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David Sinclair's lab is using AI to build a pill that reverses aging for $100. Right now, their gene therapy costs roughly $10 million to manufacture. It requires a direct injection into the target organ. That's not going to work for 8 billion people. So Sinclair's team made a...

675,004 просмотров • 6 месяцев назад •via X (Twitter)

Комментарии: 43

Фото профиля Juancho
Juancho6 месяцев назад

@YourDocGoku In case anyone wants all the details in a text format:

Фото профиля Longevity
Longevity6 месяцев назад

This is pretty cool.

Фото профиля Jason R. Williams, MD, DABR
Jason R. Williams, MD, DABR6 месяцев назад

@YourDocGoku David and I have been exchanging ideas on this for a while. What his lab calls reprogramming, we see in the clinic every day. When you make a patient's cells younger, they fight cancer better. Period.

Фото профиля Longevity
Longevity6 месяцев назад

When do you think this'll happen? In 5-10 years?

Фото профиля Toby Cunningham
Toby Cunningham6 месяцев назад

@YourDocGoku There will never be a "magic pill". You need the right diet, you need to work out, you need detox protocols like EBO2/TPE/Inuspheresis, Peptides, MUSE Stem Cells, HBOT(hard shell) Red Light Therapy etc... I am doing most of these right now. There is NO Magic Bullet here.

Фото профиля Hamish Ogilvy
Hamish Ogilvy6 месяцев назад

@YourDocGoku @davidasinclair Let’s get Michael Jordan loaded up and back into his prime!

Фото профиля Longevity
Longevity6 месяцев назад

@davidasinclair I second this.

Фото профиля Adam ∣ Building to $10K/mo live
Adam ∣ Building to $10K/mo live6 месяцев назад

@YourDocGoku We have cured aging in mice dozens of times in the last 20 years. The translation to human biology is where 99% of these chemical breakthroughs die. Call me when the human trials actually show systemic markers shifting in a controlled group.

Фото профиля NadelParis
NadelParis6 месяцев назад

@YourDocGoku @GeniusGTX I want to visit the "Willy Wonka's chocolate factory". I’d like that pill please, and some dark chocolate. 🍫 Okay, just the pill is fine.

Фото профиля Kevin
Kevin6 месяцев назад

@YourDocGoku @davidasinclair This is the same guy that sold the drug to GSK and got sued for it

Фото профиля Kevin A. Scott, PhD
Kevin A. Scott, PhD6 месяцев назад

@YourDocGoku to build a pill huh

Фото профиля Longevity
Longevity6 месяцев назад

Sounds crazy. Your thoughts on this?

Фото профиля AlphaHealth
AlphaHealth6 месяцев назад

@YourDocGoku why are we trying to prevent aging? It's natural. Humans don't live as long as they should (120) because of poor diet, environmental toxins etc. Maybe spending money on addressing those would be more beneficial?

Фото профиля inthezone
inthezone6 месяцев назад

So if people live far longer, albeit healthier then more people will exist on planet earth. Pensions will be unaffordable so you will have to continue working for decades more. But maybe AI has replaced your job. Physical jobs probably won’t be viable for those in their 70’s/80’s. Young people will be frustrated with waiting far longer for an inheritance. Live long enough to see relatives younger than you die, god forbid your children. Mental health will be an issue. Mad dictators and sickos will live decades more to terrorise people. I get it! It’s a negative take on living longer. But reality should be faced. I like the idea of living into my 80’s or even 90’s while healthy and mobile. But current life isn’t designed for such a change. Especially when it comes to pensions and financial black holes many countries find themselves in.

Фото профиля Noodles MacIntosh
Noodles MacIntosh6 месяцев назад

@YourDocGoku So does he still believe in all the supplements he is selling? NMN and all the other ones.

Фото профиля Ben
Ben6 месяцев назад

@YourDocGoku Grifter. Scammer. Both of them.

Фото профиля David Diwei Xia
David Diwei Xia6 месяцев назад

This is actually the brilliance of @davidasinclair and why his small molecule method must be the path to longevity. Gene therapies are potent and possibly very effective means of age reversal, but they are not affordable. As a society, we cannot have a situation where only the richest, most powerful, and most sadistic have access to longevity. Longevity should be available to everyone or no one.

Фото профиля Anteriojay
Anteriojay6 месяцев назад

@YourDocGoku Yea sure sure…the earth is overpopulated and we want the population to be 500 million but at the same time want people to live forever 🫠

Фото профиля Jeffrey T Miller
Jeffrey T Miller6 месяцев назад

@YourDocGoku What will you do with all the extra time? Will you alter your path and embrace joy?

Фото профиля Katherine Tidman
Katherine Tidman6 месяцев назад

@YourDocGoku Drug companies sit on the sidelines of the supplement world because they can’t patent natural substances. But David Sinclair could bridge this. He could take over-the-counter ingredients and "pharmaceuticalize" them at scale and make them available to everyone inexpensively! 🤩

Фото профиля Absurdist1988
Absurdist19886 месяцев назад

@YourDocGoku Sinclair is a grifter.

Фото профиля Cyril Gupta
Cyril Gupta6 месяцев назад

@YourDocGoku David Sinclair’s lab is using AI to turn $10M gene therapies into a $100 pill that could reverse aging, screening billions of molecules to make age-reversal accessible to everyone.

Фото профиля Longevity
Longevity6 месяцев назад

Yes, that's what I just said.

Фото профиля Clipsleuth.com
Clipsleuth.com6 месяцев назад

@YourDocGoku The Diary Of A CEO with Steven Bartlett Episode: "David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells..." Mar 23, 2026 · Clip Starts at 15:50 Full episode ↓

Фото профиля surdog007
surdog0076 месяцев назад

@YourDocGoku Stay alive till 2030

Фото профиля Akuyuki
Akuyuki6 месяцев назад

@YourDocGoku If it was real he would be silenced long ago.

Фото профиля Longevity
Longevity6 месяцев назад

He does mention how the government did try to silence him so foreign countries couldn't get access to it in the interview. The fact that he's bringing this up now probably means it's been solved 5-10 years ago imo

Фото профиля Roberto Vallarino
Roberto Vallarino6 месяцев назад

@YourDocGoku What a crock of shit.

Фото профиля Longevity
Longevity6 месяцев назад

What makes you say this?

Фото профиля Roberto Vallarino
Roberto Vallarino6 месяцев назад

@YourDocGoku Overhyped promises on all fields.

Фото профиля Real Health Freedom
Real Health Freedom6 месяцев назад

@YourDocGoku Skip the gene therapy and chemical shortcuts. Real food, daily movement, and solid sleep are the safest ways to feel great and actually enjoy a long life. What’s one simple habit that’s helped you feel younger and stronger? #RealHealthFreedom

Фото профиля Notions
Notions6 месяцев назад

@YourDocGoku @davidasinclair If he wants to make serious bank then just charge everyone a percentage of their net worth or a percentage of their last years earnings but keep it low enough so people on the breadline can still afford it?

Фото профиля H PII
H PII6 месяцев назад

@YourDocGoku @StevenBartlett Theranos, and Elizabeth Holmes, revisited

Фото профиля Most interesting man on X ☦️
Most interesting man on X ☦️6 месяцев назад

@YourDocGoku Faster please!

Фото профиля SerenityBuff
SerenityBuff6 месяцев назад

@YourDocGoku Im sure a lot of people are willing to pay any amount for it, which would give fuel to achieve the pill sooner

Фото профиля stüsentrieb
stüsentrieb6 месяцев назад

@YourDocGoku "They should know within a year or two if the molecules work" OMG GREAT NEWS "in mice." oh.

Фото профиля J.S. Pancione 🇺🇸
J.S. Pancione 🇺🇸6 месяцев назад

@YourDocGoku Okay, but understand that it will not just be the good honorable contributing kind considerate people who get to live longer...

Фото профиля Chris McAulay
Chris McAulay6 месяцев назад

@YourDocGoku @LivingForever8 We aren't going to get a pill that reverses aging. Sounds like hype

Фото профиля Longevity
Longevity6 месяцев назад

@LivingForever8 What makes you say this? Always open to hearing other's opinions. It doesn't sound too good to be true - which is why I believe in the interview he said in 5-10 years, it will happen

Фото профиля Chris McAulay
Chris McAulay6 месяцев назад

@YourDocGoku @LivingForever8 One pill isn't going to address all of the types of damage that are the hallmarks of ageing. It may have broad systemic effects and it may be more effective in younger people but even then it's a highly dubious assertion.

Фото профиля Turb0Kat
Turb0Kat6 месяцев назад

@YourDocGoku Is he suicidal? Hope he doesnt shoot himself in the back with a rifle.

Фото профиля Matthew2529🇺🇸
Matthew2529🇺🇸6 месяцев назад

@YourDocGoku @davidasinclair Are we entering Benjamin button territory

Фото профиля Clair Hu
Clair Hu6 месяцев назад

@YourDocGoku @greek_scientist

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David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

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🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

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David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

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Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair

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