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and das on protein synthesis 😤👌🏽

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Darrion Nguyen

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127,100 görüntüleme • 5 yıl önce •via TikTok

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Muscle protein synthesis caps out around 55 grams: - You assimilate all the protein you ingest, even 100 grams - But only about 50-55 grams goes into skeletal muscle protein synthesis - The rest is oxidized: used for fuel or gluconeogenesis, not stored - Hard resistance training in the hours before that meal does not raise the ceiling Dr. Gabrielle Lyon on Andrew D. Huberman, Ph.D.
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Protein timing and distribution are important, but not more important than simply eating enough protein. This doesn’t mean timing is irrelevant. Spreading protein relatively evenly across the day is a reasonable strategy for maximizing opportunities to stimulate muscle protein synthesis. But emerging evidence challenges the idea that the body can only “use” 25-30 grams of protein at a time. In one study, researchers compared 25 g vs. 100 g of protein after exercise. The 100-g dose produced a greater and more prolonged increase in muscle protein synthesis, with very little of the additional amino acids being oxidized. The extra protein wasn’t simply “wasted.” Larger protein meals take longer to digest and absorb, extending the period during which amino acids are available to support tissue protein synthesis. Practically, consuming your daily protein across 2-3 larger meals is not inherently inferior simply because individual meals contain far more than 25-30 grams.
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Protein timing and distribution are important, but not more important than simply eating enough protein. This doesn’t mean timing is irrelevant. Spreading protein relatively evenly across the day is a reasonable strategy for maximizing opportunities to stimulate muscle protein synthesis. But emerging evidence challenges the idea that the body can only “use” 25-30 grams of protein at a time. In one study, researchers compared 25 g vs. 100 g of protein after exercise. The 100-g dose produced a greater and more prolonged increase in muscle protein synthesis, with very little of the additional amino acids being oxidized. The extra protein wasn’t simply “wasted.” Larger protein meals take longer to digest and absorb, extending the period during which amino acids are available to support tissue protein synthesis. Practically, consuming your daily protein across 2-3 larger meals is not inherently inferior simply because individual meals contain far more than 25-30 grams.

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Eating protein before bed may improve muscle mass and aid recovery — if you lift weights. In the evening, especially in the hours before bed, our bodies are at their least insulin-sensitive. As melatonin levels rise, it interacts with receptors in the pancreas, signaling a reduction in insulin secretion. However, for the purposes of maximizing our adaptive response to resistance training, sleep is a period of long unbroken fasting. Evidence shows that during exercise training, consuming 30 grams of protein before enhances gains in muscle mass and strength. There’s two ways to look at this: One way is through the lens of time-restricted eating and the other is through the lens of actively optimizing for muscle protein synthesis on training days. Pre-sleep protein is just one way to increase total daily protein intake. A low-calorie protein shake on training days can support muscle growth by enhancing protein synthesis. However, keep in mind the natural drop in insulin sensitivity near bedtime, especially on non-training days when exercise isn’t boosting insulin sensitivity. Learn more by tuning into the Science of Protein podcast, available now on all major platforms. Show notes:
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Eating protein before bed may improve muscle mass and aid recovery — if you lift weights. In the evening, especially in the hours before bed, our bodies are at their least insulin-sensitive. As melatonin levels rise, it interacts with receptors in the pancreas, signaling a reduction in insulin secretion. However, for the purposes of maximizing our adaptive response to resistance training, sleep is a period of long unbroken fasting. Evidence shows that during exercise training, consuming 30 grams of protein before enhances gains in muscle mass and strength. There’s two ways to look at this: One way is through the lens of time-restricted eating and the other is through the lens of actively optimizing for muscle protein synthesis on training days. Pre-sleep protein is just one way to increase total daily protein intake. A low-calorie protein shake on training days can support muscle growth by enhancing protein synthesis. However, keep in mind the natural drop in insulin sensitivity near bedtime, especially on non-training days when exercise isn’t boosting insulin sensitivity. Learn more by tuning into the Science of Protein podcast, available now on all major platforms. Show notes:

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