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Cammy & Chunli (baronstrap) Fart edit dropped for supporters - 03/22/24 ✪ ・ Discord member get public edit first: ・ #fartfetish #fart #girlsfart #fartedit #3danimation #Rule34 #gassywoman
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![Dear David Coltart, WHY I CANNOT SUPPORT QUINTUPLE C: COLTART, CHAMISA AND CCC My attention has been drawn to your fraudulent and disgusting tweet you posted on my Twitter TL yesterday David, in which you quoted a tweet I posted four years ago on 22 January 2019 in memory of my father. I reproduce below both tweets for ease of reference: “I have always genuinely sympathized with you Jonathan - the loss of your father in such circumstances must be devastating. I just don’t understand why you continue to side with the party which brought such suffering to your family, and which still brings so much suffering.” – Tweet by David Coltart, 30 July 2023; commenting on my tweet below I posted four years ago: “1/5 On 22 January 1983 my father, Melusi Job Mlevu, was callously murdered in Tsholotsho by gukurahundi soldiers & the CIO. They tortured him upon his arrest & in front of his family; got him to dig a shallow grave, tortured him again; pumped bullets into his body & buried him!” – Jonathan Moyo tweet posted on 22 January 2019. Now David, are you really serious that you “have always genuinely sympathised with me”, because of “the loss of [my] father in such circumstances”? And since there’s no strategic ambiguity about the meaning of “always”, as it means exactly what it says, how have you “always genuinely” expressed your sympathy over all the years, since knowing about the circumstances under which I lost my father? The fact that your tweet yesterday is a response to a tweet I posted a long four years ago on 22 January 2019 – in memory of my father who was murdered by the Fifth Brigade in Tsholotsho on 22 January 1983 – shows and proves that you’re a fraud and a charlatan with neither sensitivity towards me and my family nor respect for us as Africans and human beings. All told, and typically of Zimbabweans of British colonial extraction and in particular of soul-free Rhodies, you’re contemptuous of our culture as a family and as Africans. You see David, it is fraudulent and utterly disgusting of you to claim that you have ever sympathised with me over my father’s loss. It’s actually patronising and very insulting in the extreme. Your fraud is clear even to yourself, that’s why you did not express your so-called sympathy when I first posted my tweet on 22 January 2019 in memory of my father who was murdered on 22 January 1983. In fact, until your fraudulent tweet yesterday, you had never before expressed any genuine or even non genuine sympathy for me and my family regarding the loss of my father on 22 January 1983. Even fools will immediately see that the key sentence in your tweet yesterday is not about your cruel declaration of fraudulent sympathy for me and my family over the circumstances of my father’s loss, a loss my family commemorated this year not yesterday but seven months ago on 22 January 2023, with no tweet of sympathy from you. The sentence in your tweet yesterday that captures what you really foolishly communicating to me is this: “I just don’t understand why you continue to side with the party which brought such suffering to your family, and which still brings so much suffering.” David: what I say, believe and do is without exception based on and an existential product of what I know, what I think and what I have experienced or lived. I never say, believe or do anything that I don’t know, don’t, I have not thought of or which I don’t believe. Now David, you pretend to be a democrat who believes in the rule of law as enshrined in the Constitution, so, what business of yours is my choice of what side to support or to not support in politics? Are my freedom of conscience and my right to make political choices freely now subject to your understanding, or are they my constitutional rights, as they are for every Zimbabwean, in terms of sections 60 and 67 of the Constitution of Zimbabwe? Are you aware David and do you understand that the Constitution in 67(1)(b) says every Zimbabwean citizen has the right “to make political choices freely”? And, David, are you aware that section 60 of the Constitution says every person, not just every Zimbabwean but every person, has the right to freedom of conscience which includes “freedom of thought, opinion, religion or belief”, and “freedom to practice and propagate and give expression to their thought, opinion, religion or belief, whether in public or in private and whether alone or together with others”. The fact that you quoted and abused my personal tweet I posted on 22 January 2019 in memory of my father who was brutally murdered by the Fifth Brigade on 22 January 1983 to say you “don’t understand why you [me] continue to side with the party which brought such suffering to your [my] family, and which still brings so much suffering”; shows that you are either ignorant of sections 60 and 67 of the Constitution of Zimbabwe, and proves that you are a fraud and a charlatan with no constitutional values. Why do you want to police my freedom of conscience and my right to make my political choices freely? Just why do you and your lot in CCC, think that you can interfere with my freedom of conscience and my right to my political choices that are guaranteed to me by the Constitution of Zimbabwe? If you and your lot were genuine democratic change champions, as you claim and purport to be, you would be the first to understand and to propagate freedom of conscience and the right to make political choices freely as sacrosanct constitutional values and principles that must be respected for every Zimbabwean at all times. But this has not been possible because you are frauds and charlatans. Now, your attitude towards me, the one captured in the disgusting tweet you posted yesterday, leads me to conclude without any fear of being contradicted that you are a frivolous and stupid person, David. Otherwise, if you care to know, there are three months that are cruel to me. October in which I lost my daughter Zanele in 2015, November because of what happened to me, my family and some colleagues during the 2017 military coup – it was also on 11 November 1965 that Rhodesia under which you blossomed, unilaterally declared independence – and 22 January the dark day on which my father was murdered. These are traumatic days for me in the calendar year. You see, I was a student in California in the US when my father was murdered by the Fifth Brigade in cold blood on 22 January 1983, having gone to the US before independence in 1977. When this awful tragedy happened, I did not know who my father was. I was born when my mother was barely 16 years old, and I was raised by my maternal grandparents who, like my mother, did not want me to know who my father was for reasons best known to them. Although, as I grew up, I understood their position from our cultural perspective as Africans, it nevertheless profoundly pained me. Truth be told, I was most grateful and I still am to this day, that my grandfather was a great father and my grandmother a great mother to me in ways that made me who I am today. I got to know who my father was well after I had graduated with my doctorate in 1988 and long after his gruesome murder, about which I was first told only 10 years ago. Since then, while it's been a profound rebirth for me to connect with my father through the loving Mlevu clan at large, I owe my dear sister Simiso an existential debt of gratitude. Through her, my kids have a hand-holder gateway through which to know about their grandfather. I really thank God and the spirit of the Mlevu clan for Simiso. The fact that I was born on 12 January, and that my father was brutally murdered on 22 January, makes the month of January an unbearable time of anguish for me, more so given that my father and I never met in life. When four years ago on 22 January 2019 I posted the tweet that you abused yesterday with reckless abandon, as you exposed your disconnection from the African experience, I was existentially troubled by the worst that could have happened to me and to my family on 15 November 2017, which got me thinking about what happened to my father, and even more troubling against the backdrop of the events of November 2017, I was devastated by the fact that I never met my father, and I spent the better part of 22 January 2019 wondering what life could have been for me had I known him in life and grown up under his parental care and guidance. You see David, maybe this is not true of people of European ancestry like you but, for many Africans it is very common for kids to be raised by their grandparents, like I was. As things turned out, I grew up knowing many such kids as my peers, the majority of whom never got to know who fathered them, some of whom are leading very successful lives in society as you read this. Unlike them, I was fortunate to end up knowing who my father was, but I was unfortunate not to have met him, and even more unfortunate to have known of him long after his death, made worse by the tragic circumstances of that death. I do not have a fly by night connection with Zanu PF. When I finished my high school in California, I proceeded to university there for my undergraduate education on a scholarship I got through Zanu PF. While an undergraduate, I was the political commissar of the Zanu PF branch in Los Angeles. I did my masters and doctoral degrees with academic scholarships endorsed by Zanu PF and underwritten by the Government of Zimbabwe through a staff development programme at the University of Zimbabwe. Having gone through Mgagao run by Zanu PF, and having gotten university education to the highest level under the auspices of Zanu PF, I have a long history and experience with Zanu PF, and with Zanu PF people whose complexities define who I am as an adult Zimbabwean, for better or for worse. It's my history, I'm proud of it and I own it. It’s an inescapable truth that each individual, and each therefore each person has a unique existential history best known to himself or herself, family and to a small cohort that has been intimate parts of that personal history. It's hopelessly foolish for someone to hope to prescribe a history on anyone. Every human being is who they are. And it's a fact not exclusive to me that my association with Zanu PF has not always been rosy. Life is a personal struggle between the person or the individual and the social formations through which life goes on. It’s common cause, that the military coup was a traumatic experience for me and my family and that it was profoundly painful and life changing in untold ways. It’s also common cause and not surprising to any normal human being that I blamed Zanu PF for that traumatic experience. Anyone else in my situation would have done the same at point or another. Yet the bigger story is that I, my family and my colleagues survived that 2017 ordeal with the very direct, active and truly genuine assistance and support from Zanu PF people. Working with other African Angeles, and I emphasize African Angeles, it was Zanu PF people who made sure that we were able to be safe and to get out of the country to be where I am today, all of them at great risk to their lives or livelihoods. In 2017 I was saved to be alive today by Zanu PF people. During the life threatening 2017 ordeal that my family and I went through, there was not even one person associated with the opposition as it was then, or as it is today, who reached out to find out where I was or how I was doing. It is common cause, some of it is documented, that many in the opposition then and who are still in opposition today, actually wanted me dead, all because of my political differences with them. You David Coltart, who now wants to pretend that you “have always genuinely sympathised with me”, never inquired after me. That’s why I think you are a monumental fraud and a charlatan. I repeat, I was helped out of the traumatic ordeal in 2017 by Zanu PF people, not by anyone from your lot David, not even one. Of course, at some point and largely because of the 2018 general election I found myself connected with some of your lot, especially Nelson Chamisa and others who were close to him or working with him i the election campaign, as the MDC-A presidential election candidate. I will not rehash that story here, as it has been told very well by many others. From my experience, and the lessons I have extrapolated from the late Vice President Joshua Nkomo, such as on the attached video clip, I have come to better appreciate that it is a mistake and wrong to a understand and define a political party with a deep-seated background and history like Zanu PF in terms of its leadership; rather, a grounded political party with a long history is necessarily defined by its founding values, constitution and membership, not least because the membership is permanent while the leadership comes and goes. By the same token, I have come to better appreciate that the mistakes or excesses of the leadership of grounded political parties with an entrenched history should not automatically or reflexively be ascribed or attributed to or blamed on the membership. On 15 November 2022, Patrick Zhuwao and I wrote an open letter to Zanu PF members to precisely make this point. I am attaching herewith a link to that letter, lest you missed it. It’s a self-explanatory letter which contextualises and explains everything that I did and said between 15 November 2017 and 14 November 2022. It also explains why do not support Nelson Chamisa and your CCC. I stand by the contents of that letter. In this connection, I draw your attention and that of your lot to an interview done by the late VP Joshua Nkomo in 1983 – which is attached herewith as already mentioned – in which Nkomo explains why the Fifth Brigade was not a Shona issue. Although Nkomo made it clear that gukurahundi was a political and not a tribal issue, I have come to understand and appreciate that it was a political issue not in the sense of Zanu PF as a political party in membership terms but, rather, in the sense of the political leadership and, more particularly, of individuals within that leadership. However, given your utter contempt for sections 60 and 67 of the Constitution of Zimbabwe, I do not expect you to understand the dangers of painting a tribe or a political party with one brush, or to understand the misguided consequences of conflating the leadership of a political party with the party’s membership or even of treating the leadership of a political party as a monolithic formation that always acts in concert. Basically David, and just like Nelson Chamisa’s trolls, it's clear you believe that you can abuse my personal and tragic circumstances to blackmail me for your doomed political purposes in two ways. First, you think you can abuse the circumstances of my father’s brutal death to somehow generate cheap and outrageous propaganda for yourself, Nelson Chamisa and CCC that I support Zanu PF which killed my father, and you do this under your self-indulgent presumption that everyone who is in Zanu PF as a political party is murderous by definition. Second, and based on this falsification, you’re abusing my tragic personal circumstances regarding my father’s loss to blackmail me into supporting you in particular, given my attack on your imposition as CCC's Ward 4 councillor candidate in Bulawayo; Nelson Chamisa and CCC . Your outrageous position is that if I cannot support you, I must keep quiet about you, under the ridiculous presumption that you’re all by definition virtuous, competent, capable, the only and best democratic alternative for everyone in Zimbabwe. On the back of sections 60 and 67 of the Constitution of Zimbabwe and drawing from my knowledge, thoughts, experiences and received wisdom from the late VP Joshua Nkomo, I have dealt with your self-indulgent presumption that Zanu PF is a monolithic formation with undifferentiated leadership and membership structures, in which you take everyone in it to be murderous by definition. In light of the fact that you invited this intervention by your disgusting and intrusive tweet you posted yesterday, and because we are age mates, I conclude my rejoinder to your offensive tweet by telling you what I think about you, about Nelson Chamisa and about CCC. David, as a former member of the Rhodesian security services which were murderous and which committed unspeakable atrocities across Zimbabwe and beyond its borders into Zambia and Mozambique, you have no moral authority to pontificate about human rights or anything of the sort. You David Coltart operated in Matabeleland where you did dastardly things, some of which you narrate in your autobiography and many of which you will take to your grave untold, because you never faced a commission of inquiry to be grilled under oath about your service in the Rhodesian security services. The fact that a person like you has remained active in Zimbabwean public affairs for 43 years since independence is a huge credit to our national politics because, with your background in the Rhodesian security services, you would not have survived this long in public life elsewhere. It’s mind boggling that Chamisa has imposed you to run for Ward 4 councillor in Bulawayo, after you were resoundingly defeated in your party’s Ward 4 community candidate selection caucus in which you were clobbered and you came a distant last among the contestants. Thanks to your being power hungry, you have made it possible for everyone to see that you’re a fake democrat and a charlatan who believes in the imposition of candidates. Your criticism of what you say is Zanu PF's undemocratic practices is hollow and hypocritical. Furthermore, it’s shocking is that Chamisa is bent on imposing you from Harare as Bulawayo mayor. You don’t qualify for that position not least because you do not speak the language of the local community in Bulawayo despite having been born there 66 years ago. Unlike Members of Parliament or Senators, whose chambers conduct their business mainly in English, Councillors and Mayors work in the local languages of their local communities. For the above reasons, and as an expression of my freedom of conscience and my right to make my political choices freely, I do not and cannot support you at all David. As for Chamisa, having worked closely with him between 2018 and 2021, I came to the settled conclusion in November 2021 that he is a dictator with a very dangerous God complex, in that he sees himself as having been chosen by God to lead Zimbabwe, and more ominously, he claims to have direct communication with God who has the last word on what he should do or say in public. In politics, that’s an unworkable Jim Jones proposition. Because of his God complex, Chamisa is visible only when there are elections as he was in the 2018 harmonised general election, March 2022 by-elections and now for the 23 August harmonised general election. After he ditched his supporters in August 2018 when he called them "ma stupids" [stupid people], in January 2019 and in July 2020, his unavailability to provide leadership when his supporters needed it triggered a viral political joke that: ‘in Zimbabwe there are three things that are unavailable when you need them the most, the UN, a condom and Nelson Chamisa’. But even more telling aboutChamisa is the shocking way in which he has used CCC since its formation in January 2022, and particularly in the party’s candidate selection for the forthcoming elections, to ruthlessly purge the opposition. It's been scary and it explains why the opposition in Zimbabwe today is the most clueless and the weakest since independence in 1980. How can a democratic change champion insist on running a political party with no constitution, no structures, no bank account and no accountability? I cannot support a leader like that. There’s nothing more dangerous in politics than, a young 'popular' dictator with a God complex. My conscience and freedom to political choices freely do not allow me to support a leader like that. As for CCC, it has no ideology, no values, no constitution, no structures, no bank account, no policies and no other visible office bearers besides Chamisa, Gift Siziva, Fadzayi Mahere and Amos Chibaya; and it has not been launched to boot. There’s just no way anywhere on earth that a political formation like that can be supported by rational people with rational expectations. That’s why I cannot side with you David or with Chamisa or with CCC. You’re not “the alternative”, you’re just a worse and more dangerous alternative which can only be supported by polticidal people who do not mind moving from the frying pan into the fire! Jonathan Moyo 31 July 2023](https://image.24vids.com/tw-1685915982080913408/ext_tw_video_thumb/1685887178419679232/pu/img/wgqoKPB1nJhtseEp.jpg)
![Use this prompt in OpenClaw to create your own AI agent command center that syncs up your life like Tony Stark's Jarvis in Iron Man. Adapt the specifics (agent names, data sources, branding) below to your own setup. Prompt: Build me a mission control dashboard for my OpenClaw AI agent system. Stack: Next.js 15 (App Router) + Convex (real-time backend) + Tailwind CSS v4 + Framer Motion + ShadCN UI + Lucide icons. TypeScript throughout. This is the command center where I monitor and control my autonomous AI agent(s) running on OpenClaw. The agent operates 24/7 on a Mac Mini, connected to Telegram/Discord, running cron jobs, spawning sub-agents, and reading/writing to a filesystem-based memory and state system. Dark mode only. Ultra-premium aesthetic, think Iron Man's JARVIS HUD meets a Bloomberg terminal. Subtle glass effects (backdrop-blur-xl, bg-white/[0.03]), no heavy gradients or glow. Rounded corners (16-20px on cards). Framer Motion for page transitions, stagger animations on card grids, spring physics on interactions. Mobile-first responsive. Never cookie-cutter. ## Architecture The dashboard reads live data from TWO sources: 1. **Convex**: real-time database for structured data (tasks, contacts, content drafts, calendar events, activity logs) 2. **Local API routes** (`/api/*`): read files from the agent's workspace filesystem at `~/.openclaw/workspace/` and return JSON. This is how live system state flows into the dashboard. ## Pages & Views (8 nav items, some with tab sub-views) ### 1. HOME (`/`) Dashboard overview. Grid of live status cards: - **System Health**: read from `/api/system-state` (parses `state/servers.json`). Show each service with UP/DOWN indicator, port, last check time. - **Agent Status**: read from `/api/agents` (parses `agents/registry.json` + agent workspace files). Show active agent count, healthy/unhealthy ratio, active sub-agent count from OpenClaw sessions API. - **Cron Health**: read from `/api/cron-health` (parses `state/crons.json`). Table of all scheduled jobs with name, schedule, last status (green/red dot), consecutive errors. - **Revenue Tracker**: read from `/api/revenue` (parses `state/revenue.json`). Current revenue, monthly burn, net. - **Content Pipeline**: read from `/api/content-pipeline` (parses `content/queue.md`). Kanban-style: Draft | Review | Approved | Published counts. - **Quick Stats**: total tasks, pending approvals, active sessions, uptime. All panels auto-refresh every 15 seconds. Live indicator dot + "AUTO 15S" badge in header. ### 2. OPS (`/ops`) with 3 tabs: Operations | Tasks | Calendar **Operations tab:** Full operational view. Server health table, branch status (from `state/branch-check.json`), observations feed (from `state/observations.md`), system priorities (from `shared-context/priorities.md`). **Tasks tab:** Strategic task suggestion system. API route `/api/suggested-tasks` reads/writes `state/suggested-tasks.json`. Cards grouped by category (Revenue, Product, Community, Content, Operations, Clients, Trading, Brand) with emoji headers. Each card shows title, reasoning, next action, priority badge, effort badge, approve/reject buttons. Filter bar by status and category. **Calendar tab:** Weekly calendar view from Convex `calendarEvents` table. Drag-to-create, color-coded by type, time slots. ### 3. AGENTS (`/agents`) with 2 tabs: Agents | Models **Agents tab:** Card grid of all registered agents from `/api/agents`. Each card shows name, role, model, level (L1-L4), status. Cards are CLICKABLE: expanding into a detail panel showing: - Agent personality (reads their SOUL .md) - Capabilities and rules (reads their RULES .md) - Sub-agents they can spawn - Recent outputs (reads from `shared-context/agent-outputs/`) **Models tab:** Model inventory table showing all available models, their routing (which tasks go to which model), costs, and failover chains. ### 4. CHAT (`/chat`): 2 tabs: Chat | Command **Chat tab:** Chat interface to communicate with the agent. Left sidebar shows session list (from `/api/chat-history` reading .jsonl transcript files). Main area shows messages with role-aligned bubbles (user right, assistant left), date separators, channel badges (telegram/discord/webchat). Input bar with send button + voice input (Web Speech API with SpeechRecognition). Messages sent via `/api/chat-send` which queues to a file the agent reads. **Command tab:** Quick command interface for common operations. ### 5. CONTENT (`/content`) Content pipeline management. Read from Convex `contentDrafts` table AND `/api/content-pipeline`. Show drafts in kanban columns. Each card shows title, platform target, draft text preview, status, created date. Edit/approve/reject actions. ### 6. COMMS (`/comms`) with 2 tabs: Comms | CRM **Comms tab:** Communication hub showing recent Discord digest, Telegram messages, notification history. **CRM tab:** Client pipeline kanban (Prospect → Contacted → Meeting → Proposal → Active). API route `/api/clients` reads markdown files from `clients/` directory. Each card shows client name, status, contacts, last interaction, next action. ### 7. KNOWLEDGE (`/knowledge`) with 2 tabs: Knowledge | Ecosystem **Knowledge tab:** Searchable knowledge base. Global search across all workspace files using `/api/knowledge` endpoint. **Ecosystem tab:** Product grid showing all products/apps in the ecosystem. Each card shows product name, status (Active/Development/Concept), health indicator, key metrics. Cards link to `/ecosystem/[slug]` detail pages with tabbed views (Overview, Brand, Community, Content, Legal, Product, Website, Actions). Detail pages read from `/api/ecosystem/[slug]` which parses workspace memory files. ### 8. CODE (`/code`) Code pipeline view. Shows repositories from `/api/repos` (scans ~/Desktop/Projects/ for git repos). Each repo card shows name, branch, last commit, dirty file count, language breakdown. Detail view at `/api/repos/detail` shows recent commits, file tree, open PRs. ## Navigation Top horizontal nav bar, NOT sidebar. All 8 items visible at all viewport widths. Use `flex` layout with `flex-1` items. Text size uses `clamp(0.45rem, 0.75vw, 0.6875rem)` for fluid scaling. Active item gets `text-primary bg-primary/[0.06]` static highlight (no sliding animation). Agent/app name visible at md+ breakpoints (`hidden md:inline`). Tab sub-views use a reusable `TabBar` component with pill/glass styling and Framer Motion `layoutId` transitions. Tab state stored in URL via `?tab=` search params. ## API Routes (all under `src/app/api/`) Each API route reads from the agent's workspace filesystem and returns JSON: - `/api/system-state` → reads `state/servers.json`, `state/branch-check.json` - `/api/agents` → reads `agents/registry.json`, agent SOUL .md files - `/api/agents/[id]` → reads specific agent's SOUL .md, RULES .md, outputs - `/api/cron-health` → reads `state/crons.json` - `/api/revenue` → reads `state/revenue.json` - `/api/content-pipeline` → parses `content/queue.md` (markdown with status markers) - `/api/suggested-tasks` → GET (read) / POST (approve/reject) on `state/suggested-tasks.json` - `/api/observations` → reads `state/observations.md` - `/api/priorities` → reads `shared-context/priorities.md` - `/api/chat-history` → reads .jsonl transcript files with pagination/search/channel filter - `/api/chat-send` → writes to queue file - `/api/clients` → reads markdown files from `clients/` directory - `/api/ecosystem/[slug]` → reads memory files for specific ecosystem - `/api/repos` → scans project directories for git repos - `/api/health` → returns status, uptime, memory usage, Convex connectivity All filesystem paths should be configurable via environment variable (default: `~/.openclaw/workspace/`). ## Convex Schema Define tables for: activities, calendarEvents, tasks, contacts, contentDrafts, ecosystemProducts. Include seed scripts (`convex/seed.ts`) to populate initial data. ## Key Design Rules - Mobile-first, test at 320px minimum - Font sizes 10-14px for body text, everything must fit naturally at small viewports - Cards use consistent border radius (16-20px) - Glass cards: `bg-white/[0.03] backdrop-blur-xl border border-white/[0.06]` - No heavy blur blobs or grain overlays - Stagger animations on card grids (0.05s delay per item) - Skeleton loading states for all async data - Custom scrollbar styling - Empty states with helpful messaging - All text must use Inter or system font stack - Never mix sharp and rounded corners in the same view - Premium = lighter feel, more whitespace, less visual noise ## File Structure ``` src/ app/ page.tsx, layout.tsx, providers.tsx agents/page.tsx calendar/page.tsx chat/page.tsx code/page.tsx comms/page.tsx content/page.tsx ecosystem/page.tsx, ecosystem/[slug]/page.tsx knowledge/page.tsx ops/page.tsx api/[...all routes above] components/ nav.tsx tab-bar.tsx dashboard-overview.tsx ops-view.tsx, suggested-tasks-view.tsx agents-view.tsx, models-view.tsx chat-center-view.tsx, voice-input.tsx content-view.tsx comms-view.tsx, crm-view.tsx knowledge-base.tsx, ecosystem-view.tsx code-pipeline.tsx activity-feed.tsx, calendar-view.tsx ui/ (ShadCN primitives) hooks/ lib/ convex/ schema.ts functions for each table seed.ts ``` Build the complete application. Every component, every API route, every Convex function. Production-quality code and premium design, not stubs. Dark mode only. Make it look incredibly beautiful and premium, no cookie cutter UI / AI slop.](https://image.24vids.com/tw-2022461932759060993/amplify_video_thumb/2022461533629091841/img/ccYthyhazjUQDwn3.jpg)
![Good morning. In November of 2024, I laid out why Brian Tully, Kate Peter, and Jason Broyles leaked an unredacted 15-year extraction of Lindsey Gaetani's phone. I didn't want the world to listen to me. I wanted someone, somewhere, to protect Lindsey. I can finally breathe. Here is the full text of my report (that now has 700,000 views); Okay, fine, as a special treat (on this, the day of oral arguments in the #KarenReadTrial appeal), I will lay out some of what I am thinking as to the timeline of events between August of 2023 and the spring of 2024. You are going to get a lot of inside information in this post. You have been warned. In the fall of 2023, via a woman named Natalie (who was friends with Karen Read and enjoyed talking about houseplants with Karen), I believe the Commonwealth of Massachusetts came to be in possession of evidence indicating that Read and blogger Aiden Turtle Boy Kearney were conspiring to intimidate witnesses in Read's ongoing criminal trial related to the murder of John O'Keefe. See the evidence of that contact (which started in April/May of 2023 --because of Natalie-- and occurred directly with Read and via Read's lawyers, David Yannetti and Alan Jackson) here - As a result of this information being uncovered, I believe the Commonwealth then began targeting Mr. Kearney with criminal charges related to witness intimidation in the context of Read's criminal trial (Kearney had been organizing, with Read's help, rallies at the homes of witnesses in the case and running smear campaigns to poison the jury pool in the lead up to Read's trial). I believe the intent of this targeting was multifaceted but, primarily, involved the following: 1) Getting Kearney to stop his abhorrent behavior related to witnesses in Read's case (which included, in some cases, Kearney's followers putting semen on pictures of witnesses' children and then sending those pictures to said witnesses, as explained here - 2) Placing criminal charges on Kearney in an effort to pressure him to "flip" on Karen Read and, in turn, testify that Read did, indeed, order the witness intimidation in question via a conspiracy. Kearney, when he was eventually jailed in late 2023/early 2024, confirmed that such an offer was presented while he was incarcerated. 3) Getting information for the Massachusetts State Police, and the Norfolk District Attorney, as to the nature of an ongoing federal probe into the conduct of those departments (an investigation which, in time, it turns out had moved on from investigating John O'Keefe's death and, in turn, evolved into a probe of a potential cover-up of the death of Sandra Birchmore). Read more background on that complex situation --involving two Troopers assigned to the Norfolk DA, who also worked on the Read case, that signed off on a "misleading" state-level police report into Matthew Farwell-- here - At the same time, and in furtherance of those investigatory activities, I believe the State Police began working directly with a former colleague of Aiden Kearney, a woman named Kate Peter AKA MafiaMasshole who has a small online cult following related to humiliating First Amendment Auditors (which, admittedly, is noble work). What may have not been so noble (along with Peter taking cash in a Chick-Fil-A parking lot for her "efforts" on behalf of some wealthy witnesses in the Read trial), however, is that --as Mr. Kearney became the subject of police investigations related to the aforementioned witness intimidation-- the Norfolk DA announced to the public that a Special Prosecutor would be appointed to oversee those charges (because of the numerous allegations of corruption that Kearney had made towards the DA in public). That Special Prosecutor, Ken Mello, was nonetheless assigned to work with the same State Police Trooper (Brian Tully) who worked on the Read case and who reported directly to the Norfolk DA at the time. And, furthermore, I believe the State Police and the Norfolk DA, via Brian Tully, also around this time (fall of 2023) began working directly with Kate Peter (who, for some time, was working for a Private Investigations firm with ties to a number of figures in the orbit of the Read case) in order to obtain evidence against Mr. Kearney, seek out and catalog information from sources close to Mr. Kearney and, in some cases, even help draft parts of Mr. Kearney's eventually October, 2023, criminal indictment. However, what I think the State Police (and the Norfolk DA) did not know at the time was that Aiden Kearney was working as a confidential federal informant, specifically looking into allegations of civil rights violations against said State Police, since at least May of 2023. Furthermore, I also think the State Police were not aware that it was Karen Read's lawyers, Alan Jackson and David Yannetti, who had the necessary connections in order to help Kearney obtain that status. Read more here - That said, at the same time, when Kearney was initially brought on by the federal government in May of 2023, in my view, I don't think the DOJ was finished looking into the death of John O'Keefe. In fact, I think the DOJ pulled out an old FBI tactic (which I can confirm exists) and, after the US Attorney for the District of Massachusetts wrapped-up the O'Keefe probe in the fall of 2023, Kearney was encouraged by the FBI to use his coverage of the Read case to generate leads related to other misconduct by the State Police unit attached to the Norfolk DA (in particular Brian Tully). Read more about that FBI playbook here - Indeed, that timeline perfectly synchs with a recent announcement by US Attorney Josh Levy indicating that the federal probe of Sandra Birchmore's death began in, roughly, August of 2023. See more background on Birchmore's tragic life and death here - Nonetheless, because of Kearney's ongoing work for the federal government in the fall of 2023, and because the State Police did not realize this was happening (although they should have been able to put it together, because Kate Peter and Kevin from Yellow Cottage Tails for sure knew, as early as May of 2023, that FBI agents were calling around, on behalf of Kearney, related to ongoing criminal cases entirely removed from the Read trial) I believe said State Police, stupidly, committed some of the very civil rights violations that the FBI was looking for. I believe the State Police did this, in particular Brian Tully, by way of his relationship to Kate Peter. [Side note: I will always remember talking to Kate, over winter and spring of 2024, and explaining my firm belief that Aiden Kearney was an FBI agent. Peter simply could not come to terms with that reality, despite having been the person who called the FBI back in May in order to confirm the agency was poking around some of Kearney's criminal cases, and, in that moment, I knew that pride was, indeed, about to cometh before her fall.] And, indeed, I also think Karen Read, herself, was well aware that the federal probe into John's death had ended in the fall of 2023 (for the most part) and that, in turn, the feds were going to move on to other serious allegations of corruption related to Tully and his unit at the State Police. However, for many reasons, I think Karen was happy to let the FBI (and TurtleBoy) use her trial as "cover" to get more information, and leads, related to said Troopers (this was, after all, the very same unit that had investigated Read and mocked her with horrifying language during that process). [Also, another side note, there is an intense history of tension between the Norfolk DA's office and the DOJ in Boston which dates back to the 1990's and William Delahunt, but which, in reality, really heated up during a 2015 mob trial.] Basically, there is a connection between Josh Levy (Acting US Attorney For District of Massachusetts) + Karen Read (accused murderer) + Dustin Chao (head of Boston DOJ's Public Integrity Section) + David Yannetti (lawyer for accused murderer Karen Read) + Rachael Rollins (former Suffolk County DA, and US Attorney for the district of Massachusetts, until Spring of 2023, who was also Josh Levy's boss in November of 2022 and who previously had direct contact with Read's lawyer, Mr. Yannetti) + Aiden TurtleBoy Kearney (blogger indicted with 19 felonies in relation to targeting witnesses in the Read case, until he was thrown out of Read's inner circle for exposing Read's connection to Acting US Attorney Levy). Chao (aforementioned head of the DOJ Boston's Public Integrity Section) had a grudge to use whatever means necessary take down the Norfolk DA since 2015 (After Chao's wife was passed over for a promotion and left that DA's office on bad terms) and, in turn, the proxy-battle behind all of this chaos becomes a bit more clear. Read the primary source documents laying all of this out here - and here - That said, I think there one was wild-card who came into the picture between October of 2023 that no one (be it Kate Peter, the FBI, the DOJ, the State Police, Aiden Kearney or otherwise) expected, and her name is Lindsey Gaetani. At first, between October and December of 2023, Lindsey was simply someone who had met Mr. Kearney online, chatted with him, and then begun to form a bond. Little did Ms. Gaetani realize, however, that, by virtue of a simple twist of fate, Kearney's pillow talk related to Karen Read and Josh Levy having direct contact, FBI agents, and civil rights probes of the State Police would put her directly in the middle of an unholy conflagration that was, on the night of December 23rd, 2023, about to take a turn that would change the course of history for an untold number of human lives. For, you see, in the weeks leading up to Christmas of 2023, the State Police discovered that Ms. Gaetani had information about Karen Read and TurtleBoy being in direct communication (along with information that Read and Josh Levy spoke directly). See those documents here - That, in turn, meant Ms. Gaetani was going to be forced to provide testimony at a Grand Jury scheduled for the week after Christmas (roughly December 26th, 2023). When Kearney found out this news, on or around December 22nd, it sent him into a tailspin (for good reason, it turns out, as what Mr. Kearney did next would, over time, lead to him being kicked out of Karen Read's inner circle and sent to jail...or, as Kearney says it, "...[that night] was a very expensive trip to [the city where Lindsey lives.]" Leveraging a very difficult time in Ms. Gaetani's life, Kearney demanded he be able to visit her, at home, late at night on December 23rd of 2023. Then, Kearney forced Gaetani to allow Kearney to review the contents of her phone (specifically her messages with Kate Peter) and take notes (using an ongoing medical situation that Gaetani was going through as leverage to get permission to do so). However, after Gaetani raised an objection to Kearney taking those notes, and after Gaetani retrieved her own notepad (that Kearney had used to take said notes) Kearney entirely lost his cool, pushed Gaetani onto a couch, and then began illegally recording her with his phone (an audio file Kearney would later try to edit in order to suggest Gaetani had consented to the recording, although that plan failed when a copy of the original recording, without the line about consent, was introduced into the court record). That, in turn, led to Kearney being criminally charged (again) with witness intimidation, illegal interception of an oral communication and assault and, as a result, a warrant to arrest (with probable cause) was issued. Kearney, after being a self-admitted "fugitive" from justice for multiple days with the warrant active, then turned himself in to authorities and was sent to jail after a Judge in Dedham district court revoked Kearney's bond as a result of the new charges involving Gaetani. See the post where Kearney admitted to being a fugitive here - See full coverage of the moment Kearney's bail was revoked here - In turn, Kearney then spent the next 60 days in jail (in protective custody, per my sources, because of his status as a federal informant) and, during that time, Kearney has confirmed that he would have been able to "walk free" if he "flipped" on Karen Read in the context of an ongoing conspiracy and witness intimidation probe into the pair of star-crossed attention seekers. However, Kearney did not do so and, in turn, was released from jail in late February of 2023 after serving the full 60 days on his bail revocation. For Ms. Read, however, a newly-leaked series of text messages confirm that, even thought Kearney stayed loyal and sent love-letters begging Read's forgiveness while locked up, the incident on the 23rd with Lindsey was Karen's red line and Kearney had been cut off from Read's inner circle. See that leaked text message (from March 3rd) here - Interestingly, on one of the first day's that TurtleBoy was out of jail (February 26th, 2024), I captured this fascinating moment where Karen clearly is uncomfortable around Kearney (she entirely ignores his presence outside of court and her lawyer, Alan Jackson, puts his arm on Karen's back to gently tug her away from Kearney as they walk by his hallowed-shell) - And, even more interestingly, it was also on the same day (2/26/24) that Lindsey Gaetani (under mysterious circumstances that, again, trace back to Kate Peter being shady) attended a court hearing, wherein, because of Gaetani's active restraining order on Kearney, Kearney was forced to leave the courtroom during Karen's case (and, on this same day, Kearney was also charged with a violation of that RO for hiding in the bushes outside of the court after being asked to leave the area by authorities). See video of that day here - However, sadly, I believe Gaetani's "usefulness" also quickly ended around this time as Kearney, within weeks, got his RO amended to allow TurtleBoy to attend any court hearing in the Commonwealth (even with Lindsey present) and, furthermore, the pressure tactics to get Kearney to "flip" on Karen Read had failed. Furthermore, because Karen was now in fear of TurtleBoy (having cut Aiden off), I believe Peter, Tully and the Norfolk DA took an entirely new direction. They would try to get Karen Read to cooperate regarding the ongoing investigations into TurtleBoy. This move, however, had unintended consequences (in particular for Lindsey Gaetani). In what I believe was a colloquial "crime of opportunity" -- and because Gaetani was no longer "useful" for the purposes of pressuring Kearney into a plea or for the purposes of keeping Kearney away from Karen Read hearings -- Kate Peter came up with a new idea: Kate, before knowing anyone else in the case, was connected with Jen McCabe (a witness in the Read trial who heard Karen confess to hitting John O'Keefe and who was tormented by TurtleBoy, for months, as a result of her willingness to testify on behalf of justice for John). Kate, also, had extensive connections to a network of Discord operatives who use fake profiles and hunt down bad people on the internet (again, a noble calling). However, I believe Kate weaponized some of those people (including someone named Father Mark Murphy, who used a fake profile called "The Jennings Report" and a parking clerk named Jason Broyles who moonlights as a woman online named "Hailey W.") to, in a last ditch effort now that Lindsey had no other use and because TurtleBoy could not be stopped, deflect the attention of TurtleBoy's fans (known as "TurtleRiders") away from Jen McCabe and onto --an unwitting and entirely innocent-- Lindsey Gaetani). What makes this even more shocking is that the way public attention was deflect onto Lindsey involved, what I believe, was an operation (run by Kate) to leak sensitive documents about Lindsey (along with other private information) to those fake profiles (including Jason Broyles, who Kate Peter has known since 2019). Interestingly, Broyles (and Murphy) began operations targeting Lindsey, and her support network/allies, right around the end of February, 2023 (and, interestingly, those accounts, for months, went out of their way to avoid mentioning Kate Peter or Jen McCabe, nearly entirely). Read more about the fake "Jennings Report" profile here - and read more about the disturbing tactics deployed by Jason Broyles here - and here - Anyway, that entire fiasco was the subtext (that I referenced in earlier posts) behind my question to Karen Read, in April of 2024, regarding whether Karen wanted to apologize to Lindsey for what was happening (as, by that point, Karen knew full well what it was like to become the target of Aiden's ire simply because Karen had cut him off). Karen may not have responded to my question, but she is a smart person (really, I don't mean that gratuitously: Read plays on a level I don't think most of us understand, and she does it by hiding in plain sight) and Karen knew exactly what I was talking about (she probably could have written this post herself, in fact, but she probably wouldn't have said as much about her gilt as to John's death). See video of me asking Karen that pointed question here - So, where does that leave us? Well: 1) In my view, Karen Read is vulnerable, concerned about what Aiden will do to her and her family, running out of money, and constantly at risk of having her conversations with TurtleBoy and other insiders (past and present leaked). Karen, after she loses her appeal at the SJC, is likely to look for a way to take a plea and cooperate against Aiden (Robert Cosgrove, the new special prosecutor in the Read/Kearney cases, and Hank Brennan, the new ADA in Read's murder trial, are serious legal heavy hitters and Read is in deep trouble, in my view). 2) Likewise, I think Brian Tully and Kate Peter are also deeply concerned because they didn't realize the FBI is, in reality, probably coming for them (and it has nothing to do with John O'Keefe's death, but instead it has everything to do with Kate and Tully's actions between the fall of 2023 and the summer/fall of 2024 and, also, probably Tully's actions in the context of the Sandra Birchmore investigation). I think this is why Peter is facing so many state-level criminal charges (despite trying to use her connections to get those cases to "go away" and, even in one case, managing to get the Norfolk DA not to recuse itself related to one of those charges, despite a special prosecutor being assigned to Peter's other criminal cases in the jurisdiction because of her connection to the State Police and the DA). 3) I think a lot of people are trying to keep Lindsey Gaetani and her story away from the media, and away from documentaries/podcasts that they do not control, in order to hide this information from the public, punish Lindsey for "knowing" Aiden, and insulate Peter and Brian Tully from accountability. I do not think this strategy is going to work because, and I cannot understate this enough, Lindsey is actually a genius (and none of you can see it, because you're blinded by greed, ego, jealously or otherwise). 4) I think, at the end of the day, Karen Read killed John O'Keefe, while Karen was drunk driving, at 12:31am on 1/29/22 by hitting John with her SUV and then leaving John to die. In turn, I think Karen was mad that people "flipped on her" related to Karen's actions that night, and, in turn, Karen leveraged her political connections (which I don't fully understand, but which I think are based in the intelligence community) to "punish" the Norfolk DA and the State Police Troopers who uncovered said evidence of Karen's guilt. Little did Karen realize, all the way back in November of 2022, that she had stumbled onto overlapping social circles of power that, when the dust settles, would have been consumed by their hubris --and wanton disregard for the memory of John O'Keefe-- regardless. "Remember," dear friends and readers, "it's about Justice For John." I'm a towel, and that's what I think happened (as of November, 2024). Usual disclaimer: I am a towel, not a lawyer. This is not legal advice. You are reading social media. Get a lawyer if you have questions about the law.](https://image.24vids.com/tw-1951990598375796787/amplify_video_thumb/1951989042272227328/img/AR5vFlH4FWaF-znG.jpg)
![An interview by VERY DARK AND CORRUPT Wall Street Journal aired today [1] WSJ's terrible "journalists" (and I use that term lightly) made many false statements about Sarepta's worthless, dangerous drug and Vinay Prasad's firing [1,2] I explain how the FDA sausage is made in excruciating detail Buckle up To get readers up to speed -> In June, corrupt pharma company Sarepta Therapeutics paid $40,000 to lobbying group Michael Best Strategies (MBS) to deal with a problem [3] -> MBS had recently hired Chris LaCivita, who had close connections with "MAGA" influencer Laura Loomer [4] -> With stock down 88%, Sarepta needed to sell their very bad, very dangerous drug or the company would go bankrupt [5] -> After several deaths from the drug this year, FDA official Vinay Prasad said "no way" and kicked the drug to the curb [2,6] -> Sarepta panicked and paid MBS (we believe) to deal with Prasad [3,4] -> If this story is right, LaCivita recruited Laura Loomer to take down Prasad [4,7] -> Loomer said she was defending Trump, but she was lying [7] -> She was defending taxpayer-funded payouts to a worthless, corrupt company [7] -> Laura Loomer so brave A history of bad drugs and regulatory failure -> This is one of the worst pharma scandals in American history and corrupt mainstream media isn't covering it -> Sarepta has a very long, troubled history [8] -> For more than a decade, every major Sarepta FDA drug approval has required INTENSE political intervention [8,9] -> Scientists at FDA have been repeatedly overruled [8,9] -> Many scientists have resigned, very publicly, over these POLITICAL decisions, some writing scathing public criticisms of these terrible decisions [10,11] -> The most recent resignation by Vinay Prasad is not something new; it follows in a long tradition [2,10] -> In fact, standards have dramatically deteriorated since the first controversies about the company's drugs in the 2010s [8,9] -> Prasad was trying to hold the line in the face of rapidly deteriorating standards at the agency [2,6] -> For that, pharma launched a coup--a literal coup of a drug regulator [4,6] -> This is unprecedented -> Banana republic sht, unbelievably corrupt 2016: first Sarepta drug approval and the "highly unusual" decision -> The first Sarepta drug approved by FDA was called Exondys 51 [8] -> This drug was for patients with mutations in dystrophin, a muscle protein [8] -> This is a debilitating and fatal disease affecting children [8] -> Exondys 51 increased dystrophin by 0.2% of normal levels [8,12] -> Unsurprisingly, there was no good evidence the drug worked [8,12] -> Why would it? It increases the protein from zero to 1/500th of normal levels -> One reviewer wrote: "I can find no precedent of an accelerated approval for a marketing application where the effect size on the surrogate endpoint is as small as 0.3%." [12] -> The study submitted by the company included no proper control group [12] -> The techniques used were so bad not even a first-year PhD student would do a study that way -> This the level of work you would expect from a mediocre undergraduate with no guidance -> It's almost like it was so bad on purpose -> (Narrator: it was on purpose) -> Nerd time: -> One reviewer wrote: "The Western blots submitted by the applicant for Study 201 were oversaturated, unreliable, and uninterpretable." [12] -> Another wrote: "Because CDER also determined that the conditions under which the original IHC analysis was performed were inadequate, including that the reader was not masked to sequence and time, the Center requested a re-reading of the stored images by three masked pathologists under different conditions. The IHC results from the reread were not nearly as favorable, as compared to the initial IHC results reported by Sarepta." [12] -> "The lack of concordance between the IHC and the Western Blot results is 'striking'" [12] -> "Study 201/202 had fundamental flaws, including baseline biopsies from external controls who could differ in unknown ways from study subjects, Week 180 biopsies from different muscles than baseline, and potential protein degradation in stored baseline samples." [12] -> And on and on. -> FDA commissioner Robert Califf wrote at the time: the submitted study was "characterized by major flaws in the clinical study design" and "Blinded experts assembled by the FDA fundamentally debunked this study, which has yet to be retracted and continues to be cited" [9,12] -> That's right, the FDA commissioner expressed dismay that the study that the company used to gain approval hadn't yet been retracted, it was so bad [9] -> Senior FDA official Janet Woodcock decided to approve before scientific review team had even voted [9,12] -> Woodcock be like: yeah i'm going to decide before you guys can because i know what you're going to say lol -> Despite external intense pressure, FDA scientists voted against Exondys 51's efficacy [9,12] -> They then voted against its accelerated approval [9,12] -> The review team filed an appeal with FDA commissioner after "passionate" disagreement with Woodcock [9,12] -> One reviewer called Woodcock's decision "unprecedented" [12] -> In a 126-page report, FDA commissioner Califf called Woodcock's decision "highly unusual" [9] -> The FDA board wrote: "[Woodcock's] involvement here appears to have upended the typical review and decision-making process. ... Care should be taken to avoid the appearance of interfering with the integrity of scientific reviews at the lower levels of a Center." [9] -> Again, the data were unbelievably bad, literally every technique in the study was inappropriately used [12] -> I would fire an undergraduate student who did science like this, immediately -> FDA's chief scientist accused Sarepta of "serious irresponsibility" for selectively publishing only some of the data [9] -> Even Woodcock, who approved the drug, called the research "seriously deficient" [12] -> Yes, even the person who approved the drug over the heads of FDA's scientists said the research was horrible [12] -> Still, FDA tried to bury their heads in the sand and beg that, basically, Sarepta pretty please do a better job next time -> FDA commissioner: "The utmost attention should be paid to optimizing the methodological rigor of [future] trial[s]" [9] -> FDA also demanded a clinical trial "to verify the benefit" of the drug [8] -> Welp, this was in 2016 [8] -> The trial results are supposed to be available in 2026, maybe [13] -> Or maybe later, depending on how much money needs to be made first -> As an article published in Nature three years later despaired of the decision: "The approval was conditional on the company agreeing to conduct a two-year post-approval trial to show Exondys 51’s efficacy. But by August 2019, the company had yet to begin such a trial and in the meantime had profited from sales of $300 million in 2018." [13] -> If it sounds like Sarepta used political pressure to get its drug approved and then tried to avoid actually publishing the study showing it didn't work, it sounds that way because that's exactly what happened [13] -> FDA commissioner after deferring to Woodcock: "I am confident this unique situation will not set a general precedent for drug approvals under the accelerated approval pathway, as the statute and regulations are clear each situation must be evaluated on its own merits based on the totality of data and information." [9] -> This statement was profoundly naive, and the historical record bears this out [8,14] -> Three FDA scientists resigned, including the lead reviewer of the drug, understanding the grave implications of the collapse of scientific standards and where they would lead [10,11] -> One was John K. Jenkins, M.D. Director, Office of New Drugs Center for Drug Evaluation and Research/FDA [10] -> In a presentation given just before his resignation, he wrote: -> "Path taken by Sarepta NOT a good model for other development programs" [10] -> Crucially: -> "Upholding statutory standards for approval in face of hopes and desires of patients, families, sponsors, and investors is a very difficult job" [10] -> "Personal attacks on FDA reviewers creates an atmosphere of distrust and isolation rather than collaboration" [10] This brings us to WHY Sarepta's drug was approved Facebook FDA -> So why did the drug get approved? -> Basically, Sarepta propagandized extremely desperate patients [9,15] -> They used miraculous snake oil promises and patients believed them -> Remember that this is life or death for patients, and they are extremely vulnerable -> Sarepta also professionally trained some patients to give testimonials to FDA and congress [15] -> The patients then went to congressmen who don't have time to understand the science [15] -> They gave emotional stories to congressmen [15] -> The result: -> Letter from 109 House members [15] -> Letter from 24 Senate members [15] -> And a media circus documented in the New York Times [16] -> Patients screaming at scientists during meetings [9] -> 2,792 emails written to FDA urging approval [12] -> One of them: "Dear Dr. califf: How is it that everyone in and around DMD understands this simple Idea and the science geniuses at FDA don't? You stupid fckers are costing each and every DMD kids days of their lives with your Moronic Dystrophin dance. Time to get a fcking clue" [12] -> Upon approval, a journalist for Reuters wrote: "owing to pressure from patient advocates, the U.S. Food and Drug Administration on Monday approved a treatment for Duchenne muscular dystrophy even though an outside panel of experts and the agency's own reviewers questioned the drug's efficacy" [17] -> A commentary in Nature Medicine was also published called "Railroading at the FDA" [9] -> Its author wrote: "In the words of one FDA committee member, Exondys lowers the agency's evidentiary standard for drug effectiveness 'to an unprecedented nadir.'" [9] -> A highly critical commentary was also published in Science, titled "Sarepta gets an approval - Unfortunately" [18] -> The article's author pharma veteran Derek Lowe wrote: "The company... called up Duchenne-affected boys and their families to plead with the FDA, and won over Janet Woodcock, and that appears to be enough. Is this going to be the new way to get a drug approved? Run a trial in a dozen people, generate unconvincing data, and then lobby Janet Woodcock? I share the worries that this might open the floodgates, because after all, Sarepta got their drug through." [18] -> One FDA reviewer ended in an equally grim note: ". Approval of this NDA would send the signal that political pressure and even intimidation – not science – guides FDA decisions, with extremely negative consequences. The public is well aware of this development program: the meager size of the study population, the marginal (at best) effect size, the Division’s dim view of the efficacy data, and the robust activism of some members of the DMD community. Many would be amazed at an approval action, because other DMD drugs, recently turned down for approval, appeared to provide stronger evidence of efficacy. ...The ramifications here are profound. The public will perceive that it was their unprecedented lobbying efforts that made the difference and earned eteplirsen its accelerated approval. For the future, this will have the effect of strongly encouraging public activism and intimidation as a substitute for data, which is one of the worst possible consequences for communities with rare diseases. This type of activism is not what was envisioned for patient-focused drug development." [12] -> A new era was born -> Activism had replaced data -> Facebook had fried people's brains -> And now Facebook-fried brains had fried FDA too -> FDA's credibility as a regulatory agency would now be hollowed out -> FDA's Facebook age had begun -> But the worst was yet to come Sarepta approvals: 2016 to present -> Three more drugs were approved from Sarepta on the same shoddy basis, proving Califf's promises that Exondys 51 was an isolated case empty [8,14] -> But things would take a turn for the worse with Sarepta's newest drug Elevidys in 2024 [19] -> At last a rigorous clinical trial looking at actual clinical outcomes was published [19,20] -> All would be put to rest -> At long last the issue could be resolved with HARD CLINICAL DATA -> There was only one problem -> The trial failed to show any benefit according to the primary outcome [19,20] -> The surrogate biomarker of micro-dystrophin meant absolutely nothing; it wasn't actually helping patients [19,20] -> What did FDA scientists do? They voted against approval. Of course [19] -> How could they not? The drug didn't actually work in the clinical trial [19] -> It's the only thing that made sense, since FDA is a scientific agency -> AND THEY WERE OVERRULED AGAIN BY PETER MARKS [19] -> YES THAT'S RIGHT, OVERRULED YET AGAIN -> PHARMA WINS AGAIN -> HAHAHAHAHAHA PHARMA ALWAYS WINS YOU FOOLS -> What happened is that Marks crossed his eyes somewhat, trying to make the words on the page blurry -> He prayed really hard, "my god please give me a sign, something, anything, I need this for my career" -> lzzosolsolzzolzozlslzolosllslozllzlzl -> Marks was trying really hard to see SOMETHING, come on come on, give me SOMETHIGN he said -> And he said: wait, look, there are these secondary, exploratory endpoints and a two of them look pretty good, I'LL APPROVE [19,20] -> AHAHAHHAHAHA YES PHAMRA WINS AGAIN -> And Marks said, "Thank you pharma go- I mean god, not pharma god, why did I just say that, FCK" -> The trial was explicitly designed for what Marks did NOT to happen [20] -> Once the primary endpoint was not met, the secondary endpoints couldn't even be statistically tested [20] -> And the trial explicitly said that they could not be interpreted the way Marks interpreted them [20] -> They were not adjusted for multiplicity and they were, like expression of dystrophin, simply bad endpoints [20] -> These two secondary endpoints were time to rise from lying on the floor and the 10-meter walk/run tests [20] -> Subjects who received the Elevidys performed, on average, about 0.5 seconds better than placebo recipients on these tasks [20] -> However several facts must be borne in mind when interpreting these: -> 1. At the time of testing, patients receiving the drug were receiving more corticosteroids than placebo patients, biasing the results [20] -> 2. Blinding might have been broken because those receiving the drug experienced lots of nausea and vomiting from the drug (~70%) [20] -> 3. These differences were tiny and may be attributable to chance, since the natural course of the disease varies widely [20] -> Marks knows this but who cares? Pharma I mean Facebook needed to be placated Elevidys: the drug -> To understand why this is so messed up, one must understand a few things -> On a Bayesian basis, one must assume that Elevidys is harmful until proven otherwise, for two reasons: -> 1. All drugs are potentially "toxic", but some toxins heal: by default you must assume it is a toxin that does not heal because this is what is actually usually the case; you need evidence that it actually heals -> 2. Elevidys IN PARTICULAR must be assumed to be harmful until proven otherwise because of the very nature of the drug -> Let's do a breakdown of the basic science of Elevidys that supports this (Bayesian) hypothesis: -> Gene therapy that permanently integrates into human genome [21] -> Meant to replace dystrophin, the protein that these patients cannot produce themselves [21] -> Preferentially targets muscle but gets expressed everywhere [21] -> Killed three people this year [6,21] -> Costs $3.2 million per injection [21] -> Truncated version of the protein it is supposed to replace [21] -> 3X shorter than the real protein [21] -> Has to be truncated because the technology cannot create the full protein [21] -> Because it's an abnormal protein, it's foreign, so immune system attacks it [21] -> Patients injected with drug are basically given an autoimmune disease [21] -> Patients have to be given anti-inflammatories to fight the disease that the drug causes [21] -> Causes terrible muscle inflammation [21] -> Inflames the heart, heart walls thicken because of the inflammation [21] -> Blows up the liver, causes acute liver injury and death [21] Drug should actually be assumed harmful, not beneficial -> Given all of the above, since the drug failed to meet its primary endpoint, it should actually be considered harmful by default, not beneficial [19,20] -> In other words, what we would actually expect if we added more patients and did an even larger study... -> Is that the drug would do worse than placebo, i.e., patients taking the drug would do worse than those taking placebo -> Why isn't this the default interpretation? -> They are reading the study with an intervention bias -> An intervention bias is natural, which is why "do no harm" is such a central tenet of medicine -> If I may put forward a thesis: most of Vinay Prasad's 500+-paper body of work has been dedicated to demonstrating the "do no harm" principle empirically [22] -> Rose-colored glasses study interpreters are simply not applying this principle properly and are thus failing scientifically in the most fundamental way -> Incomprehensible -> Back in 2016, scientists were adamant that the approval of Sarepta's first drug indicated the profound deterioration of scientific standards [8,9] -> But this latest approval is even worse: actual clinical data is now being overruled -> No standards at all are being enforced anymore; anything can now be approved based on any evidence whatsoever -> What Vinay was trying to do was simply to stop the unrelenting downslide -> And his firing punctuated that downslide for what it was The WSJ segment -> When Elevidys was approved, former FDA chief scientist and one of the original reviewers of Sarepta's first drug Luciana Borio said: -> "I don’t know what to say. Peter Marks makes a mockery of scientific reasoning and approval standards that have served patients well over decades. This type of action also promotes the growing mistrust in scientific institutions like the FDA." [23] -> To return to this video, these two WSJ reporters show an incredible level of ignorance and arrogance -> Finley says that the drug is "clearly" beneficial by misreading the secondary endpoints, just like Marks did -> An FDA memo from last year says about these endpoints: "Under these circumstances, they are misleading and cannot guide any stakeholders—including patients, family members and caregivers, and prescribers—in making informed decisions about the potential benefit of treatment with ELEVIDYS." [20] -> It really doesn't get any clearer than that -> But these two journalists are overruling the actual scientists, just like Marks did -> One of the most incredible comments during this interview was the complaint that "90% of clinical trials fail", as if that's bad thing [1] -> It's actually a good thing; most drugs suck; failing in clinical trial actually allows us to use only the drugs that don't suck -> These people don't understand the most fundamental purpose of the clinical trial -> They think clinical trials failing is a bad thing, as if it means that patients now won't get to use a useful drug -> No, it's a good thing, because it means that patients won't be exposed unnecessarily to a useless drug that might harm them -> The level of ignorance really is unbelievable -> What's worse is that these "journalists" defend their decision -> But what they did is exploit social media hysteria caused by Laura Loomer [1,7] -> Following up on her heels with editorials, using her as pharma attack dog [1,4] -> This is a huge blow to WSJ's credibility, and they know it -> Unbelievably shameful Where do we go from here? -> The Vinay Prasad firing creates a serious crisis of credibility at FDA [2,6] -> Up to this point, we could call these approvals a difference of opinion, but as we've seen, that's a huge stretch -> But any illusion of that is now shattered: the firing shows that drug regulation is explicitly political -> Janet Woodcock: approve, keep job -> Peter Marks: approve, keep job -> Vinay Prasad: block, transparently fired -> Make a decision that is anti-pharma and lose your job: that's the message -> Who can trust any decision at FDA anymore? -> RFK Jr. and Marty Makary both stand behind Vinay Prasad [24] -> Trump went along with lockdowns, he went along with mask mandates, he went along with all of the Covid pseudoscience that he now decries -> He should reverse course and not go along with this -> Trump has created a profound crisis of credibility at FDA and needs to fix it](https://image.24vids.com/tw-1952294845248114806/amplify_video_thumb/1952292444621451264/img/SPXp7ZpvQZ3FQV7_.jpg)
