to catastrophic levels. Only a handful of aid trucks are allowed through, too few to meet desperate needs, and each one comes at the cost of blood. For Ibrahim and hundreds of thousands like him, survival now means risking death just to feed their families. Contact Ibrahim: +972598869925 , Ibrahim Abdul Dayem Source: amer_elsultan (IG)

Dragging his body on a wheelchair across scorched earth, Ibrahim Abdul Dayem, a double amputee, reaches the al-Sudaniyya area where flour trucks trickle in through the Israeli occupation-controlled Zikim checkpoint. “Flour with blood,” he says. “If I don’t get food today, I’ll die of starvation.” Since March 2nd, 2025, the Israeli occupation's total blockade on Gaza has pushed the US-Israeli engineered famine to catastrophic levels. Only a handful of aid trucks are allowed through, too few to meet desperate needs, and each one comes at the cost of blood. For Ibrahim and hundreds of thousands like him, survival now means risking death just to feed their families. Contact Ibrahim: +972598869925 , Ibrahim Abdul Dayem Source: amer_elsultan (IG)

Translating Falasteen (Palestine)

51,814 次观看 • 1 年前

A Chief Minister Appointed by the Gun Sarfaraz Bugti was never elected by the Baloch people, he was installed to serve the interests of the Pakistani military. Not a representative, but an enforcer. A civilian face for a regime that has spent decades disappearing students, silencing poets, and turning mothers into protestors holding photographs of the disappeared. Disappearances: The Machinery of Fear In 2025 alone yet, over 117 Baloch civilians, including students and minors, were forcibly disappeared. More than Thirty-three were killed in extrajudicial operations. These aren’t “anti-terror” raids, they’re state terror against the Baloch. Bugti, as interior minister and now chief minister, has overseen and justified this campaign of violence. His talk of “security” masks a brutal war against an occupied people. Mahrang Baloch: A Voice They Fear In April 2025, the state abducted Dr. Mahrang Baloch during a peaceful protest. Her crime? Demanding answers for the missing. Bugti’s silence was damning, support for her arrest and complicity in plain sight. “Development” for the Military, Displacement for the Baloch Under Bugti, projects like CPEC and Reko Diq are pushed as progress, but for whom? The military and foreign corporations profit, while Baloch communities remain without clean water, electricity, or schools. Our minerals fund the boots that trample us. Occupation Disguised as Integration Balochistan is not neglected, it is deliberately kept underdeveloped. Every checkpoint and military raid signals one message: the Baloch are not allowed to live with dignity. Baloch child is seen as a threat. #BalochistanUnderMilitartControl

A Chief Minister Appointed by the Gun Sarfaraz Bugti was never elected by the Baloch people, he was installed to serve the interests of the Pakistani military. Not a representative, but an enforcer. A civilian face for a regime that has spent decades disappearing students, silencing poets, and turning mothers into protestors holding photographs of the disappeared. Disappearances: The Machinery of Fear In 2025 alone yet, over 117 Baloch civilians, including students and minors, were forcibly disappeared. More than Thirty-three were killed in extrajudicial operations. These aren’t “anti-terror” raids, they’re state terror against the Baloch. Bugti, as interior minister and now chief minister, has overseen and justified this campaign of violence. His talk of “security” masks a brutal war against an occupied people. Mahrang Baloch: A Voice They Fear In April 2025, the state abducted Dr. Mahrang Baloch during a peaceful protest. Her crime? Demanding answers for the missing. Bugti’s silence was damning, support for her arrest and complicity in plain sight. “Development” for the Military, Displacement for the Baloch Under Bugti, projects like CPEC and Reko Diq are pushed as progress, but for whom? The military and foreign corporations profit, while Baloch communities remain without clean water, electricity, or schools. Our minerals fund the boots that trample us. Occupation Disguised as Integration Balochistan is not neglected, it is deliberately kept underdeveloped. Every checkpoint and military raid signals one message: the Baloch are not allowed to live with dignity. Baloch child is seen as a threat. #BalochistanUnderMilitartControl

Dur Bibi

37,073 次观看 • 1 年前

Prince Harry and Meghan Markle visited Palestinian medical evacuees in Jordan on February 25, 2026, as thousands of critically ill children remain trapped in Gaza’s shattered health system. According to the World Health Organization, approximately 4,000 children are currently on urgent medical evacuation waitlists. They are part of more than 18,500 patients overall who need specialized care for war-related trauma, cancer, kidney failure, and other chronic conditions. Since the ceasefire, WHO has facilitated the evacuation of just over 740 patients, including 432 children, as of Monday. Aid agencies warn that at current rates, it could take more than four years to clear the backlog. The scale of injury is staggering. At least 44,500 children have been reported injured since October 2023, including more than 11,000 with life-changing injuries requiring long-term rehabilitation. The UK announced a publicly funded evacuation mission in July 2025 and Prime Minister Keir Starmer said severely ill children from Gaza would receive treatment in NHS hospitals. The first group of 51 children arrived in September 2025 and the government has indicated a maximum of 300 may be admitted. But evacuations remain slow. A UN spokesperson said the holdup is largely bureaucratic, citing limited checkpoint/crossing access and the need for more countries to accept patients. “Egypt and other countries in the region, I know Jordan and others have taken people in, but we need more Member States to take in more people. WHO continues to call for rebuilding Gaza’s health system, reopening medical referrals to the West Bank, including East Jerusalem, expanding acceptance of patients abroad, and ensuring children can return home after treatment. Video includes a question from Gabriel Elizondo.

Prince Harry and Meghan Markle visited Palestinian medical evacuees in Jordan on February 25, 2026, as thousands of critically ill children remain trapped in Gaza’s shattered health system. According to the World Health Organization, approximately 4,000 children are currently on urgent medical evacuation waitlists. They are part of more than 18,500 patients overall who need specialized care for war-related trauma, cancer, kidney failure, and other chronic conditions. Since the ceasefire, WHO has facilitated the evacuation of just over 740 patients, including 432 children, as of Monday. Aid agencies warn that at current rates, it could take more than four years to clear the backlog. The scale of injury is staggering. At least 44,500 children have been reported injured since October 2023, including more than 11,000 with life-changing injuries requiring long-term rehabilitation. The UK announced a publicly funded evacuation mission in July 2025 and Prime Minister Keir Starmer said severely ill children from Gaza would receive treatment in NHS hospitals. The first group of 51 children arrived in September 2025 and the government has indicated a maximum of 300 may be admitted. But evacuations remain slow. A UN spokesperson said the holdup is largely bureaucratic, citing limited checkpoint/crossing access and the need for more countries to accept patients. “Egypt and other countries in the region, I know Jordan and others have taken people in, but we need more Member States to take in more people. WHO continues to call for rebuilding Gaza’s health system, reopening medical referrals to the West Bank, including East Jerusalem, expanding acceptance of patients abroad, and ensuring children can return home after treatment. Video includes a question from Gabriel Elizondo.

Drop Site

20,847 次观看 • 6 个月前

A video filmed by the Israel Police shows the arrest of about 60 Palestinian laborers who were found crammed in inhumane conditions inside a garbage truck, at a checkpoint on Route 5 in the West Bank. The West Bank is in the throes of a dire economic crisis. Unemployment stands at 28.5%, partly due to the blanket cancellation of tens of thousands of Israeli work permits for West Bank Palestinians since October 2023. This harm is exacerbated by severe movement restrictions imposed by the military on Palestinians and the takeover of agricultural lands by settler militias and army forces. Given these circumstances, many Palestinians try to enter Israel to seek work even without permits, using various methods entailing significant risk to their lives, health, and freedom. Some attempt to cross the Separation Barrier on foot, while others try to get through checkpoints crammed inside trucks. According to PGFTU, 18 Palestinians were killed in 2025 while trying to cross the Separation Barrier in search of work. Some were shot dead by Israeli forces and others were killed while being chased. The Israeli apartheid regime’s treatment of Palestinians as cheap labor when useful and as people who can be driven into severe economic hardship at other times, reflects the deep-seated dehumanization of Palestinians among Israelis.

A video filmed by the Israel Police shows the arrest of about 60 Palestinian laborers who were found crammed in inhumane conditions inside a garbage truck, at a checkpoint on Route 5 in the West Bank. The West Bank is in the throes of a dire economic crisis. Unemployment stands at 28.5%, partly due to the blanket cancellation of tens of thousands of Israeli work permits for West Bank Palestinians since October 2023. This harm is exacerbated by severe movement restrictions imposed by the military on Palestinians and the takeover of agricultural lands by settler militias and army forces. Given these circumstances, many Palestinians try to enter Israel to seek work even without permits, using various methods entailing significant risk to their lives, health, and freedom. Some attempt to cross the Separation Barrier on foot, while others try to get through checkpoints crammed inside trucks. According to PGFTU, 18 Palestinians were killed in 2025 while trying to cross the Separation Barrier in search of work. Some were shot dead by Israeli forces and others were killed while being chased. The Israeli apartheid regime’s treatment of Palestinians as cheap labor when useful and as people who can be driven into severe economic hardship at other times, reflects the deep-seated dehumanization of Palestinians among Israelis.

B'Tselem בצלם بتسيلم

51,674 次观看 • 4 个月前

BREAKING NEWS !! 22.15 local time ! In a very unusual action, not seen before , Hungary has moved TANKS & Heavy ARMOUR up to the Ukrainian Border ! Tanks Have been taken off their Transportation units & Driving through several towns on UKRAINE border on main road routes! Is ORBAN preparing to take over the Hungarian Region inside UKRAINE when peace talks fail & Russia goes full BAGRATION to KIEV ? Hungarian towns located on or near main roads leading to the Ukraine border, where Hungarian ARMOUR has been seen massing 1. **Záhony** - Situated on the M3 motorway and near the Chop-Záhony border crossing, a major entry point for both road and rail traffic into Ukraine. 2. **Beregsurány** - Located near the Luzhanka-Beregsurány border crossing, accessible via Route 41 and connected to the M3 motorway. This crossing is open 24/7 and handles cars, buses, and trucks. 3. **Tiszabecs** - Close to the Vylok-Tiszabecs border crossing, reachable via Route 49. 4. **Barabás** - Near the Kosyno-Barabás border crossing, accessible via local roads connecting to Route 41. 5. **Nagyhódos** - Located at the Velyka Palad-Nagyhódos border crossing, a newer checkpoint opened in 2025 for passenger vehicles up to 3.5 tons. These towns are strategically positioned along key routes, including Hungary’s Main Road 4 (connected to Ukraine’s M06) and Route 491 (connected to Ukraine’s M26), part of the international E-road network (E573 and E58).

BREAKING NEWS !! 22.15 local time ! In a very unusual action, not seen before , Hungary has moved TANKS & Heavy ARMOUR up to the Ukrainian Border ! Tanks Have been taken off their Transportation units & Driving through several towns on UKRAINE border on main road routes! Is ORBAN preparing to take over the Hungarian Region inside UKRAINE when peace talks fail & Russia goes full BAGRATION to KIEV ? Hungarian towns located on or near main roads leading to the Ukraine border, where Hungarian ARMOUR has been seen massing 1. Záhony - Situated on the M3 motorway and near the Chop-Záhony border crossing, a major entry point for both road and rail traffic into Ukraine. 2. Beregsurány - Located near the Luzhanka-Beregsurány border crossing, accessible via Route 41 and connected to the M3 motorway. This crossing is open 24/7 and handles cars, buses, and trucks. 3. Tiszabecs - Close to the Vylok-Tiszabecs border crossing, reachable via Route 49. 4. Barabás - Near the Kosyno-Barabás border crossing, accessible via local roads connecting to Route 41. 5. Nagyhódos - Located at the Velyka Palad-Nagyhódos border crossing, a newer checkpoint opened in 2025 for passenger vehicles up to 3.5 tons. These towns are strategically positioned along key routes, including Hungary’s Main Road 4 (connected to Ukraine’s M06) and Route 491 (connected to Ukraine’s M26), part of the international E-road network (E573 and E58).

𝐃𝐚𝐯𝐢𝐝 𝐙 🇷🇺🇮🇪

848,460 次观看 • 1 年前

🧬 The Recipe: How One Ovarian Cancer Trial Rebuilds the Immune System the Disease Switched Off A node-by-node case for durable immunity in the cancer that has resisted checkpoint blockade $NWBO and its #DCVax dendritic-cell platform sit at the heart of a new front-line #OvarianCancer trial, the same instructor-cell technology now aimed at the cancer that checkpoint blockade has barely touched. Advanced ovarian cancer kills more women than any other gynecologic malignancy, and it has shrugged off the #immunotherapy revolution almost entirely. Checkpoint blockade on its own reaches an objective response rate near eight percent in this disease, the figure from the $MRK #KEYNOTE-100 trial. The tumors are cold, the mutational burden is low, and the peritoneal cavity is a suppressive field that shuts an immune attack down before it can start. Two decades of single-agent vaccines and single-agent checkpoint drugs have not changed the survival math. Most patients respond to first-line chemotherapy and then relapse, and once the disease returns, the odds turn hard against them. For the patient living that diagnosis, a durable response is the only outcome that counts, and that is the one thing the field has not delivered. A Phase 2 trial opening at #UPMC Hillman in the second half of 2026, #NCT07634094, takes a different route. It does not add one more drug to the pile and hope. It treats ovarian cancer as one clinical face of a single, definable failure, and it rebuilds the broken machinery one node at a time. The sponsors are Pawel Kalinski MD PhD, $NWBO and $AIM. Here is the full logic, and why it is built to produce a response that lasts. 🔒 The hidden lesion: a silencing cascade Ovarian tumors run a self-reinforcing program that switches off the immune system's command center. It starts with chronic inflammation. Senescence-associated secretions and prostaglandin E2, the product of the COX-2 enzyme, keep the signaling protein STAT3 locked on. Persistent STAT3 pulls the silencing enzymes DNMT1 and EZH2 onto a single master gene, IRF8. That gene is the identity switch for the type 1 conventional dendritic cell, the cDC1, the one cell that licenses killer T cells with bioactive Silence IRF8 and the instructor disappears. With it gone, the tumor secretes decoy chemokines that recruit regulatory T cells, killer cells never receive their orders, and the disease grows in immunological darkness. This is not a quirk of ovarian cancer. The same cascade shows up in chronic infection and in aging tissue. Ovarian cancer is one face of a convergent mechanism, which is why a fix that works here points well beyond it. 🔄 The recipe: the cascade run in reverse Every component of the regimen corrects one node of that cascade. Pull out any single arm and the suppression reasserts itself through the others. That is what separates this from a kitchen sink: each part is load-bearing. · Celecoxib lifts the upstream PGE2 brake that keeps the silencing signal switched on. · Autologous, tumor-loaded alpha-DC1 supplies the instructor function from outside the silencing field, loaded with the whole tumor. This is the rebuilt command center the disease erased. · #rintatolimod, the selective TLR3 agonist marketed as #Ampligen, plus interferon-alpha flips the chemokine code tumor-selectively, from the CCL22 that recruits regulatory cells to the CXCL10 and CCL5 that pull in killers. #Bioferon · The alpha-DC1 program imprints CXCR3 and CCR5 homing receptors on the instructed CD8 cells, so they reach the tumor instead of circulating uselessly. · Cisplatin raises stress ligands so the killers can destroy low-antigen escape variants through the DNAM-1 and NKG2D receptors, closing the door on the engine of recurrence. · Paclitaxel plus the interferons repolarize suppressive M2 macrophages back to the supportive M1 state. · $MRK #Keytruda, releases the PD-1 brake last, only after the tumor has been made hot. The order is not cosmetic. The checkpoint comes last for a reason that most combination trials get wrong. 🔗 Why the combination is required, not additive Checkpoint blockade does not activate killer T cells by itself. Published work shows that anti-PD-1 efficacy depends on dendritic cells producing IL-12 inside the tumor (Garris, Immunity 2018). If the instructor is silenced and no IL-12 is being made, pembrolizumab has nothing to set loose. It is releasing a brake on a car with no engine. So restoring the IL-12 signal is the precondition for the checkpoint to do anything in this disease, not an optional add-on to it. The alpha-DC1 vaccine rebuilds the engine. Pembrolizumab takes the brake off. Neither delivers without the other. The relationship is causal, and that is the single idea the whole regimen is organized around. ⏳ Why the response should last A response that fades is not a cure, and durability is engineered here on four fronts at once. · Breadth. The vaccine is loaded with the whole tumor, not a single antigen, so the immune system learns the entire target and the tumor cannot escape by dropping one marker. · A lowered killing threshold. The DNAM-1 and NKG2D signals let killers finish variants that have shed antigen, while the requirement for true tumor recognition is preserved, so normal tissue is passed over. · Memory programming. Bioactive IL-12p70 does what ordinary dendritic-cell expansion cannot. It programs a self-renewing, TCF1-positive stem-like CD8 reservoir, the very population that predicts lasting benefit from checkpoint blockade (Goswami, Clinical Cancer Research 2025). · A self-reinforcing organ. Restored type 1 signaling matures tertiary lymphoid structures inside the tumor, the local factories from which durable immunity is rebuilt long after the last dose. 📊 Already partly de-risked This is not a first guess. The chemokine-and-checkpoint backbone was already tested in recurrent platinum-sensitive ovarian cancer in trial NCT03734692: intraperitoneal cisplatin plus rintatolimod plus pembrolizumab. That study produced an objective response rate near fifty percent, several times the roughly eight percent checkpoint blockade reaches alone in $MRK #KEYNOTE-100, accompanied by the exact chemokine shift the model predicts, the rise in CXCL9, CXCL10, and CXCL11 that a restored type 1 program produces. $MRK collaborated on it and supported it, and the final primary endpoint reported in May 2026. #SITC26 #ASCO26 The new trial adds the missing piece, the alpha-DC1 instructor whose intellectual property traces to #RoswellPark, and moves the whole regimen to the front line, where the tumor is largest and the antigen supply is richest. It is the same spine, established in recurrent disease, now armed with the one component that was absent. 🔬 A trial built to be read, not just won NCT07634094 enrolls twenty-eight patients with Stage III to IV epithelial ovarian, tubal, or peritoneal cancer, chemo-naive, in the neoadjuvant #neoadjuvant setting. #OvarianCancerAwareness #gyncsm #BRCA Treating before surgery buys the cleanest possible readout: the resected tumor itself. The co-primary endpoints are the safety of the full combination and pathologic complete response at debulking. A pathologic complete response, meaning no viable tumor left in the surgical specimen, is one of the most demanding endpoints in solid-tumor #oncology and a recognized marker of long-term benefit. The design also reads the mechanism directly. It looks for the chemokine switch, the rise in intratumoral CD8 cells with a favorable ratio to regulatory cells and a TCF1-positive phenotype, the falling inflammatory tone, and the specific signature of restored pulsed IL-12p70 against preserved bulk IL-12. The study is built to show whether the mechanism engaged, not only whether tumors shrank. Enrollment is expected to begin in the second half of 2026, and because the central readout is the surgical specimen rather than years of follow-up, the first mechanistic signals should arrive relatively early. 🏭 Why this is a platform, not a one-off The instructor cell at the center of this regimen is the same dendritic-cell platform Northwest Biotherapeutics has built its company around. #DCVax extended survival in Phase 3 glioblastoma (JAMA Oncology, 2023), and a UK marketing application is pending with MHRAgovuk. The same approach has already worked in ovarian cancer. At the University of Pennsylvania, a personalized whole-tumor dendritic-cell vaccine in recurrent ovarian cancer was well tolerated and induced broad antitumor T-cell responses that tracked with significantly longer survival, with two-year survival of one hundred percent in the immune responders against twenty-five percent in non-responders (Tanyi et al., Science Translational Medicine, 2018). Those dendritic cells were loaded with the patient's own whole tumor and activated toward the same type 1 program this regimen rebuilds. That is the proof of principle, and this trial is the more complete version of it. The dendritic cell here is engineered for higher, sustained IL-12p70. It is given in the front line, where the antigen supply is richest, rather than in heavily pretreated relapse. The suppressive microenvironment is reprogrammed in parallel rather than left intact, and the checkpoint is released at the end. The Penn vaccine carried the immune response largely on its own. This regimen clears the field for it first, then takes the brake off. The historical knock on personalized cell therapy was manufacturing: bespoke, hand-built, hard to scale. Northwest Biotherapeutics has been answering that directly. #Flaskworks #EDEN, the closed, automated manufacturing system the company acquired, standardizes production and removes the single-site hand manufacturing that limited earlier programs. The Sawston facility #Sawston in the UK, operated by #AdventBioServices, a wholly owned Northwest Biotherapeutics subsidiary, under MHRA good-manufacturing standards, is bringing its first Grade C suite online in 2026, a step anticipated to more than double capacity, with a dedicated leukapheresis clinic already running. The company has also added senior leadership to drive the platform, naming the biopharmaceutical veteran Dr. Annalisa Jenkins as a strategic adviser. The consequence is concrete. If the mechanism reads out in the resected tumor, the system that delivers it is already being built to scale, across the many solid tumors that run the same silencing cascade. One trial, read correctly, does not validate a single drug. It tests a repeatable way of rebuilding antitumor immunity. That reach is the point. The same instructor sits at the center of the silencing cascade across most solid tumors, which is why the dendritic-cell platform is framed around the approach itself rather than a single indication. A front-line ovarian readout that confirms the mechanism would be evidence for the method, not for one tumor type alone. The needle moves on the tissue, not on the thesis, and no paragraph substitutes for the pathology report. What the design offers is a complete, testable mechanism for durable immunity in ovarian cancer, paired with a manufacturing system already capable of producing it at scale. The readout in the resected tumor will speak for itself. Not financial advice. Do your own research. #DCVaxForBraelyn

🧬 The Recipe: How One Ovarian Cancer Trial Rebuilds the Immune System the Disease Switched Off A node-by-node case for durable immunity in the cancer that has resisted checkpoint blockade $NWBO and its #DCVax dendritic-cell platform sit at the heart of a new front-line #OvarianCancer trial, the same instructor-cell technology now aimed at the cancer that checkpoint blockade has barely touched. Advanced ovarian cancer kills more women than any other gynecologic malignancy, and it has shrugged off the #immunotherapy revolution almost entirely. Checkpoint blockade on its own reaches an objective response rate near eight percent in this disease, the figure from the $MRK #KEYNOTE-100 trial. The tumors are cold, the mutational burden is low, and the peritoneal cavity is a suppressive field that shuts an immune attack down before it can start. Two decades of single-agent vaccines and single-agent checkpoint drugs have not changed the survival math. Most patients respond to first-line chemotherapy and then relapse, and once the disease returns, the odds turn hard against them. For the patient living that diagnosis, a durable response is the only outcome that counts, and that is the one thing the field has not delivered. A Phase 2 trial opening at #UPMC Hillman in the second half of 2026, #NCT07634094, takes a different route. It does not add one more drug to the pile and hope. It treats ovarian cancer as one clinical face of a single, definable failure, and it rebuilds the broken machinery one node at a time. The sponsors are Pawel Kalinski MD PhD, $NWBO and $AIM. Here is the full logic, and why it is built to produce a response that lasts. 🔒 The hidden lesion: a silencing cascade Ovarian tumors run a self-reinforcing program that switches off the immune system's command center. It starts with chronic inflammation. Senescence-associated secretions and prostaglandin E2, the product of the COX-2 enzyme, keep the signaling protein STAT3 locked on. Persistent STAT3 pulls the silencing enzymes DNMT1 and EZH2 onto a single master gene, IRF8. That gene is the identity switch for the type 1 conventional dendritic cell, the cDC1, the one cell that licenses killer T cells with bioactive Silence IRF8 and the instructor disappears. With it gone, the tumor secretes decoy chemokines that recruit regulatory T cells, killer cells never receive their orders, and the disease grows in immunological darkness. This is not a quirk of ovarian cancer. The same cascade shows up in chronic infection and in aging tissue. Ovarian cancer is one face of a convergent mechanism, which is why a fix that works here points well beyond it. 🔄 The recipe: the cascade run in reverse Every component of the regimen corrects one node of that cascade. Pull out any single arm and the suppression reasserts itself through the others. That is what separates this from a kitchen sink: each part is load-bearing. · Celecoxib lifts the upstream PGE2 brake that keeps the silencing signal switched on. · Autologous, tumor-loaded alpha-DC1 supplies the instructor function from outside the silencing field, loaded with the whole tumor. This is the rebuilt command center the disease erased. · #rintatolimod, the selective TLR3 agonist marketed as #Ampligen, plus interferon-alpha flips the chemokine code tumor-selectively, from the CCL22 that recruits regulatory cells to the CXCL10 and CCL5 that pull in killers. #Bioferon · The alpha-DC1 program imprints CXCR3 and CCR5 homing receptors on the instructed CD8 cells, so they reach the tumor instead of circulating uselessly. · Cisplatin raises stress ligands so the killers can destroy low-antigen escape variants through the DNAM-1 and NKG2D receptors, closing the door on the engine of recurrence. · Paclitaxel plus the interferons repolarize suppressive M2 macrophages back to the supportive M1 state. · $MRK #Keytruda, releases the PD-1 brake last, only after the tumor has been made hot. The order is not cosmetic. The checkpoint comes last for a reason that most combination trials get wrong. 🔗 Why the combination is required, not additive Checkpoint blockade does not activate killer T cells by itself. Published work shows that anti-PD-1 efficacy depends on dendritic cells producing IL-12 inside the tumor (Garris, Immunity 2018). If the instructor is silenced and no IL-12 is being made, pembrolizumab has nothing to set loose. It is releasing a brake on a car with no engine. So restoring the IL-12 signal is the precondition for the checkpoint to do anything in this disease, not an optional add-on to it. The alpha-DC1 vaccine rebuilds the engine. Pembrolizumab takes the brake off. Neither delivers without the other. The relationship is causal, and that is the single idea the whole regimen is organized around. ⏳ Why the response should last A response that fades is not a cure, and durability is engineered here on four fronts at once. · Breadth. The vaccine is loaded with the whole tumor, not a single antigen, so the immune system learns the entire target and the tumor cannot escape by dropping one marker. · A lowered killing threshold. The DNAM-1 and NKG2D signals let killers finish variants that have shed antigen, while the requirement for true tumor recognition is preserved, so normal tissue is passed over. · Memory programming. Bioactive IL-12p70 does what ordinary dendritic-cell expansion cannot. It programs a self-renewing, TCF1-positive stem-like CD8 reservoir, the very population that predicts lasting benefit from checkpoint blockade (Goswami, Clinical Cancer Research 2025). · A self-reinforcing organ. Restored type 1 signaling matures tertiary lymphoid structures inside the tumor, the local factories from which durable immunity is rebuilt long after the last dose. 📊 Already partly de-risked This is not a first guess. The chemokine-and-checkpoint backbone was already tested in recurrent platinum-sensitive ovarian cancer in trial NCT03734692: intraperitoneal cisplatin plus rintatolimod plus pembrolizumab. That study produced an objective response rate near fifty percent, several times the roughly eight percent checkpoint blockade reaches alone in $MRK #KEYNOTE-100, accompanied by the exact chemokine shift the model predicts, the rise in CXCL9, CXCL10, and CXCL11 that a restored type 1 program produces. $MRK collaborated on it and supported it, and the final primary endpoint reported in May 2026. #SITC26 #ASCO26 The new trial adds the missing piece, the alpha-DC1 instructor whose intellectual property traces to #RoswellPark, and moves the whole regimen to the front line, where the tumor is largest and the antigen supply is richest. It is the same spine, established in recurrent disease, now armed with the one component that was absent. 🔬 A trial built to be read, not just won NCT07634094 enrolls twenty-eight patients with Stage III to IV epithelial ovarian, tubal, or peritoneal cancer, chemo-naive, in the neoadjuvant #neoadjuvant setting. #OvarianCancerAwareness #gyncsm #BRCA Treating before surgery buys the cleanest possible readout: the resected tumor itself. The co-primary endpoints are the safety of the full combination and pathologic complete response at debulking. A pathologic complete response, meaning no viable tumor left in the surgical specimen, is one of the most demanding endpoints in solid-tumor #oncology and a recognized marker of long-term benefit. The design also reads the mechanism directly. It looks for the chemokine switch, the rise in intratumoral CD8 cells with a favorable ratio to regulatory cells and a TCF1-positive phenotype, the falling inflammatory tone, and the specific signature of restored pulsed IL-12p70 against preserved bulk IL-12. The study is built to show whether the mechanism engaged, not only whether tumors shrank. Enrollment is expected to begin in the second half of 2026, and because the central readout is the surgical specimen rather than years of follow-up, the first mechanistic signals should arrive relatively early. 🏭 Why this is a platform, not a one-off The instructor cell at the center of this regimen is the same dendritic-cell platform Northwest Biotherapeutics has built its company around. #DCVax extended survival in Phase 3 glioblastoma (JAMA Oncology, 2023), and a UK marketing application is pending with MHRAgovuk. The same approach has already worked in ovarian cancer. At the University of Pennsylvania, a personalized whole-tumor dendritic-cell vaccine in recurrent ovarian cancer was well tolerated and induced broad antitumor T-cell responses that tracked with significantly longer survival, with two-year survival of one hundred percent in the immune responders against twenty-five percent in non-responders (Tanyi et al., Science Translational Medicine, 2018). Those dendritic cells were loaded with the patient's own whole tumor and activated toward the same type 1 program this regimen rebuilds. That is the proof of principle, and this trial is the more complete version of it. The dendritic cell here is engineered for higher, sustained IL-12p70. It is given in the front line, where the antigen supply is richest, rather than in heavily pretreated relapse. The suppressive microenvironment is reprogrammed in parallel rather than left intact, and the checkpoint is released at the end. The Penn vaccine carried the immune response largely on its own. This regimen clears the field for it first, then takes the brake off. The historical knock on personalized cell therapy was manufacturing: bespoke, hand-built, hard to scale. Northwest Biotherapeutics has been answering that directly. #Flaskworks #EDEN, the closed, automated manufacturing system the company acquired, standardizes production and removes the single-site hand manufacturing that limited earlier programs. The Sawston facility #Sawston in the UK, operated by #AdventBioServices, a wholly owned Northwest Biotherapeutics subsidiary, under MHRA good-manufacturing standards, is bringing its first Grade C suite online in 2026, a step anticipated to more than double capacity, with a dedicated leukapheresis clinic already running. The company has also added senior leadership to drive the platform, naming the biopharmaceutical veteran Dr. Annalisa Jenkins as a strategic adviser. The consequence is concrete. If the mechanism reads out in the resected tumor, the system that delivers it is already being built to scale, across the many solid tumors that run the same silencing cascade. One trial, read correctly, does not validate a single drug. It tests a repeatable way of rebuilding antitumor immunity. That reach is the point. The same instructor sits at the center of the silencing cascade across most solid tumors, which is why the dendritic-cell platform is framed around the approach itself rather than a single indication. A front-line ovarian readout that confirms the mechanism would be evidence for the method, not for one tumor type alone. The needle moves on the tissue, not on the thesis, and no paragraph substitutes for the pathology report. What the design offers is a complete, testable mechanism for durable immunity in ovarian cancer, paired with a manufacturing system already capable of producing it at scale. The readout in the resected tumor will speak for itself. Not financial advice. Do your own research. #DCVaxForBraelyn

Andrew Caravello, DO

10,459 次观看 • 2 个月前

The OncoAlert🚨Weekly Round Up Covering the TOP of the week April 4-10, 2025 REGISTER at OR Discussing: ✅Prognostic implications of risk definitions from the monarchE and NATALEE trial ✅Evaluating impact of histological 🆚 nuclear grading on CPS + EG Score for HR + /HER2-early #breastcancer ✅FDA🇺🇸 approves nivolumab w/ipilimumab🧪 for unresectable/metastatic MSI-H or dMMR #ColorectalCancer ✅Circulating tumor DNA🧬analysis guiding adjuvant therapy in stage II #ColonCancer : DYNAMIC trial ✅Assessment of a Polygenic Risk Score in Screening for #ProstateCancer (BARCODE1) ✅Neoadjuvant Aumolertinib for unresectable stage III EGFR-mutant non-small cell🫁 #LungCancer #NSCLC ✅Circulating tumor DNA🧬 Clearance as a Predictive Biomarker of Pathologic Complete Response in Patients with Solid Tumors Treated with Neoadjuvant Immune-Checkpoint Inhibitors: Eva Blondeaux Matteo Lambertini, MD PhD Harold J. Burstein, MD, PhD, FASCO Toni Choueiri, MD Arndt Vogel Dr Amol Akhade Nieves Martinez Lago MD PhD Nicholas Hornstein Cem mirili Gianmarco Ricagno, MD NonsparseOncologist Udhayvir Grewal Santhosh Ambika Eric Topol Alex Strudwick Young Sasha Gusev steve hsu Jarushka Naidoo @OscarTahuahua Dipesh Uprety MD FACP よし兄 Yoshi Erick F. Saldanha, MD Vivek Subbiah, MD Carmine Valenza Solange Peters Ann Partridge MD, MPH Dario Trapani Joaquin Mateo Enrique Grande Pietro De Placido Enrique Grande #OncoAlertAF Dra. María Natalia Gandur Quiroga Alizée Camps - - Maléa @BiagioRicciutMD Emre Yekedüz Hidehito HORINOUCHI Fadi Haddad, MD Al-Ola A Abdallah MD (USMIRC) Jose Fernando Moura, PhD Elisa Agostinetto Elisabetta Bonzano MD, PhD Bárbara Melão, MD, PhD Dr Joseph McCollom DO Erman Akkus Luca Arecco, MD Gaia Griguolo Kristina Jankovic, MD

The OncoAlert🚨Weekly Round Up Covering the TOP of the week April 4-10, 2025 REGISTER at OR Discussing: ✅Prognostic implications of risk definitions from the monarchE and NATALEE trial ✅Evaluating impact of histological 🆚 nuclear grading on CPS + EG Score for HR + /HER2-early #breastcancer ✅FDA🇺🇸 approves nivolumab w/ipilimumab🧪 for unresectable/metastatic MSI-H or dMMR #ColorectalCancer ✅Circulating tumor DNA🧬analysis guiding adjuvant therapy in stage II #ColonCancer : DYNAMIC trial ✅Assessment of a Polygenic Risk Score in Screening for #ProstateCancer (BARCODE1) ✅Neoadjuvant Aumolertinib for unresectable stage III EGFR-mutant non-small cell🫁 #LungCancer #NSCLC ✅Circulating tumor DNA🧬 Clearance as a Predictive Biomarker of Pathologic Complete Response in Patients with Solid Tumors Treated with Neoadjuvant Immune-Checkpoint Inhibitors: Eva Blondeaux Matteo Lambertini, MD PhD Harold J. Burstein, MD, PhD, FASCO Toni Choueiri, MD Arndt Vogel Dr Amol Akhade Nieves Martinez Lago MD PhD Nicholas Hornstein Cem mirili Gianmarco Ricagno, MD NonsparseOncologist Udhayvir Grewal Santhosh Ambika Eric Topol Alex Strudwick Young Sasha Gusev steve hsu Jarushka Naidoo @OscarTahuahua Dipesh Uprety MD FACP よし兄 Yoshi Erick F. Saldanha, MD Vivek Subbiah, MD Carmine Valenza Solange Peters Ann Partridge MD, MPH Dario Trapani Joaquin Mateo Enrique Grande Pietro De Placido Enrique Grande #OncoAlertAF Dra. María Natalia Gandur Quiroga Alizée Camps - - Maléa @BiagioRicciutMD Emre Yekedüz Hidehito HORINOUCHI Fadi Haddad, MD Al-Ola A Abdallah MD (USMIRC) Jose Fernando Moura, PhD Elisa Agostinetto Elisabetta Bonzano MD, PhD Bárbara Melão, MD, PhD Dr Joseph McCollom DO Erman Akkus Luca Arecco, MD Gaia Griguolo Kristina Jankovic, MD

OncoAlert

18,407 次观看 • 1 年前

Operation Thousand Fronts: Update Date of Execution: April 15 – April 25, 2025 Duration: 10 Days Occasion: Martyrs’ Day Commemoration Over ten days, OLA forces engaged regime troops in over 50 districts all at the same time, spanning eight operational commands, inflicting casualties, capturing weapons, and liberating civilians from regime detention. Engagements Across Operational Commands A. Western Command 1. Laaloo Assaabii District: * Garjoo Liibanii, Arroojjii (sustained firefight) * Dongoroo Town (enemy outpost overrun) 2. Boojjii Birmajjii District: * Lataa Boobinee (ambush on reinforcements) 3. Boojjii Coqorsaa District: * Fiigaa Town (regime garrison raided) 4. Makkoo District: * Ganda Lammaffaa (tactical withdrawal after inflicting losses) 5. Hawwaa Galaan District: * Areeree (ambush) * Machaaraa Town (enemy checkpoint destroyed) 6. Haroo District: * Kusaayee (defensive action repelled) 7. Nuunnuu Qumbaa District: * Dafuraa (regime supply convoy ambushed) 8. Waamaahagaloo District: * Wanigiroo (enemy patrol eliminated) 9. Sadan Canqaa District: * Miidhagaa Birbir, Mandara Saddeettaffaa, Mandara 12ffaa (coordinated assaults) 10. Sayyoo District: * Miinkoo (hit-and-run attack) 11. Anfilloo District: * Ashii Town (enemy barracks targeted) 12. Haroo Sabbuu District: * Beellam (defensive position overrun) 13. Ayiraa District: * Boondawoo Town (regime forces dislodged) 14. Gullisoo District: * Diillaa Town (highway ambush) 15. Jimmaa Horroo District: * Burqaa Guddaa (enemy patrol destroyed) 16. Diggaa District: * Arjoo Guddattuu Town (Laga Diimtuu bridge seized) 17. Waayyuu District: * Shumboo Town (regime reinforcements intercepted) 18. Habaaboo Guduruu District: * Fincha Sugar Factory (economic target struck) * Mooraa 7ffaa, Qanaatee (enemy counterattack repelled) 19. Guduruu District: * Baroo-Qanaatee Highway (logistical interdiction) 20. Saasiggaa District: * Gabaa Sambataa (enemy rally point ambushed) 21. Eebantuu District: * Beessee (regime outpost neutralized) 22. Matakkal Buulan District: * Sayidoo (defensive skirmish) 23. Jimmaa Arjoo District: * Waayyuu Tuqaa (enemy retreat forced) 24. Baatuu District: * Mooraa 6ffaa (tactical raid) B. Southern Command 1. Qarcaa District: * Gurraachoo, Eeguu Abaayii Town (enemy patrol destroyed) 2. Surroo Barguddaa District: * Harrattuu (regime checkpoint eliminated) 3. Galaanaa District: * Giwwee Town (supply depot raided) 4. Gomolee District: * Kelaa Quufaa (hit-and-run attack) C. Harsadee Command 1. Fantaallee District: * Tuuroo, Bantii, Kaniifaa, Matahaaraa Town (multiple ambushes) * Galchaa Main Toll (roadblock destroyed) * Dheebittii Tulluu Abbaa Baalchaa (enemy reinforcements ambushed) * Gubbaa Irreessaa (regime position overrun) 2. Booset District: * Siifaa Baatee (enemy patrol eliminated) 3. Tolee District: * Abaaxii Qoree, Baasii Abukeekuu (defensive skirmishes) 4. Bochoo District: * Tajjii (regime supply route disrupted) 5. Sadeen Sooddoo District: * Aggaa Ismaan (enemy detachment destroyed) 6. Dugdaa District: * Shuubii Gamoo, Waldaa Maqdallaa (hit-and-run attacks) 7. Booraa District: * Botee Town (regime garrison raided) * Afaa Raasaa (enemy retreat forced) 8. Duukam Town: * Urban ambush on regime forces D. Northern Command 1. Baatee District: * Enemy patrol ambushed E. Eastern Command 1. Hancaar District: * Araddaa Miidhagduu (regime outpost destroyed) 2. Shanan Kooluu District: * Enemy movement disrupted 3. Daaaroo Labuu District: * Gaara Dindin, Qorii (defensive skirmish) F. Central Command 1. Cobii District: * Enemy patrol engaged 2. Special Zone, Muloo District: * Weezaroo (regime position raided) G. Madda Albuudaa Command 1. Gumii Eldalloo District: * Bulbul (enemy detachment ambushed) 2. Gooroo Doolaa District: * Qararoo Dibbee Baddannaa Town (regime supply convoy destroyed) H. Southeastern Command 1. Jajuu District: * Gurree (enemy patrol eliminated) 2. Shanan Kooluu District: * Qorii (defensive skirmish) 3. Sirkaa District: * Soolee, Soolee Nageellee, Elellee Walaanaa (multiple ambushes) 4. Heeban Arsii District: * Shophaa (enemy outpost destroyed) 5. Muneessaa District: * Heeban Laaqichaa, Heeban Dhuuboo, Gujicha (hit-and-run attacks) 6. Adaamii Tulluu Gidduu Kombolchaa: * Aalutoo (regime reinforcements intercepted) IV. Enemy Losses * Killed in Action (KIA): 741 * Wounded in Action (WIA): 949 * Prisoners of War (POW): 56 * Weapons Captured: * AKM rifles (hundreds) * PKM machine guns * Sniper rifles * SKS carbines * Civilians Liberated: 231 #Oromia #Ethiopia

Operation Thousand Fronts: Update Date of Execution: April 15 – April 25, 2025 Duration: 10 Days Occasion: Martyrs’ Day Commemoration Over ten days, OLA forces engaged regime troops in over 50 districts all at the same time, spanning eight operational commands, inflicting casualties, capturing weapons, and liberating civilians from regime detention. Engagements Across Operational Commands A. Western Command 1. Laaloo Assaabii District: * Garjoo Liibanii, Arroojjii (sustained firefight) * Dongoroo Town (enemy outpost overrun) 2. Boojjii Birmajjii District: * Lataa Boobinee (ambush on reinforcements) 3. Boojjii Coqorsaa District: * Fiigaa Town (regime garrison raided) 4. Makkoo District: * Ganda Lammaffaa (tactical withdrawal after inflicting losses) 5. Hawwaa Galaan District: * Areeree (ambush) * Machaaraa Town (enemy checkpoint destroyed) 6. Haroo District: * Kusaayee (defensive action repelled) 7. Nuunnuu Qumbaa District: * Dafuraa (regime supply convoy ambushed) 8. Waamaahagaloo District: * Wanigiroo (enemy patrol eliminated) 9. Sadan Canqaa District: * Miidhagaa Birbir, Mandara Saddeettaffaa, Mandara 12ffaa (coordinated assaults) 10. Sayyoo District: * Miinkoo (hit-and-run attack) 11. Anfilloo District: * Ashii Town (enemy barracks targeted) 12. Haroo Sabbuu District: * Beellam (defensive position overrun) 13. Ayiraa District: * Boondawoo Town (regime forces dislodged) 14. Gullisoo District: * Diillaa Town (highway ambush) 15. Jimmaa Horroo District: * Burqaa Guddaa (enemy patrol destroyed) 16. Diggaa District: * Arjoo Guddattuu Town (Laga Diimtuu bridge seized) 17. Waayyuu District: * Shumboo Town (regime reinforcements intercepted) 18. Habaaboo Guduruu District: * Fincha Sugar Factory (economic target struck) * Mooraa 7ffaa, Qanaatee (enemy counterattack repelled) 19. Guduruu District: * Baroo-Qanaatee Highway (logistical interdiction) 20. Saasiggaa District: * Gabaa Sambataa (enemy rally point ambushed) 21. Eebantuu District: * Beessee (regime outpost neutralized) 22. Matakkal Buulan District: * Sayidoo (defensive skirmish) 23. Jimmaa Arjoo District: * Waayyuu Tuqaa (enemy retreat forced) 24. Baatuu District: * Mooraa 6ffaa (tactical raid) B. Southern Command 1. Qarcaa District: * Gurraachoo, Eeguu Abaayii Town (enemy patrol destroyed) 2. Surroo Barguddaa District: * Harrattuu (regime checkpoint eliminated) 3. Galaanaa District: * Giwwee Town (supply depot raided) 4. Gomolee District: * Kelaa Quufaa (hit-and-run attack) C. Harsadee Command 1. Fantaallee District: * Tuuroo, Bantii, Kaniifaa, Matahaaraa Town (multiple ambushes) * Galchaa Main Toll (roadblock destroyed) * Dheebittii Tulluu Abbaa Baalchaa (enemy reinforcements ambushed) * Gubbaa Irreessaa (regime position overrun) 2. Booset District: * Siifaa Baatee (enemy patrol eliminated) 3. Tolee District: * Abaaxii Qoree, Baasii Abukeekuu (defensive skirmishes) 4. Bochoo District: * Tajjii (regime supply route disrupted) 5. Sadeen Sooddoo District: * Aggaa Ismaan (enemy detachment destroyed) 6. Dugdaa District: * Shuubii Gamoo, Waldaa Maqdallaa (hit-and-run attacks) 7. Booraa District: * Botee Town (regime garrison raided) * Afaa Raasaa (enemy retreat forced) 8. Duukam Town: * Urban ambush on regime forces D. Northern Command 1. Baatee District: * Enemy patrol ambushed E. Eastern Command 1. Hancaar District: * Araddaa Miidhagduu (regime outpost destroyed) 2. Shanan Kooluu District: * Enemy movement disrupted 3. Daaaroo Labuu District: * Gaara Dindin, Qorii (defensive skirmish) F. Central Command 1. Cobii District: * Enemy patrol engaged 2. Special Zone, Muloo District: * Weezaroo (regime position raided) G. Madda Albuudaa Command 1. Gumii Eldalloo District: * Bulbul (enemy detachment ambushed) 2. Gooroo Doolaa District: * Qararoo Dibbee Baddannaa Town (regime supply convoy destroyed) H. Southeastern Command 1. Jajuu District: * Gurree (enemy patrol eliminated) 2. Shanan Kooluu District: * Qorii (defensive skirmish) 3. Sirkaa District: * Soolee, Soolee Nageellee, Elellee Walaanaa (multiple ambushes) 4. Heeban Arsii District: * Shophaa (enemy outpost destroyed) 5. Muneessaa District: * Heeban Laaqichaa, Heeban Dhuuboo, Gujicha (hit-and-run attacks) 6. Adaamii Tulluu Gidduu Kombolchaa: * Aalutoo (regime reinforcements intercepted) IV. Enemy Losses * Killed in Action (KIA): 741 * Wounded in Action (WIA): 949 * Prisoners of War (POW): 56 * Weapons Captured: * AKM rifles (hundreds) * PKM machine guns * Sniper rifles * SKS carbines * Civilians Liberated: 231 #Oromia #Ethiopia

Oromo Liberation Army OLF-OLA

10,753 次观看 • 1 年前

THE REPUBLIC OF BRIBERY: WHERE CORRUPTION WEARS UNIFORM AND THE PRESIDENT WATCHES IN SILENCE I watched corruption unfold before my own eyes not in secret, not in whispers, but in broad daylight, on our roads, under the watch of the so-called law. A traffic officer stopped our matatu, demanded KSh 2,000 for a crime that doesn’t exist. When the driver offered 500, the officer barked “peleka gari station.” Passengers an old sick man and a pregnant woman among them were dumped by the roadside like garbage. And the “mkubwa” himself came to supervise the extortion. This is not policing. This is organized robbery in uniform. And the worst part? Everyone in power knows. DP Kithure Kindiki knows. CS KIPCHUMBA MURKOMEN, E.G.H knows. The PS Dr. Raymond Omollo — CBS for Ministry of Interior | Kenya knows. And President William Ruto knows because this rot is no longer hidden; it’s the new normal. Our roads are now feeding troughs for uniformed criminals. Each police checkpoint is a cash register for cartels wearing badges. The bribe isn’t a side hustle anymore it’s a system, a chain that runs from the dusty highway to the clean suits in Nairobi. When an officer dares to demand more than a matatu earns per trip, it tells you corruption isn’t just tolerated it’s protected. It has sponsors. It has managers. It has politicians who eat off it. The Interior Ministry has become a marketplace of impunity. The Transport Ministry is a factory of excuses. And the President the man who promised a new dawn is too busy campaigning for 2032 while citizens are being extorted in 2025. You’ve turned the police into predators and Kenyans into prey. You’ve turned justice into a joke. And you’ve turned our highways into hunting grounds for hungry men who know they’ll never face consequences. Don’t tell us about digitizing government when you can’t even sanitize the police. Don’t talk about the “Bottom-Up” economy when your officers are extorting matatus that carry the real hustlers. If the President, the CS, and the PS have any shred of integrity left, let them come to Thika Road, stand by the GSU gate, and see the truth for themselves where the poor pay daily taxes to the corrupt. Kenya is bleeding, not from poverty, but from theft in uniform. And those in charge have blood on their hands.

THE REPUBLIC OF BRIBERY: WHERE CORRUPTION WEARS UNIFORM AND THE PRESIDENT WATCHES IN SILENCE I watched corruption unfold before my own eyes not in secret, not in whispers, but in broad daylight, on our roads, under the watch of the so-called law. A traffic officer stopped our matatu, demanded KSh 2,000 for a crime that doesn’t exist. When the driver offered 500, the officer barked “peleka gari station.” Passengers an old sick man and a pregnant woman among them were dumped by the roadside like garbage. And the “mkubwa” himself came to supervise the extortion. This is not policing. This is organized robbery in uniform. And the worst part? Everyone in power knows. DP Kithure Kindiki knows. CS KIPCHUMBA MURKOMEN, E.G.H knows. The PS Dr. Raymond Omollo — CBS for Ministry of Interior | Kenya knows. And President William Ruto knows because this rot is no longer hidden; it’s the new normal. Our roads are now feeding troughs for uniformed criminals. Each police checkpoint is a cash register for cartels wearing badges. The bribe isn’t a side hustle anymore it’s a system, a chain that runs from the dusty highway to the clean suits in Nairobi. When an officer dares to demand more than a matatu earns per trip, it tells you corruption isn’t just tolerated it’s protected. It has sponsors. It has managers. It has politicians who eat off it. The Interior Ministry has become a marketplace of impunity. The Transport Ministry is a factory of excuses. And the President the man who promised a new dawn is too busy campaigning for 2032 while citizens are being extorted in 2025. You’ve turned the police into predators and Kenyans into prey. You’ve turned justice into a joke. And you’ve turned our highways into hunting grounds for hungry men who know they’ll never face consequences. Don’t tell us about digitizing government when you can’t even sanitize the police. Don’t talk about the “Bottom-Up” economy when your officers are extorting matatus that carry the real hustlers. If the President, the CS, and the PS have any shred of integrity left, let them come to Thika Road, stand by the GSU gate, and see the truth for themselves where the poor pay daily taxes to the corrupt. Kenya is bleeding, not from poverty, but from theft in uniform. And those in charge have blood on their hands.

𝙋𝘼𝙐𝙇. 𝐎. 𝐍𝐄𝐊𝐎

298,337 次观看 • 10 个月前

L’uomo non sta “proteggendo” sua figlia: la usa come barriera per fermare i tir che trasportano farina verso Gaza. È l’immagine più sincera di una campagna organizzata da gruppi della destra radicale israeliana per bloccare gli aiuti umanitari ai civili. Video e cronache mostrano i presìdi ai varchi e lungo le statali – da Kerem Shalom a Tarqumiyah – con manifestanti che aprono i cassoni, gettano a terra i sacchi e intimidiscono gli autisti. Nei mesi scorsi gli attacchi hanno ritardato o fermato convogli interi, come documentato da Al Jazeera: trenta camion bloccati in un solo giorno, cori «cancellate la Palestina» tra le bandiere sventolate. Non è un fenomeno spontaneo. Nel giugno 2024 gli Stati Uniti hanno sanzionato “Tzav 9”, il gruppo che rivendica i blocchi; lo stesso mese il ministro della Sicurezza nazionale Itamar Ben-Gvir dichiarò che dovrebbe essere «il governo» a fermare i camion, non i militanti. La linea politica è stata più volte sdoganata ai vertici: nell’agosto 2024 il ministro delle Finanze Bezalel Smotrich arrivò a definire «giustificata e morale» la fame di due milioni di persone, salvo ammettere che «il mondo non ce lo permetterà». Intanto, la necessità resta matematica: per invertire la carestia servono centinaia di camion ogni giorno. Secondo l’Ufficio umanitario Onu, nel picco di settembre 2025 entrava meno di un quarto delle 2.000 tonnellate di cibo richieste quotidianamente; molte forniture non raggiungevano i magazzini per saccheggi lungo le rotte. Anche dopo il cessate il fuoco, le agenzie avvertono che gli ingressi restano “gravemente insufficienti”: i convogli vengono rallentati o rimandati indietro, e il nord della Striscia riceve briciole. Dentro questa aritmetica della fame, il passeggino messo di traverso non è una provocazione: è un metodo. Trasforma un’infanzia in scudo, un marciapiede in checkpoint privato, la propaganda in politica pubblica. E racconta più di qualunque comunicato: c’è chi, pur di impedire il pane a chi muore di fame, mette i propri figli davanti alle ruote dei camion.

L’uomo non sta “proteggendo” sua figlia: la usa come barriera per fermare i tir che trasportano farina verso Gaza. È l’immagine più sincera di una campagna organizzata da gruppi della destra radicale israeliana per bloccare gli aiuti umanitari ai civili. Video e cronache mostrano i presìdi ai varchi e lungo le statali – da Kerem Shalom a Tarqumiyah – con manifestanti che aprono i cassoni, gettano a terra i sacchi e intimidiscono gli autisti. Nei mesi scorsi gli attacchi hanno ritardato o fermato convogli interi, come documentato da Al Jazeera: trenta camion bloccati in un solo giorno, cori «cancellate la Palestina» tra le bandiere sventolate. Non è un fenomeno spontaneo. Nel giugno 2024 gli Stati Uniti hanno sanzionato “Tzav 9”, il gruppo che rivendica i blocchi; lo stesso mese il ministro della Sicurezza nazionale Itamar Ben-Gvir dichiarò che dovrebbe essere «il governo» a fermare i camion, non i militanti. La linea politica è stata più volte sdoganata ai vertici: nell’agosto 2024 il ministro delle Finanze Bezalel Smotrich arrivò a definire «giustificata e morale» la fame di due milioni di persone, salvo ammettere che «il mondo non ce lo permetterà». Intanto, la necessità resta matematica: per invertire la carestia servono centinaia di camion ogni giorno. Secondo l’Ufficio umanitario Onu, nel picco di settembre 2025 entrava meno di un quarto delle 2.000 tonnellate di cibo richieste quotidianamente; molte forniture non raggiungevano i magazzini per saccheggi lungo le rotte. Anche dopo il cessate il fuoco, le agenzie avvertono che gli ingressi restano “gravemente insufficienti”: i convogli vengono rallentati o rimandati indietro, e il nord della Striscia riceve briciole. Dentro questa aritmetica della fame, il passeggino messo di traverso non è una provocazione: è un metodo. Trasforma un’infanzia in scudo, un marciapiede in checkpoint privato, la propaganda in politica pubblica. E racconta più di qualunque comunicato: c’è chi, pur di impedire il pane a chi muore di fame, mette i propri figli davanti alle ruote dei camion.

Giulio Cavalli

34,722 次观看 • 10 个月前