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Animation of Gbeta5 folding by the CCT protein folding machine. Multiple snapshots were recovered from cryo-EM image processing, which revealed the step-by-step folding trajectory of its beta-propeller fold. Paper link: Animation by Margot Riggi

Peter Shen

1,043 subscribers

28,637 views • 2 years ago •via X (Twitter)

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4 Comments

Peter Shen2 years ago

For the structure nerds: the snapshots were ordered based on increased completeness and improved local resolution of the propeller density inside the CCT chamber. This enabled us to model how the protein transforms from a molten globule to a fully folded state.

Reichow Lab2 years ago

@ShahmoraLab @MargotRiggi Awesome work, and beautifully displayed in this animation! Congrats!

John Rubinstein2 years ago

@MargotRiggi This is really cool work, Peter. Congratulations!

Rajiv Ranjan Singh2 years ago

@MargotRiggi Great work congratulations to you and your team!

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