"DMT is the missing neurotransmitter, found at similar concentrations to dopamine and serotonin." "Overloading the brain with DMT well beyond its natural levels and functions creates an alien environment in the brain." "We know of no other compound that can be administered and produce such otherworldly phenomena." "It's the... only neurotransmitter we know of that can do that." Steven Barker has been studying DMT for over 50 years and he's back on GS for a scintillating round 2.show more

Meet The World’s Greatest Endogenous DMT Psychedelic Scientist You've Never Heard Of Part 2 Youtube: Spotify:

In case you missed the news on endogenous 5-MeO-DMT, check this out. Still tentative and unpublished, but really exciting:

Oh wow! Thank you for sharing. Barker also said that 5-MeO was found. Super cool

They've known about it and bufotenine in other bodily fluids for some time, but actually taking measurements in the brain is an area where they'd been lacking a lot of data. Take a look at the whole rest of that thread too. There's some tentative speculation that it might have more of an intracellular role as opposed to being an intercellular neurotransmitter. 5-HT is more lipophobic, and doesn't really interact with the 5-HT recepors inside the cell. It generally travels between cells. DMT and 5-MeO-DMT are more lipophilic, which puts them in a better position to act as intracellular ligands, rather than intercellular neurotransmitters. DMT is also a sigma-1 ligand, too. And sigma-1 receptors are also found mostly inside cells, which is another point for DMT-as-intracellular-ligand theory. So you might have a situation that looks more like DMT inside cells, interacting with intracellular 5-HT and sigma-1 receptors, to modulate neurotransmitter traffic going in between cells, or modulating some kind of interactions with other systems. Sigma-1 has a role in modulating tons of other systems too. Lots of interesting avenues to explore there.

Awesome man! Thanks for sharing this, looks really cool.

The guys from DMT Quest seem bullish on this idea so I'd pay close attention to it. A lot of things check out about that theory if you think about a few things based on first principles, such as which ones are lipophobic/lipophilic, and where sigma-1 cells actually are in the body. It would also, theoretically, potentially explain why smaller amounts of intracellular DMT could act with disproportionately high levels of influence compared to serotonin, because it's not actually competing for the same 5-HT receptors. Maybe it handles the ones inside, serotonin handles the ones outside. They work with the same system, but don't actually compete with each other. Not confirmed yet of course, but a lot of things make a lot of sense if it does work that way.

In my experience it lifts your brain frequency above negative frequency so everything i see translates into calm perception of me and my surroundings and also can go above all thoughts all together by diving in deep thru music or meditation. So basically, nice feeling.

I have unlocked endogenously produced DMT in my Sacrum.....it vibrates and pulses and feels like an orgasm from an angel, when I listen to 40hz gamma wave frequency. it goes up my spine once a month, or when forced, and it makes me trip heavenly for a time. Not joking... 🙂‍↕️🙏❤️‍🔥

Considering we don’t know where we are or what we are, it’s difficult to answer the DMT experience.

Am I mistaken in assuming that ANY psychedelic at sufficient doses (LSD being a primary example) can produce entity encounters?

I remember when we just called doing this stuff "getting fucked up" without thinking we were really talking to Neptunians.

The experience is Frequently described as more real than real! As one DMTX participant recently stated immediately after a session:” I don’t know where I went, but it was somewhere else.” your experiences, it cannot be written off to a hallucination.

DMT continues to raise some of the biggest questions we have about consciousness. The fact that researchers are still uncovering new possibilities after decades of study makes it even more fascinating. 👽🌀

@grok Is it true that Andrew Gallimore argues that the world we see while high on DMT is actually another world inhabited by other beings and that it is real?

As a small child I had frequent natural DMT dreams. I would dream answers to 'life the universe and everything' as if they were told by a narrator. I could only remember fragments which were too big for my brain, I was convinced I was stranded on earth and belonged somewhere else.

It's probably only alien because humans donkey themselves on it so much our system does produce it like it did.

Maybe Both

Nitrous oxide enters the chat