正在加载视频...

视频加载失败

返回首页

🚀 A better, faster co-folding-based binding affinity model. Predicting how tightly a drug candidate binds to its target is critical in drug discovery. It also requires massive computational resources. State-of-the-art models can take 20 seconds to a minute per prediction, impractical for the demands of large scale early-stage programs...

RecursionPharma's profile picture

Recursion

17,373 subscribers

156,741 次观看 • 1 个月前 •via X (Twitter)

LIVE

Anya Rossi• Live Now

Private livecam show

0 条评论

暂无评论

原始帖子的评论将显示在这里

相关视频

Something NVIDIA & Google do better than anyone else is software-hardware-system co-design, and not just optimizing hardware for current model architectures, but predicting future ones. Back in early 2022, when NVIDIA started the design process for NVL72, MoE (Mixture of Experts) models were not yet the standard, and dense models were still dominant for frontier models. However, NVIDIA's strong software-hardware co-design culture enabled them to make a calculated bet that MoEs were the future, and they built NVL72 specifically for best MoE performance per TCO (Total Cost of Ownership). Furthermore, back in 2022, disaggregated prefill and wide expert parallelism (wideEP) MoE inference optimizations hadn't been invented yet, but it turns out that these MoE inference optimizations work best on large-scale systems like NVL72. While most other AI chip companies' in-house AI labs focus on training small 5B models that mainly use data parallelism, NVIDIA and Google's in-house AI labs continuously push the boundaries of model architecture and training recipes, such as NVFP4 training. Just like Super Idol & IShowSpeed, there must be a strong partnership between software engineers and hardware engineers to deliver the best systems that maximize performance per TCO.
0:14

Something NVIDIA & Google do better than anyone else is software-hardware-system co-design, and not just optimizing hardware for current model architectures, but predicting future ones. Back in early 2022, when NVIDIA started the design process for NVL72, MoE (Mixture of Experts) models were not yet the standard, and dense models were still dominant for frontier models. However, NVIDIA's strong software-hardware co-design culture enabled them to make a calculated bet that MoEs were the future, and they built NVL72 specifically for best MoE performance per TCO (Total Cost of Ownership). Furthermore, back in 2022, disaggregated prefill and wide expert parallelism (wideEP) MoE inference optimizations hadn't been invented yet, but it turns out that these MoE inference optimizations work best on large-scale systems like NVL72. While most other AI chip companies' in-house AI labs focus on training small 5B models that mainly use data parallelism, NVIDIA and Google's in-house AI labs continuously push the boundaries of model architecture and training recipes, such as NVFP4 training. Just like Super Idol & IShowSpeed, there must be a strong partnership between software engineers and hardware engineers to deliver the best systems that maximize performance per TCO.

SemiAnalysis

51,021 次观看 • 9 个月前

HOLY CRAP! I can't tell you how big this is for the medical community and drug discovery: Google Announces AlphaFold 3 AI. Details: Enhanced Molecular Prediction: AlphaFold 3 predicts the structure and interactions of all life's molecules, including proteins, DNA, RNA, ligands, and more, with unprecedented accuracy. Improved Interaction Accuracy: For protein interactions with other molecule types, AlphaFold 3 offers at least a 50% improvement over existing methods, and doubles the accuracy for some critical interactions. Transformative Potential for Science and Medicine: The model aims to deepen our understanding of biological processes and significantly advance drug discovery efforts. Accessibility for Researchers: AlphaFold 3's capabilities are largely accessible for free via the AlphaFold Server, providing an essential tool for scientific research. Drug Design Innovation: AlphaFold 3 is utilized by Isomorphic Labs in collaboration with pharmaceutical companies to accelerate drug design, potentially leading to new treatments for various diseases. Foundation in AlphaFold 2: Building on the breakthroughs of AlphaFold 2, this version extends its scope beyond proteins to a wide range of biomolecules, enhancing its utility in scientific research and application. Global Accessibility and Educational Support: The AlphaFold Server is a free platform for non-commercial research worldwide, supported by educational resources to foster wider adoption and innovation. Empowering Rapid Scientific Advancements: By making detailed molecular interactions easily accessible, AlphaFold 3 enables faster hypothesis testing and could reduce the time and cost typically associated with experimental protein-structure prediction. Responsible Development and Deployment: DeepMind has engaged with domain experts to assess the impacts and potential risks of AlphaFold, ensuring its responsible use in the scientific community. Broad Implications for Biology:AlphaFold 3 helps reveal complex cellular mechanisms and interactions, offering insights that could lead to improved agricultural crops, enhanced understanding of diseases, and novel therapeutic strategies.
0:12

HOLY CRAP! I can't tell you how big this is for the medical community and drug discovery: Google Announces AlphaFold 3 AI. Details: Enhanced Molecular Prediction: AlphaFold 3 predicts the structure and interactions of all life's molecules, including proteins, DNA, RNA, ligands, and more, with unprecedented accuracy. Improved Interaction Accuracy: For protein interactions with other molecule types, AlphaFold 3 offers at least a 50% improvement over existing methods, and doubles the accuracy for some critical interactions. Transformative Potential for Science and Medicine: The model aims to deepen our understanding of biological processes and significantly advance drug discovery efforts. Accessibility for Researchers: AlphaFold 3's capabilities are largely accessible for free via the AlphaFold Server, providing an essential tool for scientific research. Drug Design Innovation: AlphaFold 3 is utilized by Isomorphic Labs in collaboration with pharmaceutical companies to accelerate drug design, potentially leading to new treatments for various diseases. Foundation in AlphaFold 2: Building on the breakthroughs of AlphaFold 2, this version extends its scope beyond proteins to a wide range of biomolecules, enhancing its utility in scientific research and application. Global Accessibility and Educational Support: The AlphaFold Server is a free platform for non-commercial research worldwide, supported by educational resources to foster wider adoption and innovation. Empowering Rapid Scientific Advancements: By making detailed molecular interactions easily accessible, AlphaFold 3 enables faster hypothesis testing and could reduce the time and cost typically associated with experimental protein-structure prediction. Responsible Development and Deployment: DeepMind has engaged with domain experts to assess the impacts and potential risks of AlphaFold, ensuring its responsible use in the scientific community. Broad Implications for Biology:AlphaFold 3 helps reveal complex cellular mechanisms and interactions, offering insights that could lead to improved agricultural crops, enhanced understanding of diseases, and novel therapeutic strategies.

Brian Krassenstein

258,615 次观看 • 2 年前

We’re excited to introduce ShinkaEvolve: An open-source framework that evolves programs for scientific discovery with unprecedented sample-efficiency. Blog: Code: Like AlphaEvolve and its variants, our framework leverages LLMs to find state-of-the-art solutions to complex problems, but using orders of magnitude fewer resources! Many evolutionary AI systems are powerful but act like brute-force engines, burning thousands of samples to find good solutions. This makes discovery slow and expensive. We took inspiration from the efficiency of nature. ‘Shinka’ (進化) is Japanese for evolution, and we designed our system to be just as resourceful. On the classic circle packing optimization problem, ShinkaEvolve discovered a new state-of-the-art solution using only 150 samples. This is a big leap in efficiency compared to previous methods that required thousands of evaluations. We applied ShinkaEvolve to a diverse set of hard problems with real-world applications: 1/ AIME Math Reasoning: It evolved sophisticated agentic scaffolds that significantly outperform strong baselines, discovering an entire Pareto frontier of solutions trading performance for efficiency. 2/ Competitive Programming: On ALE-Bench (a benchmark for NP-Hard optimization problems), ShinkaEvolve took the best existing agent's solutions and improved them, turning a 5th place solution on one task into a 2nd place leaderboard rank in a competitive programming competition. 3/ LLM Training: We even turned ShinkaEvolve inward to improve LLMs themselves. It tackled the open challenge of designing load balancing losses for Mixture-of-Experts (MoE) models. It discovered a novel loss function that leads to better expert specialization and consistently improves model performance and perplexity. ShinkaEvolve achieves its remarkable sample-efficiency through three key innovations that work together: (1) an adaptive parent sampling strategy to balance exploration and exploitation, (2) novelty-based rejection filtering to avoid redundant work, and (3) a bandit-based LLM ensemble that dynamically picks the best model for the job. By making ShinkaEvolve open-source and highly sample-efficient, our goal is to democratize access to advanced, open-ended discovery tools. Our vision for ShinkaEvolve is to be an easy-to-use companion tool to help scientists and engineers with their daily work. We believe that building more efficient, nature-inspired systems is key to unlocking the future of AI-driven scientific research. We are excited to see what the community builds with it! Learn more in our technical report:
0:11

We’re excited to introduce ShinkaEvolve: An open-source framework that evolves programs for scientific discovery with unprecedented sample-efficiency. Blog: Code: Like AlphaEvolve and its variants, our framework leverages LLMs to find state-of-the-art solutions to complex problems, but using orders of magnitude fewer resources! Many evolutionary AI systems are powerful but act like brute-force engines, burning thousands of samples to find good solutions. This makes discovery slow and expensive. We took inspiration from the efficiency of nature. ‘Shinka’ (進化) is Japanese for evolution, and we designed our system to be just as resourceful. On the classic circle packing optimization problem, ShinkaEvolve discovered a new state-of-the-art solution using only 150 samples. This is a big leap in efficiency compared to previous methods that required thousands of evaluations. We applied ShinkaEvolve to a diverse set of hard problems with real-world applications: 1/ AIME Math Reasoning: It evolved sophisticated agentic scaffolds that significantly outperform strong baselines, discovering an entire Pareto frontier of solutions trading performance for efficiency. 2/ Competitive Programming: On ALE-Bench (a benchmark for NP-Hard optimization problems), ShinkaEvolve took the best existing agent's solutions and improved them, turning a 5th place solution on one task into a 2nd place leaderboard rank in a competitive programming competition. 3/ LLM Training: We even turned ShinkaEvolve inward to improve LLMs themselves. It tackled the open challenge of designing load balancing losses for Mixture-of-Experts (MoE) models. It discovered a novel loss function that leads to better expert specialization and consistently improves model performance and perplexity. ShinkaEvolve achieves its remarkable sample-efficiency through three key innovations that work together: (1) an adaptive parent sampling strategy to balance exploration and exploitation, (2) novelty-based rejection filtering to avoid redundant work, and (3) a bandit-based LLM ensemble that dynamically picks the best model for the job. By making ShinkaEvolve open-source and highly sample-efficient, our goal is to democratize access to advanced, open-ended discovery tools. Our vision for ShinkaEvolve is to be an easy-to-use companion tool to help scientists and engineers with their daily work. We believe that building more efficient, nature-inspired systems is key to unlocking the future of AI-driven scientific research. We are excited to see what the community builds with it! Learn more in our technical report:

Sakana AI

360,273 次观看 • 11 个月前

New open-source agent harness just landed! I got early access to TrueForge by TrueFoundry and have been running it locally for the past few days. The harness layer deserves as much attention as the model, and open source matters here because you can inspect the loop, run it on your own infrastructure, and swap to the latest or cheaper models. TrueForge handles the runtime work that makes an agent reliable. It drives the tool-calling loop, manages context, coordinates subagents, and executes code in a sandbox, with any model you choose. Every tool call re-sends the growing context to the model, so in practice the harness controls most of what an agent costs to run. A few things stood out from my testing and their published benchmarks. Vendor-Neutral by design. It runs OpenAI, Anthropic, and Google models alongside open-weight models like Kimi, GLM, and DeepSeek. Model routing is a setting, and you can send each task to the model that fits it. On a 14-task enterprise agent benchmark, it matched the accuracy of Claude Managed Agents running the same Opus 4.8 model at roughly 30% lower cost per run (3.8M tokens vs 10M for the same answers). Routing the same tasks to GLM-5.2 held accuracy and brought cost down by about 75%, around $3 per run instead of $12. Fully self-hosted and Open Source (MIT License). I had it running locally with one command, with sandboxed code execution working out of the box. It's time to own your agent harness. Thanks to TrueFoundry for partnering on this post.
0:16

New open-source agent harness just landed! I got early access to TrueForge by TrueFoundry and have been running it locally for the past few days. The harness layer deserves as much attention as the model, and open source matters here because you can inspect the loop, run it on your own infrastructure, and swap to the latest or cheaper models. TrueForge handles the runtime work that makes an agent reliable. It drives the tool-calling loop, manages context, coordinates subagents, and executes code in a sandbox, with any model you choose. Every tool call re-sends the growing context to the model, so in practice the harness controls most of what an agent costs to run. A few things stood out from my testing and their published benchmarks. Vendor-Neutral by design. It runs OpenAI, Anthropic, and Google models alongside open-weight models like Kimi, GLM, and DeepSeek. Model routing is a setting, and you can send each task to the model that fits it. On a 14-task enterprise agent benchmark, it matched the accuracy of Claude Managed Agents running the same Opus 4.8 model at roughly 30% lower cost per run (3.8M tokens vs 10M for the same answers). Routing the same tasks to GLM-5.2 held accuracy and brought cost down by about 75%, around $3 per run instead of $12. Fully self-hosted and Open Source (MIT License). I had it running locally with one command, with sandboxed code execution working out of the box. It's time to own your agent harness. Thanks to TrueFoundry for partnering on this post.

elvis

11,303 次观看 • 4 天前

STEVE-1: A Generative Model for Text-to-Behavior in Minecraft paper page: Constructing AI models that respond to text instructions is challenging, especially for sequential decision-making tasks. This work introduces an instruction-tuned Video Pretraining (VPT) model for Minecraft called STEVE-1, demonstrating that the unCLIP approach, utilized in DALL-E 2, is also effective for creating instruction-following sequential decision-making agents. STEVE-1 is trained in two steps: adapting the pretrained VPT model to follow commands in MineCLIP's latent space, then training a prior to predict latent codes from text. This allows us to finetune VPT through self-supervised behavioral cloning and hindsight relabeling, bypassing the need for costly human text annotations. By leveraging pretrained models like VPT and MineCLIP and employing best practices from text-conditioned image generation, STEVE-1 costs just $60 to train and can follow a wide range of short-horizon open-ended text and visual instructions in Minecraft. STEVE-1 sets a new bar for open-ended instruction following in Minecraft with low-level controls (mouse and keyboard) and raw pixel inputs, far outperforming previous baselines. We provide experimental evidence highlighting key factors for downstream performance, including pretraining, classifier-free guidance, and data scaling. All resources, including our model weights, training scripts, and evaluation tools are made available for further research.
0:14

STEVE-1: A Generative Model for Text-to-Behavior in Minecraft paper page: Constructing AI models that respond to text instructions is challenging, especially for sequential decision-making tasks. This work introduces an instruction-tuned Video Pretraining (VPT) model for Minecraft called STEVE-1, demonstrating that the unCLIP approach, utilized in DALL-E 2, is also effective for creating instruction-following sequential decision-making agents. STEVE-1 is trained in two steps: adapting the pretrained VPT model to follow commands in MineCLIP's latent space, then training a prior to predict latent codes from text. This allows us to finetune VPT through self-supervised behavioral cloning and hindsight relabeling, bypassing the need for costly human text annotations. By leveraging pretrained models like VPT and MineCLIP and employing best practices from text-conditioned image generation, STEVE-1 costs just $60 to train and can follow a wide range of short-horizon open-ended text and visual instructions in Minecraft. STEVE-1 sets a new bar for open-ended instruction following in Minecraft with low-level controls (mouse and keyboard) and raw pixel inputs, far outperforming previous baselines. We provide experimental evidence highlighting key factors for downstream performance, including pretraining, classifier-free guidance, and data scaling. All resources, including our model weights, training scripts, and evaluation tools are made available for further research.

AK

144,783 次观看 • 3 年前

Batch Normalization by hand ✍️ ~ 7 steps walkthrough below Batch normalization is common practice for improving training and achieving faster convergence. It sounds simple. But it is often misunderstood. 🤔 Does batch normalization involve trainable parameters, tunable hyper-parameters, or both? 🤔 Is batch normalization applied to inputs, features, weights, biases, or outputs? 🤔 How is batch normalization different from layer normalization? So I drew and calculated one entirely by hand. Goal: normalize a mini-batch of 4 examples to mean 0 and variance 1, then let the network scale it back. = 1. Given = A mini-batch of 4 training examples, each with 3 features. = 2. Linear layer = Let us multiply by the weights and add the biases. Batch norm sits after this, which answers the second question: what gets normalized is features, not inputs, weights or biases. = 3. ReLU = We apply the activation, and -2 becomes 0. Negative values are suppressed before any statistic is taken. = 4. Batch statistics = Let us compute the sum, mean, variance and standard deviation, one row at a time. A row is a feature and the four columns are the four examples, so every number here measures one feature against the rest of the batch. That is the "batch" in batch normalization, and it is exactly what layer normalization does not do. The statistics are rounded to whole numbers, which is what keeps the rest of the page doable in pen. = 5. Shift to mean 0 = We subtract the mean, in green. The four values in each feature now average to zero. = 6. Scale to variance 1 = Let us divide by the standard deviation, in orange. Each feature now has variance one, whatever scale it arrived at. = 7. Scale and shift = We multiply by a linear transformation and pass the result on. The diagonal and the last column are trainable, so having just forced every feature to mean 0 and variance 1, we hand the network the means to undo it. The outputs: Mean of each feature = [2, 1, 2] Std dev of each feature = [1, 1, 2] To the next layer = [2, -2, 2, 0], [-3, 3, 6, -3], [2, 0, 1, 2] The answers: 🤔 Both. The scale and shift are trainable, the statistics are not. Epsilon and the momentum on the running statistics are the hyper-parameters, and one mini-batch by hand needs neither. 🤔 Features, after the linear layer, not inputs, weights or biases. 🤔 Batch norm measures across the batch, one feature at a time. Layer norm measures across the features, one example at a time. 💾 Save this post!
0:17

Batch Normalization by hand ✍️ ~ 7 steps walkthrough below Batch normalization is common practice for improving training and achieving faster convergence. It sounds simple. But it is often misunderstood. 🤔 Does batch normalization involve trainable parameters, tunable hyper-parameters, or both? 🤔 Is batch normalization applied to inputs, features, weights, biases, or outputs? 🤔 How is batch normalization different from layer normalization? So I drew and calculated one entirely by hand. Goal: normalize a mini-batch of 4 examples to mean 0 and variance 1, then let the network scale it back. = 1. Given = A mini-batch of 4 training examples, each with 3 features. = 2. Linear layer = Let us multiply by the weights and add the biases. Batch norm sits after this, which answers the second question: what gets normalized is features, not inputs, weights or biases. = 3. ReLU = We apply the activation, and -2 becomes 0. Negative values are suppressed before any statistic is taken. = 4. Batch statistics = Let us compute the sum, mean, variance and standard deviation, one row at a time. A row is a feature and the four columns are the four examples, so every number here measures one feature against the rest of the batch. That is the "batch" in batch normalization, and it is exactly what layer normalization does not do. The statistics are rounded to whole numbers, which is what keeps the rest of the page doable in pen. = 5. Shift to mean 0 = We subtract the mean, in green. The four values in each feature now average to zero. = 6. Scale to variance 1 = Let us divide by the standard deviation, in orange. Each feature now has variance one, whatever scale it arrived at. = 7. Scale and shift = We multiply by a linear transformation and pass the result on. The diagonal and the last column are trainable, so having just forced every feature to mean 0 and variance 1, we hand the network the means to undo it. The outputs: Mean of each feature = [2, 1, 2] Std dev of each feature = [1, 1, 2] To the next layer = [2, -2, 2, 0], [-3, 3, 6, -3], [2, 0, 1, 2] The answers: 🤔 Both. The scale and shift are trainable, the statistics are not. Epsilon and the momentum on the running statistics are the hyper-parameters, and one mini-batch by hand needs neither. 🤔 Features, after the linear layer, not inputs, weights or biases. 🤔 Batch norm measures across the batch, one feature at a time. Layer norm measures across the features, one example at a time. 💾 Save this post!

Tom Yeh

20,638 次观看 • 1 个月前

Big win for open-source LLMs! DeepSeek V4 Pro holds the top open-weights score on SWE-bench Verified, in the GPT-5.5 range. GLM 5.2 leads the open-weight intelligence index and sits near the closed frontier on long-horizon coding. But this leaderboard number is a weak proxy for real performance. It comes from one task set, run through one harness, served at one precision. The same weights can even score differently across providers, since many hosts quantize activations to fp8 and drift the model off its reference weights. Real performance is determined based on whether a model can read a repo, make coordinated edits across files, run the tests, and recover when one breaks. By that measure, the top open models hold up, but only inside the right harness. The teams that actually put DeepSeek V4 into production pipelines as a frontier substitute got there through the harness they built around the model, not by picking a stronger model. If you want to see this in practice, Cline (64k+ stars) has actually built that harness around open models, tuned so they run at production quality. And it's tuned so that these LLMs can run at production quality, with plan and act modes, checkpoints, and terminal feedback. ClinePass is the new access layer on top of it. It runs a curated set of those models inside Cline, narrowed to the ones tested for coding-agent use, with 2 to 5x the standard rate limits and no separate provider accounts, keys, or billing to track. The video below shows the setup, and I worked with the team to put this together. It runs alongside custom keys and local models as well, not in place of them.
0:14

Big win for open-source LLMs! DeepSeek V4 Pro holds the top open-weights score on SWE-bench Verified, in the GPT-5.5 range. GLM 5.2 leads the open-weight intelligence index and sits near the closed frontier on long-horizon coding. But this leaderboard number is a weak proxy for real performance. It comes from one task set, run through one harness, served at one precision. The same weights can even score differently across providers, since many hosts quantize activations to fp8 and drift the model off its reference weights. Real performance is determined based on whether a model can read a repo, make coordinated edits across files, run the tests, and recover when one breaks. By that measure, the top open models hold up, but only inside the right harness. The teams that actually put DeepSeek V4 into production pipelines as a frontier substitute got there through the harness they built around the model, not by picking a stronger model. If you want to see this in practice, Cline (64k+ stars) has actually built that harness around open models, tuned so they run at production quality. And it's tuned so that these LLMs can run at production quality, with plan and act modes, checkpoints, and terminal feedback. ClinePass is the new access layer on top of it. It runs a curated set of those models inside Cline, narrowed to the ones tested for coding-agent use, with 2 to 5x the standard rate limits and no separate provider accounts, keys, or billing to track. The video below shows the setup, and I worked with the team to put this together. It runs alongside custom keys and local models as well, not in place of them.

Avi Chawla

44,124 次观看 • 1 个月前

DeepSeek R1 is *the* best model available right now. It's at the level of o1, but you can use it for free, and it's much faster. A huge leap forward that nobody saw coming. No wonder so many people are throwing tantrums online trying to discredit the Chinese students who built this. You can use DeepSeek in Visual Studio Code right now: 1. Install the Qodo Gen AI extension 2. Select DeepSeek R1 from their list of models The Qodo team is hosting DeepSeek on their servers, so none of your data will go to China. I've been building a Tetris game using DeepSeek, and this is the most impressive model I've seen so far.
0:17

DeepSeek R1 is *the* best model available right now. It's at the level of o1, but you can use it for free, and it's much faster. A huge leap forward that nobody saw coming. No wonder so many people are throwing tantrums online trying to discredit the Chinese students who built this. You can use DeepSeek in Visual Studio Code right now: 1. Install the Qodo Gen AI extension 2. Select DeepSeek R1 from their list of models The Qodo team is hosting DeepSeek on their servers, so none of your data will go to China. I've been building a Tetris game using DeepSeek, and this is the most impressive model I've seen so far.

Santiago

1,224,264 次观看 • 1 年前

Today we’re thrilled to announce JAM-2 — the first AI model capable of generating drug-quality antibodies straight from the computer, with industry-leading success rates. > Drug-like affinities: Picomolar to single-digit nanomolar antibody binders for half of 26 targets while testing Unlocking hard targets: Up to 11% success rate for direct on-cell GPCR binders; top antibody hits in the single-digit nanomolar range. > Unprecedented epitope breadth: JAM-2 routinely designed antibodies that hit 30–70% of user-defined epitopes, now enabling intentional design of biology — not chance discovery. > Drug-like developability: Over 50% of antibody designs passed core industry developability criteria with zero optimization. > Massive leverage: A four-person team prosecuted 16 targets in parallel in < 1 month. JAM-2 is the first de novo antibody design capability ready for front-line use in drug discovery, matching or surpassing traditional discovery approaches. We’re already deploying JAM-2 with multiple large pharma partners and seeing excellent results. If you’re interested in partnering on molecule development or accessing JAM-2, contact bd@nabla.bio. Read more in our whitepaper (link below)
0:14

Today we’re thrilled to announce JAM-2 — the first AI model capable of generating drug-quality antibodies straight from the computer, with industry-leading success rates. > Drug-like affinities: Picomolar to single-digit nanomolar antibody binders for half of 26 targets while testing Unlocking hard targets: Up to 11% success rate for direct on-cell GPCR binders; top antibody hits in the single-digit nanomolar range. > Unprecedented epitope breadth: JAM-2 routinely designed antibodies that hit 30–70% of user-defined epitopes, now enabling intentional design of biology — not chance discovery. > Drug-like developability: Over 50% of antibody designs passed core industry developability criteria with zero optimization. > Massive leverage: A four-person team prosecuted 16 targets in parallel in < 1 month. JAM-2 is the first de novo antibody design capability ready for front-line use in drug discovery, matching or surpassing traditional discovery approaches. We’re already deploying JAM-2 with multiple large pharma partners and seeing excellent results. If you’re interested in partnering on molecule development or accessing JAM-2, contact [email protected]. Read more in our whitepaper (link below)

Nabla Bio

199,762 次观看 • 9 个月前

The human brain is truly a marvel of nature. If you horribly reductive, and boiled it down to a language model, you'd be looking at roughly 100 trillon parameters running as a sparse MoE architecture Only about 1-5% of neurons fire at any given moment, meaning the brain "activates" maybe 1-5 trillion parameters per inference step. For context, the largest AI models we've built probably top out around 5 trillion parameters. The brain is roughly 100x larger. Even its active params at any given moment are larger than almost every model in existence today. Here's what melts my brain (pun intnended) though Your brain does all of this on about 20 watts of power, less than a dim light bulb. Training a frontier AI model consumes enough electricity to power small cities for months. Running inference across data centers pulls megawatts. Your brain runs 24/7 for 80+ years on the equivalent of a phone charger. We haven't come close to matching the brain's scale. And we're not even in the same universe when it comes to efficiency. Evolution spent 500 million yrs optimizing the most energy-efficient intelligence architecture ever known. we're trying to brute force our way there with compute and electricity. Nature is still the best engineer in the room.
0:12

The human brain is truly a marvel of nature. If you horribly reductive, and boiled it down to a language model, you'd be looking at roughly 100 trillon parameters running as a sparse MoE architecture Only about 1-5% of neurons fire at any given moment, meaning the brain "activates" maybe 1-5 trillion parameters per inference step. For context, the largest AI models we've built probably top out around 5 trillion parameters. The brain is roughly 100x larger. Even its active params at any given moment are larger than almost every model in existence today. Here's what melts my brain (pun intnended) though Your brain does all of this on about 20 watts of power, less than a dim light bulb. Training a frontier AI model consumes enough electricity to power small cities for months. Running inference across data centers pulls megawatts. Your brain runs 24/7 for 80+ years on the equivalent of a phone charger. We haven't come close to matching the brain's scale. And we're not even in the same universe when it comes to efficiency. Evolution spent 500 million yrs optimizing the most energy-efficient intelligence architecture ever known. we're trying to brute force our way there with compute and electricity. Nature is still the best engineer in the room.

am.will

130,841 次观看 • 4 个月前

A Letter to Our Community: The Road Ahead for Robotics To our Community and Partners, As we step into 2026, our mission at Axis is clearer than ever: Constructing the definitive End-to-End Scaling Layer for Robotics. Our goal is to accelerate the transfer of diverse human intelligence into Robotics General Intelligence (RGI). By owning the critical path of intelligence creation, we are turning the physical limitations of robotics into a scalable, software-driven future. Here is our strategic outlook and roadmap for the year ahead. The Core Thesis: Simulation is the Only Way Out The path to RGI is currently blocked by Data Scarcity, Generalization Fragility, and Hardware Fragmentation. At Axis, we believe Simulation is the only way out. Our Simulation Data Platform and Data Augmentation Engine transform raw data into "Synthetic Gold". Backed by academic milestones like Roboverse, Skill Blending, and GraspVLA, we have proven that pure simulation can achieve the generalization required for the real world. We don’t just collect data; we architect it. The Engine: Why Crypto? We believe RGI should come from all, not a few. Crypto is not just a feature; it is the primitive that powers our entire ecosystem flywheel: - Incentive Mechanism: Democratizing contribution and rewarding the trainers and developers. - Assetization: Turning proprietary data and refined models into liquid, ownable assets. - Verifiable Workflow: We are opening the "Black Box" of AI. By bringing total transparency to the Task Generation → Data Collection → Model Training pipeline, we ensure every byte of intelligence is verifiable, traceable, and secure. 2026 Strategic Deliverables This year, we are committed to delivering three foundational pillars: - The World's Largest Training Dataset for Robots: A robot training set—diverse, high-quality interaction data at an unprecedented scale. - A Robotics Foundation Model: A universal robotic brain trained on our pure simulation and synthetic data, capable of robust cross-embodiment transfer and open-world adaptability. - Evolvable Robot Hardware: Robots deployed with Axis models that autonomously evolve through continuous interaction, turning every deployment into a self-improving node within our RGI network. The Ultimate Vision We are building more than models; we are architecting the Distributed Machine Economy. A future where every dataset, model, and robotic embodiment is a verifiable asset in a global, autonomous network. Thank you for building the future of intelligence with us✌️📷
0:13

A Letter to Our Community: The Road Ahead for Robotics To our Community and Partners, As we step into 2026, our mission at Axis is clearer than ever: Constructing the definitive End-to-End Scaling Layer for Robotics. Our goal is to accelerate the transfer of diverse human intelligence into Robotics General Intelligence (RGI). By owning the critical path of intelligence creation, we are turning the physical limitations of robotics into a scalable, software-driven future. Here is our strategic outlook and roadmap for the year ahead. The Core Thesis: Simulation is the Only Way Out The path to RGI is currently blocked by Data Scarcity, Generalization Fragility, and Hardware Fragmentation. At Axis, we believe Simulation is the only way out. Our Simulation Data Platform and Data Augmentation Engine transform raw data into "Synthetic Gold". Backed by academic milestones like Roboverse, Skill Blending, and GraspVLA, we have proven that pure simulation can achieve the generalization required for the real world. We don’t just collect data; we architect it. The Engine: Why Crypto? We believe RGI should come from all, not a few. Crypto is not just a feature; it is the primitive that powers our entire ecosystem flywheel: - Incentive Mechanism: Democratizing contribution and rewarding the trainers and developers. - Assetization: Turning proprietary data and refined models into liquid, ownable assets. - Verifiable Workflow: We are opening the "Black Box" of AI. By bringing total transparency to the Task Generation → Data Collection → Model Training pipeline, we ensure every byte of intelligence is verifiable, traceable, and secure. 2026 Strategic Deliverables This year, we are committed to delivering three foundational pillars: - The World's Largest Training Dataset for Robots: A robot training set—diverse, high-quality interaction data at an unprecedented scale. - A Robotics Foundation Model: A universal robotic brain trained on our pure simulation and synthetic data, capable of robust cross-embodiment transfer and open-world adaptability. - Evolvable Robot Hardware: Robots deployed with Axis models that autonomously evolve through continuous interaction, turning every deployment into a self-improving node within our RGI network. The Ultimate Vision We are building more than models; we are architecting the Distributed Machine Economy. A future where every dataset, model, and robotic embodiment is a verifiable asset in a global, autonomous network. Thank you for building the future of intelligence with us✌️📷

Axis Robotics

27,858 次观看 • 7 个月前

Welcome to the pack, Blockframe 🐺 The vision for Matter Labs has always been to incubate, launch, and decentralize the zkSync network. Today, Blockframe officially joins as the latest core development team outside of Matter Labs onboarding to help build, maintain, and upgrade the zkSync protocol and ZK Stack. Learn more: ∎ Becoming one of many ∎ The purpose of onboarding external teams is two-fold: (1) decentralization — ensuring Matter Labs is one of many contributors to zkSync Era, and (2) bringing in teams capable of building valuable tools for crypto projects and brands building their web3 ambitions using the ZK Stack. ∎ Meet Blockframe ∎ Built with support from Matter Labs, Blockframe is an NFT marketplace and creator platform that features on-chain royalties, AI-assisted NFT creation tools, and an NFT perpetuals exchange. ∎ New tools for builders ∎ Blockframe's editable NFTs and sealed bid auctions are made possible by its new Bulk Semaphore protocol. Bulk Semaphore is a tool that can now be utilized by builders on zkSync to scale without sacrificing the privacy of the protocol and its users. ∎ Join the ZK Core Development Team ∎ We welcome and encourage more teams to join this effort. If you’re familiar with zkSync Era and ZK Stack, have made notable contributions to open source projects, and align with the values shared in the ZK Credo, DM Omar Y. ⭕, Head of Investments at Matter Labs.
0:10

Welcome to the pack, Blockframe 🐺 The vision for Matter Labs has always been to incubate, launch, and decentralize the zkSync network. Today, Blockframe officially joins as the latest core development team outside of Matter Labs onboarding to help build, maintain, and upgrade the zkSync protocol and ZK Stack. Learn more: ∎ Becoming one of many ∎ The purpose of onboarding external teams is two-fold: (1) decentralization — ensuring Matter Labs is one of many contributors to zkSync Era, and (2) bringing in teams capable of building valuable tools for crypto projects and brands building their web3 ambitions using the ZK Stack. ∎ Meet Blockframe ∎ Built with support from Matter Labs, Blockframe is an NFT marketplace and creator platform that features on-chain royalties, AI-assisted NFT creation tools, and an NFT perpetuals exchange. ∎ New tools for builders ∎ Blockframe's editable NFTs and sealed bid auctions are made possible by its new Bulk Semaphore protocol. Bulk Semaphore is a tool that can now be utilized by builders on zkSync to scale without sacrificing the privacy of the protocol and its users. ∎ Join the ZK Core Development Team ∎ We welcome and encourage more teams to join this effort. If you’re familiar with zkSync Era and ZK Stack, have made notable contributions to open source projects, and align with the values shared in the ZK Credo, DM Omar Y. ⭕, Head of Investments at Matter Labs.

ZKsync

146,716 次观看 • 3 年前

The term "continual learning" has become overloaded if you see it as an ML problem. One classic thread is about memorization: regularization-based continual learning methods, such as EWC, MAS, and SI, estimate which parameters mattered for previous tasks and resist changing them too much. One modern thread is about adaptation: test-time training and inference-time learning methods, such as TTT, adapt part of the model on the incoming test stream before making predictions. These are sometimes discussed as separate threads. But in modern scalable architectures, I think they are better seen as complementary constraints: a model that learns quickly at test time also benefits from a mechanism for deciding what not to forget. In our #ECCV2026 paper, we study this in large-scale 4D reconstruction: how to build fast spatial memory that can adapt over long observation streams while reducing collapse and forgetting. Instead of using fully plastic test-time updates, we stabilize fast-weight adaptation with an elastic prior that balances adaptation and memory. Key ideas: - Elastic Test-Time Training: Fisher-weighted consolidation for fast-weight updates - EMA anchor weights that provide a moving reference for stability - Chunk-by-chunk inference for long 3D/4D observation streams We show that this scales across large 3D/4D pretraining settings, including both LRM-style and LVSM-style models, and improves reconstruction across benchmarks including Stereo4D, NVIDIA, and DL3DV-140. We release model checkpoints across different design choices: resolution, post-training curriculum, and whether the model uses an explicit 4DGS intermediate representation. - Homepage: - Paper: - Code: - Models: This work is co-led with Xueyang Yu, contributed by Haoyu Zhen Yuncong Yang, and advised by Michigan SLED Lab Chuang Gan.
0:14

The term "continual learning" has become overloaded if you see it as an ML problem. One classic thread is about memorization: regularization-based continual learning methods, such as EWC, MAS, and SI, estimate which parameters mattered for previous tasks and resist changing them too much. One modern thread is about adaptation: test-time training and inference-time learning methods, such as TTT, adapt part of the model on the incoming test stream before making predictions. These are sometimes discussed as separate threads. But in modern scalable architectures, I think they are better seen as complementary constraints: a model that learns quickly at test time also benefits from a mechanism for deciding what not to forget. In our #ECCV2026 paper, we study this in large-scale 4D reconstruction: how to build fast spatial memory that can adapt over long observation streams while reducing collapse and forgetting. Instead of using fully plastic test-time updates, we stabilize fast-weight adaptation with an elastic prior that balances adaptation and memory. Key ideas: - Elastic Test-Time Training: Fisher-weighted consolidation for fast-weight updates - EMA anchor weights that provide a moving reference for stability - Chunk-by-chunk inference for long 3D/4D observation streams We show that this scales across large 3D/4D pretraining settings, including both LRM-style and LVSM-style models, and improves reconstruction across benchmarks including Stereo4D, NVIDIA, and DL3DV-140. We release model checkpoints across different design choices: resolution, post-training curriculum, and whether the model uses an explicit 4DGS intermediate representation. - Homepage: - Paper: - Code: - Models: This work is co-led with Xueyang Yu, contributed by Haoyu Zhen Yuncong Yang, and advised by Michigan SLED Lab Chuang Gan.

Martin Ziqiao Ma

33,698 次观看 • 2 个月前

$IREN "we haven't disclosed the specific amount of GPUs" 1. 🤮 reminds me of $NBIS 2. Setting a terrible precedent here for future deals 3. Making it purposely difficult, to not let analysts properly value your 2027 revenue 4. Increasing the polarized view on IREN by the market However: "approximately 60MW of air-cooled Blackwells" 1. You typically don't talk about gross capacity in a deployment like this 2. If it would be gross capacity, the GPU hour rate at IT level would be crazy high (at PUE 1.2, $680m / 50 = 13.6m/MW) 3. At 60MW IT load, and ~14kW draw at DGX server level, we can get to ~4,286 DGX systems with 8 GPUs per. 4. Based on this we can conclude that 60MW of IT load can run approximately 34k DGX B300. 5. 34k DGX B300 at $680m/yr, would represent a GPU hour price of $2.28 Now this is the problem with not disclosing your GPU quantity. You purposely make your business model look bad, because by approach, you get to a GPU hour price that would imply a payback period of 4 years, where only the last year of the contract is 100% margin. But of course, we can also take "the glass is half full" approach. IREN has ordered 50K B300s from Dell. They have 2 purchase orders for this, 1 between Dell Canada and IE CA Leasing Ltd for 4 phases, and 1 between Dell USA and IE US Hardware 1 Inc (amended from IE US Hardware 4 Inc on April 27, 2026). The order for Canada is divided in 4 phases, and are going to Mackenzie for 80MW of gross capacity, which happens to be 4 buildings of 20MW. The order for Childress is divided in 2 phases, and are going to DC35 and DC36, (as depicted in the earnings presentation) and those are 50MW gross. The purchase price of the order for Childress was $1.2B, and for Canada it was $2.3B If we go with 50,000 B300s for a total of $3.5B then $1.2 would represent 34.285% of the 50,000 GPUs, or 17,140 B300s rounded down. For this calculation I will consider that $IREN will deploy 17,140 GPUs in 50MW gross capacity in DC35 and DC36 of block 3 in Childress.. That would imply at 1.2 PUE, IREN can run 17,140 B300s in 41.67MW IT load. Now by that ratio, they can run 24,680 GPUs in 60MW IT load — a massive difference with 34k units through the Nvidia DGX reference calculation. If common sense is applied, you can still get to 2 completely different outcomes, that show a difference of more than 9k GPUs. The GPU hour rate at 24.68k GPUs would be $3.145 per B300, as MASSIVE difference from the earlier calculated $2.28. Sure, the DGX system may be a factor here. And I'm sure that the reality is somewhere in the middle. But I personally hate this as an investor, to be unable to calculate profitability on unit economic basis. After all, contracts are signed on a $/GPU hour basis. Why hide this from your investors? Not being able to calculate payback periods, unable to calculate ROIC. And most importantly, we cannot properly assess the $NVDA deal on a contract basis. I really hope the payback period of this contract is not 4 years. I want the glass to be half full, but by starting to censor the purchases, IREN is taking a step in the wrong direction. Not a fan of this.
0:14

$IREN "we haven't disclosed the specific amount of GPUs" 1. 🤮 reminds me of $NBIS 2. Setting a terrible precedent here for future deals 3. Making it purposely difficult, to not let analysts properly value your 2027 revenue 4. Increasing the polarized view on IREN by the market However: "approximately 60MW of air-cooled Blackwells" 1. You typically don't talk about gross capacity in a deployment like this 2. If it would be gross capacity, the GPU hour rate at IT level would be crazy high (at PUE 1.2, $680m / 50 = 13.6m/MW) 3. At 60MW IT load, and ~14kW draw at DGX server level, we can get to ~4,286 DGX systems with 8 GPUs per. 4. Based on this we can conclude that 60MW of IT load can run approximately 34k DGX B300. 5. 34k DGX B300 at $680m/yr, would represent a GPU hour price of $2.28 Now this is the problem with not disclosing your GPU quantity. You purposely make your business model look bad, because by approach, you get to a GPU hour price that would imply a payback period of 4 years, where only the last year of the contract is 100% margin. But of course, we can also take "the glass is half full" approach. IREN has ordered 50K B300s from Dell. They have 2 purchase orders for this, 1 between Dell Canada and IE CA Leasing Ltd for 4 phases, and 1 between Dell USA and IE US Hardware 1 Inc (amended from IE US Hardware 4 Inc on April 27, 2026). The order for Canada is divided in 4 phases, and are going to Mackenzie for 80MW of gross capacity, which happens to be 4 buildings of 20MW. The order for Childress is divided in 2 phases, and are going to DC35 and DC36, (as depicted in the earnings presentation) and those are 50MW gross. The purchase price of the order for Childress was $1.2B, and for Canada it was $2.3B If we go with 50,000 B300s for a total of $3.5B then $1.2 would represent 34.285% of the 50,000 GPUs, or 17,140 B300s rounded down. For this calculation I will consider that $IREN will deploy 17,140 GPUs in 50MW gross capacity in DC35 and DC36 of block 3 in Childress.. That would imply at 1.2 PUE, IREN can run 17,140 B300s in 41.67MW IT load. Now by that ratio, they can run 24,680 GPUs in 60MW IT load — a massive difference with 34k units through the Nvidia DGX reference calculation. If common sense is applied, you can still get to 2 completely different outcomes, that show a difference of more than 9k GPUs. The GPU hour rate at 24.68k GPUs would be $3.145 per B300, as MASSIVE difference from the earlier calculated $2.28. Sure, the DGX system may be a factor here. And I'm sure that the reality is somewhere in the middle. But I personally hate this as an investor, to be unable to calculate profitability on unit economic basis. After all, contracts are signed on a $/GPU hour basis. Why hide this from your investors? Not being able to calculate payback periods, unable to calculate ROIC. And most importantly, we cannot properly assess the $NVDA deal on a contract basis. I really hope the payback period of this contract is not 4 years. I want the glass to be half full, but by starting to censor the purchases, IREN is taking a step in the wrong direction. Not a fan of this.

Frans Bakker

148,167 次观看 • 3 个月前

Microsoft made 100B parameter models run on a single CPU. bitnet.cpp: The official inference framework for 1-bit LLMs. The math behind 1-bit LLMs is what makes them revolutionary. Traditional LLMs use 16-bit floating point weights. Every parameter is a number like 0.0023847 or -1.4729. When you run inference, you multiply these floats together. Billions of times. That's why you need GPUs, they're optimized for floating point matrix multiplication. BitNet b1.58 uses ternary weights: {-1, 0, 1}. That's not a simplification. That's a fundamental change in the math. When your weights are only -1, 0, or 1: → Multiply by 1 = keep the value → Multiply by -1 = flip the sign → Multiply by 0 = skip entirely Matrix multiplication becomes addition and subtraction. No floating point operations. No GPU required. This is why bitnet.cpp achieves: → 2.37x to 6.17x speedup on x86 CPUs → 1.37x to 5.07x speedup on ARM CPUs → 71.9% to 82.2% energy reduction on x86 → 55.4% to 70.0% energy reduction on ARM The speedups scale with model size. Larger models see bigger gains because there are more operations to simplify. A 100B parameter model running at human reading speed (5-7 tokens/second) on a single CPU. That's not optimization. That's a different paradigm. Why 1.58 bits? Because log₂(3) ≈ 1.58. Three possible values = 1.58 bits of information per weight. The key insight: These models aren't quantized after training. They're trained from scratch with ternary weights. The model learns to work within the constraint. No precision loss. No quality tradeoff.
0:13

Microsoft made 100B parameter models run on a single CPU. bitnet.cpp: The official inference framework for 1-bit LLMs. The math behind 1-bit LLMs is what makes them revolutionary. Traditional LLMs use 16-bit floating point weights. Every parameter is a number like 0.0023847 or -1.4729. When you run inference, you multiply these floats together. Billions of times. That's why you need GPUs, they're optimized for floating point matrix multiplication. BitNet b1.58 uses ternary weights: {-1, 0, 1}. That's not a simplification. That's a fundamental change in the math. When your weights are only -1, 0, or 1: → Multiply by 1 = keep the value → Multiply by -1 = flip the sign → Multiply by 0 = skip entirely Matrix multiplication becomes addition and subtraction. No floating point operations. No GPU required. This is why bitnet.cpp achieves: → 2.37x to 6.17x speedup on x86 CPUs → 1.37x to 5.07x speedup on ARM CPUs → 71.9% to 82.2% energy reduction on x86 → 55.4% to 70.0% energy reduction on ARM The speedups scale with model size. Larger models see bigger gains because there are more operations to simplify. A 100B parameter model running at human reading speed (5-7 tokens/second) on a single CPU. That's not optimization. That's a different paradigm. Why 1.58 bits? Because log₂(3) ≈ 1.58. Three possible values = 1.58 bits of information per weight. The key insight: These models aren't quantized after training. They're trained from scratch with ternary weights. The model learns to work within the constraint. No precision loss. No quality tradeoff.

Tech with Mak

23,036 次观看 • 4 个月前

Prediction Market is one of the leading Web3 niches in 2024! With about $4 Billion in trading volume, $192 Million in TVL and millions of users in 2024, prediction protocols have been showing tremendous growth and attracting user adoption in Web3. PolyMarket seems to be leading the pack, with over $175M in TVL, and backing from Vitalik Buterin. However, a majority of Prediction Markets, including PolyMarket, currently lacks the flexibility and capital efficiency required for seamless transactions. Also, they are all majorly focused on driving Web2 users thus neglecting the need for markets that cater for short-term, high-risk investments from Web3 Degens. To tackle these flaws, there's a need for a revolutionary contender that understands the need of Web3 Chads That's where Predict Hub comes in PredictHub is a prediction Market that transforms real world events into opportunities for everyone to participate and forecast. Launching on Arbitrum, PredictHub is already catching the attention of major players in the Space by offering something PolyMarket and others don't - Flexibility and Incentives. By offering fast market updates and innovative prediction category like ETF Forecasts, PredictHub is changing how we interact with Prediction Markets. But then, here's where it gets more interesting; PredictHub offer users a unique point system, where you don't just make predictions, you also earn rewards. The more you Predict, the more you earn. These rewards are 2-fold: Nova and Orbit Points. Nova Points are earned by traders based on their trading activity and their leaderboard ranking. Orbit Points, on the other hand, are earned by users who provide liquidity, based on their LP size and duration. Other Point systems include PolyMarket User Points, Leaderboard Bonus and Market Multipliers. These rewards offer users more competitive edge than other prediction markets. Apart from these rewards, PredictHub features a unique 3-tier referral system, rewarding users with even more as you invite your friends. The more friends you bring, the greater the rewards. On top of these, PredictHub focuses on USDC and a wide-range of yield bearing assets like GLP, gUSDC, and sUSDe, enabling users to optimise their earning while holding assets across Networks. Exciting, right? PredictHub is in its Testnet phase and you can start earning Points Right away 🔅 Here's how to Get Started on PredictHub: 1. Go to 2. Request Faucet 3. Start making predictions and earning Points Easy-Peasy ✅ More Info can be gotten from Predict Hub All eyes are on PredictHub as the fix for the flaws of Prediction Market Protocols. With its unique approach targeting untapped niches that most existing prediction markets have yet to explore, I believe the Protocol has the potential to become a breakout success I will be placing good Predictions to Position 🚀🚀🚀
0:11

Prediction Market is one of the leading Web3 niches in 2024! With about $4 Billion in trading volume, $192 Million in TVL and millions of users in 2024, prediction protocols have been showing tremendous growth and attracting user adoption in Web3. PolyMarket seems to be leading the pack, with over $175M in TVL, and backing from Vitalik Buterin. However, a majority of Prediction Markets, including PolyMarket, currently lacks the flexibility and capital efficiency required for seamless transactions. Also, they are all majorly focused on driving Web2 users thus neglecting the need for markets that cater for short-term, high-risk investments from Web3 Degens. To tackle these flaws, there's a need for a revolutionary contender that understands the need of Web3 Chads That's where Predict Hub comes in PredictHub is a prediction Market that transforms real world events into opportunities for everyone to participate and forecast. Launching on Arbitrum, PredictHub is already catching the attention of major players in the Space by offering something PolyMarket and others don't - Flexibility and Incentives. By offering fast market updates and innovative prediction category like ETF Forecasts, PredictHub is changing how we interact with Prediction Markets. But then, here's where it gets more interesting; PredictHub offer users a unique point system, where you don't just make predictions, you also earn rewards. The more you Predict, the more you earn. These rewards are 2-fold: Nova and Orbit Points. Nova Points are earned by traders based on their trading activity and their leaderboard ranking. Orbit Points, on the other hand, are earned by users who provide liquidity, based on their LP size and duration. Other Point systems include PolyMarket User Points, Leaderboard Bonus and Market Multipliers. These rewards offer users more competitive edge than other prediction markets. Apart from these rewards, PredictHub features a unique 3-tier referral system, rewarding users with even more as you invite your friends. The more friends you bring, the greater the rewards. On top of these, PredictHub focuses on USDC and a wide-range of yield bearing assets like GLP, gUSDC, and sUSDe, enabling users to optimise their earning while holding assets across Networks. Exciting, right? PredictHub is in its Testnet phase and you can start earning Points Right away 🔅 Here's how to Get Started on PredictHub: 1. Go to 2. Request Faucet 3. Start making predictions and earning Points Easy-Peasy ✅ More Info can be gotten from Predict Hub All eyes are on PredictHub as the fix for the flaws of Prediction Market Protocols. With its unique approach targeting untapped niches that most existing prediction markets have yet to explore, I believe the Protocol has the potential to become a breakout success I will be placing good Predictions to Position 🚀🚀🚀

InfoSpace OG

19,674 次观看 • 1 年前

We’re excited to introduce Text-to-LoRA: a Hypernetwork that generates task-specific LLM adapters (LoRAs) based on a text description of the task. Catch our presentation at #ICML2025! Paper: Code: Biological systems are capable of rapid adaptation, given limited sensory cues. For example, our human visual system can quickly adapt and tune its light sensitivity to our surroundings. While modern LLMs exhibit a wide variety of capabilities and knowledge, they remain rigid when adding task-specific capabilities. Traditionally, customizing these models requires gathering large datasets and performing often expensive, time-consuming fine-tuning for specific applications. To bypass these limitations, Text-to-LoRA (T2L) meta-learns a “hypernetwork” that takes in a text description of a desired task, as a prompt, and generates a task-specific LoRA that performs well on the task. In our experiments, we show that T2L can encode hundreds of existing LoRA adapters. While the compression is lossy, T2L maintains the performance of task-specifically tuned LoRA adapters. We also show that T2L can even generalize to unseen tasks given a natural language description of the tasks. Importantly, Text-to-LoRA is parameter-efficient. It generates LoRAs in a single, inexpensive step, based solely on a simple text description of the task. This approach is a step towards dramatically lowering the technical and computational barriers, allowing non-technical users to specialize foundation models using plain language, rather than needing deep technical expertise or large compute resources.
0:18

We’re excited to introduce Text-to-LoRA: a Hypernetwork that generates task-specific LLM adapters (LoRAs) based on a text description of the task. Catch our presentation at #ICML2025! Paper: Code: Biological systems are capable of rapid adaptation, given limited sensory cues. For example, our human visual system can quickly adapt and tune its light sensitivity to our surroundings. While modern LLMs exhibit a wide variety of capabilities and knowledge, they remain rigid when adding task-specific capabilities. Traditionally, customizing these models requires gathering large datasets and performing often expensive, time-consuming fine-tuning for specific applications. To bypass these limitations, Text-to-LoRA (T2L) meta-learns a “hypernetwork” that takes in a text description of a desired task, as a prompt, and generates a task-specific LoRA that performs well on the task. In our experiments, we show that T2L can encode hundreds of existing LoRA adapters. While the compression is lossy, T2L maintains the performance of task-specifically tuned LoRA adapters. We also show that T2L can even generalize to unseen tasks given a natural language description of the tasks. Importantly, Text-to-LoRA is parameter-efficient. It generates LoRAs in a single, inexpensive step, based solely on a simple text description of the task. This approach is a step towards dramatically lowering the technical and computational barriers, allowing non-technical users to specialize foundation models using plain language, rather than needing deep technical expertise or large compute resources.

Sakana AI

403,159 次观看 • 1 年前

seedance 2.0 + my v2 AI UGC prompting system is giving insane results i spent the last 24 hours generating over 200 seedance 2.0 videos to figure out the best prompting framework system for AI UGC this video was made with 1 prompt and 1 tool, no editing was done to the video this was just a prompt to a video this is by far the best model i've ever used and the craziest part is that it can be fully automated this is the first time we can actually automate high quality ai ugc at this level bytedance owns tiktok so this model is trained on millions of high quality ugc videos. you just need to know how to extract that and call it in your prompt. we are so early... it's insane
0:14

seedance 2.0 + my v2 AI UGC prompting system is giving insane results i spent the last 24 hours generating over 200 seedance 2.0 videos to figure out the best prompting framework system for AI UGC this video was made with 1 prompt and 1 tool, no editing was done to the video this was just a prompt to a video this is by far the best model i've ever used and the craziest part is that it can be fully automated this is the first time we can actually automate high quality ai ugc at this level bytedance owns tiktok so this model is trained on millions of high quality ugc videos. you just need to know how to extract that and call it in your prompt. we are so early... it's insane

Miko

81,462 次观看 • 6 个月前

NORWAY IS GOING TO BAN BITCOIN MINING WITHOUT PUBLIC CONSULTATIONS - WE NEED TO ACT NOW Norway's Ministry of Digitalisation and Public Administration responded to Open Dialogue Foundation / Fundacja Otwarty Dialog that it "has no plans to conduct a public consultation" on a ban on cryptocurrency mining. There is no doubt that the ban designed to target #Bitcoin mining. Unfortunately, that's a stance of the Stortinget and the Norwegian government. 🔴 Why we should protect our #freedomtech Bitcoin in #Norway NOW: (1) Norway is fully integrated in the European Single Market throught the European Economic Area (EEA) and Schengen Agreement. It means Norway can provide its legilsative approach as an input for new legislation for the EU/EEA both: - during the preparatory phase, when the European Commission is developing proposals; - during work of expert groups and committees of the European Commission; - submitting proposals and comments to European Free Trade Association on upcoming legislation. (2) As a co-founder of the OECD ➡️ Better Policies for Better Lives , Norway sets an example of regulation worldwide and provides its legislative recommedations for global standards. (3) Norway has historically been a place to meet, share experiences and educate human rights defenders and bitcoiners from around the world. Norwegian goverment will present its investigation a ban on cryptocurrency mining by the end od 2024. 🔴 What we should do together to prevent Bitcoin mining ban: (1) Repost this post and join our #BTC Coalition to educate local communities and media about social benefits of Bitcoin mining in Norway and worldwide; (2) Help us pool resources and best practices to convince Norwegian politicians and media to explore the social benefits of Bitcoin to prevent this repressive regulation; (3) If you are a Norwegian citizen: write a letter to your legislator and government asking for public consultation and providing arguments about the social benefits of Bitcoin mining for Norway. 🧡
0:11

NORWAY IS GOING TO BAN BITCOIN MINING WITHOUT PUBLIC CONSULTATIONS - WE NEED TO ACT NOW Norway's Ministry of Digitalisation and Public Administration responded to Open Dialogue Foundation / Fundacja Otwarty Dialog that it "has no plans to conduct a public consultation" on a ban on cryptocurrency mining. There is no doubt that the ban designed to target #Bitcoin mining. Unfortunately, that's a stance of the Stortinget and the Norwegian government. 🔴 Why we should protect our #freedomtech Bitcoin in #Norway NOW: (1) Norway is fully integrated in the European Single Market throught the European Economic Area (EEA) and Schengen Agreement. It means Norway can provide its legilsative approach as an input for new legislation for the EU/EEA both: - during the preparatory phase, when the European Commission is developing proposals; - during work of expert groups and committees of the European Commission; - submitting proposals and comments to European Free Trade Association on upcoming legislation. (2) As a co-founder of the OECD ➡️ Better Policies for Better Lives , Norway sets an example of regulation worldwide and provides its legislative recommedations for global standards. (3) Norway has historically been a place to meet, share experiences and educate human rights defenders and bitcoiners from around the world. Norwegian goverment will present its investigation a ban on cryptocurrency mining by the end od 2024. 🔴 What we should do together to prevent Bitcoin mining ban: (1) Repost this post and join our #BTC Coalition to educate local communities and media about social benefits of Bitcoin mining in Norway and worldwide; (2) Help us pool resources and best practices to convince Norwegian politicians and media to explore the social benefits of Bitcoin to prevent this repressive regulation; (3) If you are a Norwegian citizen: write a letter to your legislator and government asking for public consultation and providing arguments about the social benefits of Bitcoin mining for Norway. 🧡

Lyudmyla Kozlovska 🇪🇺🇺🇦

53,090 次观看 • 2 年前