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"DMT is the missing neurotransmitter, found at similar concentrations to dopamine and serotonin." "Overloading the brain with DMT well beyond its natural levels and functions creates an alien environment in the brain." "We know of no other compound that can be administered and produce such otherworldly phenomena." "It's the... show more

Evan McGloughlin

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44,078 görüntüleme • 12 gün önce •via X (Twitter)

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Evan McGloughlin profil fotoğrafı

Evan McGloughlin12 gün önce

Meet The World’s Greatest Endogenous DMT Psychedelic Scientist You've Never Heard Of Part 2 Youtube: Spotify:

The Psychomechanics Workshop profil fotoğrafı

The Psychomechanics Workshop12 gün önce

In case you missed the news on endogenous 5-MeO-DMT, check this out. Still tentative and unpublished, but really exciting:

Evan McGloughlin profil fotoğrafı

Evan McGloughlin12 gün önce

Oh wow! Thank you for sharing. Barker also said that 5-MeO was found. Super cool

The Psychomechanics Workshop profil fotoğrafı

The Psychomechanics Workshop12 gün önce

They've known about it and bufotenine in other bodily fluids for some time, but actually taking measurements in the brain is an area where they'd been lacking a lot of data. Take a look at the whole rest of that thread too. There's some tentative speculation that it might have more of an intracellular role as opposed to being an intercellular neurotransmitter. 5-HT is more lipophobic, and doesn't really interact with the 5-HT recepors inside the cell. It generally travels between cells. DMT and 5-MeO-DMT are more lipophilic, which puts them in a better position to act as intracellular ligands, rather than intercellular neurotransmitters. DMT is also a sigma-1 ligand, too. And sigma-1 receptors are also found mostly inside cells, which is another point for DMT-as-intracellular-ligand theory. So you might have a situation that looks more like DMT inside cells, interacting with intracellular 5-HT and sigma-1 receptors, to modulate neurotransmitter traffic going in between cells, or modulating some kind of interactions with other systems. Sigma-1 has a role in modulating tons of other systems too. Lots of interesting avenues to explore there.

Evan McGloughlin profil fotoğrafı

Evan McGloughlin12 gün önce

Awesome man! Thanks for sharing this, looks really cool.

The Psychomechanics Workshop profil fotoğrafı

The Psychomechanics Workshop12 gün önce

The guys from DMT Quest seem bullish on this idea so I'd pay close attention to it. A lot of things check out about that theory if you think about a few things based on first principles, such as which ones are lipophobic/lipophilic, and where sigma-1 cells actually are in the body. It would also, theoretically, potentially explain why smaller amounts of intracellular DMT could act with disproportionately high levels of influence compared to serotonin, because it's not actually competing for the same 5-HT receptors. Maybe it handles the ones inside, serotonin handles the ones outside. They work with the same system, but don't actually compete with each other. Not confirmed yet of course, but a lot of things make a lot of sense if it does work that way.

Anna Kovacic profil fotoğrafı

Anna Kovacic12 gün önce

In my experience it lifts your brain frequency above negative frequency so everything i see translates into calm perception of me and my surroundings and also can go above all thoughts all together by diving in deep thru music or meditation. So basically, nice feeling.

Christian 'Xander' Brown profil fotoğrafı

Christian 'Xander' Brown11 gün önce

I have unlocked endogenously produced DMT in my Sacrum.....it vibrates and pulses and feels like an orgasm from an angel, when I listen to 40hz gamma wave frequency. it goes up my spine once a month, or when forced, and it makes me trip heavenly for a time. Not joking... 🙂‍↕️🙏❤️‍🔥

FLTERTH profil fotoğrafı

FLTERTH11 gün önce

Considering we don’t know where we are or what we are, it’s difficult to answer the DMT experience.

Noah Clark profil fotoğrafı

Noah Clark12 gün önce

Am I mistaken in assuming that ANY psychedelic at sufficient doses (LSD being a primary example) can produce entity encounters?

Nippon Steel profil fotoğrafı

Nippon Steel11 gün önce

I remember when we just called doing this stuff "getting fucked up" without thinking we were really talking to Neptunians.

DreamMind profil fotoğrafı

DreamMind11 gün önce

The experience is Frequently described as more real than real! As one DMTX participant recently stated immediately after a session:” I don’t know where I went, but it was somewhere else.” your experiences, it cannot be written off to a hallucination.

PSYCHEDELIC WORLD 🌎🍄 profil fotoğrafı

PSYCHEDELIC WORLD 🌎🍄12 gün önce

DMT continues to raise some of the biggest questions we have about consciousness. The fact that researchers are still uncovering new possibilities after decades of study makes it even more fascinating. 👽🌀

Cosmic Carter profil fotoğrafı

Cosmic Carter9 gün önce

@grok Is it true that Andrew Gallimore argues that the world we see while high on DMT is actually another world inhabited by other beings and that it is real?

Armin 🌱🌏 profil fotoğrafı

Armin 🌱🌏11 gün önce

As a small child I had frequent natural DMT dreams. I would dream answers to 'life the universe and everything' as if they were told by a narrator. I could only remember fragments which were too big for my brain, I was convinced I was stranded on earth and belonged somewhere else.

Alen Coffell profil fotoğrafı

Alen Coffell11 gün önce

It's probably only alien because humans donkey themselves on it so much our system does produce it like it did.

Stefan Wriedt profil fotoğrafı

Stefan Wriedt11 gün önce

Maybe Both

Antiantianti profil fotoğrafı

Antiantianti11 gün önce

Nitrous oxide enters the chat

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"At least 50% of the volunteers on high dose DMT experience seeing beings — insects, a mantis experience, bees and ants, conscious cactus, even conscious apartments, robots, Tinkerbell, kinds of angelic figures." "DMT in the dying brain is responsible for the visual effects of the near-death state." "They determined that the brain was making DMT in very high levels, comparable to concentrations of well known neurotransmitters like serotonin and dopamine." Such an immense honour to finally speak to Rick Strassman. The Spirit Molecule, DMT entities, NDE's and endogenous DMT, we cover it all... ⬇️

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DMTx to endo-DMTx? The extended-state DMTx technology has the potential to transform mental health therapies and massively expand the reaches of our exploration of DMT realms. But what if we could eliminate external substances and needles entirely, harnessing instead our body’s own endogenous DMT production machinery? We’ve known since the 1950s that DMT naturally occurs in human blood and cerebrospinal fluid. Recent research shows that DMT levels in mammalian brains rival key neurotransmitters like serotonin and dopamine, suggesting it might play an essential role in brain function. Yet, we still have minimal understanding of how DMT production is regulated within the brain. Imagine being able to “hack” our endogenous DMT system—switching DMT production on and off at will, without invasive infusion methods. This is the future we call endo-DMTx... But, to get there, we must first pinpoint the internal mechanisms controlling endogenous DMT biosynthesis... (1/n)

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Dr. Gary Nolan suggests that it's possible that some people suffering from schizophrenia could be experiencing something real. 👇 While in the West, we view schizophrenia as a medical condition, some eastern cultures see it as a spiritual or supernatural phenomenon. Recent studies have shown that in people with schizophrenia and autism, there is an elevated presence of DMT in the urine. DMT is a psychedelic that, when taken, induces hallucinations. Many people claim to see aliens or spiritual entities when under the influence of DMT and are questioning if these encounters could be real(there are some interesting studies happening with extended DMT right now as well). This would suggest that DMT may work as some sort of connection to other realms or deminsions. So, what are your thoughts? Do people with schizophrenia have some sort of malfunction in the brain flooding them with excess amounts of DMT, causing hallucinations? Or, are these people experiencing something real? PS: If you are suffering from any sort of condition that causes psychosis, please DO NOT stop your medication. The theory of the spiritual connection is not proven, but I find some of the evidence very intriguing. #mentalhealth #spirituality #dmt #aliens #ufo

Dr. Gary Nolan suggests that it's possible that some people suffering from schizophrenia could be experiencing something real. 👇 While in the West, we view schizophrenia as a medical condition, some eastern cultures see it as a spiritual or supernatural phenomenon. Recent studies have shown that in people with schizophrenia and autism, there is an elevated presence of DMT in the urine. DMT is a psychedelic that, when taken, induces hallucinations. Many people claim to see aliens or spiritual entities when under the influence of DMT and are questioning if these encounters could be real(there are some interesting studies happening with extended DMT right now as well). This would suggest that DMT may work as some sort of connection to other realms or deminsions. So, what are your thoughts? Do people with schizophrenia have some sort of malfunction in the brain flooding them with excess amounts of DMT, causing hallucinations? Or, are these people experiencing something real? PS: If you are suffering from any sort of condition that causes psychosis, please DO NOT stop your medication. The theory of the spiritual connection is not proven, but I find some of the evidence very intriguing. #mentalhealth #spirituality #dmt #aliens #ufo

Jamie Nadia ☀️🌙🌹

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🚨 Danny Goler: "If you use Apple Vision Pro and viewed while on DMT, the static symbolic code of reality becomes visible" 😱 "You all of a sudden have an image of the code if you're on DMT that is frozen. It's no longer moving. It's frozen." Researchers captured a high-resolution image of the laser band normally. When that same still image is loaded into Apple Vision Pro and viewed while on DMT, the static symbolic code becomes visible and remains completely frozen instead of running. The code only appears meaningful in the altered state. Without DMT the image looks ordinary. Custom software built for the Vision Pro lets participants click symbols in real time while their brain is scanned, registering exact coordinates and brain events. A radial menu offers the six most commonly reported symbols so reports can be labeled and compared. AI and the open repository at 'Veilbreak AI' are cataloging thousands of independent replications from people worldwide who have never spoken to each other. The frozen snapshot raises a clear question the team is now testing: is information actually present in the light field itself, or is it still a projection? This is the first time the phenomenon has been held still long enough for rigorous measurement.

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Interstellar

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Interstellar

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Interstellar

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Holden Culotta

398,909 görüntüleme • 11 ay önce

Andrew Gallimore: "Some people are getting banned from the DMT realm" "Mantis beings are even punching people in the face" He told AJ from The Why Files how one person described a mantis being punching a user in the face right as they entered the space. The punch was felt and the entire experience ended instantly. The user snapped back to baseline consciousness with the effects just gone like that. People report getting a big X in their field of vision that says no entry. Or an entity that wags its finger and says no no no. Or a clear message that you are not welcome here and we are not letting you in. This is called a lockout. It can last for months or years. Unlike normal tolerance that builds gradually this functions like an on off switch with no straightforward pharmacological explanation. These consistent accounts from regular DMT users continue to raise deep questions about what is actually encountered in that space.

Andrew Gallimore: "Some people are getting banned from the DMT realm" "Mantis beings are even punching people in the face" He told AJ from The Why Files how one person described a mantis being punching a user in the face right as they entered the space. The punch was felt and the entire experience ended instantly. The user snapped back to baseline consciousness with the effects just gone like that. People report getting a big X in their field of vision that says no entry. Or an entity that wags its finger and says no no no. Or a clear message that you are not welcome here and we are not letting you in. This is called a lockout. It can last for months or years. Unlike normal tolerance that builds gradually this functions like an on off switch with no straightforward pharmacological explanation. These consistent accounts from regular DMT users continue to raise deep questions about what is actually encountered in that space.

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A gentleman by the name of “Danny Goler” has discovered that if you smoke DMT and look through a laser, you can see what appears to be numbers and letters/an underlying ‘code’ running through our reality. This is repeatable and has now been performed with hundreds of people all seeing the same thing.

A gentleman by the name of “Danny Goler” has discovered that if you smoke DMT and look through a laser, you can see what appears to be numbers and letters/an underlying ‘code’ running through our reality. This is repeatable and has now been performed with hundreds of people all seeing the same thing.

👽 (Ruby) 👽

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MS NOW brain rot NEEDS the world to know that women can be pilots too and they accuse Hegseth of not knowing.. These people are insufferable. We all know women can and do fly jets as well..

MS NOW brain rot NEEDS the world to know that women can be pilots too and they accuse Hegseth of not knowing.. These people are insufferable. We all know women can and do fly jets as well..

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The DMT ecosystem is on the cusp of producing yet again another major breakthrough This time ushered in by Superfan.fan and his HIRO’s project AI and DMT are two technology primitives that when combined can produce a new class of digital asset with “lifelike” properties that are generated through Bitcoin block data We discuss this in an interview with Superfan 👇 Introducing HIRO’s Bitcoin’s First Generative AI Killer App Powered By DMT | w/ SuperFan | TBR #224 Superfan is building a next-generation suite of tools that enables creators to use generative AI in their UNAT scripts. This will be showcased by the upcoming HIRO’s launch on 🅼🆂🅲🆁🅸₿🅴 August 15th. HIRO’s is a collection of 4,032 dynamic characters that are responsive to non-arbitrary data patterns that occur on Bitcoin. The HIRO asset itself is an impressive demonstration of the high-fidelity output behind the technology stack being utilized to generate them. We speak with Superfan to understand better the technology and the practical use cases moving forward as he will open source. Also, his thoughts on community building by utilizing AI and the superpower ability it can introduce in metaverse construction. 🚀Sign up to receive our Ordinal Takeover Newsletter for weekly updates! Disclaimer: The views and opinions expressed by The Block Runner are for informational purposes only and do not constitute financial, investment, or other advice.

ᴛʜᴇ ʙʟᴏᴄᴋ ʀᴜɴɴᴇʀ Podcast 🟧

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The American Academy of Achievement's Golden Plate Award has been presented for 60 years in recognition of contributions to human development. For the ingenuity that can only be realized in freedom. In today's world, we cannot afford to lose a single battle when, on one side, there is freedom, and on the other, everything we would never wish for our children. We all need victory. And we all know why.

The American Academy of Achievement's Golden Plate Award has been presented for 60 years in recognition of contributions to human development. For the ingenuity that can only be realized in freedom. In today's world, we cannot afford to lose a single battle when, on one side, there is freedom, and on the other, everything we would never wish for our children. We all need victory. And we all know why.

Volodymyr Zelenskyy / Володимир Зеленський

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The term 'ontological shock' is often used to describe the emotional response to an experience that collides with our basic assumptions about the nature of reality... In this account, one of two previously-unpublished reports from Rick Strassman's 1990s DMT study that I present in Death by Astonishment, one of his subjects is hurled into a reality so utterly and horrifying alien that it seemed to send him into a state of actual physical shock with his vital signs suddenly and markedly plummeting a few minutes after the DMT was administered... (Art by Paul Robertson)

The term 'ontological shock' is often used to describe the emotional response to an experience that collides with our basic assumptions about the nature of reality... In this account, one of two previously-unpublished reports from Rick Strassman's 1990s DMT study that I present in Death by Astonishment, one of his subjects is hurled into a reality so utterly and horrifying alien that it seemed to send him into a state of actual physical shock with his vital signs suddenly and markedly plummeting a few minutes after the DMT was administered... (Art by Paul Robertson)

Andrew Gallimore

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Dyno Therapeutics co-founder Sam Sinai on how his team cracked the blood-brain barrier well enough to reach 50% of neurons with a single injection: "For brain specifically, the brain has this extra layer of defense called the blood brain barrier. It's really put there to prevent anything to get in." "What we have done is actually in primates we can show that we can get up more than 50% of neurons, through a systemic injection." "You're just injecting in the veins, and then the virus actually makes its way into the brain." "Neurons are a primary target, but it could be in some cases glial cells, depending on the disease. Solving pan brain, meaning all of brain delivery, is a key objective there."

MTS

21,041 görüntüleme • 2 ay önce

Dr. Daniel Monti just revealed a potentially massive breakthrough in Parkinson’s disease treatment. And it’s much simpler than you think. He just published his third study on a molecule called N-acetylcysteine, or “NAC for short.” “This is a powerful antioxidant.” “It actually protects the liver.” “We know that it does a lot of different things, but the important thing for us is that it’s a precursor to something called glutathione.” “Glutathione protects the brain when there’s damage or oxidative stress and we lose it as we age.” “And when we get sick, we lose it even more.” “So we want to have a way to efficiently increase glutathione in the brain, particularly when we have a neurodegenerative disorder such as Parkinson’s disease.” “We hypothesized early on that giving infused N-acetylcysteine would increase glutathione and actually have a positive impact on Parkinson’s disease.” “We’ve published three studies on this and we look at brain scans in all of them.” “And what we’ve seen is that the N-acetylcysteine increases the efficiency of dopamine in the brain, which is the neurotransmitter or chemical that gets lost in Parkinson’s disease and causes all of those symptoms.” “Our most recent study shows that it improves the way the brain connects to itself or talks to itself the functional connectivity in the brain.” “To be in the study, you couldn’t have changes in your Parkinson's medications for a period of time.” “In both the control group and in the NAC group, people were on their Parkinson’s medications, but if they got the NAC, they did better.” “Their brain came alive in a way that wasn’t happening before.”

Dr. Daniel Monti just revealed a potentially massive breakthrough in Parkinson’s disease treatment. And it’s much simpler than you think. He just published his third study on a molecule called N-acetylcysteine, or “NAC for short.” “This is a powerful antioxidant.” “It actually protects the liver.” “We know that it does a lot of different things, but the important thing for us is that it’s a precursor to something called glutathione.” “Glutathione protects the brain when there’s damage or oxidative stress and we lose it as we age.” “And when we get sick, we lose it even more.” “So we want to have a way to efficiently increase glutathione in the brain, particularly when we have a neurodegenerative disorder such as Parkinson’s disease.” “We hypothesized early on that giving infused N-acetylcysteine would increase glutathione and actually have a positive impact on Parkinson’s disease.” “We’ve published three studies on this and we look at brain scans in all of them.” “And what we’ve seen is that the N-acetylcysteine increases the efficiency of dopamine in the brain, which is the neurotransmitter or chemical that gets lost in Parkinson’s disease and causes all of those symptoms.” “Our most recent study shows that it improves the way the brain connects to itself or talks to itself the functional connectivity in the brain.” “To be in the study, you couldn’t have changes in your Parkinson's medications for a period of time.” “In both the control group and in the NAC group, people were on their Parkinson’s medications, but if they got the NAC, they did better.” “Their brain came alive in a way that wasn’t happening before.”

Jan Jekielek

170,783 görüntüleme • 7 ay önce

Chase Hughes: "The DMT Realm is more real than reality. A thousand times more real than this." 😱 One of the few people in the world to undergo 5 hours of intravenous DMT described being ripped out of our dimension into a hyperspace that felt infinitely more vivid than everyday life. He encountered the same consistent entities that humans have reported seeing for 4,500 years. The beings performed what felt like precise neurological work on him, addressing his brain and heart issues after his wife had prayed over the vials the night before. Coming back, this world felt like a low resolution cartoon. "It's kind of like you get pulled outside of The Truman Show... and this looks like a claymation oil painting." Five hours here translated to about six months of experience there. He warns it's not recreational - it's profound, heavy, and changes how you see everything. DMT isn't viewed by studying scientists as mere hallucination due to the universal consistency across users. It peeled back the filter, revealing a reality of unlimited love, peace, and intelligence far beyond our current comprehension. Mind bending insights into consciousness and what lies beyond.

Chase Hughes: "The DMT Realm is more real than reality. A thousand times more real than this." 😱 One of the few people in the world to undergo 5 hours of intravenous DMT described being ripped out of our dimension into a hyperspace that felt infinitely more vivid than everyday life. He encountered the same consistent entities that humans have reported seeing for 4,500 years. The beings performed what felt like precise neurological work on him, addressing his brain and heart issues after his wife had prayed over the vials the night before. Coming back, this world felt like a low resolution cartoon. "It's kind of like you get pulled outside of The Truman Show... and this looks like a claymation oil painting." Five hours here translated to about six months of experience there. He warns it's not recreational - it's profound, heavy, and changes how you see everything. DMT isn't viewed by studying scientists as mere hallucination due to the universal consistency across users. It peeled back the filter, revealing a reality of unlimited love, peace, and intelligence far beyond our current comprehension. Mind bending insights into consciousness and what lies beyond.

Interstellar

26,725 görüntüleme • 4 ay önce