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DBS suppressing theta/alpha band in Huntington's? Nice new video documentation. 'A decrease of 38 points on the UHDRS total motor score. The recurrent motor stereotypes and the vocalizations completely disappeared.' FOG worsened. DBS Think Tank Lead-DBS

23,932 次观看 • 3 年前 •via X (Twitter)

4 条评论

Juan Aibar 的头像
Juan Aibar3 年前

@DBSThinkTank @leaddbs Thanks for sharing! DBS for Hungtinton might be helpful in very selected patients. Big scale multicenter studies are useful but lack therapy personalization. After 6 months of parameter’ changes FOG also improved. The patient is now espectacular I must tell! 😀@smartinezho1

Fer Cisneros 的头像
Fer Cisneros3 年前

@DBSThinkTank @leaddbs @VickyCerino

Jorge Patino 的头像
Jorge Patino3 年前

@DBSThinkTank @leaddbs @FurrStimming

la doctora de los girasoles 🌻( Mariela) 的头像
la doctora de los girasoles 🌻( Mariela)3 年前

@DBSThinkTank @leaddbs This is great , thanks for sharing , I will def be reading it

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Can you pick out who has Parkinson's disease from the video using the 'whistle-smile' reflex? Maybe? Frederic Hanes described this sign in 1943. Giulia Paparella and colleagues revisit the observation in a trial of 34 Parkinson's folks versus 34 healthy controls in Movement Disorders Clinical Practice. Key Points: - When healthy individuals are prompted to whistle during a medical examination, 'they typically comply and subsequently smile.' - In Parkinson's 'they execute the whistle but often fail to produce an immediate smile.' - In their study they showed a sensitivity of 76% and a specificity of 65% for the sign. My take: It is hard to believe that there are only two papers on this sign published since 1943. Behavioral neurologists have long been fascinated by spontaneous smiling versus posed and elicited smiling in Parkinson's disease. Though the sensitivity and specificity are too low to become a biomarker, this is a sign neurologists can keep in their pockets for teaching. Researchers may also consider studying this phenomenon with functional imaging as the limbic-motor newtowrk is fascinating and we have also observed DBS induced smiling. The brain is a fascinating supercomputer and frankly, we do not know what we do not know. Ecce signum – behold the sign of the smile in Parkinson's. #Parkinsons Smiles induced by DBS: Spontaneous and posed smiles in Parkinson: Motor cortex and facial smiling in primates by Morecraft: #Parkinsons #smilefest2024 #smile

Michael Okun

12,724 次观看 • 2 年前