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AI DISCOVERS REVOLUTIONARY NEW WAY TO REVERSE LUNG DAMAGE An AI system didn’t just design a new drug for pulmonary fibrosis; it first figured out which protein was causing the damage (TNIK), then designed a molecule to shut it down. In a 12-week trial, patients on the highest dose... show more

Mario Nawfal

3,853,845 subscribers

29,352 次观看 • 10 个月前 •via X (Twitter)

健康养生科学技术

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We are thrilled to share positive topline data from our ELEVATE IPF Phase 2b trial evaluating deupirfenidone (LYT-100) for the treatment of idiopathic pulmonary fibrosis (#IPF), a progressive and fatal lung disease. Our trial met the primary and key secondary endpoints, with deupirfenidone demonstrating the potential to serve as a new standard of care. Over 26 weeks, the highest dose of deupirfenidone studied was generally well-tolerated and reduced lung function decline to levels that approach natural lung function decline in healthy adults over sixty—a first for any investigational or approved treatment for IPF. We’re incredibly excited for what deupirfenidone could offer the IPF community, which urgently needs new treatment options with better efficacy that don’t compromise on tolerability. A heartfelt thank you to everyone who participated in the ELEVATE IPF trial, including patients, caregivers, clinical trial sites, and advocacy groups. Your courage, dedication and expertise make progress possible, and we are grateful for your trust and partnership. Read more in today’s press release:

We are thrilled to share positive topline data from our ELEVATE IPF Phase 2b trial evaluating deupirfenidone (LYT-100) for the treatment of idiopathic pulmonary fibrosis (#IPF), a progressive and fatal lung disease. Our trial met the primary and key secondary endpoints, with deupirfenidone demonstrating the potential to serve as a new standard of care. Over 26 weeks, the highest dose of deupirfenidone studied was generally well-tolerated and reduced lung function decline to levels that approach natural lung function decline in healthy adults over sixty—a first for any investigational or approved treatment for IPF. We’re incredibly excited for what deupirfenidone could offer the IPF community, which urgently needs new treatment options with better efficacy that don’t compromise on tolerability. A heartfelt thank you to everyone who participated in the ELEVATE IPF trial, including patients, caregivers, clinical trial sites, and advocacy groups. Your courage, dedication and expertise make progress possible, and we are grateful for your trust and partnership. Read more in today’s press release:

PureTech

10,892 次观看 • 1 年前

REMDESIVIR was declared TOO DEADLY & UNETHICAL to use In African Ebola Trials because it had a 53% kill rate. ~Dr. David E Martin It was the only drug Fauci allowed to be used on COVID patients in Hospitals. Families whose loved ones were killed call it 'Run-Death-Is-Near.'... Remdesivir kills kidney function, combine that with a ventilator & patients develop Pulmonary Edema, causing their lungs to fill with fluid & drown to death. Remdesivir kills the liver & causes multi organ shut down. In the halted Ebola trial, Remdesivir mortality was 53% overall & 85% mortality in those with high viral load. Anthony Fauci claimed that Remdesivir would stop Covid; instead, it stopped kidney function, then blasted the liver & other organs. • 2.81X KIDNEY FAILURE RISK—permanent damage in patients. • HEART DAMAGE: Triggers fatal arrhythmias, cardiac arrest, & bradycardia. • LIVER INJURY: Causes severe, irreversible hepatocyte damage. • INFANT APPROVED: Now FDA-approved for NEWBORNS at birth as long as they weigh 3lbs—tested on just 58 infants for 10 DAYS!

REMDESIVIR was declared TOO DEADLY & UNETHICAL to use In African Ebola Trials because it had a 53% kill rate. ~Dr. David E Martin It was the only drug Fauci allowed to be used on COVID patients in Hospitals. Families whose loved ones were killed call it 'Run-Death-Is-Near.'... Remdesivir kills kidney function, combine that with a ventilator & patients develop Pulmonary Edema, causing their lungs to fill with fluid & drown to death. Remdesivir kills the liver & causes multi organ shut down. In the halted Ebola trial, Remdesivir mortality was 53% overall & 85% mortality in those with high viral load. Anthony Fauci claimed that Remdesivir would stop Covid; instead, it stopped kidney function, then blasted the liver & other organs. • 2.81X KIDNEY FAILURE RISK—permanent damage in patients. • HEART DAMAGE: Triggers fatal arrhythmias, cardiac arrest, & bradycardia. • LIVER INJURY: Causes severe, irreversible hepatocyte damage. • INFANT APPROVED: Now FDA-approved for NEWBORNS at birth as long as they weigh 3lbs—tested on just 58 infants for 10 DAYS!

Valerie Anne Smith

157,596 次观看 • 2 个月前

Demis Hassabis, the Nobel Prize winner who runs Google DeepMind just described the most consequential project on earth, and most people have no idea it exists. The project is called Isomorphic Labs and the goal is to end the way drugs have been developed for the last century. Here is the problem it is trying to solve. Developing a single drug today takes an average of 10 years, costs billions of dollars, and fails 90 percent of the time before it ever reaches a patient. Of every 10 drugs that enter clinical trials, only one makes it through. The other nine years of work, the other billions of dollars, the other scientific careers, gone. Hassabis believes AI can collapse that entire process from identifying a disease target to designing a compound that binds to it, predicts how it behaves in the body, and minimizes side effects , end to end, on a computer, before a single experiment is run. The foundation is AlphaFold, the AI system that solved one of biology's hardest problems predicting the 3D structure of every protein in the human body and won him the Nobel Prize in Chemistry in 2024. But knowing a protein's shape is only one part of designing a drug. Isomorphic is building what Hassabis describes as adjacent systems , AlphaFold 3, AlphaFold 4, and now a unified model called IsoDDE , that take the next steps. From designing the actual chemical compound that binds to the protein, predicting its binding strength, identifying new pockets to target that no one has ever found before. IsoDDE more than doubles the accuracy of AlphaFold 3 on the hardest protein-ligand prediction benchmarks that exist. Isomorphic is already running 18 to 19 live drug programs, cardiovascular disease, cancer, immunology in partnership with Eli Lilly, Novartis, and Johnson and Johnson. The first human clinical trial of a fully AI-designed drug is expected by the end of 2026. If that trial succeeds, it will be the first time in history that a drug put into a human body was designed not by a team of chemists working for a decade but by an AI working for months. Hassabis's long-term vision is even more direct, one day you describe a disease, click a button, and a drug blueprint comes out the other side. AI will solve almost all diseases within 10 years.

Demis Hassabis, the Nobel Prize winner who runs Google DeepMind just described the most consequential project on earth, and most people have no idea it exists. The project is called Isomorphic Labs and the goal is to end the way drugs have been developed for the last century. Here is the problem it is trying to solve. Developing a single drug today takes an average of 10 years, costs billions of dollars, and fails 90 percent of the time before it ever reaches a patient. Of every 10 drugs that enter clinical trials, only one makes it through. The other nine years of work, the other billions of dollars, the other scientific careers, gone. Hassabis believes AI can collapse that entire process from identifying a disease target to designing a compound that binds to it, predicts how it behaves in the body, and minimizes side effects , end to end, on a computer, before a single experiment is run. The foundation is AlphaFold, the AI system that solved one of biology's hardest problems predicting the 3D structure of every protein in the human body and won him the Nobel Prize in Chemistry in 2024. But knowing a protein's shape is only one part of designing a drug. Isomorphic is building what Hassabis describes as adjacent systems , AlphaFold 3, AlphaFold 4, and now a unified model called IsoDDE , that take the next steps. From designing the actual chemical compound that binds to the protein, predicting its binding strength, identifying new pockets to target that no one has ever found before. IsoDDE more than doubles the accuracy of AlphaFold 3 on the hardest protein-ligand prediction benchmarks that exist. Isomorphic is already running 18 to 19 live drug programs, cardiovascular disease, cancer, immunology in partnership with Eli Lilly, Novartis, and Johnson and Johnson. The first human clinical trial of a fully AI-designed drug is expected by the end of 2026. If that trial succeeds, it will be the first time in history that a drug put into a human body was designed not by a team of chemists working for a decade but by an AI working for months. Hassabis's long-term vision is even more direct, one day you describe a disease, click a button, and a drug blueprint comes out the other side. AI will solve almost all diseases within 10 years.

Milk Road AI

36,062 次观看 • 4 个月前

10 Shocking Stories the Media Buried Today #10 - Medical doctor reveals COVID boosters AGE lung capacity in athletes by “five to ten YEARS in just ONE WEEK.” This is devastating. For Dr. Robert Sullivan, the damage was much worse. He says his lung capacity has been slashed by HALF after taking the COVID shots the government recommended. After a period of being unsure if the damage was in his head or not, Dr. Sullivan was diagnosed with pulmonary hypertension, a dangerous condition that elevates blood pressure and forces the heart to work much harder to pump blood to the lungs. “On the outside, I look fine... I’ve lost half my lung capacity. If I can look this normal while carrying that much damage, how many others are out there suffering silently?” he asked. The peer-reviewed study he referenced was conducted in 2022 and found that 19% of athletes with a mean age of 37 experienced an 8.6% drop in VO₂max just one week after receiving the Pfizer-BioNTech mRNA booster. That’s equivalent to aging about ten years in terms of aerobic capacity. It’s time to PULL THE SHOTS NOW! *SEE THE NEXT 9 STORIES BELOW* 🧵 THREAD

10 Shocking Stories the Media Buried Today #10 - Medical doctor reveals COVID boosters AGE lung capacity in athletes by “five to ten YEARS in just ONE WEEK.” This is devastating. For Dr. Robert Sullivan, the damage was much worse. He says his lung capacity has been slashed by HALF after taking the COVID shots the government recommended. After a period of being unsure if the damage was in his head or not, Dr. Sullivan was diagnosed with pulmonary hypertension, a dangerous condition that elevates blood pressure and forces the heart to work much harder to pump blood to the lungs. “On the outside, I look fine... I’ve lost half my lung capacity. If I can look this normal while carrying that much damage, how many others are out there suffering silently?” he asked. The peer-reviewed study he referenced was conducted in 2022 and found that 19% of athletes with a mean age of 37 experienced an 8.6% drop in VO₂max just one week after receiving the Pfizer-BioNTech mRNA booster. That’s equivalent to aging about ten years in terms of aerobic capacity. It’s time to PULL THE SHOTS NOW! SEE THE NEXT 9 STORIES BELOW 🧵 THREAD

The Vigilant Fox 🦊

1,789,434 次观看 • 1 年前

Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!

Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!

Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)

49,544 次观看 • 1 个月前

Jordan Peterson almost died trying to stop a drug that's prescribed to millions of people for anxiety. Most patients are never told that benzodiazepines are among the only drugs where withdrawal can actually kill you. Right alongside alcohol. And yet doctors hand them out like candy. Peterson didn’t abuse them. He didn’t chase a high. He took a low dose, as prescribed, during an extreme period of stress when he couldn’t sleep. It “worked.” So he stayed on it. And that’s when the real danger began. Getting off took years. Excruciating pain. Nerve damage. Physical collapse. A recovery that still isn’t complete. Psychiatrists were told these drugs were completely safe. The risks of dependence? Downplayed. The severity of withdrawal? Barely acknowledged. Patients stayed on them for decades because stopping felt impossible—and sometimes it was. The anxiety crisis didn’t appear out of nowhere. It was manufactured—quietly, legally, and with full institutional backing. 🧵

Jordan Peterson almost died trying to stop a drug that's prescribed to millions of people for anxiety. Most patients are never told that benzodiazepines are among the only drugs where withdrawal can actually kill you. Right alongside alcohol. And yet doctors hand them out like candy. Peterson didn’t abuse them. He didn’t chase a high. He took a low dose, as prescribed, during an extreme period of stress when he couldn’t sleep. It “worked.” So he stayed on it. And that’s when the real danger began. Getting off took years. Excruciating pain. Nerve damage. Physical collapse. A recovery that still isn’t complete. Psychiatrists were told these drugs were completely safe. The risks of dependence? Downplayed. The severity of withdrawal? Barely acknowledged. Patients stayed on them for decades because stopping felt impossible—and sometimes it was. The anxiety crisis didn’t appear out of nowhere. It was manufactured—quietly, legally, and with full institutional backing. 🧵

The Vigilant Fox 🦊

808,810 次观看 • 6 个月前

After relapsing on the only drug in development for my rare disease, my doctors told me ‘We’ve tried everything, there’s nothing more that we can do.’ To make things worse, I didn’t have a billion dollars and 10 years to develop a new drug from scratch. My only hope was to find a drug that was already FDA-approved that I could repurpose for my disease. It’s been over 9.5 years that I’ve been in remission and we have been able to identify and advance numerous treatments for diseases they weren’t initially intended for. Now through Every Cure we are utilizing artificial intelligence to maximize the potential of all existing drugs to treat every disease they possibly can. What rare disease would you like to find a repurposed drug to treat? #MedTwitter

After relapsing on the only drug in development for my rare disease, my doctors told me ‘We’ve tried everything, there’s nothing more that we can do.’ To make things worse, I didn’t have a billion dollars and 10 years to develop a new drug from scratch. My only hope was to find a drug that was already FDA-approved that I could repurpose for my disease. It’s been over 9.5 years that I’ve been in remission and we have been able to identify and advance numerous treatments for diseases they weren’t initially intended for. Now through Every Cure we are utilizing artificial intelligence to maximize the potential of all existing drugs to treat every disease they possibly can. What rare disease would you like to find a repurposed drug to treat? #MedTwitter

David Fajgenbaum, MD

138,669 次观看 • 2 年前

Dr. Robert Sullivan, MD—a board-certified anesthesiologist—stood before the U.S. Senate with a devastating admission: "I am vaccine injured." His testimony shatters the myth that COVID vaccine injuries are "rare" or "mild." A Doctor’s Body, Broken - Three weeks post-vaccination, he went from elite fitness to heart failure. - Diagnosed with pulmonary hypertension—a progressive, fatal disease caused by spike protein-induced vascular damage. - 50% lung capacity loss—yet he "looks normal." How many others are silently suffering? The Science They Ignored - December 2020: Georgetown researchers warned spike protein (from infection or vaccines) could destroy lung blood vessels. - Autopsies confirmed it: COVID victims had the same lung damage Dr. Sullivan now lives with. - Peer-reviewed studies show spike protein is directly toxic to the heart, lungs, and brain. The System Failed Him - He filed a VAERS report (a system most doctors aren’t even taught exists). - No CDC follow-up. No FDA investigation. - "If you are harmed, you are on your own." The Silent Epidemic - Athletes post-vaccine saw 5-10 years of aerobic decline in a week. - Long COVID patients show identical vascular destruction. - How many "mysterious" heart and lung cases are actually vaccine injuries? A Demand for Justice 1. ACKNOWLEDGE the injured. 2. END medical mandates—restore INFORMED CONSENT. 3. INVESTIGATE spike protein toxicity NOW. To the thousands suffering in silence: You are not "anecdotes." You are not "anti-science." You are victims of a system that refuses to see you. This is not conspiracy. This is medicine. And medicine must do better.

Dr. Robert Sullivan, MD—a board-certified anesthesiologist—stood before the U.S. Senate with a devastating admission: "I am vaccine injured." His testimony shatters the myth that COVID vaccine injuries are "rare" or "mild." A Doctor’s Body, Broken - Three weeks post-vaccination, he went from elite fitness to heart failure. - Diagnosed with pulmonary hypertension—a progressive, fatal disease caused by spike protein-induced vascular damage. - 50% lung capacity loss—yet he "looks normal." How many others are silently suffering? The Science They Ignored - December 2020: Georgetown researchers warned spike protein (from infection or vaccines) could destroy lung blood vessels. - Autopsies confirmed it: COVID victims had the same lung damage Dr. Sullivan now lives with. - Peer-reviewed studies show spike protein is directly toxic to the heart, lungs, and brain. The System Failed Him - He filed a VAERS report (a system most doctors aren’t even taught exists). - No CDC follow-up. No FDA investigation. - "If you are harmed, you are on your own." The Silent Epidemic - Athletes post-vaccine saw 5-10 years of aerobic decline in a week. - Long COVID patients show identical vascular destruction. - How many "mysterious" heart and lung cases are actually vaccine injuries? A Demand for Justice 1. ACKNOWLEDGE the injured. 2. END medical mandates—restore INFORMED CONSENT. 3. INVESTIGATE spike protein toxicity NOW. To the thousands suffering in silence: You are not "anecdotes." You are not "anti-science." You are victims of a system that refuses to see you. This is not conspiracy. This is medicine. And medicine must do better.

Camus

366,034 次观看 • 1 年前

This man applied for a job and was hired but told them he could start for 6 weeks because he wanted to do some traveling for leisure. But during the hiring process he had 72 hours to do a drug test which he failed to do. They cancelled his job offer and he feels it wasn’t because of the missed drug test, so what is he implying the reasoning behind it was then? Fresh out of college, that insurance gig was the first one I applied for and was hired for. Up until then I never had to take a drug test but then again why would I have? I didn’t do drugs on a normal basis anyways. But my best friends were pot heads. On the day before my drug test I was smoking a cigarette and my friend asked for a hit and I gave it to him. The other friend passed me a joint and I took it thinking it was my cigarette and I took a long dragged and almost coughed up a lung. I panicked, I just had taken a hit of pot when I had to be drug tested for a new job the next day. I went to the testing and did it, I got a call a few days later from HR confirming I passed and I told her I was worried because my friends smoke and I thought it would show up in my system as a second hand application. She said nah don’t worry, we only test for the hard stuff anyways. That part I didn’t know, but after that I saw my other buddies pass their work related tests too so maybe it was more widespread than I knew.

This man applied for a job and was hired but told them he could start for 6 weeks because he wanted to do some traveling for leisure. But during the hiring process he had 72 hours to do a drug test which he failed to do. They cancelled his job offer and he feels it wasn’t because of the missed drug test, so what is he implying the reasoning behind it was then? Fresh out of college, that insurance gig was the first one I applied for and was hired for. Up until then I never had to take a drug test but then again why would I have? I didn’t do drugs on a normal basis anyways. But my best friends were pot heads. On the day before my drug test I was smoking a cigarette and my friend asked for a hit and I gave it to him. The other friend passed me a joint and I took it thinking it was my cigarette and I took a long dragged and almost coughed up a lung. I panicked, I just had taken a hit of pot when I had to be drug tested for a new job the next day. I went to the testing and did it, I got a call a few days later from HR confirming I passed and I told her I was worried because my friends smoke and I thought it would show up in my system as a second hand application. She said nah don’t worry, we only test for the hard stuff anyways. That part I didn’t know, but after that I saw my other buddies pass their work related tests too so maybe it was more widespread than I knew.

SonnyBoy🇺🇸

147,948 次观看 • 1 个月前

NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

Saloni

72,565 次观看 • 10 个月前

Demis Hassabis says AI won’t just accelerate drug discovery. It will replace the process entirely. The pharmaceutical industry finds drugs the same way it has for decades. Synthesize a compound. Test it on animals. Test it on humans. Wait years for approval. Hope the molecule doesn’t kill someone along the way. Every step is physical. Every step is slow. Every step is expensive enough to make most diseases not worth curing. Hassabis: “We’re focusing on solving the rest of the drug discovery process, which is a lot of chemistry, designing the compounds, checking it’s not toxic, and all the different properties you need for drugs to be safe.” That sounds incremental. It isn’t. AlphaFold solved protein folding. Isomorphic Labs is now working through the rest of the chain. Compound design. Toxicity screening. Safety profiling. All computational. None of it requires a lab. Hassabis: “I think we’ll have that whole drug design engine ready in the next five to 10 years.” Not a tool that assists chemists. A system that replaces the chemistry. But designing the drug was never the bottleneck that killed people. Clinical trials were. A single drug takes over a decade to move from lab to patient. Most of that time isn’t science. It’s bureaucracy, logistics, and the blunt reality of testing molecules on living tissue one dose at a time. Hassabis: “Simulating parts of the human metabolism, also stratifying patients to make sure that certain patients get exactly the right type of drug that’s suitable for their genomic makeup.” Simulate the patient before you treat the patient. Map individual DNA. Model personal metabolism. Test the drug on a digital replica before it touches a vein. Not personalized medicine as a marketing phrase. Personalized medicine as an engineering output. The final wall is regulatory. The FDA exists because humans make mistakes with molecules. Every approval gate was built to catch errors that cost lives. The entire structure assumes the process is fallible. What happens when the process stops being fallible. Hassabis: “Perhaps like the animal testing is not needed anymore, maybe we can go up the dosage ladder quicker, because you can rely on these models.” He’s not speculating. He’s describing a sequence. AI-designed drugs enter the existing pipeline. A dozen compounds go through full traditional trials. Regulators collect data. They back-test model predictions against real outcomes. Hassabis: “Then the government and the regulatory bodies see that and they have enough data to sort of back-test the predictions of those models.” When the models prove more accurate than the trials they’re meant to replace, the trials become the bottleneck. Not the science. The paperwork. Animal testing shortened. Dosage ladders compressed. Entire stages of the pipeline collapsed into computation. The drug doesn’t get discovered faster. The drug gets discovered differently. The laboratory moves from a building to a server. The clinical trial moves from a hospital ward to a simulation. The patient moves from a statistic to a genome. Hassabis isn’t promising a cure for one disease. He’s describing the architecture that makes curing disease an engineering problem with a known solution path. The bottleneck was never biology. It was the speed at which humans were allowed to solve it. That speed limit is about to be revoked.

Demis Hassabis says AI won’t just accelerate drug discovery. It will replace the process entirely. The pharmaceutical industry finds drugs the same way it has for decades. Synthesize a compound. Test it on animals. Test it on humans. Wait years for approval. Hope the molecule doesn’t kill someone along the way. Every step is physical. Every step is slow. Every step is expensive enough to make most diseases not worth curing. Hassabis: “We’re focusing on solving the rest of the drug discovery process, which is a lot of chemistry, designing the compounds, checking it’s not toxic, and all the different properties you need for drugs to be safe.” That sounds incremental. It isn’t. AlphaFold solved protein folding. Isomorphic Labs is now working through the rest of the chain. Compound design. Toxicity screening. Safety profiling. All computational. None of it requires a lab. Hassabis: “I think we’ll have that whole drug design engine ready in the next five to 10 years.” Not a tool that assists chemists. A system that replaces the chemistry. But designing the drug was never the bottleneck that killed people. Clinical trials were. A single drug takes over a decade to move from lab to patient. Most of that time isn’t science. It’s bureaucracy, logistics, and the blunt reality of testing molecules on living tissue one dose at a time. Hassabis: “Simulating parts of the human metabolism, also stratifying patients to make sure that certain patients get exactly the right type of drug that’s suitable for their genomic makeup.” Simulate the patient before you treat the patient. Map individual DNA. Model personal metabolism. Test the drug on a digital replica before it touches a vein. Not personalized medicine as a marketing phrase. Personalized medicine as an engineering output. The final wall is regulatory. The FDA exists because humans make mistakes with molecules. Every approval gate was built to catch errors that cost lives. The entire structure assumes the process is fallible. What happens when the process stops being fallible. Hassabis: “Perhaps like the animal testing is not needed anymore, maybe we can go up the dosage ladder quicker, because you can rely on these models.” He’s not speculating. He’s describing a sequence. AI-designed drugs enter the existing pipeline. A dozen compounds go through full traditional trials. Regulators collect data. They back-test model predictions against real outcomes. Hassabis: “Then the government and the regulatory bodies see that and they have enough data to sort of back-test the predictions of those models.” When the models prove more accurate than the trials they’re meant to replace, the trials become the bottleneck. Not the science. The paperwork. Animal testing shortened. Dosage ladders compressed. Entire stages of the pipeline collapsed into computation. The drug doesn’t get discovered faster. The drug gets discovered differently. The laboratory moves from a building to a server. The clinical trial moves from a hospital ward to a simulation. The patient moves from a statistic to a genome. Hassabis isn’t promising a cure for one disease. He’s describing the architecture that makes curing disease an engineering problem with a known solution path. The bottleneck was never biology. It was the speed at which humans were allowed to solve it. That speed limit is about to be revoked.

Dustin

43,980 次观看 • 4 个月前

RFK Jr. on Fauci's COVID protocols: "Our protocol was NO treatment until you go to the hospital. Then your treatments are two things: Ventilators & Remdesivir." "Tony Fauci knew that Remdesivir would kill you. It was lethal to 54% of people in 5 days during the Ebola trial." "The safety monitoring board ordered him to terminate the use of that drug when the 2019 Ebola trial failed." "He contrived an absolutely fraudulent study that he manipulated & orchestrated. It is homicide." How does Remdesivir kill? RFK Jr: "Kidney failure. Heart Failure. All organ collapse." The Ebola trial safety monitoring board halted & removed Remdesivir from the clinical setting, citing it was "too lethal & unethical" to be included as a possible Ebola treatment drug. • 2.81X Kidney failure—permanent damage in patients. • Heart damage: Triggers fatal arrhythmias, cardiac arrest, & bradycardia. • Liver injury: Causes severe, irreversible hepatocyte damage. • Infant approved: Now FDA-approved for newborns at birth as long as they weigh 3lbs—tested on just 58 infants for 10 days! Doctors during COVID stated: "We've never seen a virus that attacks the kidneys. Because, it wasn't the Virus. It was Remdesivir." Share your 'Run-Death-Is-Near' Remdesivir stories below...

RFK Jr. on Fauci's COVID protocols: "Our protocol was NO treatment until you go to the hospital. Then your treatments are two things: Ventilators & Remdesivir." "Tony Fauci knew that Remdesivir would kill you. It was lethal to 54% of people in 5 days during the Ebola trial." "The safety monitoring board ordered him to terminate the use of that drug when the 2019 Ebola trial failed." "He contrived an absolutely fraudulent study that he manipulated & orchestrated. It is homicide." How does Remdesivir kill? RFK Jr: "Kidney failure. Heart Failure. All organ collapse." The Ebola trial safety monitoring board halted & removed Remdesivir from the clinical setting, citing it was "too lethal & unethical" to be included as a possible Ebola treatment drug. • 2.81X Kidney failure—permanent damage in patients. • Heart damage: Triggers fatal arrhythmias, cardiac arrest, & bradycardia. • Liver injury: Causes severe, irreversible hepatocyte damage. • Infant approved: Now FDA-approved for newborns at birth as long as they weigh 3lbs—tested on just 58 infants for 10 days! Doctors during COVID stated: "We've never seen a virus that attacks the kidneys. Because, it wasn't the Virus. It was Remdesivir." Share your 'Run-Death-Is-Near' Remdesivir stories below...

Valerie Anne Smith

130,539 次观看 • 6 个月前

ER100 is a new drug and potential gene therapy currently in its first clinical trial with 12 participants. The mechanism is not symptom management and not disease treatment. It targets the biological switch at the cellular level, instructing cells to revert to a different functional state. Conventional medicine has been built around treating disease after it occurs. This approach aims to reverse the biological aging process that underlies disease development. The trial is early and the sample size is small, but if the mechanism holds, the implications for human health and longevity are unlike anything medicine has produced. This conversation is worth following closely.

ER100 is a new drug and potential gene therapy currently in its first clinical trial with 12 participants. The mechanism is not symptom management and not disease treatment. It targets the biological switch at the cellular level, instructing cells to revert to a different functional state. Conventional medicine has been built around treating disease after it occurs. This approach aims to reverse the biological aging process that underlies disease development. The trial is early and the sample size is small, but if the mechanism holds, the implications for human health and longevity are unlike anything medicine has produced. This conversation is worth following closely.

Dr. Gabrielle Lyon

13,681 次观看 • 1 个月前

American comes out to his vehicle, there’s broken glass everywhere. He thought it had been broken into When he walks around to the other side, you can actually see there was an explosion. There was a huge fire His insurance is refusing to pay for any of it You can actually see there is an inch of water from where the fire trucks likely put out the blaze The thing is, comprehensive auto insurance should cover this kind of damage Fire and explosion damage to your own vehicle is a classic comprehensive. It covers fires from mechanical/electrical failure, fuel issues, or unknown causes while the car is parked Water damage from firefighting efforts is almost always included as “ensuing damage” from the fire Insurance companies in America just keep getting worse and worse. Denying things that should 100% be covered. This is across all American industries not just auto He may not have comprehensive coverage but that’s unlikely, most insured drivers do

American comes out to his vehicle, there’s broken glass everywhere. He thought it had been broken into When he walks around to the other side, you can actually see there was an explosion. There was a huge fire His insurance is refusing to pay for any of it You can actually see there is an inch of water from where the fire trucks likely put out the blaze The thing is, comprehensive auto insurance should cover this kind of damage Fire and explosion damage to your own vehicle is a classic comprehensive. It covers fires from mechanical/electrical failure, fuel issues, or unknown causes while the car is parked Water damage from firefighting efforts is almost always included as “ensuing damage” from the fire Insurance companies in America just keep getting worse and worse. Denying things that should 100% be covered. This is across all American industries not just auto He may not have comprehensive coverage but that’s unlikely, most insured drivers do

Wall Street Apes

56,749 次观看 • 4 个月前

The HFS on the Cybertruck is so damn strong. I just had a freak accident occur. As I was backing out of the garage, the emergency cable on the garage door opener must’ve gotten hooked onto the light bar and halfway out of the garage, the garage door slammed down on the truck. It sounded like hell. Expecting the worse, I got out, flipped on the lights and looked at the damage. There was no damage. Zero. Any other car would’ve been $2500 easy. Amazing. Also, I tied that cord up high now.

The HFS on the Cybertruck is so damn strong. I just had a freak accident occur. As I was backing out of the garage, the emergency cable on the garage door opener must’ve gotten hooked onto the light bar and halfway out of the garage, the garage door slammed down on the truck. It sounded like hell. Expecting the worse, I got out, flipped on the lights and looked at the damage. There was no damage. Zero. Any other car would’ve been $2500 easy. Amazing. Also, I tied that cord up high now.

Dan from Spotted Model: Cars & Tech

39,458 次观看 • 5 个月前

“I don’t think it’s exaggerating to say that this is the future of medicine.” For years, Dr. Rebecca Ahrens-Nicklas treated babies with rare genetic diseases knowing palliative care was often the only option. In 2023, she partnered with gene-editing researcher Dr. Kiran Musunuru to try something new: using CRISPR to correct disease-causing mutations before the damage became irreversible. In 2025, doctors delivered the first successful personalized CRISPR therapy, pointing to a future where gene therapies are custom-built for patients who once had no options. See the full TIME100 Health list of leaders, scientists, doctors, and more here:

“I don’t think it’s exaggerating to say that this is the future of medicine.” For years, Dr. Rebecca Ahrens-Nicklas treated babies with rare genetic diseases knowing palliative care was often the only option. In 2023, she partnered with gene-editing researcher Dr. Kiran Musunuru to try something new: using CRISPR to correct disease-causing mutations before the damage became irreversible. In 2025, doctors delivered the first successful personalized CRISPR therapy, pointing to a future where gene therapies are custom-built for patients who once had no options. See the full TIME100 Health list of leaders, scientists, doctors, and more here:

TIME

19,885 次观看 • 6 个月前

Dr. Dale Bredesen just revealed that the most-prescribed Alzheimer's drug makes patients WORSE than taking nothing at all. Aricept is the drug your neurologist hands out at the first sign of memory loss. It's been on the market for 30 years, and almost every patient with early dementia is on it. Dr. Lon Schneider from USC published a paper on it. He discovered Aricept patients decline FASTER than untreated patients over time. The early "boost" wears off, and the brain damage accelerates underneath while you keep filling the prescription. Most neurologists still prescribe it because there isn't a better pill, so families keep buying it every month, hoping it's slowing things down. The data shows it's actually pulling forward the decline. A new randomized trial just dropped showing what actually works for early Alzheimer's (covered in the thread below). I’ve implemented parts of the protocols mentioned in this study in my own homes and have personally seen how it can help reverse dementia and early onset Alzheimer's. PS: I’ve opened 7 more slots this month to my online community where we share these exact protocols. If you’d like to see if this could help you, book a call directly with me. Link in bio.

Dr. Dale Bredesen just revealed that the most-prescribed Alzheimer's drug makes patients WORSE than taking nothing at all. Aricept is the drug your neurologist hands out at the first sign of memory loss. It's been on the market for 30 years, and almost every patient with early dementia is on it. Dr. Lon Schneider from USC published a paper on it. He discovered Aricept patients decline FASTER than untreated patients over time. The early "boost" wears off, and the brain damage accelerates underneath while you keep filling the prescription. Most neurologists still prescribe it because there isn't a better pill, so families keep buying it every month, hoping it's slowing things down. The data shows it's actually pulling forward the decline. A new randomized trial just dropped showing what actually works for early Alzheimer's (covered in the thread below). I’ve implemented parts of the protocols mentioned in this study in my own homes and have personally seen how it can help reverse dementia and early onset Alzheimer's. PS: I’ve opened 7 more slots this month to my online community where we share these exact protocols. If you’d like to see if this could help you, book a call directly with me. Link in bio.

A Paradise for Parents

58,188 次观看 • 3 个月前

"700,000 people were pumped full of a drug that SHUTS DOWN your kidneys & fills your lungs with fluid...everyone that was dying was on REMDESIVIR." ~Dr Bryan Ardis They died of Pulmonary Edema, but Hospitals made more money & big bonuses by writing 'Death Caused by COVID.' With a 53% mortality rate, Dr Anthony Fauci & the CDC still chose Remdesivir, under the brand name Veklury, as the only approved hospital treatment. It was deemed 'too unethical & harmful' to continue as a test drug in the African Ebola drug trials...yet it is still the 1st line hospital COVID treatment today. The past 5 yrs Remdesivir has been FDA approved for ages 12 & up, the CDC & FDA have recently approved Remdesivir for infants less than 28 days old & it is now being marketed as treatment for newborns who weigh at least 3 lbs. The clinical trial to determine 'neonate pediatric safety' was based on 58 hospitalized infants who were injected with Remdesivir & monitored for only 10 days. Remdesivir is known to cause damage to the liver, heart & kidneys which leads to multi-organ shutdown. LIVER: cellular level damage & Remdesivir builds in the system thru multiple day treatments resulting in liver toxicity. HEART: post marketing heart injuries listed as sinus bradycardia (slow heart rate), T-wave abnormalities, prolonged QT interval, ventricular fibrillation & cardiac arrest. KIDNEYS: studies & data released in 2021 showed patients on a 5-10 day Remdesivir (Veklury) regimen, suffered 2.81X greater acute kidney injury & subsequent permanent renal damage.

Valerie Anne Smith

89,309 次观看 • 2 个月前