正在加载视频...

视频加载失败

加载此视频时出现问题。这可能是由于临时网络问题，或视频可能不可用。

Animation of Gbeta5 folding by the CCT protein folding machine. Multiple snapshots were recovered from cryo-EM image processing, which revealed the step-by-step folding trajectory of its beta-propeller fold. Paper link: Animation by Margot Riggi

Peter Shen

1,043 subscribers

28,637 次观看 • 2 年前 •via X (Twitter)

科学技术教育

Anya Rossi• Live Now

Private livecam show

4 条评论

Peter Shen 的头像

Peter Shen2 年前

For the structure nerds: the snapshots were ordered based on increased completeness and improved local resolution of the propeller density inside the CCT chamber. This enabled us to model how the protein transforms from a molten globule to a fully folded state.

Reichow Lab 的头像

Reichow Lab2 年前

@ShahmoraLab @MargotRiggi Awesome work, and beautifully displayed in this animation! Congrats!

John Rubinstein 的头像

John Rubinstein2 年前

@MargotRiggi This is really cool work, Peter. Congratulations!

Rajiv Ranjan Singh 的头像

Rajiv Ranjan Singh2 年前

@MargotRiggi Great work congratulations to you and your team!

相关视频

The ESM Metagenomic Atlas is the first comprehensive view of the ‘dark matter’ of the protein universe. Made possible by ESMFold, a breakthrough model for protein folding by Meta AI that allowed us to accelerate folding by up to 60x. More on this work ➡️

The ESM Metagenomic Atlas is the first comprehensive view of the ‘dark matter’ of the protein universe. Made possible by ESMFold, a breakthrough model for protein folding by Meta AI that allowed us to accelerate folding by up to 60x. More on this work ➡️

AI at Meta

66,496 次观看 • 3 年前

I believe in a future where we’re not held hostage by catastrophic threats. It’s up to us to create it, and today you can take the first step with people around the world by folding and sharing a paper crane. Please join me! #CranesForOurFuture

I believe in a future where we’re not held hostage by catastrophic threats. It’s up to us to create it, and today you can take the first step with people around the world by folding and sharing a paper crane. Please join me! #CranesForOurFuture

Yoko Ono

88,926 次观看 • 3 年前

No, this isn’t a Transformer. It’s a Leopard 2 Leguan, folding its 26-meter bridge. This bridge layer is operated by engineers of the Royal Netherlands Army.

No, this isn’t a Transformer. It’s a Leopard 2 Leguan, folding its 26-meter bridge. This bridge layer is operated by engineers of the Royal Netherlands Army.

Klaas Meijer

48,417 次观看 • 1 年前

Go beyond the bouncing ball and learn the fundamentals of animation with me! This is a super hands on, step by step way to learn animation. 🔗 below 👇

Go beyond the bouncing ball and learn the fundamentals of animation with me! This is a super hands on, step by step way to learn animation. 🔗 below 👇

Alex Grigg

28,998 次观看 • 1 年前

Fold your way to serenity with intricate paper crane Explore Step by step tutorials, creative inspirations and elegant designs. Embrace the beauty of origami and let your imagination take flight!

Fold your way to serenity with intricate paper crane Explore Step by step tutorials, creative inspirations and elegant designs. Embrace the beauty of origami and let your imagination take flight!

Craft Gallery

49,545 次观看 • 1 年前

Report on Korean folding mangals (anti drone protection). What we’re seeing: on the K2 tank, the folding hood is completely identical to the design developed by Ukrainian specialists. The K21 IFV also features a folding structure. The key question is what kind of mesh they’re using. Some versions can survive multiple hits, while others instantly bare a large surface area, making the solution far less attractive. Also, despite the fundamentally correct conceptual approach, the Korean designs can hardly be called ideal – they still leave significant uncovered areas, for example on the rear of the turret.

Report on Korean folding mangals (anti drone protection). What we’re seeing: on the K2 tank, the folding hood is completely identical to the design developed by Ukrainian specialists. The K21 IFV also features a folding structure. The key question is what kind of mesh they’re using. Some versions can survive multiple hits, while others instantly bare a large surface area, making the solution far less attractive. Also, despite the fundamentally correct conceptual approach, the Korean designs can hardly be called ideal – they still leave significant uncovered areas, for example on the rear of the turret.

Andrei_bt

11,368 次观看 • 3 个月前

Known today as compression lift, the idea of the XB-70's folding wingtips, was to use the shock waves generated by its own supersonic flight to generate lift. This clip shows what the Valkyrie could have been.

Known today as compression lift, the idea of the XB-70's folding wingtips, was to use the shock waves generated by its own supersonic flight to generate lift. This clip shows what the Valkyrie could have been.

Massimo

301,349 次观看 • 1 个月前

ANEMANIAC song by ChiliDogz for awesome pack bendy model by Viba ollie originally from 'Out of the Ink Machine', model by 🐊Taddy_Dudstare🐊 animation by.. me! :)

ANEMANIAC song by ChiliDogz for awesome pack bendy model by Viba ollie originally from 'Out of the Ink Machine', model by 🐊Taddy_Dudstare🐊 animation by.. me! :)

Coda

259,391 次观看 • 1 年前

The sensitive plant (Mimosa pudica), also called a touch-me-not, instantly responds to touch by folding its leaflets, a result of specialized cells at the leaf base rapidly losing water pressure. 📽️: Miguel Á. Padriñán

The sensitive plant (Mimosa pudica), also called a touch-me-not, instantly responds to touch by folding its leaflets, a result of specialized cells at the leaf base rapidly losing water pressure. 📽️: Miguel Á. Padriñán

Wonder of Science

106,011 次观看 • 6 天前

The animated folding screen at Japan's Sekigahara Battlefield Memorial Museum, originally unveiled in 2021 by artist Yusuke Shigeta, is going viral this week after a Japanese netizen shared a video of its extremely cool pixel art.

The animated folding screen at Japan's Sekigahara Battlefield Memorial Museum, originally unveiled in 2021 by artist Yusuke Shigeta, is going viral this week after a Japanese netizen shared a video of its extremely cool pixel art.

Jeffrey J. Hall 🇯🇵🇺🇸

28,047 次观看 • 1 年前

🪄👩🏾‍💻🏗️ Simplify the process of pretraining and fine-tuning transformer models from scratch. This step-by-step guide breaks down how KerasNLP helps to make building state-of-the-art text processing models easier. ➡️

🪄👩🏾‍💻🏗️ Simplify the process of pretraining and fine-tuning transformer models from scratch. This step-by-step guide breaks down how KerasNLP helps to make building state-of-the-art text processing models easier. ➡️

TensorFlow

16,999 次观看 • 2 年前

#ballbusting #고자킥 #踢裆 #animation #comic Tales of the Teenage Mutant Ninja Turtles s01 ep01, Guardians Of The Galaxy by Brian Michael Bendis TPB 5, The Intimidators #2, Two-Step #2

#ballbusting #고자킥 #踢裆 #animation #comic Tales of the Teenage Mutant Ninja Turtles s01 ep01, Guardians Of The Galaxy by Brian Michael Bendis TPB 5, The Intimidators #2, Two-Step #2

BB-fantastic

21,063 次观看 • 1 年前

Footage from last night’s Operation within Khan Yunis in the Southern Gaza Strip, by Elements of the 35th Paratroopers Brigade, during which the Bodies of Six Hostages that were Murdered by Hamas were Recovered from a Tunnel over 10 Meters beneath the Surface.

Footage from last night’s Operation within Khan Yunis in the Southern Gaza Strip, by Elements of the 35th Paratroopers Brigade, during which the Bodies of Six Hostages that were Murdered by Hamas were Recovered from a Tunnel over 10 Meters beneath the Surface.

OSINTdefender

111,050 次观看 • 1 年前

Today's Agent Spotlight on ASI:One is a game-changer for molecular discovery. ⚡ Built by QBio.AI, the Boltz Protein Folding Agent predicts complex 3D structures from amino acid, RNA, DNA & small molecule inputs (SMILES/CCD). Get binding affinities, confidence scores & PDB files: all via natural language on Link to agent: Watch 👇

Today's Agent Spotlight on ASI:One is a game-changer for molecular discovery. ⚡ Built by QBio.AI, the Boltz Protein Folding Agent predicts complex 3D structures from amino acid, RNA, DNA & small molecule inputs (SMILES/CCD). Get binding affinities, confidence scores & PDB files: all via natural language on Link to agent: Watch 👇

Fetch.ai

13,385 次观看 • 1 年前

Cool new model release: PaintsUndo, which takes an image and outputs step-by-step frames of how to draw it. It starts with a sketch and then fills in the colors, shading, and lighting.

Cool new model release: PaintsUndo, which takes an image and outputs step-by-step frames of how to draw it. It starts with a sketch and then fills in the colors, shading, and lighting.

Justine Moore

146,126 次观看 • 2 年前

Ninkoro first BD contain a "tour" of Shaft Aoi by Haruna Mikawa (VA of Satoko). It cover multiple departements, direction, animation, Shiage, Satsuei. Here, the kantoku, Yukihiro Miyamoto 宮本幸裕, is showing a Layout check step, the Layout is from Kazuki Kawata 川田和樹.

Ninkoro first BD contain a "tour" of Shaft Aoi by Haruna Mikawa (VA of Satoko). It cover multiple departements, direction, animation, Shiage, Satsuei. Here, the kantoku, Yukihiro Miyamoto 宮本幸裕, is showing a Layout check step, the Layout is from Kazuki Kawata 川田和樹.

Iluvatar

18,849 次观看 • 1 年前

A) Hunt down the people that just tried to kill you and throw your entire life away. B) Focus on pursuing your passion to create a better life - becoming one of the most influential rappers of all time, making 100’s of millions. That’s not folding. That’s using your brain. Which explains why there’s people incapable of understanding that. 50 realized his potential and could see a better life for himself outside the streets. While others were so consumed by it, that it became all they’d ever know - unable to see a life outside the streets, forcing them to believe anybody who chose a better life, was weak for “folding”

A) Hunt down the people that just tried to kill you and throw your entire life away. B) Focus on pursuing your passion to create a better life - becoming one of the most influential rappers of all time, making 100’s of millions. That’s not folding. That’s using your brain. Which explains why there’s people incapable of understanding that. 50 realized his potential and could see a better life for himself outside the streets. While others were so consumed by it, that it became all they’d ever know - unable to see a life outside the streets, forcing them to believe anybody who chose a better life, was weak for “folding”

Hip Hop Historian

18,149 次观看 • 5 个月前