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Creatine isn’t just for muscles—it rapidly improves brain function when you're sleep-deprived Research shows a single high dose (0.35 g/kg, around 25 g for a 70 kg person) dramatically boosts brain creatine levels in just three hours This can significantly boost memory and cognition, even after just one night... show more

FoundMyFitness Clips

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3,445,926 次观看 • 1 年前 •via X (Twitter)

健康养生教育科学技术

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FoundMyFitness Clips 的头像

FoundMyFitness Clips1 年前

From the latest episode of FoundMyFitness with @darrencandow A masterclass on all things creatine Watch it now:

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Water+ 💦1 年前

Did you know? 75% of Americans are chronically dehydrated, yet just a 2% drop in hydration can affect your mood, energy, and mental performance. 💧 Track your intake easily with our app.

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Jake Carter1 年前

Endogenous (internal) production of creatine uses up to 70% of the body’s methylation capacity via SAMe. This means supplementing with creatine can spare methyl groups for vital processes like neurotransmitter synthesis, DNA repair, and detoxification. This is especially beneficial for those with MTHFR polymorphisms, high histamine, or post-OCP hormonal recovery, where methylation demands are already high.

Jake Carter 的头像

Jake Carter1 年前

In the brain, creatine acts as a neuroenergetic buffer, rapidly regenerating ATP during stress, poor sleep, or inflammation. It’s shown to boost memory, processing speed, and mood, particularly in sleep-deprived individuals, aging adults, vegetarians, and those with chronic fatigue or TBI. In fact, low dose nicotine with creatine is great to mitigate early cognitive / neural effects of COVID.

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ZoomOutBTC1 年前

Tried it and after numerous trips to the toilet I probably lost an hour of my day taking watery dumps. I don’t know how anyone could possibly handle that dose

B P🍾💄💋⛳️🏂⚾️ 的头像

B P🍾💄💋⛳️🏂⚾️1 年前

what are the risks of that high a dose especially taken regularly?

FoundMyFitness Clips 的头像

FoundMyFitness Clips1 年前

FoundMyFitness Premium Members get access to live AMAs with Rhonda We host these once a month, and they're recorded if you miss it They also come with detailed show notes Details here:

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Dr. Julie Gurner1 年前

Creatine for brain power over fitness, is its best use case.

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Dan Go1 年前

Love the work @darrencandow is doing. Can't wait to dig into this interview.

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Jenny1 年前

25g is about 8 x heaped teaspoons. Wouldn't that cause gut issues?

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Natalie1 年前

What type of high dose are you able to take on a regular basis? For example, for chronically under arrested and fatigued mothers of young children, what dose could be taken on a daily basis that’s safe but still rapidly improving brain function and the impact of sleep deprivation?

相关视频

Taking a single high dose (25–30g) of creatine not only reverses the cognitive impairment caused by 21 hours of sleep deprivation—it actually boosts brain function beyond rested levels The mechanism? High-dose creatine quickly raises brain energy stores, powering neurons under extreme stress This rapid brain-energizing effect makes creatine promising for combating fatigue, jet lag, or even cognitive decline

Taking a single high dose (25–30g) of creatine not only reverses the cognitive impairment caused by 21 hours of sleep deprivation—it actually boosts brain function beyond rested levels The mechanism? High-dose creatine quickly raises brain energy stores, powering neurons under extreme stress This rapid brain-energizing effect makes creatine promising for combating fatigue, jet lag, or even cognitive decline

FoundMyFitness Clips

369,001 次观看 • 1 年前

Taking a single high dose (25–30g) of creatine not only reverses the cognitive impairment caused by 21 hours of sleep deprivation, it can boost brain function beyond fully rested levels Neuroimaging reveals the mechanism: ->High doses of creatine quickly replenish brain energy stores, enhancing neuronal function and metabolic efficiency under extreme stress This makes high-dose creatine a powerful tool for situations like jet lag, red-eye flights, and unavoidable sleep loss

Taking a single high dose (25–30g) of creatine not only reverses the cognitive impairment caused by 21 hours of sleep deprivation, it can boost brain function beyond fully rested levels Neuroimaging reveals the mechanism: ->High doses of creatine quickly replenish brain energy stores, enhancing neuronal function and metabolic efficiency under extreme stress This makes high-dose creatine a powerful tool for situations like jet lag, red-eye flights, and unavoidable sleep loss

FoundMyFitness Clips

896,198 次观看 • 8 个月前

Taking 10 grams of creatine daily might elevate your brain's creatine stores twice as much compared to lower doses (2–4 grams) While 5 grams per day saturates muscles, higher doses (~10 grams daily) allow creatine to "spill over" into the brain, bones, and immune system Neuroimaging studies confirm this 10-gram dose significantly boosts brain energy, improving mitochondrial function in areas critical for mood, memory, and cognition Under severe stress—like sleep deprivation—higher doses (25–30 grams) rapidly increase brain creatine and high-energy phosphates, reversing cognitive deficits and even enhancing brain function beyond normal rested levels

Taking 10 grams of creatine daily might elevate your brain's creatine stores twice as much compared to lower doses (2–4 grams) While 5 grams per day saturates muscles, higher doses (~10 grams daily) allow creatine to "spill over" into the brain, bones, and immune system Neuroimaging studies confirm this 10-gram dose significantly boosts brain energy, improving mitochondrial function in areas critical for mood, memory, and cognition Under severe stress—like sleep deprivation—higher doses (25–30 grams) rapidly increase brain creatine and high-energy phosphates, reversing cognitive deficits and even enhancing brain function beyond normal rested levels

FoundMyFitness Clips

149,444 次观看 • 1 年前

Creatine dose, benefits & safety from Dr. Rhonda Patrick: - Standard muscle dose is 5 g/day of creatine monohydrate - the most well-researched form - but muscles are "very greedy" and consume most of it before it reaches the brain. - Getting creatine into the brain requires higher doses: one German study found that at 10 g/day, MRI scans showed creatine levels rising in key brain regions above what the brain produces on its own. - Creatine shines under brain stress - sleep deprivation, intense cognitive work, travel fatigue. One study gave sleep-deprived subjects 0.35 g per kg bodyweight (roughly 20-25 g) and they performed not just at baseline but above it. - The phosphocreatine system has a frontal bias - the brain areas most associated with strategic planning and working memory rely on it most heavily. "It's one of the most well-studied supplements out there. If it was unsafe, we really would know." Dr. Rhonda Patrick on Andrew D. Huberman, Ph.D.

Creatine dose, benefits & safety from Dr. Rhonda Patrick: - Standard muscle dose is 5 g/day of creatine monohydrate - the most well-researched form - but muscles are "very greedy" and consume most of it before it reaches the brain. - Getting creatine into the brain requires higher doses: one German study found that at 10 g/day, MRI scans showed creatine levels rising in key brain regions above what the brain produces on its own. - Creatine shines under brain stress - sleep deprivation, intense cognitive work, travel fatigue. One study gave sleep-deprived subjects 0.35 g per kg bodyweight (roughly 20-25 g) and they performed not just at baseline but above it. - The phosphocreatine system has a frontal bias - the brain areas most associated with strategic planning and working memory rely on it most heavily. "It's one of the most well-studied supplements out there. If it was unsafe, we really would know." Dr. Rhonda Patrick on Andrew D. Huberman, Ph.D.

Huberman Lab Clips

36,723 次观看 • 4 个月前

One high dose (25–30 grams) of creatine rapidly reverses (and even surpasses) the cognitive deficits caused by severe sleep deprivation In controlled studies, people given a high-dose creatine supplement after 21 hours of sleep deprivation not only recovered their cognitive abilities, they performed better than their baseline (fully rested) levels Neuroimaging reveals the mechanism: high doses of creatine quickly replenish brain energy stores, enhancing neuronal function and metabolic efficiency under extreme stress This immediate brain-boosting effect makes high-dose creatine promising for combating fatigue caused by something like sleep loss or jet lag

One high dose (25–30 grams) of creatine rapidly reverses (and even surpasses) the cognitive deficits caused by severe sleep deprivation In controlled studies, people given a high-dose creatine supplement after 21 hours of sleep deprivation not only recovered their cognitive abilities, they performed better than their baseline (fully rested) levels Neuroimaging reveals the mechanism: high doses of creatine quickly replenish brain energy stores, enhancing neuronal function and metabolic efficiency under extreme stress This immediate brain-boosting effect makes high-dose creatine promising for combating fatigue caused by something like sleep loss or jet lag

FoundMyFitness Clips

946,075 次观看 • 1 年前

Rhonda Patrick dropped a wild science nugget on Diary of a CEO. It made me rewind twice. After 21 hours with zero sleep, a single high dose of creatine (~25-30g or 0.35 g/kg) didn’t just fix the brain fog. It made people perform better than when fully rested. (Key 2024 study by Gordji-Nejad et al. using brain imaging.) I’ve powered through too many all-nighters on caffeine and stubbornness. This felt like a real cheat code. It makes you wonder what else our biology can do with the right fuel. Would you try a high-dose creatine reset on your roughest sleep-deprived days? Or does 25-30g sound insane?

Rhonda Patrick dropped a wild science nugget on Diary of a CEO. It made me rewind twice. After 21 hours with zero sleep, a single high dose of creatine (~25-30g or 0.35 g/kg) didn’t just fix the brain fog. It made people perform better than when fully rested. (Key 2024 study by Gordji-Nejad et al. using brain imaging.) I’ve powered through too many all-nighters on caffeine and stubbornness. This felt like a real cheat code. It makes you wonder what else our biology can do with the right fuel. Would you try a high-dose creatine reset on your roughest sleep-deprived days? Or does 25-30g sound insane?

Camus

42,722 次观看 • 5 个月前

A clinical trial just found a SINGLE 20g dose of creatine increased cognitive processing speed by 24.5% within 3.5 hours. Creatine RAPIDLY improved brain bioenergetics and enhanced cognitive performance during sleep deprivation.

A clinical trial just found a SINGLE 20g dose of creatine increased cognitive processing speed by 24.5% within 3.5 hours. Creatine RAPIDLY improved brain bioenergetics and enhanced cognitive performance during sleep deprivation.

Nicolas Hulscher, MPH

185,811 次观看 • 3 个月前

Taking 10 grams of creatine daily may boost brain creatine levels twice as effectively as lower doses (like 2-4 grams) While 5 grams saturates muscles, research shows higher doses (i.e., 10 grams) allow creatine to "spill over" into the brain, improving mental clarity and energy Rhonda has personally noticed that at 10 grams daily, her typical mid-afternoon energy crash disappears Creatine isn't just for muscles; your brain needs it too

Taking 10 grams of creatine daily may boost brain creatine levels twice as effectively as lower doses (like 2-4 grams) While 5 grams saturates muscles, research shows higher doses (i.e., 10 grams) allow creatine to "spill over" into the brain, improving mental clarity and energy Rhonda has personally noticed that at 10 grams daily, her typical mid-afternoon energy crash disappears Creatine isn't just for muscles; your brain needs it too

FoundMyFitness Clips

48,451 次观看 • 1 年前

Joe Rogan takes creatine every day, and says it’s one of the few things that can almost completely wipe out the mental effects of sleep deprivation. Gary Brecka backed it up: excellent for cognitive function, especially when sleep is off. If monohydrate causes bloating (common for women), switch to HCL. Pairing it with HMB improves uptake even more. Multiple studies (including a 2024 trial in Scientific Reports) show a high single dose of creatine significantly reduces cognitive decline during sleep deprivation, improving memory, processing speed, and vigilance by supporting brain energy stores. A simple daily supplement that helps protect your brain when life gets in the way of good sleep. What’s your experience with creatine, worth it or overhyped?

Joe Rogan takes creatine every day, and says it’s one of the few things that can almost completely wipe out the mental effects of sleep deprivation. Gary Brecka backed it up: excellent for cognitive function, especially when sleep is off. If monohydrate causes bloating (common for women), switch to HCL. Pairing it with HMB improves uptake even more. Multiple studies (including a 2024 trial in Scientific Reports) show a high single dose of creatine significantly reduces cognitive decline during sleep deprivation, improving memory, processing speed, and vigilance by supporting brain energy stores. A simple daily supplement that helps protect your brain when life gets in the way of good sleep. What’s your experience with creatine, worth it or overhyped?

Camus

79,454 次观看 • 4 个月前

Creatine is not just for muscle. At the right dose, it may meaningfully support brain energy too. About 5 g/day is enough to keep muscle stores saturated, but research suggests around 10 g/day may be needed to meaningfully increase brain creatine. Doses used during sleep deprivation (around 0.35 g/kg body weight, often landing near 20–30+ g) have been shown to blunt or even reverse cognitive deficits under extreme stress. If you supplement, creatine monohydrate is the most studied form, and choosing an NSF Certified for Sport product adds an extra layer of quality assurance.

Creatine is not just for muscle. At the right dose, it may meaningfully support brain energy too. About 5 g/day is enough to keep muscle stores saturated, but research suggests around 10 g/day may be needed to meaningfully increase brain creatine. Doses used during sleep deprivation (around 0.35 g/kg body weight, often landing near 20–30+ g) have been shown to blunt or even reverse cognitive deficits under extreme stress. If you supplement, creatine monohydrate is the most studied form, and choosing an NSF Certified for Sport product adds an extra layer of quality assurance.

FoundMyFitness Clips

29,876 次观看 • 6 个月前

A single high-dose creatine supplement (~25-30 grams) rapidly reverses (and even improves) the cognitive impairment caused by severe sleep loss In studies, sleep-deprived people given creatine not only regained lost cognitive function but improved processing speed beyond fully rested conditions Neuroimaging reveals the mechanism: Creatine swiftly restores the brain’s depleted energy stores, significantly enhancing neuronal performance during periods of intense stress This makes it highly effective for combatting something like jet lag/sleep deprivation

A single high-dose creatine supplement (~25-30 grams) rapidly reverses (and even improves) the cognitive impairment caused by severe sleep loss In studies, sleep-deprived people given creatine not only regained lost cognitive function but improved processing speed beyond fully rested conditions Neuroimaging reveals the mechanism: Creatine swiftly restores the brain’s depleted energy stores, significantly enhancing neuronal performance during periods of intense stress This makes it highly effective for combatting something like jet lag/sleep deprivation

FoundMyFitness Clips

827,611 次观看 • 11 个月前

Rhonda Patrick now takes 10 grams of creatine per day — double the standard dose. Why? Once your muscles are saturated at 5g, the extra starts reaching your brain. German research showed 10g meaningfully raises brain creatine levels. Even more striking: 20–30g can completely erase the cognitive damage from 21 hours of sleep deprivation — and in some cases, people performed better than when fully rested. Rhonda uses the higher dose on jet-lagged or high-demand days and says she no longer gets the usual mid-afternoon crash. Many of her vegan friends report more energy and needing less sleep after starting. Creatine is quietly shifting from “muscle supplement” to powerful brain performance tool. Have you tried higher-dose creatine (above 5g)? Did you notice changes in energy, focus, or sleep needs?

Rhonda Patrick now takes 10 grams of creatine per day — double the standard dose. Why? Once your muscles are saturated at 5g, the extra starts reaching your brain. German research showed 10g meaningfully raises brain creatine levels. Even more striking: 20–30g can completely erase the cognitive damage from 21 hours of sleep deprivation — and in some cases, people performed better than when fully rested. Rhonda uses the higher dose on jet-lagged or high-demand days and says she no longer gets the usual mid-afternoon crash. Many of her vegan friends report more energy and needing less sleep after starting. Creatine is quietly shifting from “muscle supplement” to powerful brain performance tool. Have you tried higher-dose creatine (above 5g)? Did you notice changes in energy, focus, or sleep needs?

Camus

289,650 次观看 • 6 个月前

Creatine doesn't just build muscle, it also accelerates brain recovery after a concussion Animal studies clearly show creatine taken before a head injury reduces recovery time and inflammation—and early human research strongly supports this One clinical trial reported rapid, significant improvements in children given high-dose creatine immediately after traumatic brain injuries If you play contact sports, daily creatine supplementation could be crucial preventive care

Creatine doesn't just build muscle, it also accelerates brain recovery after a concussion Animal studies clearly show creatine taken before a head injury reduces recovery time and inflammation—and early human research strongly supports this One clinical trial reported rapid, significant improvements in children given high-dose creatine immediately after traumatic brain injuries If you play contact sports, daily creatine supplementation could be crucial preventive care

FoundMyFitness Clips

36,491 次观看 • 1 年前

If you’re only taking 5 grams of creatine, your brain might be missing out Research comparing doses shows that 10 grams daily doubles brain creatine content compared to lower amounts—especially in critical brain regions linked to memory and cognition While 5 grams may be sufficient for muscle benefits, it's likely inadequate for fully unlocking creatine’s brain-boosting potential During periods of stress—like sleep deprivation, jet lag, or intense mental demands—upping your dose to 10 grams (or even higher) ensures your brain gets the support it needs most

If you’re only taking 5 grams of creatine, your brain might be missing out Research comparing doses shows that 10 grams daily doubles brain creatine content compared to lower amounts—especially in critical brain regions linked to memory and cognition While 5 grams may be sufficient for muscle benefits, it's likely inadequate for fully unlocking creatine’s brain-boosting potential During periods of stress—like sleep deprivation, jet lag, or intense mental demands—upping your dose to 10 grams (or even higher) ensures your brain gets the support it needs most

FoundMyFitness Clips

1,259,405 次观看 • 1 年前

Creatine isn’t just for athletes anymore. Research shows this supplement also supports brain energy, which matters even more as we age.

Creatine isn’t just for athletes anymore. Research shows this supplement also supports brain energy, which matters even more as we age.

ᴀʀᴛ ᴏꜰ ᴘʜʏꜱɪQᴜᴇ

34,026 次观看 • 8 个月前

Supplementing with creatine (20 grams/day) improved cognitive function in Alzheimer’s patients by nearly 5% after just 8 weeks Patients experienced notable gains in memory, fluid cognition, inhibitory control, and attention (likely due to creatine’s key role in brain energy metabolism) Creatine seems to especially benefit the brain under stress (whether Alzheimer's, sleep deprivation, or depression), making it a promising tool for supporting cognitive health

Supplementing with creatine (20 grams/day) improved cognitive function in Alzheimer’s patients by nearly 5% after just 8 weeks Patients experienced notable gains in memory, fluid cognition, inhibitory control, and attention (likely due to creatine’s key role in brain energy metabolism) Creatine seems to especially benefit the brain under stress (whether Alzheimer's, sleep deprivation, or depression), making it a promising tool for supporting cognitive health

FoundMyFitness Clips

114,549 次观看 • 1 年前

Joe Rogan hit Elon with this one: creatine isn’t just for muscles, it’s a legit nootropic. Naturally in meat. No real downsides. Especially strong for mental performance when sleep-deprived. Recent studies show a single high dose can measurably improve processing speed, logic, and memory tasks even after 21 hours without sleep. Benefits also pop for post-menopausal women. Simple, cheap backup for tired brains. What’s one supplement that actually surprised you with results?

Joe Rogan hit Elon with this one: creatine isn’t just for muscles, it’s a legit nootropic. Naturally in meat. No real downsides. Especially strong for mental performance when sleep-deprived. Recent studies show a single high dose can measurably improve processing speed, logic, and memory tasks even after 21 hours without sleep. Benefits also pop for post-menopausal women. Simple, cheap backup for tired brains. What’s one supplement that actually surprised you with results?

Camus

131,155 次观看 • 4 个月前

1. Creatine Isn't Just for Gym Bros - It's Brain Fuel Taking 25-30 grams of creatine completely negated cognitive deficits from sleep deprivation. Not only did it negate them - people functioned BETTER than when well-rested.

1. Creatine Isn't Just for Gym Bros - It's Brain Fuel Taking 25-30 grams of creatine completely negated cognitive deficits from sleep deprivation. Not only did it negate them - people functioned BETTER than when well-rested.

Joey Yochheim

67,315 次观看 • 1 年前

A SINGLE 20g dose of creatine increases cognitive processing speed by 24.5% within 3.5 hours. A placebo-controlled trial found that creatine rapidly enhanced brain bioenergetics and improved cognitive performance during sleep deprivation, with effects lasting up to nine hours.

A SINGLE 20g dose of creatine increases cognitive processing speed by 24.5% within 3.5 hours. A placebo-controlled trial found that creatine rapidly enhanced brain bioenergetics and improved cognitive performance during sleep deprivation, with effects lasting up to nine hours.

Nicolas Hulscher, MPH

446,751 次观看 • 7 个月前