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Boltz-2 was released recently. It is an Open Source protein-ligand co-folding model, which means it can predict the structure of a protein along with the ligand. It has various applications from drug discovery to protein design. I thought why not make a OSS web app for it.

Ravi Sharma

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43,911 görüntüleme • 1 yıl önce •via X (Twitter)

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We've just released a new video tutorial on how to run protein–ligand docking (one of our most popular workflows). Here's some highlights:

We've just released a new video tutorial on how to run protein–ligand docking (one of our most popular workflows). Here's some highlights:

Rowan

11,300 görüntüleme • 4 ay önce

Just because you sprinkle protein on a dog turd doesn’t make it health food. 🙄 Now it’s protein Pop-Tarts, protein Doritos, and Starbucks turning your morning coffee into a 300-calorie milkshake with “protein foam.” Khloé Kardashian says protein popcorn is a diet hack. It’s not. Sugar is still sugar. Grains are still grains. Adding protein to junk just means you're eating protein-fortified junk. Don’t fall for the marketing. 🥩 Stay motivated. #NSNG #DietMyths #RealFood

Just because you sprinkle protein on a dog turd doesn’t make it health food. 🙄 Now it’s protein Pop-Tarts, protein Doritos, and Starbucks turning your morning coffee into a 300-calorie milkshake with “protein foam.” Khloé Kardashian says protein popcorn is a diet hack. It’s not. Sugar is still sugar. Grains are still grains. Adding protein to junk just means you're eating protein-fortified junk. Don’t fall for the marketing. 🥩 Stay motivated. #NSNG #DietMyths #RealFood

Vinnie Tortorich

15,119 görüntüleme • 4 ay önce

Guess which country this national dish Is from? I added a protein component to it 🤝

Guess which country this national dish Is from? I added a protein component to it 🤝

PrincessFromBabylon

73,395 görüntüleme • 2 yıl önce

Ex-CDC Director Robert Redfield raises concerns over “significant vaccine injury” from the COVID jab. Says he is no longer an advocate, calls the spike protein “immunotoxic.” “When I give you an mRNA vaccine…” “I turn your body into a spike protein factory.” “I don’t know how much spike protein you make…” “I don’t know how long you make it…” “I don’t know where you make it in your body. And I can’t control any of that.” “And we now know that the spike protein is really an immunotoxic protein that causes a lot of illness.”

Ex-CDC Director Robert Redfield raises concerns over “significant vaccine injury” from the COVID jab. Says he is no longer an advocate, calls the spike protein “immunotoxic.” “When I give you an mRNA vaccine…” “I turn your body into a spike protein factory.” “I don’t know how much spike protein you make…” “I don’t know how long you make it…” “I don’t know where you make it in your body. And I can’t control any of that.” “And we now know that the spike protein is really an immunotoxic protein that causes a lot of illness.”

The Vigilant Fox 🦊

122,944 görüntüleme • 2 ay önce

Sattu vs Protein Powder? Only idiots like Sonal Mehrotra Kapoor can compare food items with supplements and say supplement is better. Never seen anyone drinking multiple glasses of Sattu for Protein. Sattu is good source of protein, it also has daily requirements of fibre, iron, magnesium and Potassium. Sattu is good for digestion, doesn't have bloating effect like Protein Powder. Sattu has more calories but it also keeps you full for long, so you consume less calories in total. Sattu is zero cholesterol, so good for heart. Most protein powders have cholesterol. Sattu is wholefood, it can be taken as a meal. Protein powder is supplement, you will need meal. Also Sattu is much much cheaper. Even your hifi branded organic sattu is not even 5% cost of protein supplements. Also Sattu is super tasty, no need of added flavours like in Protein Powder. Compare food with Food, supplements with Supplements Consume Sattu Daily, take protein powder when you are short of your daily protein intake. If your aim is to promote Protein Powders, do it. Nothing wrong with Protein Powders. But Comparison with Sattu is stupidity.

Sattu vs Protein Powder? Only idiots like Sonal Mehrotra Kapoor can compare food items with supplements and say supplement is better. Never seen anyone drinking multiple glasses of Sattu for Protein. Sattu is good source of protein, it also has daily requirements of fibre, iron, magnesium and Potassium. Sattu is good for digestion, doesn't have bloating effect like Protein Powder. Sattu has more calories but it also keeps you full for long, so you consume less calories in total. Sattu is zero cholesterol, so good for heart. Most protein powders have cholesterol. Sattu is wholefood, it can be taken as a meal. Protein powder is supplement, you will need meal. Also Sattu is much much cheaper. Even your hifi branded organic sattu is not even 5% cost of protein supplements. Also Sattu is super tasty, no need of added flavours like in Protein Powder. Compare food with Food, supplements with Supplements Consume Sattu Daily, take protein powder when you are short of your daily protein intake. If your aim is to promote Protein Powders, do it. Nothing wrong with Protein Powders. But Comparison with Sattu is stupidity.

Ankur Singh

21,833 görüntüleme • 11 gün önce

Still incredible that the DeepMind documentary has footage of exact moment Demis is told that AlphaFold can “easily” predict all known (1-2B) protein sequences “in a month” and he says to do it. Then, it shows the moment AlphaFold is released to the world.

Still incredible that the DeepMind documentary has footage of exact moment Demis is told that AlphaFold can “easily” predict all known (1-2B) protein sequences “in a month” and he says to do it. Then, it shows the moment AlphaFold is released to the world.

Trung Phan

1,323,909 görüntüleme • 2 ay önce

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

Alex Rives

227,253 görüntüleme • 1 yıl önce

MIT CSAIL, MIT Jameel Clinic for AI & Health, & Recursion have released a protein-binding affinity model called "Boltz-2" that could expand the role of AI in drug discovery. The system predicts how molecules interact — & how tightly they bind — in record time:

MIT CSAIL, MIT Jameel Clinic for AI & Health, & Recursion have released a protein-binding affinity model called "Boltz-2" that could expand the role of AI in drug discovery. The system predicts how molecules interact — & how tightly they bind — in record time:

MIT CSAIL

18,904 görüntüleme • 1 yıl önce

We've been tinkering with protein structure design. Our (new?) method works like a language model, but instead of a discrete token, it samples the placement of the next amino acid backbone from a continuous distribution. Meet the Generative Invariant Angle Transformer (GIAT):

We've been tinkering with protein structure design. Our (new?) method works like a language model, but instead of a discrete token, it samples the placement of the next amino acid backbone from a continuous distribution. Meet the Generative Invariant Angle Transformer (GIAT):

Ben Murrell

68,093 görüntüleme • 2 yıl önce

Literature review is often a starting point for drug discovery campaigns, but it is a time consuming step. The NVIDIA Healthcare team created a reference framework for a Biomedical Research Agent that uses the Llama Nemotron reasoning model to review 100+ manuscripts in minutes, generate complex hypotheses, and identify potential target/small molecule pairs for a particular disease. The results can be handed off to the BioNeMo virtual screening agent that continues the thought experiment by predicting protein–ligand interactions. Github details in 🧵 Note: This is a simplified example intended to demonstrate software capabilities.

Literature review is often a starting point for drug discovery campaigns, but it is a time consuming step. The NVIDIA Healthcare team created a reference framework for a Biomedical Research Agent that uses the Llama Nemotron reasoning model to review 100+ manuscripts in minutes, generate complex hypotheses, and identify potential target/small molecule pairs for a particular disease. The results can be handed off to the BioNeMo virtual screening agent that continues the thought experiment by predicting protein–ligand interactions. Github details in 🧵 Note: This is a simplified example intended to demonstrate software capabilities.

Vega Shah

12,562 görüntüleme • 1 yıl önce

🚩 Fmr. CDC Director Robert Redfield Makes a Series of Stunning Admissions That Were Once Deemed 'Misinformation' "There was a decision not to do anything that made the vaccine sound like it didn't work." "Two thirds of the people that I'm seeing infected in Maryland have been vaccinated." "If you came down and visited me and interviewed my patients...you'd interview patient after patient after patient that did not have COVID but are very sick. You would say very sick, long COVID patients. And it's all from the vaccine." "The spike protein is immunotoxic. You get infected, it's immunotoxic. But when you give the vaccine, we make the spike protein." "When I give you an mRNA vaccine...I don't know how much spike protein you make because I give you mRNA and then your body goes and makes it...You may make it for a week...You may make it for a month." "I use the protein vaccine so I know exactly how much spike protein you get. Your body's not becoming a [spike protein] manufacturing plant."

🚩 Fmr. CDC Director Robert Redfield Makes a Series of Stunning Admissions That Were Once Deemed 'Misinformation' "There was a decision not to do anything that made the vaccine sound like it didn't work." "Two thirds of the people that I'm seeing infected in Maryland have been vaccinated." "If you came down and visited me and interviewed my patients...you'd interview patient after patient after patient that did not have COVID but are very sick. You would say very sick, long COVID patients. And it's all from the vaccine." "The spike protein is immunotoxic. You get infected, it's immunotoxic. But when you give the vaccine, we make the spike protein." "When I give you an mRNA vaccine...I don't know how much spike protein you make because I give you mRNA and then your body goes and makes it...You may make it for a week...You may make it for a month." "I use the protein vaccine so I know exactly how much spike protein you get. Your body's not becoming a [spike protein] manufacturing plant."

Chief Nerd

2,623,377 görüntüleme • 2 yıl önce

Brett Weinstein, Professor of Evolutionary Biology. Host of the DarkHorse podcast. "The mRNA platform is brilliant. But it has a giant gaping flaw in it, which is ; Any cell of yours that produces a foreign protein, will be targetted by your immune system and destroyed. You will create an autoimmune disorder. When it works. How do you keep it out of your heart. Not by coding it in a lipid nanoparticle. So, they had no way to deliver it safely to market. So then they had a pandemic, the emergency allowed them to do it. This technology, in my opinion, was at least 3 decades out from being usefully and safely deployed at all, if at all. They did not want to wait, this crisis gave them the opportunity not to wait. And now, they will blame the spike protein, we picked the wrong protein. When in actual fact there are 2 problems, the spike protein and the platform itself."

Brett Weinstein, Professor of Evolutionary Biology. Host of the DarkHorse podcast. "The mRNA platform is brilliant. But it has a giant gaping flaw in it, which is ; Any cell of yours that produces a foreign protein, will be targetted by your immune system and destroyed. You will create an autoimmune disorder. When it works. How do you keep it out of your heart. Not by coding it in a lipid nanoparticle. So, they had no way to deliver it safely to market. So then they had a pandemic, the emergency allowed them to do it. This technology, in my opinion, was at least 3 decades out from being usefully and safely deployed at all, if at all. They did not want to wait, this crisis gave them the opportunity not to wait. And now, they will blame the spike protein, we picked the wrong protein. When in actual fact there are 2 problems, the spike protein and the platform itself."

RefugeOfSinners (ROS)

1,204,566 görüntüleme • 2 yıl önce

This is a Kinesin protein. It transports vital cargo from the cell nucleus. I don't have enough faith to be an Atheist.

This is a Kinesin protein. It transports vital cargo from the cell nucleus. I don't have enough faith to be an Atheist.

Against Atheism

200,675 görüntüleme • 8 ay önce

He said...I shit you not: (In reference to "protein cupcakes") "That protein will immediately be expelled from your body, because your body doesn't want that kind of protein; it wants protein that's in something that's healthy"

He said...I shit you not: (In reference to "protein cupcakes") "That protein will immediately be expelled from your body, because your body doesn't want that kind of protein; it wants protein that's in something that's healthy"

BroSydePhil | The 220 KingSnake

18,766 görüntüleme • 5 ay önce

80% of India is protein deficient. This deficiency is even more in the poor which results in millions of stunted children. Instead of giving Parle G to the needy, I recently conducted a buttermilk (chaas) drive in Kolkata. While Chaas is not high in protein, it is a decent source of protein and the best part is that it is very affordable. I have decided to do a monthly chaas drive to promote protein consumption in India. I would love to see many of you conducting this drive in your own cities. If you want to join me in a drive, or lead your own, you can email me at pharmerfood@gmail.com Note: I know we used plastic glasses this time. Next time, we will try to do better.

80% of India is protein deficient. This deficiency is even more in the poor which results in millions of stunted children. Instead of giving Parle G to the needy, I recently conducted a buttermilk (chaas) drive in Kolkata. While Chaas is not high in protein, it is a decent source of protein and the best part is that it is very affordable. I have decided to do a monthly chaas drive to promote protein consumption in India. I would love to see many of you conducting this drive in your own cities. If you want to join me in a drive, or lead your own, you can email me at [email protected] Note: I know we used plastic glasses this time. Next time, we will try to do better.

Revant Himatsingka “Food Pharmer”

131,731 görüntüleme • 1 yıl önce

Today I am giving a 6 month deadline to Saffola to change their misleading peanut butter packaging. Saffola’s peanut butter says 31% protein RDA which clearly implies that people will get 31% of their daily protein needs from Saffola peanut butter. But in tiny font in the back on the package, they write the protein requirements mentioned are for 7-9 year olds. In order to make their protein content seem big, Saffola compares their protein content to a kid’s protein requirement since kids need lesser protein. A low protein diet is one of the major causes behind several Indian illnesses. Companies must market their protein content honestly because many Indians opt to have peanut butter to increase protein in their diet. I am giving Saffola 2 options: Option 1: Don’t make any changes and I might take legal action Option 2: Change your packaging and remove this 31% protein RDA claim and I will make a video praising you It is time for Indians to stand fearless and united against misleading ads which prompt us to eat junk food and lead unhealthy livestyles. #EndFalseMarketing

Today I am giving a 6 month deadline to Saffola to change their misleading peanut butter packaging. Saffola’s peanut butter says 31% protein RDA which clearly implies that people will get 31% of their daily protein needs from Saffola peanut butter. But in tiny font in the back on the package, they write the protein requirements mentioned are for 7-9 year olds. In order to make their protein content seem big, Saffola compares their protein content to a kid’s protein requirement since kids need lesser protein. A low protein diet is one of the major causes behind several Indian illnesses. Companies must market their protein content honestly because many Indians opt to have peanut butter to increase protein in their diet. I am giving Saffola 2 options: Option 1: Don’t make any changes and I might take legal action Option 2: Change your packaging and remove this 31% protein RDA claim and I will make a video praising you It is time for Indians to stand fearless and united against misleading ads which prompt us to eat junk food and lead unhealthy livestyles. #EndFalseMarketing

Revant Himatsingka “Food Pharmer”

706,497 görüntüleme • 1 yıl önce

The ESM Metagenomic Atlas is the first comprehensive view of the ‘dark matter’ of the protein universe. Made possible by ESMFold, a breakthrough model for protein folding by Meta AI that allowed us to accelerate folding by up to 60x. More on this work ➡️

The ESM Metagenomic Atlas is the first comprehensive view of the ‘dark matter’ of the protein universe. Made possible by ESMFold, a breakthrough model for protein folding by Meta AI that allowed us to accelerate folding by up to 60x. More on this work ➡️

AI at Meta

66,496 görüntüleme • 3 yıl önce

🚨FORMER CDC DIRECTOR: "I'd like to see mRNA vaccines eliminated." "When I give you an mRNA vaccine, what I do is I turn your body into a spike protein production factory." "Spike protein is a very immunotoxic protein. I don't know how much you make and how long you make it."

🚨FORMER CDC DIRECTOR: "I'd like to see mRNA vaccines eliminated." "When I give you an mRNA vaccine, what I do is I turn your body into a spike protein production factory." "Spike protein is a very immunotoxic protein. I don't know how much you make and how long you make it."

Nicolas Hulscher, MPH

308,938 görüntüleme • 4 ay önce