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AMMs were a solid start, but now we’re seeing a clear demand for CLOBs, especially for highly liquid assets. Why? --- CLOBs are significantly more capital efficient than AMMs. In this simulation, CLOBs required 80% less capital while providing: - Lower slippage across all trade sizes - Less leakage...

17,318 просмотров • 1 год назад •via X (Twitter)

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To replace animal testing with AI, we need MASSIVE human datasets. Today, we're thrilled to share Axiom's new data exploration tool, providing the ability to visually explore the world's largest primary human liver toxicity dataset. Built with Axiom's proprietary wetlab protocols, our dataset includes detailed liver toxicity profiles for over 100,000 distinct molecules. The key to this dataset is our ability to do high-throughput, multiplexed high-content screening with primary human liver cells. Traditionally, toxicity assays either sacrifice throughput or sacrifice biological relevance (using easy-to-grow immortalized cell lines instead of real human cells). We managed to combine throughput, physiological relevance, and multiplexing in one platform. The assays run in a high throughput format using automation, meaning thousands of compound-dose conditions can be tested in one experiment. We achieved this using pooled primary human hepatocytes, which are often fragile and expensive. By systemizing our automation and quality control processes, we were able to run over 120+ batches on the same donor pool with incredible reproducibility and consistency. We did this while integrating many readouts per well, whereas many existing toxicity assays only do a single readout. Our multiplexed approach provides far more data per experiment enabling us to measure 10-20 different toxicity phenotypes such as apoptosis, necrosis, mitochondrial fission, endoplasmic reticulum stress, stress granule formation, microtubules, and more all from a single well on a 384-well plate! The combination of scale, high content information, and data quality is exactly what is needed to train highly accurate AI models in biology. If you're interested, please explore the dataset in the comments below and let me know if you want to chat about the details!

Brandon White

25,117 просмотров • 1 год назад

Pyth Price Feeds are blasting off 🚀 Blast has entered into orbit as a new Ethereum Layer 2 and the first of its kind to offer native yield for ETH and stablecoins. Blast is now live on mainnet. Learn more about Pyth’s deployment on Blast: ℹ️ About Blast Blast is the latest advancement in Ethereum Layer 2 solutions, delivering native yield for ETH and stablecoins. It accelerates and economizes transactions, with the backing of industry leaders like Paradigm, Standard Crypto, and eGirl Capital. 🔮 Pyth's Data-Powered Vision on Blast Over 15 apps have launched on the Blast and are harnessing Pyth’s low-latency, high-resolution price data: meathook—a gateway to 100+ crypto assets with high-leverage options. 100x—a high-speed perpetual DEX experience. Aark Digital—1000x perpetual DEX powered by LST/LRT. Blast Futures—a platform integrating perpetuals with native yield. Bloom—a leveraged trading DEX for rebasing assets. Curvance—a modular multi-chain money market with boosted yield. Deriblast—blends trading with gaming to create a unique experience. Easy X—a reimagined perpetual protocol for diverse asset exposure. Fragment—a new foundation for liquidity and lending protocols. HMX 🐉—a decentralized perpetual protocol with versatile collateral options. Juice Finance—an innovative approach to cross-margin DeFi. @Laser_on_Blast—a liquidity layer for on-chain banking on Blast. Orbit Protocol 🥮—a decentralized protocol for asset lending and borrowing. SynFutures—a decentralized derivatives trading protocol. YOLO GAMES—the go-to for high-stakes Degen Gaming. Zest 👾⚡️Genesis Version⚡️—a collateralized stablecoin with 100% capital efficiency. Pac Finance—a new pioneering DeFi hub on Blast. Seismic Finance—a new Blast native lending market. Thanks to the Pyth oracle, Blast is charting a new course for DeFi—one where accuracy and speed are not just nice-to-have features, but fundamentals that redefine users’ expectations and standards for on-chain finance.

Pyth Network 🔮

202,523 просмотров • 2 лет назад

The final Epoch is now complete. DNA becomes fully deflationary. 3 years ago, we bet on a revenue-share model before it was the meta. While the market was chasing high inflation tokens, we were building a sustainable system for the first truly on-chain DAO on Multiversᕽ. It was an experiment, and it is now battle-tested. The proof is on-chain. Over the last 4 epochs, the DAO generated enough revenue to buy back over 6m $DNA from the total supply. Even with EGLD dropping ~90% since our token fair-launch (with no raise, pre-mine, allocations, or hidden unlocks) $DNA sits at roughly the same USD price today as it did on Day 1. The DNA/EGLD pair has outperformed the market and remained healthy, proving the model works even in the toughest conditions. Now, the dynamic flips. Emissions have officially ended. We are entering a full deflationary cycle. No more DNA will be printed, but the DAO will keep buying. We expect the value of DNA to reflect this scarcity, while the power of your Subject X NFTs remains the key to accessing that value. What’s next? We switch our focus fully to strengthening the MultiversX ecosystem. We are here to build tools, products, and open-source tech that grow the chain. When EGLD grows, our products grow. When our products grow, the DAO earns more. When the DAO earns more, $DNA gets stronger. Thank you to everyone who made this journey possible. History is written. Now we continue building.

Project X 🧬

11,336 просмотров • 8 месяцев назад

Everyone is waiting for the next big move in crypto. Meanwhile, the market underneath is already changing. Institutional crypto products are becoming more sophisticated. 21shares is adding staking directly to its ETH and DOT ETF names, while BlackRock and Fidelity are also moving deeper into staked ETH products. That matters because institutional exposure is evolving beyond simply holding an asset and waiting for price appreciation. Yield is becoming part of the product. But the market itself still has the same weakness we’ve seen for years: leverage. XRP went from roughly $0.99 to $1.69 in five days before the reversal wiped out hundreds of millions in leveraged longs. BTC, ETH and SOL were pulled into the move too. So while the financial rails are getting better, positioning can still get reckless very quickly. And this isn’t limited to crypto-native assets. RWA adoption is expanding through networks like BNB Chain, putting more real-world assets in front of more users. Now the problem shifts from issuance to liquidity. More assets across more chains means more distribution, but without interoperability, liquidity can remain fragmented. Even gaming sits somewhere in this transition. The fight around GTA 6’s physical ownership model is a reminder that digital assets are increasingly becoming licenses, access rights and programmable products rather than things people physically own. That’s the bigger shift I’m watching. Crypto isn’t developing in isolation anymore. ETFs, RWAs, digital ownership, tokenized assets and onchain markets are all moving toward the same direction: more financial and economic activity becoming digitally accessible. The question isn’t whether this transition is happening. It’s whether the infrastructure can keep up once everyone stops waiting and starts participating.

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23,583 просмотров • 1 месяц назад