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35,230 views • 9 months ago •via X (Twitter)

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NAD is the molecule behind energy, recovery, and aging. But most people still can’t explain what it actually does or what it means to “raise” it. In this episode, Dr. Charles Brenner (Charles Brenner, PhD), the scientist who discovered nicotinamide riboside, walks through NAD biology to explain how it's part of the “wiring” that moves energy through living systems, powering ATP production, building new tissue, and fueling repair. We dig into why NAD matters for DNA repair, how inflammation and metabolic disease put the NAD system “under attack,” and why blood NAD levels don’t always tell you what’s happening inside tissues like liver, muscle, or brain. We also discuss the real differences between NR and NMN, conditions where NAD boosting shows promise, such as inflammation, peripheral artery disease, respiratory infections, cognitive impairment, and fertility, and important safety concerns, including sourcing, product quality, and cancer. If you’ve ever wondered whether NAD boosters are legit, what they’re actually doing in the body, and how to leverage them for health and longevity, this is the episode. Dr. Charles Brenner is a true pioneer in NAD science. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:58 - Why disease states disrupt NAD 6:42 - How coronavirus infection affects NAD 9:55 - Inflating NAD with diet & supplements 11:49 - Why blood NAD can mislead 13:20 - Can obesity drain NAD resources? 16:01 - Does poor sleep reduce NAD? 16:53 - Anti-inflammatory effects of NR 21:38 - Can one lifestyle change fix NAD? 24:22 - NAD precursors & cognitive benefits 27:58 - Should you measure NAD levels? 30:59 - Exercise for boosting NAD 33:01 - NR for exercise recovery 35:35 - How acute sleep loss affects NAD 37:07 - NR during pregnancy 43:48 - Does NR benefit fertility? 44:58 - NAD precursors for jet lag & shift work 47:41 - Best time to take NR? 50:41 - NAD supplements vs. precursors 54:28 - NAD IV drips 55:36 - Oral vs. IV nicotinamide riboside 57:06 - Do oral NAD supplements work? 58:58 - NMN vs. NR 1:02:06 - Gut microbiome & NAD levels 1:04:44 - NR supplements & immune function 1:08:02 - NR for peripheral artery disease 1:12:26 - Can NR reduce liver fat? 1:17:33 - Recovery benefits 1:19:18 - Safe dosage for nicotinamide riboside 1:21:21 - Resveratrol & pterostilbene 1:22:57 - NAD precursors—why sourcing matters 1:25:09 - NAD supplements & cancer risk 1:30:55 - Should healthy people take NR? 1:33:43 - Charles Brenner’s NAD journey 1:38:13 - NAD’s role in energy & repair 1:45:00 - Why NAD fuels DNA repair 1:46:50 - How PARP enzymes consume NAD 1:49:29 - NAD’s role in gene regulation 1:51:49 - Why NAD shortages hit the brain hardest

Dr. Rhonda Patrick

144,973 views • 4 months ago

Farage has just attacked me for backing mass deportations - let me be clear about what happened. What he is referring to is my support for removing foreign/dual nationals who were aware that their husband/brother/uncle/son was raping vulnerable young white girls on an industrial scale. If they knew, and did nothing, then yes. They should be removed from our country. I make absolutely NO apologies for stating that. I do not want such evil walking our streets. Deport them all. If that results in entire communities being deported, then that is what must happen. Obviously. The number is irrelevant. Everyone who knew and did nothing must go. If a Pakistani woman knew that her husband was raping a young white girl, facilitating it? Then yes - she should go back to Pakistan with her husband. It’s shocking that Farage doesn’t agree. At a Reform event in Essex, Farage even removed the line ‘mass deportation’ from my speech. He later told the Telegraph he thought it was 'a very grave, dark and dangerous use of language.' What's changed? In that same speech he instructed me to remove a reference to deporting these complicit foreign nationals. I refused. I'm glad I did. He says millions can't go? I disagree. My position is clear, and it’s one the British people agree with. Mass deportation of every single illegal migrant. Abolish the entire asylum system. Review all refugee claims given to illegal arrivals, with deportation the default. And actually, the biggest problem of them all? Legal immigration. A large number of legal migrants, who have failed to uphold their end of the deal, need to go home too. Not working, not contributing, not integrating, not even speaking English? Go home. From what I can see - the Reform plan is nowhere near enough. Even on deporting illegals. It's just not enough. It's weak. They ALL must go. Not some, ALL. Farage was also questioned why my plan would cost far more than his? His response? Because "Zia is really good at maths". No. It's because it's because your plan is weak. All very disappointing. We need to be brave to take our country back, and this is not brave. We have already shifted the entire public debate in six months. Let’s keep pushing. Mass deportations, and I mean proper mass deportations, must happen.

Rupert Lowe MP

13,664,720 views • 9 months ago