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🧬A new imaging technique developed by the Liu Lab uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples, providing a full picture of how these structures are organized inside tissues.

HHMI | Janelia

27,505 subscribers

79,589 次观看 • 1 年前 •via X (Twitter)

健康养生教育科学技术

Anya Rossi• Live Now

Private livecam show

11 条评论

Molecule 的头像

Molecule1 年前

Combining RNA and protein tracking in context will drive major discoveries

NOVOS Labs 的头像

NOVOS Labs1 年前

Generic products cut corners with proprietary blends and fewer pathways. NOVOS delivers results by targeting 12 root causes of aging, backed by real science. Explore NOVOS today.

Anna Montell Magnusson 的头像

Anna Montell Magnusson1 年前

Hi Nelson, you are still having fun in the lab I see, great. See you at some point. Are you going to a GRC this summer? Best, Anna

Independent Solutions 的头像

Independent Solutions1 年前

Innovative! (rt @Hyun_neuron_10)

Yang Fan 范阳的头像

Yang Fan 范阳1 年前

cool, like using drones to live-stream a cell’s hidden delivery network.

TrolliProf 的头像

TrolliProf1 年前

So ducking cool

DeepFish📐 的头像

DeepFish📐1 年前

🤯🤯🤯

Korr Neuro 的头像

Korr Neuro1 年前

Woah! Nice... and very useful. 👍

The Stick 的头像

The Stick1 年前

This is awesome.

Jarrett Foust 的头像

Jarrett Foust1 年前

Holy shit. I can see my entire college education in real time now.

Vina Tikiyani 的头像

Vina Tikiyani1 年前

This is awesome!

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NIH researchers are exploring how immature cells called stem cells develop into specialized cells like heart or lung cells. This research on how cells keep their DNA organized during that specialization process could help advance the development of lab grown organs for thousands of people waiting on a transplant. Watch the full video to learn more:

NIH researchers are exploring how immature cells called stem cells develop into specialized cells like heart or lung cells. This research on how cells keep their DNA organized during that specialization process could help advance the development of lab grown organs for thousands of people waiting on a transplant. Watch the full video to learn more:

NIH

19,895 次观看 • 6 个月前

This is one of the strongest points for intelligent design that evolutionists mostly ignore. The body is highly organized. Without specific organization, Life couldn't survive. Evolution claims random mutation + selection within the DNA is able to create virtually limitless change, transforming a single cell all the way to Man. But DNA mutations can't build new body plans. Even if DNA mutations produced new proteins... ...Proteins must be organized into functional systems... ...which are then organized within cells... ...which are then organized into tissues... ...which are then organized into organs... ...which are then organized into a full body plans. But the instructions for organizing all these layers of specified complexity is not found solely in the DNA. Which means genetic mutations can't explain the creation of novel body plans. On top of that, evolution builds step-by-step. But this system of organization must be complete for Life to survive, from the smallest proteins all the way to the larger organs. This type of specified, complex organization has only ever been observed to arise from intelligence. Vehicles, computers, factories, and all kinds of human-made articlfacts have similar hierarchies of organization. We regularly observe intelligence creating complex systems of organization. We've never seen natural forces do anything remotely close.

This is one of the strongest points for intelligent design that evolutionists mostly ignore. The body is highly organized. Without specific organization, Life couldn't survive. Evolution claims random mutation + selection within the DNA is able to create virtually limitless change, transforming a single cell all the way to Man. But DNA mutations can't build new body plans. Even if DNA mutations produced new proteins... ...Proteins must be organized into functional systems... ...which are then organized within cells... ...which are then organized into tissues... ...which are then organized into organs... ...which are then organized into a full body plans. But the instructions for organizing all these layers of specified complexity is not found solely in the DNA. Which means genetic mutations can't explain the creation of novel body plans. On top of that, evolution builds step-by-step. But this system of organization must be complete for Life to survive, from the smallest proteins all the way to the larger organs. This type of specified, complex organization has only ever been observed to arise from intelligence. Vehicles, computers, factories, and all kinds of human-made articlfacts have similar hierarchies of organization. We regularly observe intelligence creating complex systems of organization. We've never seen natural forces do anything remotely close.

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23,127 次观看 • 16 天前

In Blade Runner 2049 it was Ryan Gosling’s idea to use the baseline test that “K” recites back ("A system of cells interlinked within / Cells interlinked within cells") His acting technique called "dropping in", which gave trance-like hypnotic effect.

In Blade Runner 2049 it was Ryan Gosling’s idea to use the baseline test that “K” recites back ("A system of cells interlinked within / Cells interlinked within cells") His acting technique called "dropping in", which gave trance-like hypnotic effect.

Emir Han

612,385 次观看 • 1 年前

DARPA—who developed the Operation Warp Speed Death Jabs (see tweet 2)—now wants to inject people with "protein complexes" that, when hit with "different wavelengths of light" will "synthesize specific DNA or RNA sequences on demand." DARPA = literal Nazis. Nuremberg for DARPA! ----------------Partial transcription of clip--------------- "Synthetic DNA and RNA molecules could enable a host of next-generation technologies crucial for national security and global well-being. However, current methods for creating these molecules from scratch face significant limitations in terms of their scale, complexity, and use of hazardous chemicals. DARPA's Generative Optogenetics Program. "GO seeks to harness the power of light to direct the synthesis of DNA and RNA directly within living cells. If successful, this high-risk, high-reward research program has the potential to revolutionize medicine, agriculture, and manufacturing. "GO aims to unlock an era of programmable biology where we can communicate with and direct cell behavior with unprecedented speed, precision, and reach via optical signals. Performers on GO will design protein complexes that, when expressed in a living cell, use light-triggered signaling to deliver genetic information, instructing cells to incorporate specific building blocks based on different wavelengths of light to synthesize specific DNA or RNA sequences on demand. "The GO program focuses on two main research objectives. The first is achieving the core capability of synthesizing DNA or RNA directly in living cells using optical signals. The second focuses on developing error-mitigation methods that ensure high-fidelity nucleic acid synthesis."

DARPA—who developed the Operation Warp Speed Death Jabs (see tweet 2)—now wants to inject people with "protein complexes" that, when hit with "different wavelengths of light" will "synthesize specific DNA or RNA sequences on demand." DARPA = literal Nazis. Nuremberg for DARPA! ----------------Partial transcription of clip--------------- "Synthetic DNA and RNA molecules could enable a host of next-generation technologies crucial for national security and global well-being. However, current methods for creating these molecules from scratch face significant limitations in terms of their scale, complexity, and use of hazardous chemicals. DARPA's Generative Optogenetics Program. "GO seeks to harness the power of light to direct the synthesis of DNA and RNA directly within living cells. If successful, this high-risk, high-reward research program has the potential to revolutionize medicine, agriculture, and manufacturing. "GO aims to unlock an era of programmable biology where we can communicate with and direct cell behavior with unprecedented speed, precision, and reach via optical signals. Performers on GO will design protein complexes that, when expressed in a living cell, use light-triggered signaling to deliver genetic information, instructing cells to incorporate specific building blocks based on different wavelengths of light to synthesize specific DNA or RNA sequences on demand. "The GO program focuses on two main research objectives. The first is achieving the core capability of synthesizing DNA or RNA directly in living cells using optical signals. The second focuses on developing error-mitigation methods that ensure high-fidelity nucleic acid synthesis."

Sense Receptor

50,875 次观看 • 8 个月前

🔬🤖Excited to share permittivity tensor imaging (PTI), a label-free computational imaging module for high-resolution 3D imaging of dry mass and 3D orientation of organelles, cells, and tissues! 🧬🧫 Just published in Nature Methods Shout out to Li-Hao Yeh , Talon Chandler, Ivan Ivanov, Janie Byrum, Bryant , Syuan-Ming Guo, Cameron Foltz at Chan Zuckerberg Biohub Network, Peter Kazansky lab ORC Southampton, BruceConklin lab at Gladstone Institutes, and May Han lab at Stanford Medicine. 🧵1/n

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Divinely Designed

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Nancy Grace warns sending crucial DNA to a private lab could risk destroying limited evidence, questioning why it’s not being handled by the FBI: “There are cases where DNA is sent to a particular lab, a specialty lab, a lab that could have expertise in diluted, destroyed, old, or degraded DNA. But even if that’s why he’s hanging his hat on an excuse to send it to a private lab in Florida, they don’t have anything that the FBI doesn’t have, so that’s not going to wash. If there’s a small amount of DNA inside one of those gloves and it is sent to a lab for testing, that DNA could be used up in the testing. So what I’m saying is, if that lab in Florida uses up that touch DNA, it’s over. Does he not realize what he is risking? He needs to go back to his basketball game.”

Nancy Grace warns sending crucial DNA to a private lab could risk destroying limited evidence, questioning why it’s not being handled by the FBI: “There are cases where DNA is sent to a particular lab, a specialty lab, a lab that could have expertise in diluted, destroyed, old, or degraded DNA. But even if that’s why he’s hanging his hat on an excuse to send it to a private lab in Florida, they don’t have anything that the FBI doesn’t have, so that’s not going to wash. If there’s a small amount of DNA inside one of those gloves and it is sent to a lab for testing, that DNA could be used up in the testing. So what I’m saying is, if that lab in Florida uses up that touch DNA, it’s over. Does he not realize what he is risking? He needs to go back to his basketball game.”

Sean Hannity 🇺🇸

600,421 次观看 • 6 个月前

"we take 92-year old human skin cells back to a biological age of around 25 using OSK." David Sinclair says AI could help make age reversal a reality. 👀 - AI screened up to 1 trillion molecules in just a few months, a task that would have taken hundreds to thousands of years using traditional drug discovery. - AI narrowed 1 trillion molecules to around 200 promising drug candidates for laboratory testing. - Researchers used Google DeepMind's AlphaFold protein predictions to virtually test molecules against human proteins before entering the lab. - AI is also helping determine whether human cells have become biologically younger simply by analyzing images of the cells. - Sinclair says his lab can already reprogram 92-year-old human skin cells to a biological age of around 20-25 using OSK partial cellular reprogramming. - "All my students can do this." - "It's not hard at all to reverse aging in isolated human cells." - "The hard part over the last 10 years has been turning it into a safe and effective drug for people." - Biological age is measured using DNA methylation clocks, which Sinclair says are more informative than relying only on telomeres. - Sinclair believes that one day you may no longer be able to tell how old someone is just by looking at them. - Sinclair says his team has early evidence that lost memories can return after brain rejuvenation, adding that the work has not yet been published. - He believes Alzheimer's patients may still retain their memories but have difficulty accessing them. - He believes making the entire body biologically younger could one day cure diseases that are currently incurable. 🤯 - He also said, making the entire body biologically younger could enable it to heal diseases that are currently incurable. Sinclair's approach is simple: "Make the body young, and it will heal itself."

"we take 92-year old human skin cells back to a biological age of around 25 using OSK." David Sinclair says AI could help make age reversal a reality. 👀 - AI screened up to 1 trillion molecules in just a few months, a task that would have taken hundreds to thousands of years using traditional drug discovery. - AI narrowed 1 trillion molecules to around 200 promising drug candidates for laboratory testing. - Researchers used Google DeepMind's AlphaFold protein predictions to virtually test molecules against human proteins before entering the lab. - AI is also helping determine whether human cells have become biologically younger simply by analyzing images of the cells. - Sinclair says his lab can already reprogram 92-year-old human skin cells to a biological age of around 20-25 using OSK partial cellular reprogramming. - "All my students can do this." - "It's not hard at all to reverse aging in isolated human cells." - "The hard part over the last 10 years has been turning it into a safe and effective drug for people." - Biological age is measured using DNA methylation clocks, which Sinclair says are more informative than relying only on telomeres. - Sinclair believes that one day you may no longer be able to tell how old someone is just by looking at them. - Sinclair says his team has early evidence that lost memories can return after brain rejuvenation, adding that the work has not yet been published. - He believes Alzheimer's patients may still retain their memories but have difficulty accessing them. - He believes making the entire body biologically younger could one day cure diseases that are currently incurable. 🤯 - He also said, making the entire body biologically younger could enable it to heal diseases that are currently incurable. Sinclair's approach is simple: "Make the body young, and it will heal itself."

SciTech Era

10,180 次观看 • 23 天前

The Pfizer COVID-19 “vaccine” injected into billions of arms was not the same one used in Pfizer’s clinical trials. There was a “bait-and-switch.” The public received vials contaminated with plasmid DNA. A new study by Kevin McKernan and colleagues found "the presence of billions to hundreds of billions of DNA molecules per dose in these vaccines. Using fluorometry, all vaccines exceed the guidelines for residual DNA set by FDA and WHO of 10 ng/dose by 188 to 509-fold." "That's not 500%, that 500 times the amount that's acceptable," added Del Bigtree.

The Pfizer COVID-19 “vaccine” injected into billions of arms was not the same one used in Pfizer’s clinical trials. There was a “bait-and-switch.” The public received vials contaminated with plasmid DNA. A new study by Kevin McKernan and colleagues found "the presence of billions to hundreds of billions of DNA molecules per dose in these vaccines. Using fluorometry, all vaccines exceed the guidelines for residual DNA set by FDA and WHO of 10 ng/dose by 188 to 509-fold." "That's not 500%, that 500 times the amount that's acceptable," added Del Bigtree.

The Vigilant Fox 🦊

1,245,999 次观看 • 2 年前

Where do we actually store memories? Our memories are encoded through the vibrational frequency of our DNA and stored within the crystalline matrix of EZ water, the 4th phase of water. What if they found out how to turn off our dna by flushing our cells of minerals with 8 glasses of water a day.

Where do we actually store memories? Our memories are encoded through the vibrational frequency of our DNA and stored within the crystalline matrix of EZ water, the 4th phase of water. What if they found out how to turn off our dna by flushing our cells of minerals with 8 glasses of water a day.

ConsciouSean

16,986 次观看 • 5 个月前

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

KanekoaTheGreat

499,849 次观看 • 23 天前

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Claude

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