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A Simian Symphony (1/2): #Neural probe recording from CA1 #hippocampus. #Sonification and #visualization driven by Local Field Potential (LFP) and Current Source Density (CSD). Single-unit spikes each associated different piano keys. #b3d #neuroscience #dataviz #electrophysiology

12 Kommentare

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

I’m excited to share our latest #neuro #visualization. This project spanned many months, and grew in scope to beyond data #visualization to include #sonification. I hope you’ll sit back, put on your headphones, and enjoy a multi-sensory #neuroscience experience.

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

We explore a compressed pattern of brain activity seen in all mammals, that is thought to underlie the creation and consolidation of memories. The Sharp Wave Ripples (#SWRs) in the #hippocampus are the largest oscillation in the #brain, involving 10’s of thousands of #neurons.

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

A Simian Symphony (2/2): CA1 unit ensembles during Sharp Wave Ripples (#SWRs). Spike-sorted units are visualized / sonified across 20 ripples, represented by 3D cell morphology of the #hippocampal #neuron type. Morph between anatomical layer to UMAP space. #neurosience #b3d

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

This video is the result of a fascinating collaboration with @perpl_lab @SAbbaspoor @DiagBiochips @neuroscott. Also grateful to @NeuroMorphoOrg for the neuron models. What follows is a detailed description of what you're seeing in each scene:

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

We start by zooming into the #brain, where we see a @DiagBiochips DeepArray probe recording in the #hippocampus. We zoom in further to see the probe sites flickering with voltage changes around the neurons, the Local Field Potential (LFP).

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

Original data is sampled at 30kHz, so we slow down. The audio #sonification is being driven by the LFP, and the background Current Source Density shows the flow of electrical charges between the cell layers. A multisensory experience of 'ripples' at 1/200th of their real speed.

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

From the #LFP data, a statistical technique ‘spike sorting’ identified individual spiking neurons (‘units’). Groups of neurons fire together as a #cellassembly , a unit of #neural computation. We introduce the spike #sonification, where each unit is given a unique piano key.

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

We then look at a sequence of individual Sharp Wave Ripples and their neuronal ensembles. The cell types of each unit are inferred from their depth and their spiking statistics, and are represented by their 3D neuron morphology.

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

We’ve selected 20 ripples and measured by how many times each unit spikes during the ripple. Assemblies in the first 10 ripples are similar to each other, and those in the last 10 are similar to each other.

Profilbild von Tyler Sloan
Tyler Sloanvor 3 Jahren

For this sequence, the piano notes are assigned to units that had spikes in both sets of ripples. Units who spiked only in the first group were assigned the timbre of an acoustic bass, while the units who spiked only in the second group were assigned that of a marimba.

Profilbild von Earl K. Miller
Earl K. Millervor 3 Jahren

It just needs Tony Levin and Bill Bruford.

Profilbild von Eri
Erivor 3 Jahren

@EdwinRobertoRa4 chécate esta sinfonía, doc!

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Spike 1%

45,609 Aufrufe • vor 2 Monaten

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Mathelirium

40,835 Aufrufe • vor 8 Monaten

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Tom Yeh

16,752 Aufrufe • vor 2 Monaten

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Mathelirium

20,456 Aufrufe • vor 5 Monaten

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37,258 Aufrufe • vor 1 Monat

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Tom Yeh

30,489 Aufrufe • vor 8 Monaten

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Paul Maley

153,765 Aufrufe • vor 2 Monaten

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Dutchsinse

14,548 Aufrufe • vor 1 Monat

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Clinton Desveaux

23,492 Aufrufe • vor 8 Monaten

What if #AI became as decentralized as #Bitcoin? We sat down with our new friend 3700 from Bitcoin Virtual Machine to hear what their incredible team of anons are working on - "Truly Open AI." Full interview here:👇 1: What positive impact will Layer 2s have on Bitcoin? Layer 2s on Bitcoin open up opportunities for innovation, allowing developers to build dApps and smart contracts on top of Bitcoin, expanding its utility and use cases. By submitting transactions for final settlement on the Bitcoin network, Bitcoin Layer 2 networks claim to achieve the same (or close to) level of security and decentralization as the Bitcoin blockchain. Building a separate execution layer allows them the freedom to employ several technologies (such as rollups). Layer 2 can significantly improve Bitcoin's scalability by processing transactions off-chain, reducing congestion on the main blockchain. Overall, Layer 2s on Bitcoin have the potential to address some of Bitcoin's key limitations, making it more efficient, accessible, and versatile in the long run. 2: What does the ETF approval mean for Layer 2 on Bitcoin? The approval of ETF could potentially have several implications for Layer 2 on Bitcoin: Innovation and Development: With a growing interest in Bitcoin spurred by ETF approval, there could be a surge in research and development efforts focused on enhancing Layer 2. Developers and projects may be incentivized to create new and improved Layer 2 protocols to meet the evolving needs of the expanding Bitcoin ecosystem. An ETF approval could boost mainstream Bitcoin adoption and liquidity. This influx of users may also drive interest in Layer 2 on Bitcoin as a means to enhance the scalability and functionality of Bitcoin. 3: What are the primary challenges facing L2s on Bitcoin? The interoperability of different Layer 2s and their compatibility with Bitcoin's main blockchain can be a challenge. Ensuring seamless interaction between various Layer 2 networks and the Bitcoin blockchain is essential for a cohesive and efficient ecosystem. Some Layer 2s may introduce centralization risks if they rely heavily on centralized entities or trusted intermediaries. Maintaining decentralization and censorship resistance, which are core tenets of Bitcoin, while scaling with Layer 2s is a challenge. 4: What aspects of Layer 2 solutions for Bitcoin are you most enthusiastic about? AI represents one of the cornerstones of our modern era. However, achieving a decentralized AI infrastructure, owned and managed by users, has posed significant challenges. The primary obstacle has been the limited capacity to store and execute AI models due to size and computational limitations. To address this challenge, we propose a new blockchain architecture enabling developers to deploy their own Bitcoin Layer 2 solutions tailored specifically for AI tasks, called Truly Open AI. These Layer 2 blockchains are optimized to handle computationally intensive tasks, such as matrix multiplication, directly on-chain. These Bitcoin Layer 2 solutions offer exceptional throughput, minimal latency, and cost-effectiveness. AI dApps are programmed as Solidity smart contracts, ensuring they operate precisely as intended, free from interference or manipulation. Our BVM AI Contracts Library simplifies the integration of neural networks into dApps, empowering developers to embed AI seamlessly. In summary, I'm particularly enthusiastic about the potential of Layer 2 solutions for Bitcoin to revolutionize decentralized AI by providing scalability, security, and accessibility. 5: How is your Layer 2 different from others being built? BVM distinguishes itself as a Modular infrastructure that empowers thousands of distinct Bitcoin Layer 2 networks, spanning Gaming, DeFi, Social, and AI applications. We're continuously enriching the BVM Module Store with new modules to enhance its capabilities. With each new module, builders gain access to a wider array of tools to explore different use cases on the Bitcoin network. Recent additions include the Filecoin module for affordable storage and the AI Contracts Library for constructing AI-powered Bitcoin Layer 2 chains. We're also gearing up to release a ZK roll-up module in the coming weeks to offer an alternative to the standard optimistic roll-up. We aim to simplify the process of launching a Bitcoin Layer 2 network customized to specific requirements. Think of it as a SaaS offering with predefined best practices. Whether it's a DeFi Bitcoin Layer 2 or a GameFi Bitcoin Layer 2, we provide default solutions tailored to each use case. We're dedicated to expanding the BVM ecosystem by incentivizing more builders to join the Bitcoin network. Through various programs and grants, we support builders in covering their operational costs for Bitcoin Layer 2. Additionally, we offer rewards akin to 'L2 mining' to those who contribute to expanding the user base and total value locked on the network. In summary, BVM stands out with its modular infrastructure, tailored solutions, and efforts to grow the Bitcoin ecosystem.

Supra

83,548 Aufrufe • vor 2 Jahren

🚨BREAKING: Violent protest erupts in Pucheng, Shaanxi Province following tragic student death A violent mass protest has erupted in Pucheng, Shaanxi Province in the last 24 hours, following the mysterious death of 17-year-old Dang Changxin. This is the first large-scale protest in China of 2025. Videos circulating online show heavily armed police using batons, kicking protesters, and deploying tear gas to disperse the crowds. The unrest, sparked by public outrage over the handling of Dang’s death and alleged attempts at a cover-up by local authorities, has escalated into one of the most visible challenges to public order in recent months. The Public Security Bureau has been deployed to maintain control as tensions continue to rise. 📆 Timeline of Events 1 January 2025: Dang Changxin allegedly fell to his death from the roof of Pucheng Vocational Education school. 2 January 2025 (Early Morning): Dang’s parents were summoned to the school, informed only that something urgent had happened. Dang’s mother arrived but was not permitted to see her son. His classmates appeared flustered and avoided her questions before quickly dispersing. She was taken to a room, confined there, and denied updates on her son's condition. Later that morning: The deputy director of the local police station informed Dang’s mother that her son had committed suicide by jumping from the school roof. The investigation was declared complete and closed within 24 hours. Afternoon: After repeated demands, Dang’s mother was allowed to see her son at the funeral home. Her brief viewing revealed a bruise on his neck, but teachers forcibly stopped her from inspecting the body further or taking photos. This was her only opportunity to see her son’s body. ⚠️ Suspicious Circumstances The school reportedly confiscated and wiped the mobile phones and smartwatches of all students with potential knowledge of the incident. Witnesses noted signs of a struggle in Dang’s dormitory, but the school has not addressed these claims. Online speculation suggests Dang may have been pushed from the roof, allegedly by children of local officials. Dang’s family has rejected the official explanation, recording videos to publicize their demands for justice. Censors have aggressively suppressed these efforts. Public anger has surged over perceived indifference and a cover-up by the local government and police. Crowds gathered at the school, demanding accountability. ❗️Breakout into violence Although the exact trigger for the clash with police remains unclear, videos circulating on X show protesters storming the school gates and struggling against armed police. The violent response from authorities, including baton strikes and tear gas, has further inflamed tensions. The death of Dang Changxin and the violent crackdown on protests in Pucheng reveal systemic failures of transparency, accountability, and governance in China’s local institutions. The situation remains volatile. (video source: 李老师不是你老师 )

中国人权-Human Rights in China

21,362 Aufrufe • vor 1 Jahr

Deconstructed: How a Lancet Study Manufactured the "Vaccine Safer Than COVID" Headline. A recent headline from The Independent, based on a Lancet study, claims the COVID jab presents less harm than the virus itself. But a closer look reveals a masterclass in how to manipulate data to reach a predetermined conclusion. Here’s how the study was engineered: 1. Rigged Timeline for the "Infection" Group: - The study defined its "COVID infection" cohort from Jan 2020 to March 2022. - This crucially includes the pandemic's darkest period: no vaccines, no natural immunity, failed lockdown policies, and the highest mortality. This group was set up to look as bad as possible. 2. Stacked the Deck for the "Vaccinated" Group: - The vaccinated cohort was studied from Aug 2021 to Dec 2022. - By this time, natural immunity was widespread and the virus had evolved to be less severe (IFR decreased by an order of magnitude). This group was already at a massively lower risk before the vaccine was even factored in. 3. Narrowed the Focus to Hide the Truth: - The alarming graphs you see are based on outcomes in the FIRST SIX MONTHS for each group. - This further hones in on the absolute peak of the pandemic for the unvaccinated, versus a much calmer period for the vaccinated. 4. The "Vaccinated" Group is a Misonomer: - The study's definition of "vaccinated" was a record of a SINGLE Pfizer dose. - We know from robust data that myocarditis risk spikes dramatically after the SECOND and THIRD doses. By ignoring this, the study completely sidesteps the primary source of vaccine-associated harm. The result? A chart showing infection as dangerously red and vaccination as safely blue. But when you analyze ALL the data from the same study—without the cherry-picked windows—the graph flips. It shows the vaccinated group with significantly higher rates of myocarditis, inflammatory conditions, pulmonary embolism, and stroke. This isn't science; it's narrative support. It's starting with a headline and working backward, twisting every parameter until the numbers comply. The days of accepting these "cooked-book" studies at face value are over. It's time for the objective, transparent science the public deserves.

Camus

22,083 Aufrufe • vor 10 Monaten

🚨 BREAKING… the top performing 5m & 15m Polymarket Claude setup is now fully open-source Sounds insane? 100%. Unreal? NOT at all. A modest wallet deployed a fully automated system that scaled up to roughly ~$1.8M in profit No affiliation with the Polymarket team Just a developer operating a bot directly connected to Polymarket Profile → Copytrade → Everything is fully automated His FULL strategy: 1. 5 & 15-minute BTC & ETH latency arbitrage The bot trades ultra-short Bitcoin and Ethereum markets with 5 & 15-minute expirations - and similar logic applies to fast 5m markets often associated with claude-style execution. When BTC moves on Binance, Polymarket pricing reacts slower. For around 30 seconds, odds reflect stale data. The system enters during that gap, when YES + NO combined is below $1, waits for repricing, and exits the moment the market corrects. No predictions, no bias - just harvesting mispriced odds 2. Automation over reaction When volatility spikes, humans pause. The system doesn’t. It triggers instantly when the window opens. No emotion, no hesitation, no missed fills. By the time manual traders click, the inefficiency has already disappeared 3. Scale through repetition Each trade earns small spreads, not headline wins. But automation allows continuous execution at scale, every 15 minutes - and on faster 5m rotations running 24/7 without burnout Scale is the edge 23,457 trades placed - irrelevant on their own. Together, they compounded into ~$1.8M in profit, with a largest single gain of $41,2K and an equity curve that trends almost vertically

Shelpid.WI3M

31,101 Aufrufe • vor 6 Monaten

🚀 Introducing PantheonOS ( A Fully Open-Source Agent OS for Science PantheonOS began as a research project in my Stanford lab and has since evolved into a vision to redefine data science in the era of AI—starting with computational biology, especially single-cell and spatial genomics. PantheonOS is a general agent platform built from the ground up. It is arguably the first distributed agent framework designed for scientific data analysis. 🔑 Key Features 1. Multi-Agent Collaboration – Built-in paradigms for distributed, cross-machine cooperation among agents and toolsets. 2. Native Toolset Support – Python, R, Julia, LaTeX, and more—designed for real scientific workflows. 3. Modular & Extensible – Developer-friendly design with shallow wrappers, plus LLM-driven toolset generation. 4. Evolvable Agents – Capable of evolving large-scale code projects to achieve superhuman performance (e.g., evolving upon the original Harmony [I Korsunsky, 2019, Nature Biotechnology] and Scanorama [BL Hie, 2019, Nature Biotechnology] implementations), and even evolving the system itself to adapt to new fields. 🎉 Stepwise Release Strategy We’re releasing PantheonOS in stages: Pantheon-CLI (today!), followed by Pantheon-Lab, Pantheon-Notebook, Pantheon-Slack, and more. 🌟 Pantheon-CLI Highlights - We're not just building another CLI tool. We're defining how scientists will interact with data in the AI era. - Open, Powerful, Python-First – The first fully open-source, endlessly extendable scientific “vibe analysis” framework. - Mixed Programming Magic – Combine Python, natural language, R, or Julia—seamlessly in the same environment. - PhD-Level Assistant – A command-line agent for complex real-world genomics and beyond, handling workflows at the PhD level. - Privacy by Design – Run entirely offline with local LLMs—your data never leaves your computer. ✅ Proven Applications (10 Demonstrations) Computational biology: 1. ATAC-seq: From raw reads to peak matrix 2. RNA-seq: From raw reads to expression matrix 3. Complex single-cell workflows (PhD-level) 4. Hybrid natural language + R for Seurat annotation 5. Learning from web tutorials + invoking single-cell foundation models 6. Cell segmentation on 10x Genomics HD Visium data And beyond: 7. Mixed Python & R programming examples 8. Molecular docking & structural analysis 9. Exploratory factor analysis for behavioral survey data 10. Customer segmentation & finance analytics 🌐 Learn More & Get Started Website: Pantheon-CLI Documentation: GitHub Repo: 💬 Join our community: PantheonOS Slack: PantheonOS Discord:

evo-devo

17,446 Aufrufe • vor 1 Jahr

3D scanning and rendering is moving so fast - got my splats up and running and I'm mind blown getting ~100fps for this complex 3D scene ⬇️ 🤯 1. WAY faster than NeRF: For comparison, NeRFs would takes around 10 seconds per frame (!) Instead I'm zipping around with FPV controls without breaking a sweat - though I do crash a few times towards the end of the video lol 2. Old Meets New: Gaussian Splatting is cool in that it fuses classical graphics and deep learning techniques. Like NeRFs, this is still a radiance field - just without the slower (ne)ural rendering part. 3. Explicit Representation: Instead you represent a 3D scene as a collection of ellipsoidal "splats" called gaussians. Each gaussian has a position, size, and color. Rendering in real-time is done by projecting into the image plane and alpha blending. 4. Photorealistic Effects: Gaussian splatting use spherical harmonics to represent the view-dependent effects and lighting - allowing surfaces to change color when viewed from different angles, enabling greater photorealism. It doesn't use a neural network, but the training loop is similar to deep learning. 5. Enables Direct Editing: But it's not just speed - with Gaussian Splatting you also get 3D editing support! So you can select, move, and delete stuff, even relight stuff. This type of editing has been more tedious to do with NeRFs and their implicit black box representations. 📲 More tests cooking! Much more to unpack here including simpler explanations. If you enjoyed this post, you might enjoy my feed: Bilawal Sidhu

Bilawal Sidhu

337,090 Aufrufe • vor 3 Jahren