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🧬A new imaging technique developed by the Liu Lab uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples, providing a full picture of how these structures are organized inside tissues.

HHMI | Janelia

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79,585 görüntüleme • 1 yıl önce •via X (Twitter)

Sağlık & İyilik Eğitim Bilim & Teknoloji

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Molecule profil fotoğrafı

Molecule1 yıl önce

Combining RNA and protein tracking in context will drive major discoveries

NOVOS Labs profil fotoğrafı

NOVOS Labs1 yıl önce

Generic products cut corners with proprietary blends and fewer pathways. NOVOS delivers results by targeting 12 root causes of aging, backed by real science. Explore NOVOS today.

Anna Montell Magnusson profil fotoğrafı

Anna Montell Magnusson1 yıl önce

Hi Nelson, you are still having fun in the lab I see, great. See you at some point. Are you going to a GRC this summer? Best, Anna

Independent Solutions profil fotoğrafı

Independent Solutions1 yıl önce

Innovative! (rt @Hyun_neuron_10)

Yang Fan 范阳 profil fotoğrafı

Yang Fan 范阳1 yıl önce

cool, like using drones to live-stream a cell’s hidden delivery network.

TrolliProf profil fotoğrafı

TrolliProf1 yıl önce

So ducking cool

DeepFish📐 profil fotoğrafı

DeepFish📐1 yıl önce

🤯🤯🤯

Korr Neuro profil fotoğrafı

Korr Neuro1 yıl önce

Woah! Nice... and very useful. 👍

The Stick profil fotoğrafı

The Stick1 yıl önce

This is awesome.

Jarrett Foust profil fotoğrafı

Jarrett Foust1 yıl önce

Holy shit. I can see my entire college education in real time now.

Vina Tikiyani profil fotoğrafı

Vina Tikiyani1 yıl önce

This is awesome!

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NIH researchers are exploring how immature cells called stem cells develop into specialized cells like heart or lung cells. This research on how cells keep their DNA organized during that specialization process could help advance the development of lab grown organs for thousands of people waiting on a transplant. Watch the full video to learn more:

NIH researchers are exploring how immature cells called stem cells develop into specialized cells like heart or lung cells. This research on how cells keep their DNA organized during that specialization process could help advance the development of lab grown organs for thousands of people waiting on a transplant. Watch the full video to learn more:

NIH

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This is one of the strongest points for intelligent design that evolutionists mostly ignore. The body is highly organized. Without specific organization, Life couldn't survive. Evolution claims random mutation + selection within the DNA is able to create virtually limitless change, transforming a single cell all the way to Man. But DNA mutations can't build new body plans. Even if DNA mutations produced new proteins... ...Proteins must be organized into functional systems... ...which are then organized within cells... ...which are then organized into tissues... ...which are then organized into organs... ...which are then organized into a full body plans. But the instructions for organizing all these layers of specified complexity is not found solely in the DNA. Which means genetic mutations can't explain the creation of novel body plans. On top of that, evolution builds step-by-step. But this system of organization must be complete for Life to survive, from the smallest proteins all the way to the larger organs. This type of specified, complex organization has only ever been observed to arise from intelligence. Vehicles, computers, factories, and all kinds of human-made articlfacts have similar hierarchies of organization. We regularly observe intelligence creating complex systems of organization. We've never seen natural forces do anything remotely close.

This is one of the strongest points for intelligent design that evolutionists mostly ignore. The body is highly organized. Without specific organization, Life couldn't survive. Evolution claims random mutation + selection within the DNA is able to create virtually limitless change, transforming a single cell all the way to Man. But DNA mutations can't build new body plans. Even if DNA mutations produced new proteins... ...Proteins must be organized into functional systems... ...which are then organized within cells... ...which are then organized into tissues... ...which are then organized into organs... ...which are then organized into a full body plans. But the instructions for organizing all these layers of specified complexity is not found solely in the DNA. Which means genetic mutations can't explain the creation of novel body plans. On top of that, evolution builds step-by-step. But this system of organization must be complete for Life to survive, from the smallest proteins all the way to the larger organs. This type of specified, complex organization has only ever been observed to arise from intelligence. Vehicles, computers, factories, and all kinds of human-made articlfacts have similar hierarchies of organization. We regularly observe intelligence creating complex systems of organization. We've never seen natural forces do anything remotely close.

Divinely Designed

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In Blade Runner 2049 it was Ryan Gosling’s idea to use the baseline test that “K” recites back ("A system of cells interlinked within / Cells interlinked within cells") His acting technique called "dropping in", which gave trance-like hypnotic effect.

In Blade Runner 2049 it was Ryan Gosling’s idea to use the baseline test that “K” recites back ("A system of cells interlinked within / Cells interlinked within cells") His acting technique called "dropping in", which gave trance-like hypnotic effect.

Emir Han

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DARPA—who developed the Operation Warp Speed Death Jabs (see tweet 2)—now wants to inject people with "protein complexes" that, when hit with "different wavelengths of light" will "synthesize specific DNA or RNA sequences on demand." DARPA = literal Nazis. Nuremberg for DARPA! ----------------Partial transcription of clip--------------- "Synthetic DNA and RNA molecules could enable a host of next-generation technologies crucial for national security and global well-being. However, current methods for creating these molecules from scratch face significant limitations in terms of their scale, complexity, and use of hazardous chemicals. DARPA's Generative Optogenetics Program. "GO seeks to harness the power of light to direct the synthesis of DNA and RNA directly within living cells. If successful, this high-risk, high-reward research program has the potential to revolutionize medicine, agriculture, and manufacturing. "GO aims to unlock an era of programmable biology where we can communicate with and direct cell behavior with unprecedented speed, precision, and reach via optical signals. Performers on GO will design protein complexes that, when expressed in a living cell, use light-triggered signaling to deliver genetic information, instructing cells to incorporate specific building blocks based on different wavelengths of light to synthesize specific DNA or RNA sequences on demand. "The GO program focuses on two main research objectives. The first is achieving the core capability of synthesizing DNA or RNA directly in living cells using optical signals. The second focuses on developing error-mitigation methods that ensure high-fidelity nucleic acid synthesis."

DARPA—who developed the Operation Warp Speed Death Jabs (see tweet 2)—now wants to inject people with "protein complexes" that, when hit with "different wavelengths of light" will "synthesize specific DNA or RNA sequences on demand." DARPA = literal Nazis. Nuremberg for DARPA! ----------------Partial transcription of clip--------------- "Synthetic DNA and RNA molecules could enable a host of next-generation technologies crucial for national security and global well-being. However, current methods for creating these molecules from scratch face significant limitations in terms of their scale, complexity, and use of hazardous chemicals. DARPA's Generative Optogenetics Program. "GO seeks to harness the power of light to direct the synthesis of DNA and RNA directly within living cells. If successful, this high-risk, high-reward research program has the potential to revolutionize medicine, agriculture, and manufacturing. "GO aims to unlock an era of programmable biology where we can communicate with and direct cell behavior with unprecedented speed, precision, and reach via optical signals. Performers on GO will design protein complexes that, when expressed in a living cell, use light-triggered signaling to deliver genetic information, instructing cells to incorporate specific building blocks based on different wavelengths of light to synthesize specific DNA or RNA sequences on demand. "The GO program focuses on two main research objectives. The first is achieving the core capability of synthesizing DNA or RNA directly in living cells using optical signals. The second focuses on developing error-mitigation methods that ensure high-fidelity nucleic acid synthesis."

Sense Receptor

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🔬🤖Excited to share permittivity tensor imaging (PTI), a label-free computational imaging module for high-resolution 3D imaging of dry mass and 3D orientation of organelles, cells, and tissues! 🧬🧫 Just published in Nature Methods Shout out to Li-Hao Yeh , Talon Chandler, Ivan Ivanov, Janie Byrum, Bryant , Syuan-Ming Guo, Cameron Foltz at Chan Zuckerberg Biohub Network, Peter Kazansky lab ORC Southampton, BruceConklin lab at Gladstone Institutes, and May Han lab at Stanford Medicine. 🧵1/n

🔬🤖Excited to share permittivity tensor imaging (PTI), a label-free computational imaging module for high-resolution 3D imaging of dry mass and 3D orientation of organelles, cells, and tissues! 🧬🧫 Just published in Nature Methods Shout out to Li-Hao Yeh , Talon Chandler, Ivan Ivanov, Janie Byrum, Bryant , Syuan-Ming Guo, Cameron Foltz at Chan Zuckerberg Biohub Network, Peter Kazansky lab ORC Southampton, BruceConklin lab at Gladstone Institutes, and May Han lab at Stanford Medicine. 🧵1/n

Shalin Mehta

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Many protein complexes that drive key processes in cells are “molecular motors”—assemblies that consume (electro)chemical energy to produce mechanical work. A 2023 #SciencePerspective discusses how insights from biophysical, biochemical, and structural studies are starting to yield an understanding of the mechanism by which these motors extrude loops of DNA to structure genomes. Learn more:

Many protein complexes that drive key processes in cells are “molecular motors”—assemblies that consume (electro)chemical energy to produce mechanical work. A 2023 #SciencePerspective discusses how insights from biophysical, biochemical, and structural studies are starting to yield an understanding of the mechanism by which these motors extrude loops of DNA to structure genomes. Learn more:

Science Magazine

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Neat new system to evolve protein-protein interactions - while altering both sides of the interface! Watch for a description of the clever method, read the paper to get the deets on how these interfaces evolved & predictive models trained on screen data.

Neat new system to evolve protein-protein interactions - while altering both sides of the interface! Watch for a description of the clever method, read the paper to get the deets on how these interfaces evolved & predictive models trained on screen data.

Julia Bauman

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1.Stem cells reside in specialized microenvironments that precisely regulate their behavior. For this reason they are best studied in their in vivo context. A new paper from our lab describes a method for long-term imaging & quantitative analysis of hematopoiesis in vivo in flies

1.Stem cells reside in specialized microenvironments that precisely regulate their behavior. For this reason they are best studied in their in vivo context. A new paper from our lab describes a method for long-term imaging & quantitative analysis of hematopoiesis in vivo in flies

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The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein. Triggering the immune system to attack them.

The stark reality is that the inflammation, myocarditis is a symptom of the damage done to the heart by the immune system in response to the cells in the heart producing a foreign protein. Triggering the immune system to attack them.

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By collecting information about the past found within core samples, #geologists contribute towards a better understanding of how conditions may change in the future. Ready for a virtual tour of the USGS Sediment Core Lab? We thought you'd never ask!

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USGS Coastal Change

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This is how DNA turns raw data into functional proteins - the building blocks of all your cells. This system requires a minimum of 3 key players working together: DNA: the master blueprint with the instructions RNA Polymerase: reads the DNA and makes a temporary copy called mRNA which carries the instructions to the Ribosome for how to create the Protein Ribosome: the tiny factory that reads the mRNA and strings amino acids together in a specific sequence to create a protein Without all three molecules working together, Proteins cannot be created, cells don't function, and Life ends. Everything needs to fit together, precisely & perfectly, or it all falls apart. In other words: this system cannot evolve, one step at a time. DNA relies other machines made of proteins to create those very proteins - but those proteins can't be made without the information in the DNA. And on top of that, this whole system relies on OTHER systems! You need other things like ATP Synthase that makes energy to power everything, tRNA to carry the amino acids to the Ribosome, other helper proteins, processing enzymes, etc. It's an extremely complex, interdependent network of parts & systems that all rely on each other. The cell is an astounding level of complexity that surpasses anything in human engineering. It's obvious this is intelligently designed. To deny that is absurd.

This is how DNA turns raw data into functional proteins - the building blocks of all your cells. This system requires a minimum of 3 key players working together: DNA: the master blueprint with the instructions RNA Polymerase: reads the DNA and makes a temporary copy called mRNA which carries the instructions to the Ribosome for how to create the Protein Ribosome: the tiny factory that reads the mRNA and strings amino acids together in a specific sequence to create a protein Without all three molecules working together, Proteins cannot be created, cells don't function, and Life ends. Everything needs to fit together, precisely & perfectly, or it all falls apart. In other words: this system cannot evolve, one step at a time. DNA relies other machines made of proteins to create those very proteins - but those proteins can't be made without the information in the DNA. And on top of that, this whole system relies on OTHER systems! You need other things like ATP Synthase that makes energy to power everything, tRNA to carry the amino acids to the Ribosome, other helper proteins, processing enzymes, etc. It's an extremely complex, interdependent network of parts & systems that all rely on each other. The cell is an astounding level of complexity that surpasses anything in human engineering. It's obvious this is intelligently designed. To deny that is absurd.

Divinely Designed

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Nancy Grace warns sending crucial DNA to a private lab could risk destroying limited evidence, questioning why it’s not being handled by the FBI: “There are cases where DNA is sent to a particular lab, a specialty lab, a lab that could have expertise in diluted, destroyed, old, or degraded DNA. But even if that’s why he’s hanging his hat on an excuse to send it to a private lab in Florida, they don’t have anything that the FBI doesn’t have, so that’s not going to wash. If there’s a small amount of DNA inside one of those gloves and it is sent to a lab for testing, that DNA could be used up in the testing. So what I’m saying is, if that lab in Florida uses up that touch DNA, it’s over. Does he not realize what he is risking? He needs to go back to his basketball game.”

Nancy Grace warns sending crucial DNA to a private lab could risk destroying limited evidence, questioning why it’s not being handled by the FBI: “There are cases where DNA is sent to a particular lab, a specialty lab, a lab that could have expertise in diluted, destroyed, old, or degraded DNA. But even if that’s why he’s hanging his hat on an excuse to send it to a private lab in Florida, they don’t have anything that the FBI doesn’t have, so that’s not going to wash. If there’s a small amount of DNA inside one of those gloves and it is sent to a lab for testing, that DNA could be used up in the testing. So what I’m saying is, if that lab in Florida uses up that touch DNA, it’s over. Does he not realize what he is risking? He needs to go back to his basketball game.”

Sean Hannity 🇺🇸

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Where do we actually store memories? Our memories are encoded through the vibrational frequency of our DNA and stored within the crystalline matrix of EZ water, the 4th phase of water. What if they found out how to turn off our dna by flushing our cells of minerals with 8 glasses of water a day.

Where do we actually store memories? Our memories are encoded through the vibrational frequency of our DNA and stored within the crystalline matrix of EZ water, the 4th phase of water. What if they found out how to turn off our dna by flushing our cells of minerals with 8 glasses of water a day.

ConsciouSean

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The Pfizer COVID-19 “vaccine” injected into billions of arms was not the same one used in Pfizer’s clinical trials. There was a “bait-and-switch.” The public received vials contaminated with plasmid DNA. A new study by Kevin McKernan and colleagues found "the presence of billions to hundreds of billions of DNA molecules per dose in these vaccines. Using fluorometry, all vaccines exceed the guidelines for residual DNA set by FDA and WHO of 10 ng/dose by 188 to 509-fold." "That's not 500%, that 500 times the amount that's acceptable," added Del Bigtree.

The Pfizer COVID-19 “vaccine” injected into billions of arms was not the same one used in Pfizer’s clinical trials. There was a “bait-and-switch.” The public received vials contaminated with plasmid DNA. A new study by Kevin McKernan and colleagues found "the presence of billions to hundreds of billions of DNA molecules per dose in these vaccines. Using fluorometry, all vaccines exceed the guidelines for residual DNA set by FDA and WHO of 10 ng/dose by 188 to 509-fold." "That's not 500%, that 500 times the amount that's acceptable," added Del Bigtree.

The Vigilant Fox 🦊

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🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

KanekoaTheGreat

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A Ghanaian man shares a video of the inside of the biggest Apple Store in New York, United States, showing how iPhones and Apple gadgets are cheaper there compared to Ghana, and highlighting how organized and beautiful the place is.

A Ghanaian man shares a video of the inside of the biggest Apple Store in New York, United States, showing how iPhones and Apple gadgets are cheaper there compared to Ghana, and highlighting how organized and beautiful the place is.

we love ghana

65,579 görüntüleme • 2 ay önce

🥇Research track: NCypher by Faith Ogundimu from Dublin, Ireland A tool for a childhood brain cancer that’s nearly always fatal. It searches the stretches of DNA between genes and narrows thousands of suspect DNA changes down to the handful most worth testing in the lab.

🥇Research track: NCypher by Faith Ogundimu from Dublin, Ireland A tool for a childhood brain cancer that’s nearly always fatal. It searches the stretches of DNA between genes and narrows thousands of suspect DNA changes down to the handful most worth testing in the lab.

Claude

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What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Patrick Hsu

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It’s pretty rare to find a typo in a book thanks to the work of eagle-eyed editors. Check out the latest NIH Intramural SciBites video to learn about NIH graduate student Darren Boydston's investigations into how our cells edit the messenger RNA molecules that help turn DNA’s genetic instructions into hard-working proteins:

It’s pretty rare to find a typo in a book thanks to the work of eagle-eyed editors. Check out the latest NIH Intramural SciBites video to learn about NIH graduate student Darren Boydston's investigations into how our cells edit the messenger RNA molecules that help turn DNA’s genetic instructions into hard-working proteins:

NIH

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