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AMMs were a solid start, but now we’re seeing a clear demand for CLOBs, especially for highly liquid assets. Why? --- CLOBs are significantly more capital efficient than AMMs. In this simulation, CLOBs required 80% less capital while providing: - Lower slippage across all trade sizes - Less leakage...

17,318 views • 1 year ago •via X (Twitter)

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To replace animal testing with AI, we need MASSIVE human datasets. Today, we're thrilled to share Axiom's new data exploration tool, providing the ability to visually explore the world's largest primary human liver toxicity dataset. Built with Axiom's proprietary wetlab protocols, our dataset includes detailed liver toxicity profiles for over 100,000 distinct molecules. The key to this dataset is our ability to do high-throughput, multiplexed high-content screening with primary human liver cells. Traditionally, toxicity assays either sacrifice throughput or sacrifice biological relevance (using easy-to-grow immortalized cell lines instead of real human cells). We managed to combine throughput, physiological relevance, and multiplexing in one platform. The assays run in a high throughput format using automation, meaning thousands of compound-dose conditions can be tested in one experiment. We achieved this using pooled primary human hepatocytes, which are often fragile and expensive. By systemizing our automation and quality control processes, we were able to run over 120+ batches on the same donor pool with incredible reproducibility and consistency. We did this while integrating many readouts per well, whereas many existing toxicity assays only do a single readout. Our multiplexed approach provides far more data per experiment enabling us to measure 10-20 different toxicity phenotypes such as apoptosis, necrosis, mitochondrial fission, endoplasmic reticulum stress, stress granule formation, microtubules, and more all from a single well on a 384-well plate! The combination of scale, high content information, and data quality is exactly what is needed to train highly accurate AI models in biology. If you're interested, please explore the dataset in the comments below and let me know if you want to chat about the details!

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25,117 views • 1 year ago

Pyth Price Feeds are blasting off 🚀 Blast has entered into orbit as a new Ethereum Layer 2 and the first of its kind to offer native yield for ETH and stablecoins. Blast is now live on mainnet. Learn more about Pyth’s deployment on Blast: ℹ️ About Blast Blast is the latest advancement in Ethereum Layer 2 solutions, delivering native yield for ETH and stablecoins. It accelerates and economizes transactions, with the backing of industry leaders like Paradigm, Standard Crypto, and eGirl Capital. 🔮 Pyth's Data-Powered Vision on Blast Over 15 apps have launched on the Blast and are harnessing Pyth’s low-latency, high-resolution price data: meathook—a gateway to 100+ crypto assets with high-leverage options. 100x—a high-speed perpetual DEX experience. Aark Digital—1000x perpetual DEX powered by LST/LRT. Blast Futures—a platform integrating perpetuals with native yield. Bloom—a leveraged trading DEX for rebasing assets. Curvance—a modular multi-chain money market with boosted yield. Deriblast—blends trading with gaming to create a unique experience. Easy X—a reimagined perpetual protocol for diverse asset exposure. Fragment—a new foundation for liquidity and lending protocols. HMX 🐉—a decentralized perpetual protocol with versatile collateral options. Juice Finance—an innovative approach to cross-margin DeFi. @Laser_on_Blast—a liquidity layer for on-chain banking on Blast. Orbit Protocol 🥮—a decentralized protocol for asset lending and borrowing. SynFutures—a decentralized derivatives trading protocol. YOLO GAMES—the go-to for high-stakes Degen Gaming. Zest 👾⚡️Genesis Version⚡️—a collateralized stablecoin with 100% capital efficiency. Pac Finance—a new pioneering DeFi hub on Blast. Seismic Finance—a new Blast native lending market. Thanks to the Pyth oracle, Blast is charting a new course for DeFi—one where accuracy and speed are not just nice-to-have features, but fundamentals that redefine users’ expectations and standards for on-chain finance.

Pyth Network 🔮

202,443 views • 2 years ago

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Catalyst

72,222 views • 2 years ago

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Patricia Marins

103,224 views • 7 months ago

📣 Puffer UniFi V2 testnet is now live! 🐡 The UniFi V2 testnet is officially live, and we’re inviting builders to explore the stack and join the next phase of Ethereum-native infrastructure. With the advancement of based rollup technology, UniFi offers a practical path forward to address Ethereum’s fragmentation and foster ecosystem growth. UniFi-OP enables Ethereum builders and users to avoid choosing a “winning” L2 or giving up revenue. Based sequencing keeps rollups, appchains, and general-purpose chains fully composable with Ethereum. Thanks to UniFi AVS, rollup owners can now share priority fees and MEV with validators. This upgrade was made possible in collaboration with Gattaca, , Automata Network, and Ethereum. ⚒️ What Builders Get • Governance‑optional rollups 🗳️ • Custom fee markets (subsidize, burn, or share) • KYC‑gated or fully permissionless chains 💆 What Users Feel • Sub‑10 ms confirmations ⚡ • One‑click exits to L1 (no 7‑day wait) • Seamless L1 interaction—AMMs, CLOBs, RWAs “just work” 📈 Economic Win‑Win Based sequencing ≠ giving up MEV and Priority fees. Rollup owners, gateways, and L1 proposers share MEV & congestion fees through @puffer_unifiAVS. Alignment without sacrifices. 🧩Pragmatic Composability How composable is UniFi V2? • L2 → L1 withdrawal supported • EIP‑7702 smart‑wallet standard baked in • Atomic withdrawals in the same block (no more 7 day wait) 🛡️Trust‑Minimized, Real‑Time Proving Real time proving is a must have to achieve composability and security that a rollup needs. We came up with a trust minimized pragmatic approach with TEEs for the first phase. In collaboration with Automata Network we now have: • Multi‑TEE provers (Intel TDX + AMD SEV) attest each block in less than 1s. • Hardware diversity = reduced trust assumptions. 🏎️UniFi AVS (Gateway Registry) For Preconfimrations (preconfs), we take advantage of delegated proposing to gateways to bring the speed. This service requires shared security. 🏗️Built on : • Validators opt in and delegate proposer rights. • They earn extra yield for serving preconfs. • Restaking validators solve the cold‑start problem. 💻 Preconf Phases • Centralized gateways at launch. • Progressive onboarding → many independent gateways for decentralization. • Proposer‑delegated based sequencing (speed). 🗺️Roadmap • ✅ Hybrid Based‑OP stack with TEE proving & fast gateways • 🔜 ZK proving • 🔜 Universal Registry Contract (URC) by ****@fabric_ethereum for slashing • 🔜 Commit boost Commit-Boost 📻 🕶️ 🦇🔊 integration • 🔜 Native L1 ↔ L2 ↔ L2 calls All upgrades are backward‑compatible and shipped incrementally. ⚔️Security Model at a Glance • Restaked ETH → slashable backing • Multi‑vendor TEEs → hardware redundancy • ZK fallback → cryptographic safety net No single point of failure. 🎯Metrics That Matter The KPI moves from TVL to transaction volume & speed. High‑frequency order‑flow is real revenue—and UniFi lets dApps capture it instead of donating it to someone else’s sequencer. 🧑‍💻Code & Collaboration UniFi V2 extends the open work by Gattaca on Gattaca‑OP. Dive into the repos and contribute. 📚TL;DR • Pragmatic composability with atomic withdrawals from the L2. • Trust‑minimized, real‑time proving • UniFi AVS bootstrapped by EigenLayer • Based rollups that share income 🪖Builders: stop choosing between UX, composability, and revenue. DM us or visit to spin up your Based Appchain and join the UniFi Based Rollup testnet—or fork the stack and run it yourself. 👷‍♂️ Build with us: 🪙 Faucet: 🌍Ecosystem resources:

Puffer Finance 🐡

157,839 views • 11 months ago