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Brand-new research (PMID: 42102814) has uncovered a bizarre link between a compound found in aged garlic and longevity. 🧄 It's called: S1PC. Remarkably, it causes fat cells to release tiny vesicles carrying an enzyme that travels to the brain, boosting levels of the energy molecule NAD in just minutes.... show more

Nick Norwitz MD PhD

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15,234 views • 2 months ago •via X (Twitter)

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If your goal is to lose fat, the last thing you want to lose is your muscle. Muscle is one of the greatest predictors of longevity. It helps regulate blood sugar, improves insulin sensitivity, and acts as a powerful metabolic engine. As you age, maintaining strength becomes even more important. Research has linked factors like grip strength and muscle mass to healthier aging and longevity. The message is simple: if you want to live a long time, lift heavy weights.

If your goal is to lose fat, the last thing you want to lose is your muscle. Muscle is one of the greatest predictors of longevity. It helps regulate blood sugar, improves insulin sensitivity, and acts as a powerful metabolic engine. As you age, maintaining strength becomes even more important. Research has linked factors like grip strength and muscle mass to healthier aging and longevity. The message is simple: if you want to live a long time, lift heavy weights.

Gary Brecka

22,509 views • 2 months ago

Dyno Therapeutics co-founder Sam Sinai on how his team cracked the blood-brain barrier well enough to reach 50% of neurons with a single injection: "For brain specifically, the brain has this extra layer of defense called the blood brain barrier. It's really put there to prevent anything to get in." "What we have done is actually in primates we can show that we can get up more than 50% of neurons, through a systemic injection." "You're just injecting in the veins, and then the virus actually makes its way into the brain." "Neurons are a primary target, but it could be in some cases glial cells, depending on the disease. Solving pan brain, meaning all of brain delivery, is a key objective there."

Dyno Therapeutics co-founder Sam Sinai on how his team cracked the blood-brain barrier well enough to reach 50% of neurons with a single injection: "For brain specifically, the brain has this extra layer of defense called the blood brain barrier. It's really put there to prevent anything to get in." "What we have done is actually in primates we can show that we can get up more than 50% of neurons, through a systemic injection." "You're just injecting in the veins, and then the virus actually makes its way into the brain." "Neurons are a primary target, but it could be in some cases glial cells, depending on the disease. Solving pan brain, meaning all of brain delivery, is a key objective there."

MTS

21,041 views • 2 months ago

New 2026 published in Nature research reveals a fascinating mechanism by which mutant inflammatory cells develop with age and can drive atherosclerosis ❤️‍🔥. But the good news is that there are 2 things you can do to help slow or stop the process. And they're 100% free. Here’s a 56 sec clip, plus a link to the deep-dive video 🔗Deep dive 19 min:

New 2026 published in Nature research reveals a fascinating mechanism by which mutant inflammatory cells develop with age and can drive atherosclerosis ❤️‍🔥. But the good news is that there are 2 things you can do to help slow or stop the process. And they're 100% free. Here’s a 56 sec clip, plus a link to the deep-dive video 🔗Deep dive 19 min:

Nick Norwitz MD PhD

20,888 views • 15 days ago

The Codex deep dive that dominik kundel and I streamed last week is now on YouTube in case you missed it. (recording in thread 👇) We discuss how Codex has changed in the last two months and dive deep on the latest features with tips and best practices for getting the most out of it. Let us know what you think! We want to do a lot more of these.

The Codex deep dive that dominik kundel and I streamed last week is now on YouTube in case you missed it. (recording in thread 👇) We discuss how Codex has changed in the last two months and dive deep on the latest features with tips and best practices for getting the most out of it. Let us know what you think! We want to do a lot more of these.

pranav

46,688 views • 1 year ago

Dr. Daniel Monti just revealed a potentially massive breakthrough in Parkinson’s disease treatment. And it’s much simpler than you think. He just published his third study on a molecule called N-acetylcysteine, or “NAC for short.” “This is a powerful antioxidant.” “It actually protects the liver.” “We know that it does a lot of different things, but the important thing for us is that it’s a precursor to something called glutathione.” “Glutathione protects the brain when there’s damage or oxidative stress and we lose it as we age.” “And when we get sick, we lose it even more.” “So we want to have a way to efficiently increase glutathione in the brain, particularly when we have a neurodegenerative disorder such as Parkinson’s disease.” “We hypothesized early on that giving infused N-acetylcysteine would increase glutathione and actually have a positive impact on Parkinson’s disease.” “We’ve published three studies on this and we look at brain scans in all of them.” “And what we’ve seen is that the N-acetylcysteine increases the efficiency of dopamine in the brain, which is the neurotransmitter or chemical that gets lost in Parkinson’s disease and causes all of those symptoms.” “Our most recent study shows that it improves the way the brain connects to itself or talks to itself the functional connectivity in the brain.” “To be in the study, you couldn’t have changes in your Parkinson's medications for a period of time.” “In both the control group and in the NAC group, people were on their Parkinson’s medications, but if they got the NAC, they did better.” “Their brain came alive in a way that wasn’t happening before.”

Dr. Daniel Monti just revealed a potentially massive breakthrough in Parkinson’s disease treatment. And it’s much simpler than you think. He just published his third study on a molecule called N-acetylcysteine, or “NAC for short.” “This is a powerful antioxidant.” “It actually protects the liver.” “We know that it does a lot of different things, but the important thing for us is that it’s a precursor to something called glutathione.” “Glutathione protects the brain when there’s damage or oxidative stress and we lose it as we age.” “And when we get sick, we lose it even more.” “So we want to have a way to efficiently increase glutathione in the brain, particularly when we have a neurodegenerative disorder such as Parkinson’s disease.” “We hypothesized early on that giving infused N-acetylcysteine would increase glutathione and actually have a positive impact on Parkinson’s disease.” “We’ve published three studies on this and we look at brain scans in all of them.” “And what we’ve seen is that the N-acetylcysteine increases the efficiency of dopamine in the brain, which is the neurotransmitter or chemical that gets lost in Parkinson’s disease and causes all of those symptoms.” “Our most recent study shows that it improves the way the brain connects to itself or talks to itself the functional connectivity in the brain.” “To be in the study, you couldn’t have changes in your Parkinson's medications for a period of time.” “In both the control group and in the NAC group, people were on their Parkinson’s medications, but if they got the NAC, they did better.” “Their brain came alive in a way that wasn’t happening before.”

Jan Jekielek

170,003 views • 6 months ago

Exercise doesn’t just build muscle—it rewrites how a critical hormone, IGF-1, functions in the body Instead of circulating freely in ways that could fuel harmful cell growth, exercise redirects IGF-1 to where it matters most: your muscles and brain This shift promotes muscle repair, boosts neurogenesis (the growth of new brain cells), and even strengthens your body’s defense against cancer Yet another benefit of exercise to add to the list Go lift some weights

Exercise doesn’t just build muscle—it rewrites how a critical hormone, IGF-1, functions in the body Instead of circulating freely in ways that could fuel harmful cell growth, exercise redirects IGF-1 to where it matters most: your muscles and brain This shift promotes muscle repair, boosts neurogenesis (the growth of new brain cells), and even strengthens your body’s defense against cancer Yet another benefit of exercise to add to the list Go lift some weights

FoundMyFitness Clips

30,000 views • 1 year ago

Imagine a compound that claims to improve focus, boost learning, increase BDNF, and even help protect the brain after a stroke. Sounds like science fiction. It's called Semax—a peptide developed in the Soviet Union that's been used clinically in Russia for over 30 years. So... is it actually a real brain booster? In this video I break down: • The actual human and animal data • How Semax works • Whether it can really make you "smarter" • Side effects and safety • The biggest risk most people completely overlook: the bottle it's coming from I also cover the upcoming FDA PCAC meeting that could determine the future of legal access to Semax and several other peptides in the U.S. If you're interested in evidence—not hype—this one's for you. Have you tried Semax? Did it help your focus, or did you feel absolutely nothing? Let me know below. 👇

Imagine a compound that claims to improve focus, boost learning, increase BDNF, and even help protect the brain after a stroke. Sounds like science fiction. It's called Semax—a peptide developed in the Soviet Union that's been used clinically in Russia for over 30 years. So... is it actually a real brain booster? In this video I break down: • The actual human and animal data • How Semax works • Whether it can really make you "smarter" • Side effects and safety • The biggest risk most people completely overlook: the bottle it's coming from I also cover the upcoming FDA PCAC meeting that could determine the future of legal access to Semax and several other peptides in the U.S. If you're interested in evidence—not hype—this one's for you. Have you tried Semax? Did it help your focus, or did you feel absolutely nothing? Let me know below. 👇

Dr. Alex Tatem

11,600 views • 2 months ago

Saunas Can Reduce Food Intake?! – New Insights from Nature 🔥🧠 (2 min science breakdown clip) It’s been observed that heat exposure reduces food intake both in humans and animals, leading some to suggest heat stress may be a weight management tool. And new science is beginning to unpack how heat may suppress appetite. Get ready for a steam burst of jargon, then I’ll simplify: A 2024 paper published in nature (PMID: 38538787) found that heat 🔥activates specialized cells that line the fluid-filled spaces in the brain called, “tanycytes.” 🎯These tanycytes are optimally placed to communicate external signals to regions of the brain, in particular the hypothalamus, that control things like metabolism and food intake. 🔥This study found that heat stress in a mouse model at 40°C for 1 hour increased activity in a temperature sensing brain region, the “pontine parabrachial nucleus (PBN)” 👉which signals to tanycytes and causes them to 👉produce a brain chemical VEGFA, which in turn 👉 signals to the hypothalamus to change the activity of dopamine and AGRP neurons and leads to reduce food intake. (Please see clip for a visual explanation) 🚨High-Level Takeaway: The researchers discovered a causal mechanism for the effects of heat on reducing food intake, and aligns with data in humans that heat can reduce food intake. More details about sauna in today’s #StayCurious Newsletter (linked in first reply), including discussion of heart health, brain health, longevity, and with a healthy shoutout to Dr. Rhonda Patrick (who I suspect might be interested in this Tanycytes Mechanism, if it's not already on her radar) Some folks interesting in Sauna and/or Neuroscience Mechanisms: Dan Go Gary Brecka Andrew D. Huberman, Ph.D. (Wonder what will be in #Protocols: An Operating Manual for the Human Body on Saunas?📖🐰🕳️?) Rob Mohr Robb Wolf Nicholas Fabiano, MD Amy Berger Meat Head Chris Palmer, MD #sauna #neuroscience #longevity #healthspan #appetite #metabolichealth

Saunas Can Reduce Food Intake?! – New Insights from Nature 🔥🧠 (2 min science breakdown clip) It’s been observed that heat exposure reduces food intake both in humans and animals, leading some to suggest heat stress may be a weight management tool. And new science is beginning to unpack how heat may suppress appetite. Get ready for a steam burst of jargon, then I’ll simplify: A 2024 paper published in nature (PMID: 38538787) found that heat 🔥activates specialized cells that line the fluid-filled spaces in the brain called, “tanycytes.” 🎯These tanycytes are optimally placed to communicate external signals to regions of the brain, in particular the hypothalamus, that control things like metabolism and food intake. 🔥This study found that heat stress in a mouse model at 40°C for 1 hour increased activity in a temperature sensing brain region, the “pontine parabrachial nucleus (PBN)” 👉which signals to tanycytes and causes them to 👉produce a brain chemical VEGFA, which in turn 👉 signals to the hypothalamus to change the activity of dopamine and AGRP neurons and leads to reduce food intake. (Please see clip for a visual explanation) 🚨High-Level Takeaway: The researchers discovered a causal mechanism for the effects of heat on reducing food intake, and aligns with data in humans that heat can reduce food intake. More details about sauna in today’s #StayCurious Newsletter (linked in first reply), including discussion of heart health, brain health, longevity, and with a healthy shoutout to Dr. Rhonda Patrick (who I suspect might be interested in this Tanycytes Mechanism, if it's not already on her radar) Some folks interesting in Sauna and/or Neuroscience Mechanisms: Dan Go Gary Brecka Andrew D. Huberman, Ph.D. (Wonder what will be in #Protocols: An Operating Manual for the Human Body on Saunas?📖🐰🕳️?) Rob Mohr Robb Wolf Nicholas Fabiano, MD Amy Berger Meat Head Chris Palmer, MD #sauna #neuroscience #longevity #healthspan #appetite #metabolichealth

Nick Norwitz MD PhD

10,902 views • 1 year ago

Dr. McCullough on the COVID Jab: “I have never seen something so injurious to the human body.” • It invades the brain. • It invades the heart. • It causes brain and heart damage. • It invades the bone marrow. • It stimulates antibodies to cells and platelets. • It causes blood clotting and damage to blood vessels like we've never seen. • Data from the University of Pittsburgh suggests it causes cancer. “Since when do we have a protein that actually injures the brain, injures the heart, the bone marrow, the immune system, causes blood clotting, and potentially causes cancer in a single protein?” Peter A. McCullough, MD, MPH® asked. “It's a weapon,” he concluded. “According to strict military criteria, it's a bioweapon.”

Dr. McCullough on the COVID Jab: “I have never seen something so injurious to the human body.” • It invades the brain. • It invades the heart. • It causes brain and heart damage. • It invades the bone marrow. • It stimulates antibodies to cells and platelets. • It causes blood clotting and damage to blood vessels like we've never seen. • Data from the University of Pittsburgh suggests it causes cancer. “Since when do we have a protein that actually injures the brain, injures the heart, the bone marrow, the immune system, causes blood clotting, and potentially causes cancer in a single protein?” Peter A. McCullough, MD, MPH® asked. “It's a weapon,” he concluded. “According to strict military criteria, it's a bioweapon.”

The Vigilant Fox 🦊

361,464 views • 1 year ago

Dr. McCullough on the COVID Jab: “I have never seen something so injurious to the human body.” • It invades the brain. • It invades the heart. • It causes brain and heart damage. • It invades the bone marrow. • It stimulates antibodies to cells and platelets. • It causes blood clotting and damage to blood vessels like we've never seen. • Data from the University of Pittsburgh suggests it causes cancer. “Since when do we have a protein that actually injures the brain, injures the heart, the bone marrow, the immune system, causes blood clotting, and potentially causes cancer in a single protein?” Peter A. McCullough, MD, MPH® asked. “It's a weapon,” he concluded. “According to strict military criteria, it's a bioweapon.”

Dr. McCullough on the COVID Jab: “I have never seen something so injurious to the human body.” • It invades the brain. • It invades the heart. • It causes brain and heart damage. • It invades the bone marrow. • It stimulates antibodies to cells and platelets. • It causes blood clotting and damage to blood vessels like we've never seen. • Data from the University of Pittsburgh suggests it causes cancer. “Since when do we have a protein that actually injures the brain, injures the heart, the bone marrow, the immune system, causes blood clotting, and potentially causes cancer in a single protein?” Peter A. McCullough, MD, MPH® asked. “It's a weapon,” he concluded. “According to strict military criteria, it's a bioweapon.”

The Vigilant Fox 🦊

2,576,712 views • 1 year ago

Now on YouTube! Discover the powerful link between diet and mental health in this deep dive. It’s not nearly as simple as most people think. Learn six different ways that your food choices can impact mood, energy, and even severe mental health conditions. From nutrient deficiencies to the Mediterranean and ketogenic diets, I unpack the science of food for brain health. Don’t miss this transformative guide to eating for your mind!

Now on YouTube! Discover the powerful link between diet and mental health in this deep dive. It’s not nearly as simple as most people think. Learn six different ways that your food choices can impact mood, energy, and even severe mental health conditions. From nutrient deficiencies to the Mediterranean and ketogenic diets, I unpack the science of food for brain health. Don’t miss this transformative guide to eating for your mind!

Chris Palmer, MD

13,865 views • 1 year ago

Saying "NO AI data centers" won't end in victory. They'll just build them anyways. If you truly want to make a difference, you need to say, "No data centers, UNLESS..." Turn it into a negotiation instead of a war, so we can fight over what really matters. No data centers UNLESS they're not draining our energy. In fact, you could say, "you want 10 gigawatts of power? Ok, YOU pay for it. And because we’re allowing you to do it, you have to produce 15 gigawatts of power and give the excess to the grid." It's a win-win and YOU control the terms.

Saying "NO AI data centers" won't end in victory. They'll just build them anyways. If you truly want to make a difference, you need to say, "No data centers, UNLESS..." Turn it into a negotiation instead of a war, so we can fight over what really matters. No data centers UNLESS they're not draining our energy. In fact, you could say, "you want 10 gigawatts of power? Ok, YOU pay for it. And because we’re allowing you to do it, you have to produce 15 gigawatts of power and give the excess to the grid." It's a win-win and YOU control the terms.

Glenn Beck

70,799 views • 3 months ago

Mitochondria aren’t just the powerhouses of our cells. They are the link between energy and the human experience. This week, we published a video on The Science and Experience of Energy YouTube channel that gives an overview of this idea. Interested in learning more? Below are two articles from our Substack archives that touch on this topic and may stimulate your thinking while we’re on our summer publishing pause this month. • A New View of Mental Illnesses as Disorders of Brain Energy: • Feeling Energy and Bringing People Together: Thank you for being part of this movement to highlight the importance of mitochondria and energy in our health and what it means to be human!

Mitochondria aren’t just the powerhouses of our cells. They are the link between energy and the human experience. This week, we published a video on The Science and Experience of Energy YouTube channel that gives an overview of this idea. Interested in learning more? Below are two articles from our Substack archives that touch on this topic and may stimulate your thinking while we’re on our summer publishing pause this month. • A New View of Mental Illnesses as Disorders of Brain Energy: • Feeling Energy and Bringing People Together: Thank you for being part of this movement to highlight the importance of mitochondria and energy in our health and what it means to be human!

Martin Picard

12,821 views • 2 months ago

University of Houston Texas paper published at the end of 2022 is sparking a wave of interest Reducing the level of sugar and insulin in the blood for diabetics after eating by 52% (better than many diabetes medications) with a very simple movement and you do not need to make an effort or take any medications. Only by moving a very small muscle located in the calf muscle behind the leg, called the soleus muscle. By moving this muscle while you are sitting in your chair and watching TV, the blood sugar level decreases by a large percentage (by half), and this muscle does not suffer any fatigue, even if you continue to move it for long hours. One of the advantages of this muscle is that it consumes the glucose present in the blood after eating for energy (Glucose) and not the glycogen stored in the muscles like the rest of the body's muscles. Interesting research, and it could be an effective solution for diabetes without the need for drugs, strenuous exercise, and exhausting diets.

University of Houston Texas paper published at the end of 2022 is sparking a wave of interest Reducing the level of sugar and insulin in the blood for diabetics after eating by 52% (better than many diabetes medications) with a very simple movement and you do not need to make an effort or take any medications. Only by moving a very small muscle located in the calf muscle behind the leg, called the soleus muscle. By moving this muscle while you are sitting in your chair and watching TV, the blood sugar level decreases by a large percentage (by half), and this muscle does not suffer any fatigue, even if you continue to move it for long hours. One of the advantages of this muscle is that it consumes the glucose present in the blood after eating for energy (Glucose) and not the glycogen stored in the muscles like the rest of the body's muscles. Interesting research, and it could be an effective solution for diabetes without the need for drugs, strenuous exercise, and exhausting diets.

Basit Alvi

120,133 views • 3 years ago

Revisiting the Effects of the Covid Jab Dr. McCullough: “I have never seen something so injurious to the human body.” • It invades the brain. • It invades the heart. • It causes brain and heart damage. • It invades the bone marrow. • It stimulates antibodies to cells and platelets. • It causes blood clotting and damage to blood vessels like we've never seen. • Data from the University of Pittsburgh suggests it causes cancer. “Since when do we have a protein that actually injures the brain, injures the heart, the bone marrow, the immune system, causes blood clotting, and potentially causes cancer in a single protein?” Peter A. McCullough, MD, MPH® asked. “It's a weapon,” he concluded. “According to strict military criteria, it's a bioweapon.”

Revisiting the Effects of the Covid Jab Dr. McCullough: “I have never seen something so injurious to the human body.” • It invades the brain. • It invades the heart. • It causes brain and heart damage. • It invades the bone marrow. • It stimulates antibodies to cells and platelets. • It causes blood clotting and damage to blood vessels like we've never seen. • Data from the University of Pittsburgh suggests it causes cancer. “Since when do we have a protein that actually injures the brain, injures the heart, the bone marrow, the immune system, causes blood clotting, and potentially causes cancer in a single protein?” Peter A. McCullough, MD, MPH® asked. “It's a weapon,” he concluded. “According to strict military criteria, it's a bioweapon.”

The Vigilant Fox 🦊

118,372 views • 1 year ago

Dr. William Li reveals the single probiotic that hacks your brain to release social hormones "I take a probiotic called lactobacillus reuteri. It lowers inflammation, builds immunity, and it's actually the bacteria that text messages the brain. It causes our brain to release social hormones like oxytocin, which makes us feel good." "The kind I take is chewable. It turns out that the same bacteria is good for the gut, but if you chew it up, this is the bacteria that kills the bacteria that causes cavities and gum disease." "I haven't had a cavity in well over a decade. This is one of these types of practical things that just knowing the science can change."

Dr. William Li reveals the single probiotic that hacks your brain to release social hormones "I take a probiotic called lactobacillus reuteri. It lowers inflammation, builds immunity, and it's actually the bacteria that text messages the brain. It causes our brain to release social hormones like oxytocin, which makes us feel good." "The kind I take is chewable. It turns out that the same bacteria is good for the gut, but if you chew it up, this is the bacteria that kills the bacteria that causes cavities and gum disease." "I haven't had a cavity in well over a decade. This is one of these types of practical things that just knowing the science can change."

Health Almanac

85,695 views • 2 months ago

Introducing DuoNano🐸 Become the star of your own epic language adventure. -Just upload a pic of yourself or any character you like and dive right into the story in our Adventure Mode🐸 -One second you're wandering a lively market in Mexico City, the next you're uncovering some ancient temple in Kyoto, and through it all, it's still totally you in the mix. -Use your camera to upload pictures with Visual Vocabulary to learn how to say anything in a new language! Our visual model will detect the objects in the image and explain it to you in whatever language you select. -If you want to test your mettle, try the conversation practice tutor to test your skills against a native speaking AI. Try DN today. You're gonna love it. Link Below 👇

Introducing DuoNano🐸 Become the star of your own epic language adventure. -Just upload a pic of yourself or any character you like and dive right into the story in our Adventure Mode🐸 -One second you're wandering a lively market in Mexico City, the next you're uncovering some ancient temple in Kyoto, and through it all, it's still totally you in the mix. -Use your camera to upload pictures with Visual Vocabulary to learn how to say anything in a new language! Our visual model will detect the objects in the image and explain it to you in whatever language you select. -If you want to test your mettle, try the conversation practice tutor to test your skills against a native speaking AI. Try DN today. You're gonna love it. Link Below 👇

bone

40,423 views • 1 year ago

If you were in a car accident and suffered brain swelling, no one would call the swelling itself a disease. They'd call it an injury. I think autism works the same way. It isn't a disease in itself. It's a symptom of a brain injury. A vaccine works by triggering an inflammatory response in the immune system, because that inflammation produces the antibody response the vaccine is designed to elicit. For some children, the body absorbs that event without consequence. But what if the inflammation is severe, or what if a child has an underlying mitochondrial disorder, a weakness in the cellular energy needed to stop that inflammatory event before it reaches the brain? I think that's where autism comes from, when the inflammatory event makes it to the brain and causes swelling there. Most vaccine inserts list encephalitis and encephalopathy as a side effect, which is exactly that, a brain swelling event. Once that swelling goes down, the outcome depends on how severe it was. Tourette's, which is also a symptom of brain injury. Autism. Or something like ADD or ADHD.

If you were in a car accident and suffered brain swelling, no one would call the swelling itself a disease. They'd call it an injury. I think autism works the same way. It isn't a disease in itself. It's a symptom of a brain injury. A vaccine works by triggering an inflammatory response in the immune system, because that inflammation produces the antibody response the vaccine is designed to elicit. For some children, the body absorbs that event without consequence. But what if the inflammation is severe, or what if a child has an underlying mitochondrial disorder, a weakness in the cellular energy needed to stop that inflammatory event before it reaches the brain? I think that's where autism comes from, when the inflammatory event makes it to the brain and causes swelling there. Most vaccine inserts list encephalitis and encephalopathy as a side effect, which is exactly that, a brain swelling event. Once that swelling goes down, the outcome depends on how severe it was. Tourette's, which is also a symptom of brain injury. Autism. Or something like ADD or ADHD.

Del Bigtree

52,099 views • 6 days ago