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😍ExA-SPIM: new clearing+ expansion method, new microscope with large field of view & working distance. 3D connectomics in whole mouse, macaque & human brains at diffractionlimited resolution Adam Glaser allen institute karel svoboda HHMI | Janelia

126,094 次观看 • 3 年前 •via X (Twitter)

9 条评论

Kevin Terretaz 的头像
Kevin Terretaz3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia Thank you so much for this wonderful video! I really enjoyed playing with it 😄

Michael Morehead 的头像
Michael Morehead3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia Wow, look at these! Go full screen!

Mariel Goddu (@marielgoddu.bsky.social) 的头像
Mariel Goddu (@marielgoddu.bsky.social)3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia Could you say a little bit about what we’re looking at in this (very entrancing & cool) visualization?

Kilian Rolle 的头像
Kilian Rolle3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia More videos please, I could spend hours watching these.

Uri Manor 💔 的头像
Uri Manor 💔3 年前

@TheBorisLab @adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia @get_this_v

Brandon Christopher King 的头像
Brandon Christopher King3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia This is truly a groundbreaking development! Understanding the complex neural pathways at such high resolution can help us further understand the intricate RL flows within the human brain and the role consciousness plays in it.

Anna Schueth, PhD (she/her) 的头像
Anna Schueth, PhD (she/her)3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia Congrats! This looks so awesome. 😍

Michael 的头像
Michael3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia When can we get the screensaver?

VIZCIE | SCIENTIFIC VISUALS 的头像
VIZCIE | SCIENTIFIC VISUALS3 年前

@adam_k_glaser @AllenInstitute @svoboda314 @HHMIJanelia It looks amazing! 😍

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We’re thrilled to share that our MERFISH+ preprint is now live on bioRxiv!👉 In this work, the Bintu and Zhu labs (UCSD) developed MERFISH+, a next-generation spatial genomics platform that combines genome-wide RNA and epigenetic imaging over a large field of view. By introducing acrydite-modified probes covalently anchored to hydrogels, MERFISH+ achieves remarkable imaging stability and enables >1,800-gene, multi-modal, and multi-month experiments. With this platform, they, together with the Chi lab at UCSD, profiled a whole developing human heart at 12 post-conception week with merely two slides, resulting in a total of 53 slides, 3.1 million single cells and more than 30 cell types. Building upon our previous 3D reconstruction and modeling framework, Spateo ( we reconstruct the 3D human heart that nicely captures the anatomical structure of the heart, including the intricate vasculature network. Sophisticated analyses provide a holistic view of an entire organ and enable systematic characterization of 3D cellular neighborhoods and transcriptional gradients of substructures such as the descending arteries. Furthermore, using a generative integration framework for spatial multimodal data (Spateo-VI), we harmonized these MERFISH+ transcriptomic and chromatin data to reconstruct a 3D spatially-resolved multi-omics atlas of the developing human heart, shared at and MERFISH+ thus sets a new standard for large-format, multi-omic spatial profiling, enabling holistic, 3D characterization of organs at subcellular resolution. Huge congratulations to first authors Colin Kern, qingquan Zhang, Yifan Lu , and Jacqueline Eschbach, and to all collaborators from the Bintu, Zhu, Chi, and Qiu labs for this amazing team effort. Thanks for your diligence, creativity, and hard work on this project. We’re grateful for support from Arc Institute and our generous donors. Our lab is expanding—if you’re excited about building the next generation of single-cell and spatial genomics techniques and predictive single cell and spatial foundation models, we’re hiring! If you are interested, please reach out to me via direct message or email at [email protected]. We are excited for any potential collaborations along this line of research in Stanford, UCSF and Berkeley and other labs as well.

evo-devo

42,307 次观看 • 9 个月前

⚡️📣👇Tremendously excited to share our new Cell article, where we develop TriPath, a method for analyzing 3D pathology samples using weakly supervised AI. Article: TriPath enables 3D computational pathology via 3D multiple instance learning allowing AI models to capture intricate morphological details from pathology volumes. Code: Blog post: Tested on two different imaging modalities, and patient cohorts from two institutions. Our superstar Andrew H. Song put in a monumental effort of leading the study, in a fantastic collaboration with Jonathan Liu at University of Washington . Interesting aspects: - Utilizing the whole tissue volume and leveraging 3D deep learning enable superior risk prediction performance compared to 2D deep learning baselines based on a few sampled tissue sections that emulate standard clinical practice. This indicates TriPath can harness additional information provided by 3D tissue morphology. - The performance is also superior to clinical baselines from a reader study that involved six expert pathologists. - The morphologically heterogeneous tissue volume could lead to opposing patient-level outcome predictions, dependent on which portion of the tissue volume is used. This concurs with current clinical literature warning that tissue sampling bias can lead to misdiagnosis. Some limitations: - While the 3D pathology cohort size is unprecedented, it is smaller than typical 2D pathology cohorts. Further large-scale studies will be required for validation. Nevertheless, we believe that this study will initiate a positive cycle, encouraging academic institutions and pharmaceutical companies to contribute large banks of human tissue blocks with paired clinical outcomes, thus speeding up advancements in 3D computational pathology. Concluding insights: We believe that 3D pathology is just around the corner - It has the huge potential to not only augment/improve the current clinical practice centered around 2D examination of human tissue, but also help reveal novel biomarkers for prognosis and therapeutic response.. Harvard Medical School Harvard Data Science Initiative Mass General Brigham Broad Institute

Faisal Mahmood

65,541 次观看 • 2 年前

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Juan Benet

83,578 次观看 • 3 天前

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10,820 次观看 • 17 天前

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Foresight Institute

10,355 次观看 • 7 个月前

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Global Statistics

237,211 次观看 • 1 年前

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Mo Lotfollahi

11,819 次观看 • 5 个月前

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New Crescent Society

16,069 次观看 • 1 年前

🔥👽 This is REALLY good! 👽🔥 "In my view, there absolutely is an adversarial actor in our world. There is a human-engagement program underway. I don't think it's the rainbow that everyone kind of hopes that it is." ~Reed (IMO, Reed Summers is an unsung, VERY important voice in this community, and what he says in this clip, currently, resonates with me in a big way. Take the time to read or watch. Then we have what Ross Coulthart says about the "deliberate lifting of consciousness" and "frequency," which is more on the side of love, light and space brothers. I don't see that right now, and none of my contacts have ever mentioned it. If it's there, maybe its hands are tied with how it can help us?) ~ "Genetic interventions, cultural influence, right? Social engineering. All of these could be at play in a subversive sense. NHI is operating in a strategic silence, in a state of non-disclosure. Intelligence indicates intent, intentful engagement indicates a program. And so what is their program? We talk about the Legacy-human program. What about the non-human program? ~Reed ~ Ross: "I've been told that the United States has developed quite advanced weaponry, particularly plasma-beam technology that might, in part, have been inspired by what they've seen or recovered from non-human technology. I think, also, just to add the concern of NHI with what humanity is doing. There's also a very deliberate lifting of consciousness. And I really am struck by what Chris (Bledsoe - Chris Bledsoe) says about the frequency. This is something that I'm getting from so many people. That the level of intensity of public reporting of their engagement with NHI, of a clear intent by NHI, to essentially give up on governments from ever disclosing. But to raise human consciousness and awareness. "And I think they're doing this, increasingly (laughs), through direct engagement with individuals. I've got many friends and colleagues and people I've interviewed - witnesses - who've had incredible experiences. I've just been recording for a TV show, something that we're doing here in Australia, where people are inviting or summoning the phenomenon. And there seems to be an interest in the phenomenon engaging with humans much, much more overtly. And I do think that stems from a concern about us primitive monkeys playing with matches." (Were they concerned when this abduction-like event allegedly happened to Jim Semivan and his wife? Semivan: "I had a hole in the back of my neck, and my wife...unexplained bleeding for 17 days." Source: Engaging The Phenomenon's interview with Jim ~ Jim Garrison: "But Reid, speak to us about this interplay between malevolence and benevolence." Reed: "Sure, well, and you described, Jim, the first part of my life in which I was focused primarily on supporting my father, Marshall (Vian Summers and The Allies of Humanity), who had direct encounters with NHI, communications with NHI." (Was Marshall really in contact with extraterrestrial intelligence, known as The Allies of Humanity? I don't know. But a lot of what he has said rings true to me. Doesn't mean it's true. Read one transcript I did in 2021: “It’s Probably Not Human” – Elizondo, Blumenthal & The Allies Of Humanity ~ Reed: "And my family felt the full force and impact of what that was like, as well as what comes with it ("it" being his dad's alleged contact with ET intelligence). Which is, what might be called the hitchhiker effect, the anomalous effects that attend those who have been selected by the phenomenon without their understanding or knowing why." (Add another few names to the list of people who have now said they experienced the hitchhiker effect: Jay Stratton, George Knapp, Kelleher, Davis, Bigelow, Brandon Fugal, Thomas Winterton, Semivan, and more. That includes poltergeist-like events, shadow people, orbs, etc.) Reed: ""But my later work is really about assessing intent with a structured framework. I think we need to step back from belief systems, hopeful or fearful interpretations, and lay out the spectrum of possibilities, right? From curiosity on the left, salvation and assistance, even further on the left, to transaction, integration on the right, or even something more hostile. And in the end, intent is all about human outcomes. We can't know their consciousness. The project, in my mind right now, is not, let's set out to understand what they're like, who they are, how they think, how they cognate. That's impossible, in my perspective. But we can assess the real human outcomes that stem from the hazard and the risk and the possible threat of a non-human factor acting upon. Like a forcing, an environmental or evolutionary-forcing upon humanity at a historically-unprecedented time." (From what I have seen, whatever this is, has, overall, NOT helped humanity. If that's happening, it's going on behind the scenes. I know some experiencers report having their lives changed in a positive way, and some say they have been healed of illnesses. But others say their lives have been ruined and they've been hurt, intentionally or not, by coming in close contact with the phenomenon. Also, various people have come down with several auto-immune diseases after close contact, and some of that was detailed in the must-read book, "Skinwalkers at the Pentagon." jakebarber also mentioned that. Is it multiple intelligences with multiple intents, or one intelligence mixing in some positive outcomes as a propaganda effort? We don't know.) Reed: "And there are significant signals and indicators in the history of the phenomenon that give very good anchors for assessing intent, and for going from possibilities to probabilities and ultimately making a starting assessment, which informs the research pathway, which is the other part of my work in supporting the human institute, devising an intelligent, scientific research and investigatory citizen-led effort to uncover the phenomenon, to disclose it, to interrogate its activity, lest we just be interrogated, unknowingly, ourselves. So, a lot of good work to do there." (Interrogate the activity of the phenomenon. I really like that approach. Let's not assume anything.) Reed: "But, in my view, when you look at all that the sensor data has given us, technologically, when you corroborate that with the geographic, circumstantial [and] temporal aspects of how the phenomena appears, who it manifests to, and the considerable problem it presents to the international community and to national laws and frameworks that govern territorial sovereignty, these incursions into sensitive sites and the potential, programmatic engagement with civilians in the form of physical NHI-initiated contact - abductions - it builds a picture. It bounds those possibilities into a zone of probabilities. "And whether it's a transactional presence, whether it's an integrative or one that wants to integrate with humanity, or ultimately replace humanity, I think there are multiple possibilities at play and multiple intents at play. Although, I don't think it's the rainbow that everyone kind of hopes that it is. It's not, everything the Universe has to offer is gonna come all at once, now, and function harmoniously in our skies and oceans. No. The hostile intent will not tolerate a beneficial actor who themselves would have to arm themselves and militarily confront the hostile actor, which we do not see indications of." (My translation: If, there's a benevolent intelligence here that wants to help humanity break free from the chains of an alleged malevolent intelligence that may be using us, the benevolent force would need to somehow arm themselves in order to militarily take on this malevolent force, potentially, defeat them, and rescue us from a bad predicament. And we see no evidence of that.) Reed: "So, you know, we have analogs in our own human history to this, the natives of the new world. They looked out on the quay and they saw the ships, different flags, different vessels, and they assumed it's gotta be either the angels from the spirit realm - it has to comport to our belief system - or a variety of intentions, and we should work with and collaborate. And it may not be that way. "It's not about, it's all hostile or it's all beneficial or benevolent. In my mind, it's exo-systemic. It's an ecosystem arriving on our shores at a specific 20th-century moment in which we have detonated nuclear weapons, we have flashed the Universe with technology capability, and we have triggered an engagement event. This is really what this is. And a program to engage humanity over a longitudinal time period." (I think it was here and intersecting with us a long time before we first detonated our nukes.) Karla Turner: "We know from some of our own research that the abduction phenomenon has affected families going back four generations and that would be around the turn of the century (1900). In my husband's family, his grandmother had an encounter with a non-human entity that led her off into a swampy area where there was a period of missing before she was returned, when she was only five-years old. That was 1903. So if you think it's new and you think it's something the media has spread, you start looking into the cases and find out how far back it's goes in some of these families' generations. I know of an African American family in East Texas that has had it going on since the early 1900s and it's still going on today with that same family. Three to four generations is fairly typical." ~ Reed: "And so, we need to step back and really look at the human project of getting our act together to diplomatically engage now and in the future, to manage the NHI presence internationally, and coordinate responses, lest we divide and conquer ourselves over this issue. And that's where the reframing of disclosure as fundamentally belonging to the human species, being one that should, I think, be framed in first principles - to Karl Nell's point - with a naturalistic framework, a science-informed, data-driven framework. "And with that, we go out into the field and collect evidence on the phenomenon. We go out to where it is interacting with people. That's the key missing data set that would be necessary to inform decision makers." (We had that with AAWSAP and can have it again. Plus, the Vallée/AAWSAP Capella database of approximately 250,000 cases. Using AI and the best human minds on this planet, all of that may inform us of the intent of these alleged NHI actors.) Reed: "In my view, there absolutely is an adversarial actor in our world. There is a human-engagement program underway. And that's not the whole story, but if that is true, that should marshal our human response above all other possibilities, initially, because we may wake up in 30 years and find that we are not the human beings we used to be. Genetic interventions, cultural influence, right? Social engineering. All of these could be at play in a subversive sense." (If it's true, it should be the most important thing for human beings to address, ASAP. We need to find out now.) Reed: "And, you know, NHI is operating in a strategic silence, in a state of non-disclosure. They're operating covertly and selectively with military-defense organizations, internationally, which are already in competition." (I'd like to hear more about the claim that NHI are operating covertly and selectively with military-defense organizations. We've all heard those claims but is there evidence of that?) Reed: "And that, to me, is another one of a number of alarming signals that should just command us to take a cautionary response. And and we've gotta get out there and use the best of science, research and investigation to do reconnaissance - reconnai-science, as I call it, on behalf of the human interest, and not just national interests." Garrison: "Yeah, that's a profound way to put it, Reed. You know that we've triggered an interaction event." Reed: "And so, intelligence indicates intent, intentful engagement indicates a program. And so what is their program? We talk about the Legacy-human program. What about the non-human program? We do not query that nearly as much as we should. And in my view, disclosure. How do we get disclosure moving? If we recenter the controversy not on human actors, human governments, but on the non- human presence itself, that allows the human actors a way to rapidly and catastrophically disclose their involvements, which is what is keeping this back in part. Thank you."

Joe Murgia

66,960 次观看 • 10 个月前

I’m seeing a lot of questions on the launch of China’s Chang’e 6 mission yesterday to get samples - for the first time - from the far side of the moon. We don’t know (afaik) why specifically they’re doing that, but we have a pretty good idea what grand vision China is working towards with their space program. How? From this 2022 video by Chas Freeman (former Assistant Secretary of Defense and Nixon's interpreter during his era-defining 1972 China visit), who imho is undoubtedly one of the most knowledgeable former US officials on China. He says that according to his own discussions with people running China’s space program, they’re following the vision described in the book "The high frontier" by Gerard K. O'Neill, which Freeman says has "become the bible of the Chinese space program". I read the book. So what vision does it describe? The book was written in 1976 by O'Neill who was a professor of physics at Princeton University. He also founded the Space Studies Institute, an organization devoted to funding research into space manufacturing and colonization. In other words, he knew his stuff. The book makes the very fair point that we have massive resource constraints on earth, especially given the growing population. He estimated in 1976 that we should be "about six and a half billion people in the year 2000", and we were 6.114 billion back then so he was pretty prescient. He estimates that these constraints will progressively give rise to more and more social tensions as the growing earth population competes for our limited resources as well as faces global problems like climate change. In his view, dealing with this will either require "an authoritarian regime capable of mounting the immense task of social reorganization needed to escape catastrophe" or, alternatively, “mankind would [need to adopt] a static society [that would be] forced in self-defense to suppress new ideas". The 3rd alternative is of course the colonization of space. The most interesting aspect of the book is that he claims everything he writes is feasible with knowledge and technology that already existed in the late 70s. In short he calls for the establishment of large human habitats in the Earth-Moon system, located at stable Lagrange points ("parking spots" in space where gravity from different spatial bodies cancel each other out). In particular he developed the concept of what's known today as the "O'Neill cylinder" which he says "could support quite easily a population of ten million people, growing its food in agricultural cylinders near but outside the main habitat". Energy-wise, it'd simply make use of solar energy via a system of mirrors. As he describes it: "the concentration of the unvarying, intense sunlight of space by very lightweight, inexpensive mirrors can provide all the energy that industry will ever need [...] at a fraction of a cent per kilowatt-hour". He envisages building these habitats with material from the moon, shot into space via "mass drivers", a form of electromagnetic catapult. Also "the habitats would have artificial gravity similar as that of earth by rotating about twenty-eight times an hour”, but he also envisages low-gravity areas, especially for recreational activities such as swimming pools or dancing representations. To trade with earth, he develops the idea of beaming solar power back to earth via "microwave from solar power stations in orbit". As he describes it "the microwave beam would arrive at Earth with a beam width of about seven kilometers. Its intensity would be modest, less than half that of sunlight. In contrast to sunlight, though, it would be there all the time, even at night or in clouds or rain, and it would be in a form ready for conversion to DC current with a loss of only 10 percent. The areas receiving these beams’ output on Earth would be fenced, and outside the fence the intensity of microwave radiation would be no higher than outside a microwave oven with the door closed. He estimates that if "Satellite Solar Power Stations (SSPS) were to become the sole source of electric energy in the United States in the year 2000, the land area necessary for the SSPS antennas would still be only 0.2 percent of that of the continental United States". In short, the establishment of space colonies could lead to the fulfillment of a good share of Earth's energy needs. Last but not least he describes life in space habitats as better than that of earth, largely thanks to the level of control we'd have over the environment (total climate control which would enable an abundance of food and no natural disaster) as well as unlimited cheap energy. To conclude, Chas Freeman typically really knows his stuff when it comes to China and he’s very intellectually honest (a rare trait among US officials) so I have no doubt he tells the truth when he says the Chinese told him that was the vision. And China famously thinks very big and very long term so it would be quite like them to go for something like this. There are also quite a few tangible signs that China is working towards that vision. See for instance this November 2022 news where “China’s space station will join a project to collect solar power from space and send it to Earth in a high-energy microwave beam”: That’s exactly O’Neill’s vision! Or check this October 2022 news that says China is developing new "electromagnetic sledges" that can propel a carriage weighing a few tonnes to a record speed, with a key application for this being “aerospace”: Remember: O’Neill’s vision is to build his habitats with material from the moon, shot into space via "mass drivers", a form of electromagnetic catapult. So there you go… Or also the fact that the Chinese will build, together with the Russians, a moon base - planned for 2028 - powered by a “space nuclear reactor” that’s already been developed (on Earth) and has passed review by China’s Ministry of Science: The space nuclear reactor can generate 1MW of electricity, enough to power 10 International Space Stations. Enough power, maybe, to undertake mining activity and power an electromagnetic catapult… After visions change, the world changes, so it’s also possible that China’s view on what they want to do has evolved. In any case, Chas Freeman is right that China’s motivation for all its initiatives in space can’t just be to “boldly explore where no-one has been before”, they have to be working towards something. And Freeman is also absolutely right to lament that the U.S. decided to ban any cooperation in space with the Chinese. Those endeavors are something that could have been jointly developed as a multilateral effort to unite us all as a species… Instead China is now forced to go at it alone with Russia and we face a future where our petty divisions on Earth will be carried with us to space…

Arnaud Bertrand

265,181 次观看 • 2 年前

Here's a devlog made by an anonymous Chinese fan replicating the surprisingly brand new technique that I developed for detecting asteroids which wound up being so powerful that it can easily track Stealth Fighters from over 100km away even when it’s only using three $30 webcams as sensors meaning it easily outperforms all modern stealth tracking techniques in precision, range and cost. And while this demo is using optical light, this same technique which I call pixel motion to voxel projection, can be used interchangeably with thermal infrared cameras to work at night and also majorly boosts the effectiveness of radar allowing you to track fighters much more effectively through clouds and over the horizon. This technique will also always eventually give the exact location of the target even if the image is blurry as those blurs will always average out from the different perspectives into revealing the precise location of the target in the voxel grid. There is definitely a Mandela effect with this technique as it feels as though it should already exist, especially because at first as it sounds like it is performing triangulation (which has existed for years and is what we do for mocap and tennis ball tracking). But triangulation is entirely separate to this as triangulations only works if you have already identified where the ball is in a 2D image because you’re able to rely on being able to use at least 2 separate high quality cameras which are much closer to the ball making the ball’s apparent size much much bigger and therefore gives you hundreds of pixels to work with which makes it much easier to use object recognition techniques to recognize where it is in the image aka in 2D and then you’re just using the other cameras view to project out lines which intersect in 3D to find out where the ball is in 3D. The major difference is that pixel motion to voxel projection allows you to find where the object is in 3D without having already found it in 2D which is an unbelievable difference as it allows you to use much lower quality cameras together to accumulate data together into 3D space. If this seem like it doesn’t mean much then what it actually means is that you don’t understand what I’m saying as what I’m saying means a LOT in practical terms as it means you go from having to use an imaging system that has to be able to image the object to the point that it is over a hundred total pixels in surface area to have enough data to recognize it to instead be able to use something that is only images the object to be 1 pixel in surface area and only changes the brightness value by 1 value every now and then. I’d recommend an amazing video by DST studios called “Lowlight cameras can’t defeat stealth” if you want a great video which goes over the difficulty of even using telescopes to recognize stealth fighters and why this is so impressive compared to other techniques and ironically it is what inspired me to realize the asteroid tracker I was working on actually could do this. Which brings me to the point that if this wasn’t a new technique then not only would there be at least one example of an asteroid survey that points distant telescopes at the same place at the same time in order to be able to add the light together to detect asteroids which as I was shocked to learn isn’t a thing despite the fact that it would make detecting asteroids trivial by comparison to modern 2D imaging while also having no impact on the normal scientific operations of those surveys other than small changes to scheduling. But there would also be an example of a drone tracker that uses this instead of using the aforementioned high quality zoomable telescope which has to be able to zoom in close enough to be able to recognize a drone. If you want to tell me that this is something that already exists give me an exact example of a product that uses it, not the general outline of a concept that you think it is, the actual product and then also tell me the asteroid survey that uses distant telescopes that point at the exact same place at the exact same time because I can guarantee that if you google what you think uses this you won’t even find the steps of subtracting the images from each other to get motion and will definitely not get the added step of projecting that motion into a voxel grid (It would blow your mind if you found out how Xbox kinect cameras work.) Also I want to make it clear, I’m not saying you should just use web cams to do this, I’m just using them as an example to show you the power of this in reality you would probably want to use 5 high quality zoomable thermal cameras which pan across the sky in sync with each other which due to using lower frequency are much less prone to the Rayleigh scattering that scatters visible light at 150 or so km away and again, you can also use this to majorly upgrade radar. Pretty much all of the problems you could think of for this are incredibly easy to overcome if you apply even a small amount of brainpower into fixing the problem. And yes, this gives you the exact location down to the meter of whatever you are tracking even if the image is blurry as those blurs will always average out to the exact location down to the meter in the voxel grid. Which is what makes this technique so powerful since the cost of adding each camera to The network grows linearly while the rate at which each camera gives more information grows exponentially due to the increasing unlikeliness of all of them having more movement in the same place. And given the size of the cameras it really wouldn’t be that hard to hide and network these cameras together in other countries and on sea buoys to know where planes are everywhere in the world. Which brings me to the point that I personally really don’t care about the military uses of this technology, if all it could do is precisely track stealth fighters then I wouldn’t have cared enough to work on it, I could have used any of the many other life saving techniques as the subject of the video, stealth fighters just sounds the most clickable and the scale of the problem is more intuitive to most people and if I did use any of those as subjects for the demo it would inevitably result in the stealth fighter technique being figured out anyway and all of the other uses are so useful that I don't think anyone would reasonably complain about the upside. The real purpose of this video is that since this is a new technique that hasn’t been used to detect stealth fighters despite the billions we have spent on that, then what else can you apply this to that could go on to improve billions of people’s lives that you or others are working on. For example this also allows you to majorly improve the effectiveness of cryo electron microscopy and CT scanners. This part also is kind of hard to explain as it also sounds like it exists but again, when you look through all of the places where you think it is being used you will find that it wasn’t. What I’m saying here isn’t that this is a Radon transform or gaussian splat or whatever, I’m saying that this is able to get new information that wasn’t being accessed before due to the added information about depth you get from the correlation of movement between each perspective which adds to the information that you already have. This allows you to directly subtract foreground and background objects as well as noise faster than you would be able to before and works better than super resolution for your images since super resolution won’t remove foreground and background objects like this does and instead just scales up target, foreground and background objects indiscriminately. And while with enough data Radon transforms or other scanning techniques would eventually get you a correct answer this will get you there a lot faster since those are mostly averaging techniques which average out noise whereas this gets you the ability to directly subtract noise. I’m not expecting you to think that this would do anything but if you try it for yourself you will find that it does majorly improve your ability to perform 3d scans. Again, cryo EM is a field where you would expect this technique to exist but when you look through all the papers on the topic there is no mention of tilting the grid slightly in order to be able to change your perspective slightly on the order of the feature size (if you tilt the grid then you only need precision on the order of an arc minute to do this) and doing multiple exposures from multiple different known tilts and then using those difference images to correlate depth from motion. In fact, in cryo EM you would normally want to do the opposite of this and have your exposures all taken from the same grid angle and just use the variations in how many of the same proteins are oriented in order to be able to scan them for a 3D model but this will generate you far more data faster. There is so much information that I can’t really explain in text so if you have any questions such as why this hasn’t been made before then they will most likely be answered in the video I originally posted which I have added to the end of the first Devlog for your convenience. And again, pretty much all of the problems with the technique can be fixed with a little bit of brainpower, in reality you would probably want to use 5 high quality zoomable thermal cameras which pan across the sky in sync with each other which due to using lower frequency are much less prone to the Rayleigh scattering that scatters visible light at 150 or so km away and again, you can also use this to majorly upgrade radar.

ConsistentlyInconsistent

50,799 次观看 • 1 年前

War Diary Day 1,391 Blaise Metreweli, the Chief of Britain's Secret Intelligence Service, sticks it to the Killer in The Kremlin. And all his creepy helpers. I agree with every fucking word. VPDFO! (Transcript of the speech, exactly as it was delivered) 📷 Welcome inside MI6. This iconic building, familiar to movie fans everywhere, is the home of Britain’s foreign intelligence agency. But whilst hundreds of my team pass through the entry pods each day, the truth is that most of our work happens many miles away from this place - out of sight, hidden from the world, undercover, recruiting and running agents who choose to place their trust in us, sharing secrets to make the UK and the world safer. You might pass one of our officers on the street or sit next to them on a plane when you’re about to set off on an adventure of your own, or in a foreign city taking selfies by the sights. Whether it’s in seemingly everyday places, or on the front line embedded with our military, MI6 is there. In my first few weeks, I’ve heard repeatedly that MI6 is trusted and respected globally, two things that we never take for granted. We are seen as a source of hard power, soft influence and rapid innovation. I’ve also heard that people want to believe in MI6. It’s my job to make sure they can. Today, I want to talk about human agency. We all have choices to make about how we deal with the undercurrents shaping our world. About how, in our new, faster, more dangerous and technology-mediated world, it will be our rediscovery of our shared humanity, our ability to listen, and our courage that will determine how our future unfolds. Conflict is not inevitable. Understanding human nature is in my bones. From a family shaped by devastating conflict, I grew up with a deep sense of gratitude for the UK’s precious democracy and freedom. I spent much of my childhood overseas, which is where my passion for travel and adventure began. I studied anthropology, and later psychology and AI, exploring how we make sense of the world and each other. It’s why I was drawn to MI6: it offers strong purpose, a chance to serve and a belief in the positive power of human connection. Like the Service, I’m operational to my very core. Over nearly three decades, my career has involved recruiting and running agents in hostile territory; and leading operations in warzones to defuse threats and support peace. Always in teams, always learning from others. Over the years, I’ve worked with hundreds of brilliant partners – and indeed occasionally those we’d label as adversaries – across dozens of countries, tackling weapons proliferation and terrorism. During my time at MI5, I saw close up what it takes to defend Britain from being targeted by hostile states. You’ll find many like me in my organisation: powerfully motivated to protect our precious country; curious about how our world is changing, joining dots and taking action, across domains. But it was in my last role as ‘Q’, where it was my job to turn emerging technologies from threats to opportunities that I could most see the world changing. As I dug deep into data and extraordinary innovation, I could see how technology was rapidly reshaping not just our capabilities but also conflict and trust, truth and global power. Let me lay out how I see the global issues MI6 must tackle. Because the greatest danger we face is to misunderstand the nature of the problem. Let’s be in no doubt. Our world is more dangerous and contested now than it has been for decades. Conflict is evolving and trust eroding, just as new technologies spur both competition and dependence. We are being contested from sea to space, from the battlefield to the boardroom. And even our brains, as disinformation manipulates our understanding of each other and ourselves. Across the globe, we are now confronting not one single danger, but an interlocking web of security challenges – military, technological, social, ethical even – each shaping the other in complex ways. We are now operating in a space between peace and war. This is not a temporary state or a gradual, inevitable evolution. Our world is being actively remade, with profound implications for national and international security. Institutions which were designed in the ashes of the Second World War are being challenged. New blocs and identities forming and alliances reshaping. Multipolar competition in tension with multilateral cooperation. But there’s something distinctive that will make this change unlike any other: the impact of advanced technologies, which will accelerate the pace and scale of every threat and opportunity, and increasingly, individualise them too. Advances in artificial intelligence, biotechnology, and quantum computing are not only revolutionising economies but rewriting the reality of conflict, as they ‘converge’ to create science-fiction-like tools. There’s incredible promise in all this for all of us, from green technologies to hyper-personalised medicine. But also peril. AI-powered robots and drones are brilliant for scaled manufacturing but devastating on the battlefield. Discoveries that cure disease can also create new weapons. And as states race for tech supremacy, or as some algorithms become as powerful as states, those hyper-personalised tools could become a new vector for conflict and control. Power itself is becoming more diffuse, more unpredictable as control over these technologies is shifting from states to corporations, and sometimes to individuals. And at the same time, the foundations of trust in our societies are eroding. Information, once a unifying force, is increasingly weaponised. Falsehood spreads faster than fact, dividing communities and distorting reality. We live in an age of hyper-connection yet profound isolation. The algorithms flatter our biases and fracture our public squares. And as trust collapses, so does our shared sense of truth – one of the greatest losses a society can suffer. The defining challenge of the twenty-first century is not simply who wields the most powerful technologies, but who guides them with the greatest wisdom. Our security, our prosperity, and our humanity depend on it. Our world is being remade. And for the first time, we are all at the heart of it. My Service must now operate in this new context too: not just expert on hostile states, terrorism, proliferation and more, but also fluent in technology, able to anticipate the second and third order effects of advances that reshape the world in minutes not months. And as China will be a central part of the global transformation taking place this century, it is essential that we, as MI6, continue to inform the government’s understanding of China’s rise and the implications for UK national security. I’m going to break with tradition and won’t give you a global threat tour, but will focus here on Putin’s Russia. We all continue to face the menace of an aggressive, expansionist and revisionist Russia, seeking to subjugate Ukraine and harass NATO. I find it harrowing that hundreds of thousands have died, with the toll mounting every day, because of Putin’s historical distortions and his compromised desire for respect. He is dragging out negotiations and shifting the cost of war onto his own population. But Putin should be in no doubt, our support is enduring. The pressure we apply on Ukraine’s behalf will be sustained. Because it is fundamental not just to European sovereignty and security but to global stability. Alongside the grinding war, Russia is testing us in the grey zone with tactics that are just below the threshold of war. It’s important to understand their attempts to bully, fearmonger and manipulate, because it affects us all. I am talking about: Cyberattacks on critical infrastructure. Drones buzzing airports and bases. Aggressive activity in our seas, above and below the waves. State-sponsored arson and sabotage. Propaganda and influence operations that crack open and exploit fractures within societies. Countering this activity is the work of intelligence and security services across Europe and the globe. And as the Foreign Secretary made clear in a speech last week, the UK is defending itself against this Russian information warfare – sanctioning Russian media outlets pushing Kremlin narratives. The export of chaos is a feature not a bug in this Russian approach to international engagement; and we should be ready for this to continue until Putin is forced to change his calculus. So, how should we respond? It’s not enough now just to understand the world. We must shape it too. MI6 is well-positioned to respond to these threats and wider global instability. And we will continue to evolve, just as we have throughout our long history. The UK government has invested in our intelligence agencies and we are all using our unique powers to keep the British people safe. Our ‘open and connected’ partnerships across the UK Intelligence Community, with HMGCC, NSSIF and the wider tech ecosystem in the UK will become even more important – because in the digital battleground, no single organisation can prevail alone. As a global agency, MI6’s inbuilt strength is our partners and our people. The risks I have set out require us to work ever more closely with our colleagues in MI5, GCHQ and in defence and diplomacy. But also with our Five Eyes partners, with the E3, the EU, NATO, those across the Middle East, the Indo-Pacific and beyond. And with many valued partners whose identity needs to remain secret. Together, we integrate our diverse talent, data and tools to meet the threat. AI is a domain in which we will excel, using the technology to augment, not replace, our human skills. Every digital trace, every byte of data, every algorithmic decision has implications for the safety of the lives of the courageous people who work with us as officers and agents, and for the UK’s strategic advantage. Mastery of technology will infuse everything we do. Not just in our labs, but in the field, in our tradecraft, and even more importantly, in the mindset of every officer. We will become as comfortable with lines of code as we are with human sources, as fluent in Python as we are in multiple other languages. Under my leadership, MI6 will continue to attract Britain’s best and most creative minds: linguists and data scientists, case officers and engineers, behavioural experts and technologists. We need people who walk in the shoes and get in the heads of our adversaries. We need people who think differently, challenge assumptions, and act decisively. All can thrive and make a difference at MI6. At an operational level, we will sharpen our edge and impact with audacity, tapping into – if you like – our historical SOE instincts. We’re at our best when we’re hustling to make things happen, because our intelligence is most valuable when it changes reality on the ground. We will take calculated risks, where the prize is significant and the national interest clear. We will never stoop to the tactics of our opponents. But we must seek to outplay them. In every domain. In every way. So intelligence must drive action. Action must deliver advantage. And advantage must serve Britain’s security and prosperity. But at the core, our deeper contribution is also our simplest – how we unlock human agency. Our fast-paced, tech and threat-infused world now generates more heat than light. As nations retrench and rearm, we are losing opportunities to listen to what’s really going on. I’ve seen time and again throughout my career, that this is where MI6 matters most: we listen and we hear. We understand, because we take time to learn languages and cultures, complex technical and historical detail, immerse ourselves in what’s really driving the situation. Across the globe, right now, our officers are finding people with the courage to step forward, and they are taking time to sit and listen to break these tightening cycles of violence. They listen for nuance, for connection, for opportunity. Over the years, I’ve listened to terrorists who have told us how to defuse the bomb because they know that more violence won’t help. To proliferators and smugglers who’ve told us where to find the dangerous material, motivated to protect their children’s future. To people trapped in authoritarian regimes who know, deep down, that their humanity is being chipped away – and that telling us what’s really going on is an important release, allowing us all to find better ways to navigate our changing world. So, we will work with our agents. And we will continue to engage directly, and with respect, with states and organisation currently working against us. Away from the glare of the media, we will use MI6’s convening power wherever we can to make a material difference, bringing parties together to defuse tensions. But the response to the increasing risks we face won’t be delivered by the UK intelligence community alone. Wider society has a role to play too. That includes work taking place in schools across the country so our children don’t get duped by information manipulation. Let’s all check sources, consider evidence, and be alive to those algorithms that trigger intense reactions, like fear. It also means everyone in society really understanding the world we are in – a world where terrorists plot against us, where our enemies fearmonger, bully and manipulate, and the front line is everywhere. Online, on our streets, in our supply chains, in the minds and on the screens of our citizens. We must all stand together against this. As we do today with our friends in Australia after the shocking antisemitic terrorist attack this weekend. My thoughts -and those of my whole organisation – are with the family, friends and loved ones of the victims. Light will always win over darkness. In rising to meet these challenges we, in MI6, will remain anchored to our values: courage, creativity, respect and integrity. And to our principles: accountability and trust are not constraints on our work; they are the foundations of our legitimacy with the British public. Recently, I had the privilege of meeting and thanking a foreign agent who has worked with us for decades, taking extraordinary risks to help keep the UK safe. I asked why. They said simply, ‘Your values. Your integrity and respect. None of us have a future without them’. This moment reinforced to me that we must remain a very human agency. And so, to sustain that trust, MI6 will continue to be more open. Not for the sake of visibility, but because it matters – and as my MI5 counterpart Sir Ken McCallum said recently - because it is a strength. We will continue the practice of speaking publicly, broaden our channels of engagement, and sustain our focus on attracting the most diverse talent to join our Service. Transparency does not mean revealing what must remain secret. It means showing the British people who we are, what we stand for, and why our work matters. We need your trust and support for the difficult and often dangerous work our agents pursue, every day of the year. In an age of uncertainty, one constant remains: the choices made by human beings still determine the shape of the world. Yes, technology can illuminate possibilities: but information requires judgement; complexity demands clarity; and only people can decide which path to follow. The United Kingdom’s global voice has never rested solely on strength – it has rested on trust, principle, and the ability to understand others as well as ourselves. That is also the essence of intelligence: not simply knowing the world, but interpreting it through a uniquely human lens. Ours is the quiet service, the hidden service. It is one rooted in a profound belief that when human beings act with purpose and integrity, they can steady a faltering world. When the Berlin Wall fell, it was our shared belief in freedom that carried Europe forward. When acts of terror targeted open societies, it was intelligence, cooperation and resolve that preserved them. And when adversaries blur fact and falsehood, our task is to defend the space where truth can still stand. As we step into the future, the tools at our disposal will evolve. But what will always matter most is the human element – the person who stands in the shadows and says: this is right, and that is wrong. That choice – the exercise of human agency – has shaped our world before, and it will shape it again. Because in the end, it is not what we can do that defines us, but what we choose to do. Thank you. Published 15 December 2025

John Sweeney

42,257 次观看 • 8 个月前

The US is well advanced in preparations for a war on China. Here are 28 steps taken. Bookmark this, and please add others. 1. BATAN: The US quietly carried out a major operation last summer to deepen the harbour on the island of Batan, south of Taiwan—so that warships can use it on their way to the China coast. 2. LANDING STRIPS: A US team has compiled a list of long flat areas in Asia that can be used as aircraft runways for use in launching fighter jets to bomb China. 3. PRACTICE RUNS: US troops held exercises specifically preparing for an invasion of China last year with armies from Japan, Australia, and Indonesia. 4. TAIWAN TRAINING: The US military landed troops in Taiwan secretly to train soldiers---and they are now learning how to attack amphibious vehicles. 5. TROOPS IN PLACE. More than 100,000 US troops have already been assigned to what the US calls the "Pacific Theatre". 6. SHIFTING SUBS: The US has told Australia that its subs may not be delivered in time (or ever) because all attack subs will be needed close to China. 7. FLOATING ARMS DEPOTS: The US admits it has placed vast amounts of ready-to-grab weapons in places such as Taiwan. 8. DIVISION OF LABOR: Europe has already been told to replace all US troops and weapons in their own parts of the world with local equivalents, so that US troops and hardware can head to China. 9. FIRST WAVE: The first wave of fighters will be Taiwanese using the "proxy war" model to keep actual Americans at a safe distance, as specified in US strategy books. 10. DISINFORMATION: The Pentagon has set up a division called Perception Management to tell the public that China is an expansionist military power, not the USA. Mainstream media is hiding the fact that Taiwan is legally part of China and instead reporting that China "claims" Taiwan. 11. CONFLICT CREATION: The Philippines under new pro-Washington leader President Ferdinand Marcos Jr. has been working hard already for months to create conflicts in the seas. (Video includes specialist analysis of a ship-to-ship dispute.) 12. NINE BASES: Large sums of money have been paid in the Philippines so that it now hosts NINE China-facing bases. 13. OKINAWA: The US has quietly abandoned its 12-yr-old plan to reduce the number of troops in Okinawa. 14. CAMP SCHWAB: Nearby, a landfill bigger than the entire Pentagon will house US helicopters and Osprey rotating-rotor airplanes for use in attacking China. 15. PNG PROBLEMS: The US flew in to PNG to buy the use of three airports, two ports and one naval base, and are renovating a military base on the island to the north. 16. COMMS JAM: Electronic magnetic pulse weapons will be employed to jam communications in China. 17. VANISHING GPS: The US will weaponize the GPS system to force the Chinese to use their much younger homemade system. 18. BANKING ON TROUBLE: The world's main money transfer system, called SWIFT, will be instructed to allow no money into or out of China. 19. DOORSTEP DELIVERY: Standing by in the Pacific right now are special ships [image supplied] which beach themselves on enemy land to discharge 900 tons of attack forces. 20. DANGER FROM THE SKIES: Army paratroopers have recently been training in Hawaii for a mission that would see them ready to land in rural areas outside Chinese cities. 21. STAR WARS: The Pentagon has a special division working specifically on how to attack China from space. 22. SEAPATHS BLOCKED: The US plans a blockade of everything that could go in and out of China by sea by using what they call The First Island Chain and The Second Island Chain—basically friends that Washington has bought and paid for. 23. LAWFARE: Acts will be passed in the US demanding that the whole world boycotts China, exactly as the US did with Russia three years ago. 24. BLACK OPS: The US has been quietly penetrating parts of China with trained troublemakers, as they did in Hong Kong. These people will trigger street battles which the western media will portray as "pro-democracy" protests. CIA and US army intelligence groups will conduct "black ops" inside China in a bid to create chaos. 25. DRONES: The US has a long record of successfully using killer drones. The new generation ones, still under wraps, have AI built in so they can kill people without human help. 26. AIRSTRIKES: The US is currently letting its F-35 pilots practice dropping "bunker buster" bombs on Yemen—these bombs can go through 20 feet of solid rock to kill people hiding in shelters—and are preparing to target China. 27. CASH THEFT: Political leaders in the US and the UK and European nations have already said that they consider themselves entitled to freeze, take, and spend the assets of countries they judge to have behaved aggressively. 28. TECH BROS: The Pentagon has a division that monitors all major tech companies to pull them as needed into the war effort—and they won't be given a choice. .

Nury Vittachi

715,443 次观看 • 1 年前

👽 Minimal, Firsthand Legacy Witnesses? 👽 (Sorry for the Debbie Downer posts but I think most people wanna hear the truth and not have smoke blown up their ass. We're all aware of folks who do that. Maybe...in the Senate, "we have a problem that there's not been quite enough of what members in the Senate would say are firsthand sources with direct involvement in the Legacy program." ~Former Senate Staffer, Kirk McConnell (In August 2024, I was told the following by a contact: "I don’t think firsthand whistleblowers are on our horizon. Tons of credible sounding second hand, though. Some with decent credentials or rank, but none with particularly great (credentials or rank), however." I shared that on here but most people didn't wanna hear it. I'm lucky to have contacts who give it to me straight, with zero hype. Some hope? "I don't think that we have to be so discouraged by the defeat of the UAPDA for the third time." ~McConnell ~~~ Kirk McConnell: "First, let me say that I'm greatly encouraged by Mr. Rep. Eric Burlison comments. He's a he's a politician. He has a way better sense of, you know, having his finger on the pulse of the Congress and the nation than I do. "I will also say that I, respectfully, don't agree with my friend Karl Nell. I don't think that we have to be so discouraged by the defeat of the UAPDA for the third time. I think there's a lot of reasons for hope that this issue, is not gonna be in a significant down cycle. And that's what I certainly hope. As we've seen from Mr. Burlison, there is certainly a lot of energy in the house among members of the Oversight Committee, and that in itself is encouraging. "You know, I hope that what I'm about to say is not true, but I think it might be, and I definitely feel that this is maybe the case in the Senate: That maybe we have a problem that there's not been quite enough of what members in the Senate would say are firsthand sources with direct involvement in the Legacy program. Looking back on history, my sense is that Congress undertakes these really historically important investigations when it is broadly clear that there's a there there and they know kind of what the outcome [will] be, at least in its broad strokes. "You know, you think about Watergate, the Church/Pike committees, Iran Contra, all of these are examples where Congress was finally moved to not take no for an answer and to just go full-speed and full-depth into exhaustive investigations when they knew that it had to be done, and that there was a pony at the end, you know, there was something very significant at the end of the process. "So, I have been getting this feedback as well from folks I've worked with in the Senate, that there needs to be more firsthand witnesses. And how do you encourage that? I think we also hear that there's quite a number of other people out there that could come forward. Their concern, though, is, as we've seen, they feel that there's not, by any means, sufficient whistleblower protections, and that despite the existence of protections in the law on paper, that really doesn't get at the problem. And that they're fearful of losing their careers, their security clearances, which translates into their careers, and that they're gonna suffer immense, legal expenses and perhaps legal jeopardy. So I think whistleblower protection is extremely important. "That said, it's really hard to get whistleblower protections passed in Congress. And so you have a kind of Catch-22, and I think that's the kind of problem that needs to be overcome, incrementally. So, I also would say that it's obvious that Congress is heavily influenced by public opinion, of course, and it's really important to keep up the pressure. But that in turn, you know, the public is motivated by what they see in the news and what they hear about from from experts, and therefore, you know, that's another dependency here, "But on that score, you know one of our panelists here, Dr. Anna Brady-Estevez, I loved when she, with a bright smile on her face, has said repeatedly that, in a sense, disclosure has already happened, or is certainly happening. A significant fraction of the population believes that we are being visited by non-human intelligence and that this belief is only likely to grow. The scientific community is much more friendly to this issue than in the past. "I would also say that the NHI itself gets a vote here, and they drive a lot of this. How much interaction are they going to....how much are they going to expose what they're doing and what they're doing here? And yet, at the same time, we've got an awful lot of people out there now with the ability to, and the interest in, detecting and tracking and trying to document what is happening out there. You think about efforts like the Galileo Project, Garry P. Nolan at the The Sol Foundation and Stanford, Beatriz Villarroel and the astrophysics community, and many others are tracking fundamental aspects of this problem. And a number of scientists and engineers working on new physics concepts to explain UAP characteristics and behavior is unprecedented. You know, you think about Skywatcher as another example of a private initiative. "There's also the experiencer community, you know, the people who have had actual direct interactions, and certainly a large number of folks who report abduction experiences, who retain the ability to communicate with NHI. This can be used, and is very likely to be used or exploited to gain insight into physics and intentions and so forth. "So, I'm actually on the optimistic side. I think with work and perseverance of groups like this, we can continue to amp up the interest and the pressure on the part of the American people, and that will translate into action by the government."

Joe Murgia

38,924 次观看 • 10 个月前

TRUMP, THE ANTIKRYST? Pt 1 (Update 12/14/24) On 8/28/24 Donald Trump posts this video of a cross. What does that really mean, and why at exactly 11:11? Does anyone understand what the cross really is? It's an unfolded tesseract, also known as Metatron's Hypercube. Who is Metatron? It is one of Thoth's many names across the ages. He was also known as Hermes, son/daughter of Enki Lucifer. And while I've never had it explained to me in absolute detail, there is reason to believe this Anunnaki shape-shifting hybrid could be one and the same as Marduk Lucifer Satain. An awful lot of water has gone under this bridge since the Leviathans arrived 798k years ago, so each of the Babylonian fake gods could have thousands of different personas and names by this time. In any case, Marduk appears to be the leviathan that keeps reincarnating over and over as the savior of mankind. His/her most recent being the 'jesus' character that poses as if being Jesheua Sananda Melchizedek that is one of the guardian alliance team who came to restore the purity of the bloodline of the Human Elohim development that are in captivity here in the Tara earth simulation, and really could walk on water. Identity theft is always the middle names of all your captors. It is what they do to maintain control over the sheep. Like I've said countless times now, Sananda is not 'god' anymore than you are. He is not a savior of mankind, he is here on mission to help your avatar's vibration reach sympathetic harmonic resonance with the 4th dimension to help you escape. By having children with human females carrying very pure human DNA, those children will multiply and raise the vibration of the plane, making your chances that much better to make this ascension happening now. We do not worship Sananda, and unless you like playing subservient to others, you won't either. He is still here, and so are your captors. The ancient false gods of Babylon never left. They just keep taking different forms under different names, hiding in plain sight. They have MANY bodies here. Some are identical to each other, some look totally different. I know because I've met them and had them explain to me who they were in ancient times and what really happened that is totally unlike the his-story you've been told. Sometimes they allow you to know who they really are, such as they did in Babylon, but most of the time they're posing as regular people, just like you, so they can infiltrate human spaces, rise to positions of great influence and steer the masses. Who is Donald Trump? Do you know anyone alive who is more adored, more worshipped, more feared than the Donald? No. He's the most famous person alive. And why is that? Because he's the most perfect person on the plane? Hardly. He's also famous for grabbing women by the pussy. It is because he's using psychological manipulation he knows at a master-class level because he has unbroken recollection of his time across hundreds of thousands of lives. So his mental 'magic' is simply knowledge and wisdom humans could never possibly even understand, much less duplicate. It is a form of very powerful hypnosis. There is overwhelming evidence now that Trump is considered the king of earth as you will see in the masterpiece film by Good Lion Films. His 'capitulation tour' (THE GREATEST SHOW ON EARTH) in 2017-18 made it clear he's the one in charge. THE GREATEST SHOW ON EARTH Video: 👉 Not just this, but Trump was officially crowned the 'Messiah of Jerusalem' they had been waiting to return for thousands of years. That's right, this really happened. He is 'ben David' (son of King David). Something I know a bit about, since that's my avatar's bloodline I'm in here for mission reasons that has to do with the Co-Evolution BioRegenesis Treaty that gives 'J3wish' people a mechanism for ascension. [For more see my article: 👉 THE TWO CHRISTS] Trump, Messiah of Jerusalem Video: 👉 Trump is also a time traveler. Believe or don't believe, but I now have far more than just a few examples that prove this to be fact. He also has multiple other bodies he uses at the golf course, at rallies, and Mar-a-Lago that are clearly different weights, heights, ages. Here is one that is much older than the ones we see in the spotlight. Who has the technology to do all these things? The Anunnaki. Word has it that Trump has been working with the Anuhazi Elohim during his entry into politics. I would suggest he's been working with them for 798k years. They are known as the fallen angels, the original captors of this simulation. All the invader races (over 50 species) have been working together as a single team to enslave humankind since the hostage began over 1/2 billion years ago. I don't profess to know who each of these actors really were in the last drama, or Babylon, Greece, Rome and countless other eras, since, as mentioned, it is a 560 million year story involving quadrillions of events and dramas, but you likely understand what I'm trying to say is we're dealing directly with ancient gods here, not 'business men' or 'politicians'. These people held lightning in their hands last time they decided to let us see them for who they really are. Thoth could literally fly when he was using the name Hermes and there's no question he still can. As briefly reference above, the cross he released this morning is secretly the Nibiru Scalar Vibrational Mechanics platform called a tesseract or hypercube, in unwrapped form. If you fold it back into a 6-sided cube again, you're seeing the shape of the device that powers our counterfeit hologram. You will come to learn at some point that every geometric shape is an operating system, not just a form, called the Platonic Solids in science. Which is why grown men pilgrimage to Mecca to walk around the Kaaba, wearing a little black cube on their forehead. So don't think the cube cross is only worshipped in America. Metatron's Hypercube is used at CERN known as ALICE that keeps you inside an artificial reality called the 'Beyond The Looking Glass Chimera Reality Simulation'. Typically you'll hear the keeper refer to it as the Chimera Reality for short. All down through your current history, the cross has stood for purity, perfection, and hope that one day the savior would return and usher in a utopia, when in truth, it was the very symbol of your eternal enslavement. They keep rolling out this same savior trope, civilization after civilization, always with a different face of the program, but always the same hope. Hope, by the way, is a weaponized spell that was designed to keep you perpetually in bondage and trudging forward like a good little slave, doing your job because 'one day he will return and THEN by golly, he'll save us all'. These are all the same guy/girl. When Sananda (I'm not talking about the fake jesus here) said 'come out of her my peoples', he meant stop falling in line with the prison machine you're trapped in. Stop acquiescing to your own enslavement. I was told in person that humans 'have to rise up and take their world back or they will never move forward'. It means letting go of fear and stand up for what is right. Enslavement of any kind, is not that. The great deceiver will fool 'even the elect' is not a fictional claim in the M@sonic bible for entertainment. They have to tell you what they're doing in order to have you cast that reality they want to play out in your world. The person who wrote the bible also wrote demonology. [For more on this subject see my article 👉 THE SCIENCE OF PREDICTIVE PROGRAMMING and the 2ND COMING] Why would that be? Because the bible is the most elaborate talisman on earth that hypnotizes those who read it, enslaving their minds to passively accept the chimera reality, so when the simulation glitches, you will second guess yourself instead of the holographic world around you. "Did I just see a bird in the sky not flapping its wings and remaining perfectly still? Of course not, that's preposterous." ‘Mithra the Savior’ was gifted to T-Amerikaans (America) by Frédéric Auguste Bartholdi of France in 1886. Freddy was a 33rd degree (master) Freem@son and you now call Mithra your 'Statue of Liberty'. She is literally the symbol of this nation and is making her second coming at the time when the economy has been utterly destroyed, your politics have been weaponized against you, your courts have been utterly corrupted, your people have been openly attacked with bioweapons, your country flooded with 20m illegal aliens and your police have been defunded & refuse to arrest criminals. All by design and deliberately manufactured. Albert Pike, 33rd degree (master) Freemason stated: "Whenever the people need a hero, we'll supply him." Almost as if Freem@sons plan TO role out some very hard times to achieve a certain agenda. Oh, that's right, Pike also stated this: “We shall unleash the nihilists and the atheists and we shall provoke a great social cataclysm which in all its horror will show clearly to all nations the effect of absolute atheism; the origins of savagery and of most bloody turmoil. Then everywhere, the people will be forced to defend themselves against the world minority of the world revolutionaries and will exterminate those destroyers of civilization and the multitudes disillusioned with Christianity whose spirits will be from that moment without direction and leadership and anxious for an ideal, but without knowledge where to send its adoration, will receive the true light through the universal manifestation of the pure doctrine of Lucifer brought finally out into public view. A manifestation which will result from a general reactionary movement which will follow the destruction of Christianity and Atheism; both conquered and exterminated at the same time.” Sound familiar? If I were going to infiltrate a world & pose as the savior of the peoples that would be allowed to take the last tiny bits of freedom from them in return for pulling them out of a hellscape, I would first reduce them all to the most quivering and broken mess possible just shy of their death, and arrive like a knight in shining armor. Think a hundred-vehicle motorcade, 500 special-ops swat team & my own rolling hospital. When Trump had to go to court in New York it cost them something like $25m to lock down the city for 1 appearance. Nothing gets more high-profile than that anywhere. You've been under predictive programming since the day you were born for this time when the 'antichrist' would appear (that would 'loose his demons' and tear the world asunder), and also for the 2nd coming to 'save humanity' at the same time. But what you weren't told is these will secretly be the same person. Of course everyone will think it was "Barack" who brought about the destruction because Dolores Cannon alluded to it, but who is actually 'showing you a movie' right now while secretly holding the office of CIC and allowing millions of aliens across the border? Because he's your real border czar. This is Armageddon, you're in the 'little season of satan' (Satain). The 1000 years of heaven-like reign ended around 1893, and your entire life has been inside of what you could call hell, where you are literally surrounded by demons you believe are human because they look like you. You know more demons than you do humans. This is actual reality, not fiction. Take at look at Not Op Cue's article on the heavenly heritage of Trump, suggesting why he is the reincarnation of jesus. The evidence is overwhelming. The Lincoln Kahlooni Druze Minority Bloodline: The Jesus Strand Video 👉 11:11 I had just flown in from half way across the world to meet up with the keeper of the Tara earth simulation for a mission that would involve some of the most astonishing things I would ever live to see in this life. It was getting late and we were talking in a dark, cramped trailer that the keeper and crew had been reduced down to, illuminated only be a couple of small candles. They had been trapped in an area where they were not allowed to escape from by the Anunnaki hybrids. The dark agencies had frozen their bank accounts, forced them out of their compound and left them homeless for the past few years, on the run daily. My mission was to escort them away from that area to a safe space, as the others who had tried to break them free previously had been maimed and even killed. It took 2 years to pull off, 7 months of which living in a car, but the mission was successful. [That's a story for another time, when I am allowed to talk about it. It involved crazy metaphysical anomalies, black helos, giant venomous snakes (I know that sounds crazy, but the whole thing was way crazier than just that), a cross-leyline vortex acting as protection at the safe house we directly on top of, massive aerial DEW attack, fire tornadoes and 'celestial' escorts. None of this is fiction, just to be totally clear.] I was extremely interested in duplicate numbers on my clocks I was seeing 2-3x everyday and wanted to know what they meant. As the words were coming out of my mouth about this, in the relative darkness suddenly my phone lit up all by itself for no reason with the time in large numbers at 11:11pm, apparently to prove to the keeper I wasn't making this phenomenon up. What is that? I was told duplicate numbers are a distraction, to not give them mind, as it is just numerology the system uses in what I took to mean it is part of the complex mechanism of our simulation that hypnotizes us to keep us from being clear and aware to decipher the holographic illusion around us. The more awake we are, the more the system will flash out 3:33 or 11:11 to put you back to sleep by distracting you from the moment that is taking place in front of you. Such as when the most heralded man in the world shares a video depicting a giant cross which insinuates the 2nd coming of the christ (the Kryst or Krystos, is the series title of the Human Elohim eternal-life bloodline and is not 'a guy'). Discernment is more critical now than any other time since you were born. Pay attention, keep your vibration high and know that the next step is you moving on to the next level of the simulation where Lucifer and Satain will no longer be part of your world. This is but a short time to test which path you want to take moving forward is all. It is the 'sifting' phase of humanity at the end of the final long-cycle of human evolution. If you resonate in fear, hate, anger, you lose. React in love, appreciation, kindness and compassion and never give in to the devolution. You can do this. See my article 👉 THE WORLD TOMORROW for more on what to expect moving forward into your next experience. And yes, you always move on to a new experience, because you're an eternal spirit essence having a human experience in this one drama. The dramas never run out or get too boring, because there are trillions of ways to stage 'living a mortal life'. For more on the separation, see my articles: 👉THE SEPARATION 👉DESTINATIONS AFTER THE SEPARATION 👉THE SURGICAL SEPARATION OF THE 2 PLANES See the second part to this thread in my article: 👉TRUMP, THE ANTIKRYST PT 2 On X, to search for my articles, simply type in the name of the piece, enter one space, then from: & my username in parenthesis such as shown here: THE HISTORY OF THE CHIMERA PT 1 (from:iontecs_pemf) Off-site, you can look up any of my writings through this link below for my other more than 100 recent articles and many thousands of comments on X, regularly updated thanks to Justin This message will only be seen by your eyes if not shared, and if you want to reference this article again later, you will need to cut and paste it in your own notes off line, as it will surely be erased. This is the most accurate translation of these events I am aware of at this time.

W.R. Schock, QBD

130,789 次观看 • 1 年前

TRUMP, THE ANTIKRYST? On 8/28/24 Donald Trump posts this video of a cross. What does that really mean, and why at exactly 11:11? Does anyone understand what the cross really is? It's an unfolded tesseract, also known as Metatron's Hypercube. Who is Metatron? It is one of Thoth's many names across the ages. He was also known as Hermes, son/daughter of Enki Lucifer. And while I've never had it explained to me in absolute detail, there is reason to believe this Anunnaki shape-shifting hybrid could be one and the same as Marduk Lucifer Satain. An awful lot of water has gone under this bridge since the Leviathans arrived 798k years ago, so each of the Babylonian fake gods could have thousands of different personas and names by this time. In any case, Marduk appears to be the leviathan that keeps reincarnating over and over as the savior of mankind. His/her most recent being the 'jesus' character that poses as if being Jesheua Sananda Melchizedek that is one of the guardian alliance team who came to restore the purity of the bloodline of the Human Elohim development that are in captivity here in the Tara earth simulation, and really could walk on water. Identity theft is always the middle names of all your captors. It is what they do to maintain control over the sheep. Like I've said countless times now, Sananda is not 'god' anymore than you are. He is not a savior of mankind, he is here on mission to help your avatar's vibration reach sympathetic harmonic resonance with the 4th dimension to help you escape. By having children with human females carrying very pure human DNA, those children will multiply and raise the vibration of the plane, making your chances that much better to make this ascension happening now. We do not worship Sananda, and unless you like playing subservient to others, you won't either. He is still here, and so are your captors. The ancient false gods of Babylon never left. They just keep taking different forms under different names, hiding in plain sight. They have MANY bodies here. Some are identical to each other, some look totally different. I know because I've met them and had them explain to me who they were in ancient times and what really happened that is totally unlike the his-story you've been told. Sometimes they allow you to know who they really are, such as they did in Babylon, but most of the time they're posing as regular people, just like you, so they can infiltrate human spaces, rise to positions of great influence and steer the masses. Who is Donald Trump? Do you know anyone alive who is more adored, more worshipped, more feared than the Donald? No. He's the most famous person alive. And why is that? Because he's the most perfect person on the plane? Hardly. He's also famous for grabbing women by the pussy. It is because he's using psychological manipulation he knows at a master-class level because he has unbroken recollection of his time across hundreds of thousands of lives. So his mental 'magic' is simply knowledge and wisdom humans could never possibly even understand, much less duplicate. It is a form of very powerful hypnosis. There is overwhelming evidence now that Trump is considered the king of earth as you will see in the masterpiece film by Good Lion Films. His 'capitulation tour' in 2017-18 made it clear he's the one in charge. 👉 Not just this, but Trump was officially crowned the 'Messiah of Jerusalem' they had been waiting to return for thousands of years. That's right, this really happened. He is 'ben David' (son of King David). Something I know a bit about, since that's my avatar's bloodline I'm in here for mission reasons that has to do with the Co-Evolution BioRegenesis Treaty that gives 'J3wish' people a mechanism for ascension. [For more see my article: THE TWO CHRISTS] 👉 Trump is also a time traveler. Believe or don't believe, but I now have far more than just a few examples that prove this to be fact. He also has multiple other bodies he uses at the golf course, at rallies, and Mar-a-Lago that are clearly different weights, heights, ages. Here is one that is much older than the ones we see in the spotlight. Who has the technology to do all these things? The Anunnaki. Word has it that Trump has been working with the Anuhazi Elohim during his entry into politics. I would suggest he's been working with them for 798k years. They are known as the fallen angels, the original captors of this simulation. All the invader races (over 50 species) have been working together as a single team to enslave humankind since the hostage began over 1/2 billion years ago. I don't profess to know who each of these actors really were in the last drama, or Babylon, Greece, Rome and countless other eras, since, as mentioned, it is a 560 million year story involving quadrillions of events and dramas, but you likely understand what I'm trying to say is we're dealing directly with ancient gods here, not 'business men' or 'politicians'. These people held lightning in their hands last time they decided to let us see them for who they really are. Thoth could literally fly when he was using the name Hermes and there's no question he still can. As briefly reference above, the cross he released this morning is secretly the Nibiru Scalar Vibrational Mechanics platform called a tesseract or hypercube, in unwrapped form. If you fold it back into a 6-sided cube again, you're seeing the shape of the device that powers our counterfeit hologram. You will come to learn at some point that every geometric shape is an operating system, not just a form, called the Platonic Solids in science. Which is why grown men pilgrimage to Mecca to walk around the Kaaba, wearing a little black cube on their forehead. So don't think the cube cross is only worshipped in America. Metatron's Hypercube is used at CERN known as ALICE that keeps you inside an artificial reality called the 'Beyond The Looking Glass Chimera Reality Simulation'. Typically you'll hear the keeper refer to it as the Chimera Reality for short. All down through your current history, the cross has stood for purity, perfection, and hope that one day the savior would return and usher in a utopia, when in truth, it was the very symbol of your eternal enslavement. They keep rolling out this same savior trope, civilization after civilization, always with a different face of the program, but always the same hope. Hope, by the way, is a weaponized spell that was designed to keep you perpetually in bondage and trudging forward like a good little slave, doing your job because 'one day he will return and THEN by golly, he'll save us all'. These are all the same guy/girl. When Sananda (I'm not talking about the fake jesus here) said 'come out of her my peoples', he meant stop falling in line with the prison machine you're trapped in. Stop acquiescing to your own enslavement. I was told in person that humans 'have to rise up and take their world back or they will never move forward'. It means letting go of fear and stand up for what is right. Enslavement of any kind, is not that. The great deceiver will fool 'even the elect' is not a fictional claim in the M@sonic bible for entertainment. They have to tell you what they're doing in order to have you cast that reality they want to play out in your world. The person who wrote the bible also wrote demonology. [For more on this subject see my article 👉 THE SCIENCE OF PREDICTIVE PROGRAMMING and the 2ND COMING] Why would that be? Because the bible is the most elaborate talisman on earth that hypnotizes those who read it, enslaving their minds to passively accept the chimera reality, so when the simulation glitches, you will second guess yourself instead of the holographic world around you. "Did I just see a bird in the sky not flapping its wings and remaining perfectly still? Of course not, that's preposterous." Mithra the savior was gifted to T-Americaans (America) by Frédéric Auguste Bartholdi of France in 1886. Freddy was a 33rd degree (master) Freem@son and you now call Mithra your 'Statue of Liberty'. She is literally the symbol of this nation and is making her second coming at the time when the economy has been utterly destroyed, your politics have been weaponized against you, your courts have been utterly corrupted, your people have been openly attacked with bioweapons, your country flooded with 20m illegal aliens and your police have been defunded & refuse to arrest criminals. All by design and deliberately manufactured. Albert Pike, 33rd degree (master) Freemason stated: "Whenever the people need a hero, we'll supply him." Almost as if Freem@sons plan TO role out some very hard times to achieve a certain agenda. Oh, that's right, Pike also stated this: “We shall unleash the nihilists and the atheists and we shall provoke a great social cataclysm which in all its horror will show clearly to all nations the effect of absolute atheism; the origins of savagery and of most bloody turmoil. Then everywhere, the people will be forced to defend themselves against the world minority of the world revolutionaries and will exterminate those destroyers of civilization and the multitudes disillusioned with Christianity whose spirits will be from that moment without direction and leadership and anxious for an ideal, but without knowledge where to send its adoration, will receive the true light through the universal manifestation of the pure doctrine of Lucifer brought finally out into public view. A manifestation which will result from a general reactionary movement which will follow the destruction of Christianity and Atheism; both conquered and exterminated at the same time.” Sound familiar? If I were going to infiltrate a world & pose as the savior of the peoples that would be allowed to take the last tiny bits of freedom from them in return for pulling them out of a hellscape, I would first reduce them all to the most quivering and broken mess possible just shy of their death, and arrive like a knight in shining armor. Think a hundred-vehicle motorcade, 500 special-ops swat team & my own rolling hospital. When Trump had to go to court in New York it cost them something like $25m to lock down the city for 1 appearance. Nothing gets more high-profile than that anywhere. You've been under predictive programming since the day you were born for this time when the 'antichrist' would appear (that would 'loose his demons' and tear the world asunder), and also for the 2nd coming to 'save humanity' at the same time. But what you weren't told is these will secretly be the same person. Of course everyone will think it was "Barack" who brought about the destruction because Dolores Cannon alluded to it, but who is actually 'showing you a movie' right now while secretly holding the office of CIC and allowing millions of aliens across the border? Because he's your real border czar. This is armageddon, you're in the 'little season of satan' (Satain). The 1000 years of heaven-like reign ended around 1893, and your entire life has been inside of what you could call hell, where you are literally surrounded by demons you believe are human because they look like you. You know more demons than you do humans. This is actual reality, not fiction. Take at look at Not Op Cue's article on the heavenly heritage of Trump, suggesting why he is the reincarnation of jesus. The evidence is overwhelming. 👉 11:11 I had just flown in from half way across the world to meet up with the keeper of the Tara earth simulation for a mission that would involve some of the most astonishing things I would ever live to see in this life. It was getting late and we were talking in a dark, cramped trailer that the keeper and crew had been reduced down to, illuminated only be a couple of small candles. They had been trapped in an area where they were not allowed to escape from by the Anunnaki hybrids. The dark agencies had frozen their bank accounts, forced them out of their compound and left them homeless for the past few years, on the run daily. My mission was to escort them away from that area to a safe space, as the others who had tried to break them free previously had been maimed and even killed. It took 2 years to pull off, 7 months of which living in a car, but the mission was successful. [That's a story for another time, when I am allowed to talk about it. It involved crazy metaphysical anomalies, black helos, giant venomous snakes (I know that sounds crazy, but the whole thing was way crazier than just that), a cross-leyline vortex acting as protection at the safe house we directly on top of, massive aerial DEW attack, fire tornadoes and 'celestial' escorts. None of this is fiction, just to be totally clear.] I was extremely interested in duplicate numbers on my clocks I was seeing 2-3x everyday and wanted to know what they meant. As the words were coming out of my mouth about this, in the relative darkness suddenly my phone lit up all by itself for no reason with the time in large numbers at 11:11pm, apparently to prove to the keeper I wasn't making this phenomenon up. What is that? I was told duplicate numbers are a distraction, to not give them mind, as it is just numerology the system uses in what I took to mean it is part of the complex mechanism of our simulation that hypnotizes us to keep us from being clear and aware to decipher the holographic illusion around us. The more awake we are, the more the system will flash out 3:33 or 11:11 to put you back to sleep by distracting you from the moment that is taking place in front of you. Such as when the most heralded man in the world shares a video depicting a giant cross which insinuates the 2nd coming of the christ (the Kryst or Krystos, is the series title of the Human Elohim eternal-life bloodline and is not 'a guy'). Discernment is more critical now than any other time since you were born. Pay attention, keep your vibration high and know that the next step is you moving on to the next level of the simulation where Lucifer and Satain will no longer be part of your world. This is but a short time to test which path you want to take moving forward is all. It is the 'sifting' phase of humanity at the end of the final long-cycle of human evolution. If you resonate in fear, hate, anger, you lose. React in love, appreciation, kindness and compassion and never give in to the devolution. You can do this. See my article 👉 THE WORLD TOMORROW for more on what to expect moving forward into your next experience. And yes, you always move on to a new experience, because you're an eternal spirit essence having a human experience in this one drama. The dramas never run out or get too boring, because there are trillions of ways to stage 'living a mortal life'. For more on the separation, you can search these article titles here on X, just add (from:iontecs_pemf) after the title to bring it right up. 👉THE SEPARATION 👉DESTINATIONS AFTER THE SEPARATION 👉THE SURGICAL SEPARATION OF THE 2 PLANES This message will only be seen by your eyes if not shared, and if you want to reference this article again later, you will need to cut and paste it in your own notes off line, as it will surely be erased. This is the most accurate translation of these events I am aware of at this time.

W.R. Schock, QBD

145,211 次观看 • 2 年前

Charlie Munger spent 50 years studying why intelligent people make catastrophically stupid decisions. It is the most useful thing I have ever watched: 1. Incentives are more powerful than anyone thinks. Munger says he has been in the top 5% of his age cohort his entire life in understanding the power of incentives and he has still underestimated it every single year. Federal Express could not get their night shift to work efficiently until someone realized they were paying by the hour. They switched to paying by the shift. The problem disappeared immediately. 2. People rationalise terrible behavior when their incentives point that way, and they do not even know they are doing it. A doctor in Nebraska was removing perfectly healthy gallbladders for years. When Munger asked an old colleague whether the doctor knew he was harming patients, the answer was no. he genuinely believed the gallbladder was the source of all medical evil and that removing it was an act of love. That is incentive-caused bias at its most extreme. 3. Psychological denial is real, and it is not just for weak people. A family friend's son flew off a carrier in the North Atlantic and never came back. His mother, a completely sane woman, simply never believed he was dead. Reality was too painful, so she distorted it until it was bearable. Munger says we all do this to some extent, and it causes terrible problems. 4. Consistency and commitment tendency are one of the most powerful forces in the human mind. Once you have stated a position publicly, you are psychologically locked into it. Max Planck said the really important new physics was never accepted by the old guard. A new guard came along that was less brain blocked by its previous conclusions. If this happened to the deans of physics, Munger says, imagine what it does to ordinary people. 5. The Chinese brainwashing system used on prisoners of war worked better than torture. They did not start with big demands. They maneuvered people into making tiny little commitments and declarations and slowly built from there. The same mechanism operates in every cult, every sales system, and every ideology that gets deeply embedded in people's heads. 6. Pavlovian association shapes buying behavior at a level most people never consciously process. Munger estimates three quarters of all advertising works on pure Pavlov. Coca-Cola does not want to be associated with funerals. They want to be associated with the Olympics, wonderful music, heroics. The association itself changes how people feel about the product at a subconscious level. Raising the price of a product can actually increase its market share because price and quality are associated in the human mind, and people use price as a signal of value. 7. Persian messenger syndrome is alive and running every major organization. The Persians killed the messenger who brought bad news. Bill Paley in his last 20 years, did not hear one thing he did not want to hear. everyone around him knew bringing bad news was dangerous. The result was that one of the most powerful men in media made terrible decisions for two decades because reality never reached him. 8. Social proof causes otherwise intelligent people to follow each other off cliffs. When one oil company bought a fertilizer company in the 1970s, practically every other major oil company rushed out and did the same. There was no rational reason for oil companies to own fertilizer companies. But if Exxon was doing it, it was good enough for Mobil. Every single acquisition was a disaster. 9. The efficient market theory persisted in academia for decades despite Berkshire Hathaway existing as a living contradiction. One economist kept adding sigmas to explain away the anomaly. two sigma, then three, then four, eventually six sigma. Munger's observation: It is better to add a sigma than change a theory just because the evidence comes in differently. That economist later went into money management himself and sank like a stone. 10. Contrast bias warps perception constantly and invisibly. Put your hand in hot water, then room temperature water. It feels cold. Put your hand in cold water, then room temperature water. It feels hot. same bucket. The human sensory apparatus has no absolute scale, only a contrast scale. Real estate agents exploit this deliberately. They show you two overpriced, awful houses first, then take you to a merely overpriced house, and it feels like a bargain. 11. The frog in slowly heating water is the business version of contrast bias. If something bad comes to you in small pieces, you are likely to miss it entirely. Munger says he has known many high-powered brilliant businessmen who were destroyed this way. not because they were stupid but because each incremental change was too small to trigger alarm. The contrast was never large enough to notice. 12. Authority bias is so powerful it can make trained professionals watch a plane crash. In flight simulator experiments, when the pilot, the authority figure, does something that any trained co-pilot knows will crash the plane, 25% of the time, the co-pilot sits there and lets it crash anyway. They have been trained to know better. The authority relationship overrides the training. 13. Deprivation super reaction syndrome explains why people go insane over small losses. Munger's neighbor had a 180 degree view of the harbor. the neighbor put in a pine tree about 3 feet high that turned it into a 179 and three-quarter degree view. They had a blood feud that went on for years. The New Coke disaster is the corporate version. Coca-Cola told customers they were changing a flavor and triggered a deprival super reaction so powerful that Pepsi was weeks away from releasing old Coke in a Pepsi bottle. smart engineers. brilliant lawyers. armies of psychologists. All missed it. 14. Envy and jealousy are far more powerful than greed and almost entirely absent from psychology textbooks. Munger says Warren Buffett has said half a dozen times that it is not greed that drives the world but envy. In a thousand-page psychology textbook, the index entry for envy and jealousy is blank. One of the most powerful forces in human behavior and academia essentially ignores it. 15. Gambling addiction is not explained by variable reinforcement alone. Skinner thought he had fully explained gambling by showing that variable reward schedules pound in behavior more powerfully than fixed ones. But the people who design modern slot machines know things Skinner did not. Lotteries where you pick your own number get far more play than lotteries where the number is assigned to you. People who commit to a number believe it has more validity because they chose it. Near misses on slot machines trigger deprival super reaction syndrome. It is four or five psychological tendencies working together, not one. 16. The most dangerous situations are when multiple psychological tendencies combine toward the same end at once. Munger calls this the lollapalooza effect. Tupperware parties use four or five tendencies simultaneously. Moonie conversion methods combine multiple tendencies and work extraordinarily well. alcoholics anonymous achieves a 50% no drinking rate when everything else fails because it also combines multiple tendencies toward a constructive end. The Milgram experiment is not just about obedience. it involves authority bias, consistency and commitment tendency, and contrast effects all working together. That combination turns human brains into mush. 17. Boards of directors are structurally designed to fail as corrective mechanisms. The top executive is the authority figure. He is doing something questionable. You look around, and nobody else is objecting, which is social proof that it is fine. He flies you around in the corporate jet and raises your director fees every year, which triggers reciprocation tendency. Munger's rule: boards only act when the behavior gets so bad it starts making them look foolish or threatens legal liability. That is the only forcing function that reliably works. 18. John Goodfriend of Salomon Brothers destroyed his career and reputation because he did not fire a trusted employee who had lied to the government. Every psychological tendency pointed toward keeping the man. He was a close colleague. His wife was known. He was part of a group that had made over a billion dollars for the firm. He said he had never done it before and would never do it again. Goodfriend looked into his eyes and believed him. The man did it again. The lesson: everyone who gets caught embezzling says they have never done it before and will never do it again. That is what they all say. 19. Darwin avoided confirmation bias by deliberately seeking out disconfirming evidence. Munger says Darwin was not especially smart by ordinary standards of human acuity. Yet he is buried in Westminster Abbey. Munger studied how Darwin worked and realized he had psychological tricks worth learning. Darwin always paid extra attention to evidence that contradicted his theories. Munger started doing the same and credits it as one of the most important intellectual habits of his life. 20. Why is the most important word in communication? Carl Braun designed oil refineries with spectacular skill, and you got fired in his company if you wrote a communication without explaining why. not just who, what, where, and when, but why. Braun knew that in a complex system where things can blow up, a communication system that always explains the reason behind an instruction works dramatically better than one that does not. Forstein, the general counsel of Salomon, told Goodfriend on multiple occasions that he had to report the employee's misconduct. He explained it was the right thing to do. He never explained what would happen to Goodfriend personally if he did not. he failed to use the most powerful tool of persuasion. Goodfriend ignored him. When Goodfriend went down, Forstein went with him.

Jaynit

777,169 次观看 • 2 个月前

In attempts to understand zionist mindset, i discovered some EXTREMELY disturbing facts; Textbooks -Palestine - genocides, murders, perversion, rape, torture, hate, death to all but "Judaism." Part 1. Transcripts (some spelling errors) In every synagogue library, we find hundreds of books. But there are a few which tower above the rest in authority. These include the Encyclopedia Judaica, the Universal Jewish Encyclopedia. The Jewish Encyclopedia. In the oldest of these, the Jewish Encyclopedia. We encounter fascinating new perspectives on the inner teachings of Judaism and perspectives, which are well known to most religious Jews, but are (UNknown) to Christians. 00:01:50:05 - 00:02:17:24 Most Christians believe that the Judaism of the Old Testament is very similar to Judaism today. Yet the Jewish Encyclopedia and its article on Judaism says modern Judaism and the Judaism of the Old Testament are very different. It says that after Nebuchadnezzar conquered Judah in the sixth century B.C. and led the Jews to distant Babylon, the Jews were faced with challenges to their faith they had never before experienced. 00:02:17:26 - 00:02:45:08 Ever since the time of Solomon. The religion of Israel had centered around the magnificent temple in Jerusalem with its sacrifices and ritual. The question now became How could one be a true Jew in a very foreign, even hostile environment? The need arose for a certain class of lay priests called scribes or so for them to interpret the law in this new setting and make it workable. 00:02:45:10 - 00:03:11:26 In time, these scribes became what the New Testament calls the scribes and Pharisees the greatest legal authorities of Israel for all ages. The Pharisees said there were really two inspired revelations to the Jews. There was the written law of Moses received atop Sinai. But there was also the oral tradition acquired by 70 elders who came to the base of the mountain but were forbidden to proceed. 00:03:11:26 - 00:03:39:03 Father. The Pharisees said that these 70 elders or Sanhedrin received a much more extensive and profound revelation than Moses. A revelation which was never written down, yet took precedent over the written law. When Jesus came on the scene, his reaction was to bitterly denounce this counterfeit tradition. Raised, said the Pharisees, by their tradition, had made the law of God have none effect. 00:03:39:06 - 00:04:10:01 He considered the Pharisees the most dangerous leadership Israel ever had. In 70 A.D., Jerusalem was destroyed by the Romans. Although Jewish sects such as the Sadducees now disappeared. The Pharisees emerged with even greater power over the Jewish people. The Jewish Encyclopedia describes the new role of the Pharisees with the destruction of the temple. The Sadducees disappeared altogether, leaving the regulation of all Jewish affairs in the hands of the Pharisees. 00:04:10:04 - 00:04:39:01 Henceforth, Jewish life was regulated by the Pharisees. The whole history of Judaism was reconstructed from the very same point of view. Parasitism shaped the character of Judaism and the life and thought of the Jew for all of the future. In 135 A.D., all Jews were expelled from Palestine. The Pharisees led most Palestinian Jews in a mass migration back to Babylon. 00:04:39:03 - 00:05:05:15 The majority of Jews were already in Babylon and had been since the time of Nebuchadnezzar 600 years earlier. Yet around 140 A.D., Babylon became the acknowledged land of refuge for world jewelry. For another thousand years, Judaism flourished in Babylon under the leadership of the Pharisees, Great academies of the rabbis were established and thousands of new laws formulated there. 00:05:05:16 - 00:05:12:01 Those same parishes who killed Jesus Christ remain the undisputed rulers of Judaism. 00:05:12:03 - 00:05:45:02 In Babylon, the Pharisees codified their oral traditions into the Babylonian Talmud. The written form of that oral tradition which Jesus so bitterly rebuked the Talmud, reveals How deep was Israel's apostasy? In her beginning, God gave the Hebrews the loftiest, the most upright literature and ethics the world has ever known. Yet when they turned their backs on him, they produced the Talmud, a work which has aptly been called a monument to human folly. 00:05:45:04 - 00:05:52:01 The Talmud also helps us understand the basis for Christ's unflattering descriptions of the Pharisees. 00:05:52:04 - 00:06:23:06 Jesus described the Pharisees as hypocrites. Children of Hell Blind Guides. Why did Sepulcher was full of dead men's bones even describe the Pharisees as children of their father, The devil? A murderer. From the beginning, the Talmud confirms Christ's words in the Talmud. In treatise Sanhedrin and extensive passage describes the right of the Pharisee to kill anyone, just as long as he did so indirectly as one of dozens of examples. 00:06:23:09 - 00:06:50:05 The Talmud tells us that if one bound his neighbor and he died of starvation, he is not liable to execution in such an indirect manner. The Pharisees also killed Christ. Manipulating the Romans to actually wield the spear and sword the Pharisees claimed, as their descendants do today, that since the Romans worthy direct cause of the death of Christ, it is the Romans, not the Jews who are guilty. 00:06:50:07 - 00:07:18:25 Christ also called the Pharisees adulterers and adulterous generation. The Talmud provides generous loopholes for adultery. It says the penalty for adultery does not include sex with a minor. The wife of a minor or the wife of a heathen. The Talmud also encourages seduction of unwed adolescent girls called designated bond maids. But it's important how such rapes are performed with the designated bond made. 00:07:18:26 - 00:07:46:03 One is guilty only in the case of natural connection, but not in the case of perverse connection. The Pharisees reasoned that rape in a perverted manner is outside of the jurisdiction of the law. Normal rape, however, was punishable. In Babylon, sexual perversion of every kind had been a way of life for millenniums. The Pharisees were deeply influenced by such practices. 00:07:46:06 - 00:08:16:00 In three of the major treatises of the Talmud are found extensive passages which give legal endorsement to seduce and marry three year old baby girls. In fact, many of the greatest rabbis of the Talmud, including Simeon Ben Yo Hai, upheld this privilege. Today in Israel, thousands of Jews go to Iran every year to venerate the memory of Simeon Daniel High, one of the most respected rabbis in the history of Judaism. 00:08:16:02 - 00:08:37:09 In one of dozens of endorsements of child sex, Simeon Ben YOHE said a process of light under the age of three years and a day is permitted to marry a priest. Agreeing with Ben YOHE, the great robber, said When a grown up man has intercourse with a little girl, it is nothing for when the girl is less than this three years and a day. 00:08:37:12 - 00:09:02:00 It is as if one put the finger into the eye. The footnote to this passage says, as tears come to the eye again and again. So does virginity come back to the little girl under three years? The same section confirms that sexual activity with small boys is in the same category. The intercourse of a small boy is not regarded as a sexual act. 00:09:02:03 - 00:09:25:21 In addition to adulterers, Christ, in the story of the Good Samaritan, portrayed the Pharisees as racial bigots, too self-righteous to respond to the suffering of one who was not a Jew. It is true because of the wickedness of the Canaanites, which included sodomy and infant sacrifice. Israel had been commanded by God to be harsh in her treatment of the inhabitants of the land. 00:09:25:24 - 00:09:43:10 God made it clear that the Canaanites were not simply to be avoided, but destroyed by the time of the New Testament. This method of preserving God's kingdom by separation and the sword had become obsolete. God no longer made a racial difference between men. 00:09:43:13 - 00:10:17:14 But the Pharisees were unfazed by God's new agenda. The Talmud was finally written down nearly five centuries after Christ hit its critical, even homicidal attitudes toward Gentiles might have been lifted out of the Book of Joshua. However, the quickest way to grasp the Talmudic view of Gentiles is not directly from the Talmud, but from the Jewish encyclopedias. If we quote an isolated opinion from the Talmud, a rabbi may quickly object, saying, But that is not the overall opinion of the Talmud. 00:10:17:16 - 00:10:35:02 That is not the definitive view of what the Jewish Encyclopedia provides us is a definitive overview of perhaps hundreds of rabbinic statements on any subject giving us accurate summaries of what the Talmud generally teaches. 00:10:35:04 - 00:10:52:00 In its article on Gentiles. The Jewish Encyclopedia begins to define what makes a Jew so different from a Gentile. According to the rabbis, only Israelites are men Gentiles. They class not as men, but as barbarians. 00:10:52:02 - 00:11:35:23 Since Gentiles are not men in the fullest sense. So the Gentile is not a neighbor of a Jew. Further, since Gentile laws were too crude to admit of reciprocity, meaning too crude to be taken seriously, the Gentile was forever beneath the Jew. Gentiles were outlawed by God from the beginning and thus had no property rights. The Almighty offered the Torah to the Gentile nations also, but since they refused to accept it, he withdrew his shining legal protection from them and transferred their property rights to Israel, who observed his law since the Talmud outlawed the child or issue of a Gentile as that of a beast. 00:11:35:29 - 00:12:04:24 A Gentile had as little legal rights than a Jewish court as did an animal. The Talmud states that if a Gentile sue an Israelite, the verdict is for the defendant. The Israelite. Conversely, if the Israelite is the plaintiff, he obtains full damages because the Talmud conspires against Gentiles. If a Jew was ever caught telling a Gentile what the Talmud really says, such a person deserves death. 00:12:04:26 - 00:12:30:06 So vile was the nature of a Gentile that the great Simeon Ben YOHE said the best among the Gentiles deserves to be killed. The best of snakes ought to have its head crushed. Jews, however, are exalted beings in the Talmud worthy of praise. Christ described the Pharisee who blessed himself, saying, I thank the Lord that I am not his other man. 00:12:30:09 - 00:12:57:19 At imminent Talmudic rabbi says, the same blessed be thou who has not made me a goy or gentile. There is a special antagonism between the Talmud and Jesus. The Talmud attacks everywhere it can. Even his mother, Mary, the Talmud, says, was a whore who mated with carpenters. She, who was the descendant of princes and governors, played the harlot with carpenters. 00:12:57:21 - 00:13:26:06 It naturally followed that the scribes declared Christ to be a bastard. In its article on Jesus. The Jewish Encyclopedia says that Jewish writings defame Christ. It is the tendency of all these sources to belittle the person of Jesus by ascribing to him illegitimate birth, magic and a shameful death. Jesus, according to this article, was considered one of the three worst enemies of Judaism who came to an ignoble end. 00:13:26:09 - 00:13:54:27 The Talmud says they subjected him to four deaths stoning, burning, decapitation and strangling. The Talmud also says he is now in hell, punished with boiling hot excrement. What is Christ advice as he speaks to us? Out of hell? The Jewish Encyclopedia quotes Jesus as telling us above all to bless the Jews. He says further their well-being do nothing to their detriment. 00:13:54:29 - 00:14:29:29 Whoever touches them touches even the apple of his eye. Christians, as followers of the false Prophet Jesus also deserve death. The Jewish Encyclopedia again recaps the Talmud to position a Gentile. Observing the Sabbath deserves death. It says the Talmud hatred was probably directed against the Christian Jews. These Judeo Christians invasively called Men Minute or Minim, were considered by the rabbis to be the most dangerous form of heretics of ancient times. 00:14:30:01 - 00:15:01:25 The New Testament gospels were writings which the rabbis considered more dangerous to the unity of Judaism and those of the pagans. A Talmudic rabbi said the writings of Christians deserved to be burned or paganism as less dangerous than minute or Christianity. The Jewish Encyclopedia, in its article on men, continues to illustrate the Talmudic hatred of Christianity. Again, we must remember venom usually indicates the Judeo Christian. 00:15:01:27 - 00:15:26:03 It was forbidden to partake of meat, bread or wine with the Christian scrolls of the law. Tefillin and mezuzah written by a Christian were burned, and animals slaughtered by a Christian was forbidden to food. The relatives of the Christian were not permitted to observe the laws of mourning after his death, but were required to assume festive garments and rejoice. 00:15:26:05 - 00:15:38:02 The testimony of a Christian was not admitted in evidence in Jewish courts and an Israelite who found anything belonging to one who was a Christian was forbidden to return it to him. 00:15:38:04 - 00:15:58:08 The Pharisees, through the Talmud, thus gave the Jews an ethic which encouraged bigotry and isolation. But they did worse than that. It invited persecution. By the 11th century, inhabitants of Babylon, growing weary of the self-righteousness and dishonesty of the Jews, expelled them to the West. 00:15:58:10 - 00:16:25:27 Migrating across North Africa and Central Europe. The great majority of Jews who had lived in Babylon for almost 600 years now began to find their destinies in the cities of the West. Yet in coming to the West, Jews found their Christian neighbors extremely intolerant of the anti-social deviations Jews had taken for granted in Babylon. In order to survive, it was necessary to abandon such Babylonian traditions. 00:16:25:29 - 00:16:53:06 But that was not as easy as it sounds. For a thousand years, the Pharisees had commanded such deviations. Most Jews could not bring themselves to defy the authority of the Pharisees. Enter one of the giants of Judaism of all time, the great Maimonides. Maimonides, a physician and philosopher, knew that no Jew who practiced Babylonian perversions could remain alive in Christian lands. 00:16:53:09 - 00:17:04:19 He attempted to harmonize Greek philosophy with the best points of Judaism. He hoped his rationalizations would enable Jews to abandon their antisocial customs. 00:17:04:22 - 00:17:21:06 Yet my monarchies was only partly successful. He was excommunicated by the Jewish community on the charge of making new laws. Nevertheless, his moderation and intellect did in fact temper the old Judaism of Babylon. 00:17:21:09 - 00:17:49:24 Gradually, over the centuries, Jews abandoned immoral practices of the Talmud. Such practices are not observed today. In fact, most Jews are so ignorant of the Talmud itself that they do not even know that such teachings exist within their sacred literature. Yet the fact remains that when the Jews came to the West in the Middle Ages and attempted to accommodate the Talmud to Christian society, a tremendous conflict was created in Babylon. 00:17:49:24 - 00:18:12:22 Judaism could be perfectly consistent with the teachings of the Pharisees, because the Babylonians were immoral as well. In the Christian lands of the West, it became necessary to pretend that many of those teachings did not exist. Even today, religious Jews continue to venerate the Pharisees and their Talmud as the greatest source of light that Judaism will ever know. 00:18:12:25 - 00:18:28:22 Yet living in Christian lands, no Jew can fully perform what the Pharisees commanded. This conflict in Jewish responsibility has created a dilemma over the last thousand years from which Jews and the West have not emerged. 00:18:28:24 - 00:18:44:02 Yet, even before my monitors came on the scene in the 12th century, another dilemma was being created in Judaism far to the east. This was a dilemma not concerning the doctrines of the Jews, but over who actually was a Jew. 00:18:44:04 - 00:19:07:12 In their articles on the Khazars. The Jewish Encyclopedia tell us that in the eighth century A.D., Jewish missionaries ventured north of Babylon to the land of the Khazars between the Caspian and the Black Seas. Azaria was a vast grassland on what is now the plains of southern Russia, inhabited by a race of merchants, artisans and warriors of honey. 00:19:07:12 - 00:19:34:23 Turkish stock. About 740 A.D., the king of the Khazars converted to Judaism and made it the state religion. Incredibly, within a few centuries, the people of Ghazaliya convinced themselves that they were not Gentiles after all, but the physical descendants of Abraham. Thus, by the 10th century A.D., a nation across the late Jews thrived in what is now central Russia. 00:19:34:25 - 00:20:05:21 During the Middle Ages, the fierce Mongols from the East and Russians from the north drove the Khazars west out of their ancient homeland. Most settled in Eastern Europe, especially Poland, where they established communities of artisans and traders. Judaism thus became divided into two basic groups which remain today the Ashkenazim, which are the Khazars of the East and the Sephardic Oriental, which are Jews of Spain, Turkey and lands bordering on the Mediterranean. 00:20:05:23 - 00:20:40:06 Today, the Ashkenazim or Khazars are the vast majority, about 80% of those who call themselves Jews. The two most recent premiers of Israel illustrate these two racial types. Shimon Perez is a Sephardic Jew from authentic Jewish stock. Yitzhak Shamir, like Menachem Begin, is Ashkenazim or Khazar in origin. In Poland, these ancestors of most modern Jews thrived. In fact, they actually became more zealous Jews than their theological cousins to the West. 00:20:40:06 - 00:21:12:18 The Sephardim, like Czars, were fascinated with that mystical aspect of Judaism called Kabbalah. Kabbalah was the Jewish form of ancient Gnosticism, a belief that God is unconscious, yet everywhere revealed in different levels of refinement throughout the universe. Of course, Judaism was always unique among ancient religions and its belief in a single conscious God, a God not only capable of creating the world's, but of punishing evil and rewarding good. 00:21:12:20 - 00:21:48:07 Like Eastern religions, however, the Polish cable has believed that God in his purest form is utterly remote, unknowable, without opinions about right and wrong. Instead, his being filtered down through many gradations or separate until it reached Israel. Israel, according to the Kabbalah, was the visible, rational emanation of God in this world. Below Israel was confusion and darkness represented by demons and the chaotic world of the Gentiles. 00:21:48:09 - 00:22:09:07 What excited the Khazars was that Kabbalah preached revolution. It said that Jews are superior beings were destined to rule the world in the Zohar, which is the written text of Kabbalistic lore. We find the arrogance and ambition of the ancient Pharisees very much alive. 00:22:09:09 - 00:22:37:24 In a typical passage, the Zohar teaches a living soul refers to Israel who have holy living souls from above and cattle and creeping thing and beasts of the earth to the other peoples who are not living soul only by the overthrow of the Gentiles, the Zohar asserts. Can Israel regain its position as God's Shekinah glory on Earth. The Zohar calls Gentiles Hammill a case in a passage typical of many. 00:22:37:28 - 00:23:04:07 The Zohar says they caused the destruction of the temple. So when God reveals himself, they will be wiped off the earth. Redemption will not be complete until al-Malaki will be exterminated. But once Israel shakes off Gentile, dominion and Christian influence, heaven will descend to earth. The Zohar says Israel will fulfill her predestined role, ruling the world under the leadership of her Messiah. 00:23:04:09 - 00:23:28:13 Since the Kabbalah or Zohar was not merely a theological system but taught the overthrow of existing order, it was natural that before long Jews should begin to put it in the practice. With the age of Voltaire and the so-called Enlightenment. During the 18th century, we see a host of Jewish lists migrating west out of Poland and penetrating the very capitals of Europe. 00:23:28:15 - 00:23:43:09 Jewish wonder workers walsham's, as they were called Saint Germain, carefully astral frank folk men of vast wealth and mystery, came upon the European scene at the end of the 18th century. 00:23:43:12 - 00:24:16:08 In Europe in the years preceding the French Revolution. The foundations were laid for a new order in the world. Cable, as such as Adam Bice, had helped establish the ultra secret Illuminati, which became a cover for plots and intrigues that would begin the erosion of Christian civilization. At the same time, beginning with Jewish philosopher Moses Mendelssohn, many Jews began to perceive their religion not simply as a means of personal salvation, but as a way to reform society at large. 00:24:16:10 - 00:24:52:29 Many Jewish activists said that starting with such revolutionaries as Moses and the prophets, Israel had always had the social objective of writing injustice and taking the part of the downtrodden. It was the duty of every Jew, they said, to come to the aid of the oppressed working masses, called the proletariat in their historic struggle against capitalistic bondage. Many Jews thus came out of the ghetto and took part in all the great revolutions of the 19th century, including the revolution of 1829 and the revolution of 1848. 00:24:53:02 - 00:25:20:00 It is thus not surprising that as the 20th century dawns, we find Jews turning their attentions to the overthrow of one of the last monarchies still opposing Jewish advancement. The Romanoff dynasty of Russia. It is well known that the Jews had long hoped to overthrow the Czar. It was natural then that Jewish philosophers such as Moses, Hess and Karl Marx should contrive a philosophy that could make such overthrow possible. 00:25:20:03 - 00:25:48:20 It was also natural that international Jewish bankers of New York, London and Hamburg should finance it. The U.S. State Department, in its three volume report on the origins of communism in Russia, published in 1931, reveals how Jewish controlled German banks under the leadership of Max Warburg, conspired as early as 1914 to send large payments to Lenin, Trotsky and others in their attempts to bring down the Czar. 00:25:48:22 - 00:26:12:21 As part of this conspiracy. Jacob Schiff, head of the New York Jewish Banking House of Could, Loeb invested at least 20 million, which would be close to $1 billion today toward the establishment of Bolshevism in Russia. In its article on socialism, the Jewish Encyclopedia published in 1905, freely admits that Jews in Russia were ripe for revolution in Russia. 00:26:12:22 - 00:26:18:23 Yet socialism has become a movement of the Jewish masses. 00:26:18:26 - 00:26:56:14 The later Encyclopedia Judaica tells us the communist movement and ideology played an important part in Jewish life, particularly in the 1920s and 1930s and during and after World War Two. The Judaica, in fact, presents an extensive list of the most powerful Jewish leaders of Bolshevism, which included Trotsky, spared La Zinoviev, Communist Lebanon, Hagana, Vic and many others. The Judaica also tells us just how many Jews filled the communist ranks. continue to..... .. PART 2 transcripts

TMJ

48,907 次观看 • 2 年前

HYBE and Min Hee-jin NewJeans Controversy from the Perspective of a 20-Year Entertainment Industry Expert | Kim Yoon-ji, Senior Researcher at the Overseas Economic Research Institute of the Export-Import Bank of Korea #1 [Investment Insight] 증시각도기TV HYBE has shown a somewhat immature side throughout this process. The essence of the issue has become less important. Hello, viewers and investors of Stock TV. Recently, there has been a lot of societal concern about the entertainment industry. Last year, it did well, but the question remains about how it will fare this year. We’re joined by Kim Yoon-ji, Senior Researcher at the Korea Eximbank Overseas Economic Research Institute, to discuss this. Welcome. Today, I brought a drink because this topic is not easy to discuss soberly. The situation between HYBE, Min Hee-jin, and NewJeans has escalated, and unfortunately, it’s no longer just management fighting but the artists have joined the fray. I’ve heard from someone in the industry that the close relationship between a producer and an artist is inevitable. In the past, there have been similar cases where producers and artists were tightly knit. Now, something similar has happened with Min Hee-jin and HYBE. Most people outside the industry don’t know the exact terms of the contract between Min Hee-jin and HYBE. As my own son works in the entertainment field, I’m well aware of how important it is to work with a good producer. For a company like HYBE, which has invested tens or even hundreds of billions of won, it’s unthinkable that they would allow NewJeans to separate and go independent after establishing their position. Many in the industry agree that this doesn’t make sense. To the general public, NewJeans might seem like the underdogs, and people might feel they should be allowed to leave. But from the perspective of the entertainment industry, which requires substantial capital to grow, the relationship between investors and artists is key. You can’t discuss this industry without acknowledging the role of investors. This case is different from situations where individual members leave, as seen in the past with groups that had Chinese members. This isn’t about a single member leaving; it’s more about the fact that, in this industry, the producers are as important as the artists themselves. From the beginning, NewJeans has been marketed as Min Hee-jin’s girl group, so the idea of them continuing without her feels different. We need to approach this from a different angle. That said, it doesn’t mean HYBE should completely cut ties. Many people have different initial thoughts about the situation, but the core issue here is the importance of the relationship between producers and the company, especially when substantial investment is involved. From my perspective, the fundamental question is: what exactly was attempted? I still find this unclear. In any company, it's common to hear people say, "I want to quit, I can't work with this boss, I'm leaving tomorrow." We all talk about this with friends or colleagues. Sometimes, we even ask others to let us know if there’s a good opportunity elsewhere. But actually submitting a resignation is a whole different issue. But in the new premise, I still wonder what exactly they were trying to do. What exactly was attempted? We always talk about it at work, right? "I'm going to quit. I can't work with that boss anymore. I'm leaving tomorrow." We always have those conversations. We talk about it with our friends, with team members, and even ask friends outside of work to let us know if they hear of any good positions. But actually submitting a resignation is a whole different issue, isn't it? Looking at how the situation first unfolded, it seems like HYBE was the one to bring things to light. They shared a lot with the press, and Min Hee-jin, the CEO, responded with a strong counterstatement. HYBE was saying, "Min Hee-jin is trying to do this and that," but CEO Min was like, "What else have I done apart from that message on KakaoTalk?" The court also judged that they weren't sure what actions had actually been attempted. To me, this seems like the fact of the matter. Clearly, HYBE's relationship with CEO Min Hee-jin might not be good. There could have been friction about how a subsidiary operates so independently from the parent company. There were likely various issues internally, but they should have been resolved within the company without making the problems visible externally. The fact that they let it spill outside before resolving it was a huge mistake on HYBE's part, revealing weaknesses in their management abilities. In my view, this has greatly devalued HYBE, becoming a powerful force that has dragged down their valuation. Throughout this process, HYBE displayed a level of immaturity, and the core of the issue became less important. The real concern for investors now is whether the company can effectively handle issues like these. Once this problem is resolved, can the remaining HYBE groups continue to grow securely? This business is all about reputation. HYBE is now seen as a company that ousts female CEOs simply because she didn't follow their orders. That perception leaves a lasting impression on people's minds, damaging the company's future operations. From an investor's perspective, two major incidents have happened in quick succession. The first was the boost in value during 2020 when HYBE sold a huge number of albums during COVID-19, creating the sense that the entertainment industry was Korea's next big sector. But then, this recent issue with Min Hee-jin, alongside BLACKPINK's contract situation, has put a serious damper on things. BLACKPINK didn't renew their contract as a group, and though they claim to continue working together in some capacity, it's not the same as before. YG Entertainment's profitability has plummeted, revealing how dependent they were on BLACKPINK. This has left investors wondering whether the entertainment business is just a limited-time, seven-year affair. If BLACKPINK had carried on smoothly into the next generation, it would have seemed like a sustainable business, and investors would have continued to trust in the long-term future of Korean entertainment. But now, we're seeing the cracks in that perception. It’s become a question of how to invest in a business with a lifespan of only seven years, when even the manufacturing industry lasts longer than that. The BLACKPINK incident and the NewJeans situation have both severely harmed investor confidence. HYBE's struggles with its artists are analogous to a manufacturing company facing a revolt from its workers. When investors look at this instability, they start questioning whether the business is even viable. The concept of sustainability has been seriously undermined, and the fact that the seven-year contract issue has been a long-standing concern doesn’t make it any easier to deal with. What used to reassure investors was the belief that when a seven-year contract ended, the company would already have the next seven years planned out, ready to sustain their business. That faith in the big entertainment companies has been shaken. Achieving the kind of success that BTS or BLACKPINK did is incredibly difficult, and passing the baton to the next generation is no simple task. Even though investors had faith that YG would produce another BLACKPINK-level group, now that trust is faltering. However, I do think people are now looking at contracts a bit differently. In the past, when a group disbanded, the members would scatter. But now, groups like BLACKPINK continue to work together even while pursuing solo projects. This shows that they understand the importance of sticking together, and I thought that this might help extend the longevity of these groups. But in reality, very few cases of disbanded groups have seen much success with individual members pursuing separate careers. There aren’t many examples where groups have stayed active for long, especially when individual members run into personal issues. Take Big Bang, for instance—they’ve been around for a while, but their personal scandals have made it hard for the group to recover fully. In the entertainment business, it’s rare for groups to last more than seven years, and age is also a factor. Once a group surpasses the seven-year mark, the members tend to be quite a bit older. With BTS, they need to show a fresh side if they’re to keep running strong. One of the most disheartening things mentioned by the members was that they didn’t feel respected. This ties into a larger issue in our society, as we're seeing with the national discussion around workplace bullying. If we think about how BTS achieved success, it's clear why this is such a serious issue. Back when BTS rose to fame, they shared how they weren’t from one of the top three agencies and positioned themselves as underdogs who worked hard to gain recognition. This resonated with many young people who felt that if you work hard enough, you can succeed, even without the backing of a major company. This message gave hope to many, not only in Korea but also globally. BTS’s fan base, especially in the U.S., includes many people who identify as outsiders, those who don’t feel they belong to the mainstream—whether in terms of race, culture, or social standing. For them, BTS was a source of inspiration, showing that you can still succeed even if you start from the margins. With NewJeans, though there’s talk about Min Hee-jin, the allegations of bullying within the company are hitting a sensitive nerve for fans. It’s unfortunate that the company allowed things to reach a point where such accusations were made. Even if the situation was mostly an internal conflict among the adults in charge, they should have handled it better to avoid involving the artists. In the past, we've seen similar issues, like with Big Bang’s various scandals, which were almost at the level of criminal activity. The current situation with NewJeans might not be as severe, but bullying and exclusion are still serious concerns. Ultimately, experiences like these can serve as valuable lessons for the entertainment industry. This situation has highlighted that the entertainment business is fundamentally about human relationships. From the artists to the products they create, everything revolves around people. The moment someone’s feelings are hurt or relationships are damaged, the entire business can collapse. The entertainment business is all about personal connections, something I've always believed. Recently, I heard about Naver Webtoon’s global success, and it's fascinating to think about how it has outgrown Kakao Webtoon, despite being a later player. Many factors contributed to this success, but someone mentioned that webtoons are also a "personal connection" business. Webtoon creators are tough to manage—they're artists, after all, and keeping them on schedule, especially with weekly deadlines, is a challenging task. CEO Kim Joong has managed to nurture relationships with these creators, making personal connections the backbone of the business. In the entertainment industry, particularly with idols, you can't overlook the importance of personal relationships. The key skill for managing this industry is the ability to connect deeply with both the creators and the artists. HYBE, for instance, doesn’t just need skilled managers who are good with finance or operations. What they truly need are people who can foster those personal relationships, especially when they’re dealing with artists as young as 13 or 15. It’s about ensuring that these young talents feel understood and cared for, so they can be inspired to do their best work. Managing young artists is tricky because their idea of success might be completely different from what adults think. A 13-year-old might not care about owning multiple houses—they might just want to spend time with their family or have the freedom to eat out whenever they want. The manager’s job is to tap into what motivates them and help them thrive in a way that’s meaningful to them. This kind of nurturing is not easy to scale. When a company grows too big, it’s challenging to maintain those close relationships. That's why multi-label approaches, like those seen in large entertainment agencies, are supposed to help. But if personal connections within those labels break down, the whole system can fall apart. This business model seems uniquely suited to Korea. It’s hard to imagine it working the same way in Japan, where there's a more hierarchical, command-driven structure. Japan's entertainment industry often depends on strong, central producers who direct everything. In contrast, Korean idols often rise through collective effort and personal connection, like BTS did. Despite the challenges, I believe Korea’s entertainment sector has room for long-term growth. Many of today’s youth are drawn to this field because it allows them to express their talents and passions. If scandals like the one with NewJeans continue to arise, however, it might dissuade some young people from pursuing these dreams. When you look at what NewJeans members have said, there’s not much to disagree with. They simply want to keep doing what they’ve always done and follow their own creative paths. Ensuring they have the freedom to do so can lead to even greater success. These days, if you ask middle or elementary school students what they want to be when they grow up, many of them will say they want to become idols or YouTubers. They believe that with enough effort, they can make it. The entertainment industry needs to be able to channel that passion and potential into something positive. If Min Hee-jin were to leave HYBE, it’s clear that many companies would be eager to work with her. She mentioned once that “everyone is crazy about money,” and I think that’s why there would be a long line of people wanting to meet with her if she decided to move on. Right now, for example, there are people in the entertainment industry, like CJ, who may not have fully established themselves, or even private investors, just waiting for an opportunity. Many of them are keeping an eye on Min Hee-jin leaving HYBE. This was evident during the recent Tokyo performance, where her creativity was on full display. It was incomparable. That’s why this situation is even more unfortunate. Some people say, "If it wasn’t for the money, how could that group have been created?" But I believe there are people who could have made it happen with or without money. That’s the crucial difference in this case. While I'm not an expert, I was touched by the process of recreating a hit song from a legendary Japanese female singer from the '80s. It felt like a major event. It was amazing because I had never seen anything like it before. Even though I wasn’t familiar with the original song, just seeing it was enough to draw in so much attention and make it feel like a historic moment. That’s what talent is—turning something simple, like a cover song, into a major event. I remember thinking, "How do the Japanese people feel about this?" because the crowd's reaction was incredible. The enthusiasm was surprising, and I wondered what they were thinking while watching it. This is the true power of Korean culture—it’s not just about promoting our own culture but also deeply resonating with others. The entertainment industry’s core business is making audiences happy and even obsessed. Min Hee-jin is undeniably a top-tier artist in this field. If she were to leave HYBE, there would be countless opportunities for her. But if HYBE mishandles this situation, it won’t just be about losing one person—it could destabilize everything. They really need to handle this carefully. As for stocks and investments, that's up to everyone’s individual decisions. We're just having a casual chat here about the entertainment industry. As someone with a child in the business and another who's analyzed the industry, we’re just relaxing with a casual discussion. So, let’s pour a drink and enjoy this conversation. Watch the full video:

1tokki

104,638 次观看 • 1 年前

$NWBO #𝗗𝗖𝗩𝗮𝘅-𝗟: 𝗧𝗵𝗲 𝗘𝘃𝗶𝗱𝗲𝗻𝗰𝗲 𝗶𝗻 𝗣𝗹𝗮𝗶𝗻 𝗧𝗲𝗿𝗺𝘀 A short, plain-language reading of the survival evidence for DCVax-L in #glioblastoma, and what it means under the MHRAgovuk guideline on external control arms. 📊 𝗣𝗔𝗥𝗧 𝗢𝗡𝗘: 𝗪𝗛𝗔𝗧 𝗧𝗛𝗘 𝗧𝗥𝗜𝗔𝗟 𝗙𝗢𝗨𝗡𝗗, 𝗔𝗡𝗗 𝗪𝗛𝗬 𝗜𝗧 𝗠𝗔𝗧𝗧𝗘𝗥𝗦 DCVax-L more than doubled five-year survival, and the benefit is durability: a subset gets lasting disease control and simply stays alive. 💉 𝗪𝗵𝗮𝘁 𝘁𝗵𝗲 𝗱𝗿𝘂𝗴 𝗶𝘀 DCVax-L is a personalized cancer vaccine for glioblastoma, the deadliest form of brain cancer and a designated orphan disease. It is a living drug: its active ingredient is the patient's own immune cells, primed with proteins from that patient's surgically removed tumor, so the immune system learns to attack the cancer. Unlike a chemical drug that is metabolized and cleared, it switches on a living immune response that keeps working long after the injection. Glioblastoma comes back in almost everyone: even with the full standard of surgery, radiation, and temozolomide chemotherapy, most patients live under two years, and only about one in twenty reaches five. DCVax-L is given on top of that standard care, not in place of it: every patient in the trial received surgery, radiation, and temozolomide, and the vaccine was added to it, so the comparison measures what the vaccine adds. For two decades, nearly every new drug tried in this disease has failed. That is the backdrop against which any positive result must be judged. 📈 𝗪𝗵𝗮𝘁 𝘁𝗵𝗲 𝘁𝗿𝗶𝗮𝗹 𝗳𝗼𝘂𝗻𝗱 In a Phase 3 trial of 331 patients, those who received DCVax-L lived longer. At the median the gain looks modest, about three months (19.3 versus 16.5). The number that matters sits at the far end of the survival curve: more than twice as many vaccine patients were alive at five years, 13.0% versus 5.7%, and a few reached ten years in a disease that usually kills within three. In patients whose tumor had already returned, the effect was larger still, cutting the risk of death by about 42%. 👥 𝗘𝘃𝗲𝗿𝘆 𝗴𝗿𝗼𝘂𝗽 𝗯𝗲𝗻𝗲𝗳𝗶𝘁𝗲𝗱, 𝗲𝘃𝗲𝗻 𝘁𝗵𝗲 𝗵𝗮𝗿𝗱𝗲𝘀𝘁 𝘁𝗼 𝘁𝗿𝗲𝗮𝘁 The benefit was not confined to the easy cases. Of the six prespecified subgroups the trial examined, every single one favored DCVax-L, and there was no group in which it did worse than standard care. The largest gains came in patients whose tumors carry MGMT methylation, who reached a median survival of 30.2 months from randomization against 21.3 for the controls. But even the hardest-to-treat patients, whose tumors lack that methylation, resist standard chemotherapy, and carry the worst prognosis in this disease, still came out ahead with the vaccine, at a hazard ratio of 0.93. A treatment that helps across the whole population, and helps most where the biology is most favorable, is acting like a real drug. 📉 𝗪𝗵𝘆 𝘁𝗵𝗲 𝗺𝗲𝗱𝗶𝗮𝗻 𝗵𝗶𝗱𝗲𝘀 𝘁𝗵𝗲 𝗿𝗲𝗮𝗹 𝘀𝘁𝗼𝗿𝘆 That five-year number is the whole story, and the median buries it. Almost every treatment that ever helped in glioblastoma did the same modest thing: it slid the survival curve a few months to the right, then let it fall back. Doubling five-year survival is different in kind. A three-month gain at the median cannot, by itself, double the fraction alive at five years. The only shape that produces both numbers is a split: most patients get the small delay the median measures, while a subset gets durable disease control that lasts for years, well past where glioblastoma should have ended them. That subset is the long tail of the curve, and it is where the benefit lives. A median ignores extremes, the way a town's median income tells you nothing about its millionaires. The real story is not a longer delay; it is that a meaningful share of patients simply stay alive. 🧬 𝗪𝗵𝘆 𝘁𝗵𝗲 𝗯𝗶𝗼𝗹𝗼𝗴𝘆 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝘀 𝘁𝗵𝗶𝘀 𝘀𝗵𝗮𝗽𝗲 The tail is not luck. It is what this biology is built to produce. The vaccine carries proteins from the patient's own tumor, so it aims the immune system at whatever that tumor is made of, not a fixed short list of targets. And it amplifies: one trained immune cell drives many others that multiply into cancer-killers. Andres Salazar, the neurologist who developed poly-ICLC into the clinical adjuvant given with the vaccine, puts it in a line: you start the fire, and you keep it burning. A response like that does not produce a one-time bump. It builds and widens over time. What matters is not just that a response forms, but what kind. Dendritic cells are the immune system's master switch for that, the cells that set what kind of attack the body mounts, and this vaccine is built from them. It drives what immunologists call a type 1 polarized response: an interferon-driven, cytotoxic program aimed squarely at the tumor. That direction comes from the vaccine itself; the poly-ICLC adjuvant given with it drives the same interferon program and sustains it. That is the active ingredient, and it has been measured. In UCLA studies of this approach, the patients whose immune systems mounted the strongest interferon response lived the longest. The response also spreads. In a different cancer, a vaccine carried on this same poly-ICLC adjuvant drove more than 70% of a patient's cancer-killing T cells to target proteins that were never in the vaccine: the immune system outgrew its original targets and went after the rest of the tumor on its own. This is called epitope spreading, and it is not particular to one tumor; it is what this kind of response does, and it is the kind of response DCVax-L builds. That breadth is the likeliest thing separating the long-term survivors from everyone else, a response that breaks past its targets and clears the disease rather than one that stays caged and stops. There is even a tell in who benefits most: the effect is largest in tumors whose biology builds up more mutations under chemotherapy, and more mutations mean more targets for a whole-tumor vaccine to find. The same logic explains what the vaccine is not, and what it does not need. Checkpoint inhibitors, the drugs that release the immune system's brakes, have failed on their own in glioblastoma because there was no active response to release; the vaccine supplies that response first. That makes the vaccine the natural foundation for combination therapy. Combining it with its poly-ICLC adjuvant, made by Oncovir, has already shown meaningful survival gains in a published analysis. In the pivotal trial, the vaccine's proven benefit came added on top of standard chemotherapy and radiation; the newer question is how much the immune response can carry on its own. A UCLA trial is now testing that in patients whose tumors have returned, adding #Keytruda (pembrolizumab), the checkpoint antibody from $MRK, in a regimen built entirely around the immune response with no chemotherapy or radiation in it at all. Its interim survival curve shows the shape the biology predicts. In the arm given the vaccine and Keytruda together after surgery, the curve does not fall away but flattens into a plateau, with roughly 65% of patients still alive well past the point where recurrent glioblastoma kills nearly everyone. That plateau is the signature of a response that took hold and lasted, the type 1 attack forming durable immune memory so that once the disease is controlled it stays controlled. That is where this points, and where it is already arriving, a treatment that works through the response itself, one that could in time lean less on the harsh radiation and chemotherapy that have defined glioblastoma care and barely moved its survival. These are interim results, from Prins, Cloughesy, and Liau at UCLA. 🔍 𝗣𝗔𝗥𝗧 𝗧𝗪𝗢: 𝗜𝗦 𝗜𝗧 𝗥𝗘𝗔𝗟? The trial was randomized, an independent experiment shows the outside comparison is trustworthy, and every separate check points the same way. 🤔 𝗧𝗵𝗲 𝗼𝗯𝗷𝗲𝗰𝘁𝗶𝗼𝗻, 𝗮𝗻𝗱 𝘄𝗵𝘆 𝗶𝘁 𝗺𝗶𝘀𝘀𝗲𝘀 𝘁𝗵𝗲 𝗺𝗮𝗿𝗸 So much for what happened; the harder question is whether to believe it. The trial has the feature critics attacked: it could not keep a normal placebo group, because patients assigned to placebo were allowed, by design and by medical ethics, to switch to the vaccine once their cancer returned, and almost all did. That erased the internal comparison, so survival was measured against closely matched patients from other completed trials, an approach called an external control, which critics argued could tilt toward the vaccine. What the objection misses is where the randomization went. This was a randomized, blinded trial. The patients who got the vaccine were assigned to it at random, not hand-picked, so the treated group is an ordinary slice of the trial population, not a favorable one. The crossover removed the placebo group but never touched how patients were assigned. That leaves exactly one place for bias to enter, the outside comparison group, which is precisely what the next checks test. ✅ 𝗧𝗵𝗲 𝗰𝗵𝗲𝗰𝗸 𝘁𝗵𝗮𝘁 𝗺𝗮𝗸𝗲𝘀 𝗶𝘁 𝘁𝗿𝘂𝘀𝘁𝘄𝗼𝗿𝘁𝗵𝘆 Before trusting a scale to weigh something unknown, you confirm it reads zero with nothing on it. That is what the calibration does, and it is the strongest part of the case. A separate, independent randomized trial called INSIGhT was run through the very same external-control method, and it gave two answers. First, three experimental drugs that had already failed were run through it, and it correctly found nothing (hazard ratios of 1.00, 0.93, and 0.88): the method does not manufacture a benefit where none exists. Second, INSIGhT's external controls were set head to head against its own randomized internal controls, and they were statistically indistinguishable. In this disease, an external control reproduces the answer a real randomized control would have given, and because that trial belonged to a different group, no one can say a sponsor graded its own work. The one place bias could enter, the control side, is the one place an independent randomized experiment certified as clean. There is a deeper fit worth naming, and it is what makes the two halves of this case one. The same instrument that reported those three failures as failures reads the vaccine as a success, and the biology says why: those drugs could not hold a tumor this varied, and the vaccine builds the broad, lasting response that finally does. One method, opposite readings, and one mechanism behind both. The statistics and the biology are not two arguments. They are the same argument seen twice. 🃏 𝗪𝗮𝘀 𝘁𝗵𝗲 𝗰𝗼𝗺𝗽𝗮𝗿𝗶𝘀𝗼𝗻 𝘀𝘁𝗮𝗰𝗸𝗲𝗱 𝗶𝗻 𝘁𝗵𝗲 𝘃𝗮𝗰𝗰𝗶𝗻𝗲'𝘀 𝗳𝗮𝘃𝗼𝗿? A natural worry is that the outside comparison was arranged after the fact to flatter the vaccine. The trial was built to prevent that. The patients to compare against, and the rules for matching them, were fixed in writing before anyone saw results, and an independent firm, not the company, chose the comparison trials against those rules. The trial also switched its main measure partway through, from delaying tumor growth to overall survival, but that was not a maneuver: immune treatments cause a harmless swelling that mimics tumor growth on scans and made the growth measure unreliable, and the switch was made while everyone was still blinded. Three further checks point the same way. Survival in this disease has not improved over the years the comparison spans, so same-era controls are sound. When the borrowed controls were tested directly, the comparison came out conservative rather than flattering. And the controls were counted from the same point in the disease as the vaccine patients, so neither side got a head start. Where the comparison can err, it errs against the drug. 🔬 𝗧𝗵𝗲 𝗺𝗼𝗿𝗲 𝗰𝗮𝗿𝗲𝗳𝘂𝗹 𝗮𝗻𝗮𝗹𝘆𝘀𝗶𝘀 𝗺𝗮𝗱𝗲 𝘁𝗵𝗲 𝗯𝗲𝗻𝗲𝗳𝗶𝘁 𝗯𝗶𝗴𝗴𝗲𝗿, 𝗻𝗼𝘁 𝘀𝗺𝗮𝗹𝗹𝗲𝗿 The first comparison used whole groups. A sharper one became possible once patient-level records from three other trials could be obtained, pairing each vaccine patient with controls matched on the traits that drive survival in glioblastoma, above all MGMT methylation status, matched exactly, plus age, sex, extent of surgery, residual disease, and performance status. When the comparison got sharper, the benefit grew in every one of these analyses. The original cohort-level estimate was 2.8 months. Patient-level matching across the three trials put the gain between 3.4 and 6.3 months, and a method that weights patients rather than pairing them put it between 3.4 and 4.3, with several of the matched comparisons roughly doubling the original figure. The hazard ratio moved the same way, from 0.80 to between 0.69 and 0.77. The direction matters. A real effect blurred by crude matching gets clearer when the matching improves, while a biased one tends to shrink. It got stronger. 🕵️ 𝗛𝗼𝘄 𝗺𝘂𝗰𝗵 𝗵𝗶𝗱𝗱𝗲𝗻 𝗯𝗶𝗮𝘀 𝘄𝗼𝘂𝗹𝗱 𝗶𝘁 𝘁𝗮𝗸𝗲 𝘁𝗼 𝗲𝘅𝗽𝗹𝗮𝗶𝗻 𝘁𝗵𝗶𝘀 𝗮𝘄𝗮𝘆 A fair question is how much hidden bias it would take to erase the result. Statisticians measure that with the E-value, and here a hidden factor would have to be about as strong as age is on survival, would also have to drive who received the vaccine, and would have to have escaped the decades of research that mapped every known risk factor in this disease. A second, independent check, Rosenbaum's Gamma, comes at it from the other side, asking how large an unseen imbalance between matched patients it would take to break the result, and it reaches the same verdict. Every factor strong enough to matter was already matched. A hidden one that clears that bar is not plausible. 🔒 𝗪𝗵𝘆 𝘁𝗵𝗲 𝗿𝗲𝘀𝘂𝗹𝘁 𝗶𝘀 𝗵𝗮𝗿𝗱 𝘁𝗼 𝗳𝗮𝗸𝗲 The strongest point is not any single result. It is that a hidden bias big enough to explain the effect away would have to produce the same answer in every independent test at once: • The independent randomized calibration trial. • Three separate comparison trials, drawn from different studies. • Two different statistical methods that handle the data in different ways. • A separate pooled analysis of other dendritic-cell vaccine trials. • The internal math of the survival curve, which points to the same result (about 0.71 at five years) that the patient matching found. And it would have to fall in the exact direction the biology predicted before any data existed: a slow, widening benefit concentrated in long-term survivors. A single hidden factor that could forge all of that at once is not a hidden factor. It is a coincidence that does not happen. 🩺 𝗣𝗔𝗥𝗧 𝗧𝗛𝗥𝗘𝗘: 𝗪𝗛𝗔𝗧 𝗜𝗧 𝗠𝗘𝗔𝗡𝗦 The drug is nearly free of harm, the evidence fits an established and approved regulatory path, and what remains unrun changes nothing about the case. 🛡️ 𝗧𝗵𝗲 𝘀𝗮𝗳𝗲𝘁𝘆 Two things decide whether a real effect reaches patients: whether the drug is safe enough to use, and whether regulators will accept the evidence. The first is settled. Across 2,151 doses, only five serious side effects were even possibly related to the vaccine, with no autoimmunity and no cytokine storm. It is made once, in about eight days, then stored and given as a simple injection. When a treatment barely harms, the benefit needed to justify it falls, and the benefit here clears that lower bar easily. ⏳ 𝗪𝗵𝘆 𝘁𝗵𝗲 𝘀𝘁𝗿𝗼𝗻𝗴𝗲𝗿 𝗱𝗮𝘁𝗮 𝗮𝗽𝗽𝗲𝗮𝗿𝗲𝗱 𝗼𝗻𝗹𝘆 𝗻𝗼𝘄 A reasonable person asks why the sharper analysis appeared in 2026 and not in 2023. The answer is access, not choice. The patient-level analysis was written into the trial's plan from the start, to run if and when the data could be obtained. The company tried and could not get it in 2023, because the trials that held it had not released it; it became available later through a data-sharing repository, on the data owners' timeline, not the company's. The stronger analysis was always the plan. It was waiting on data that other parties control. 🔄 𝗣𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗵𝗼𝘀𝗲 𝗰𝗮𝗻𝗰𝗲𝗿 𝗿𝗲𝘁𝘂𝗿𝗻𝗲𝗱 𝗮𝗹𝘀𝗼 𝗯𝗲𝗻𝗲𝗳𝗶𝘁𝗲𝗱 The vaccine helped not only newly diagnosed patients but also those whose tumor had already come back, and there the effect was the largest seen anywhere in the trial. In that group, median survival ran 13.2 months from recurrence against 7.8 for the controls. The separation opened immediately, with 90.6% of vaccine patients alive at six months against 64.0% of controls, and the lead held to the later marks, where survival more than doubled: 20.7% against 9.6% at two years, 11.1% against 5.1% at two and a half. These are the original cohort-level results, already published. The high-resolution patient-level matching that was applied to the newly diagnosed group has not yet been done here, for a practical reason: it needs patient records from other recurrent-cancer trials, held by a European research organization that shares them through its own formal request. Obtaining them is a routine next step, not an obstacle, and the newly diagnosed experience suggests the sharper analysis would only make the recurrent result stronger. The approval case rests on the newly diagnosed evidence, so nothing important depends on this step; it would simply sharpen a result that is already the strongest in the trial. 🏛️ 𝗪𝗵𝗮𝘁 𝘁𝗵𝗶𝘀 𝗺𝗲𝗮𝗻𝘀 𝗳𝗼𝗿 𝗮𝗽𝗽𝗿𝗼𝘃𝗮𝗹 Regulators do not treat an external control as a first choice, but the MHRA's guideline allows it in exactly this situation: a severe disease where a placebo trial is not ethical or feasible, and an effect large enough to interpret despite the design. The guideline even gives its own worked example of an acceptable external control, and it reads almost like a description of this trial: a rare disease, no ethical placebo, same-era standard-of-care controls, an objective survival endpoint, and an effect too large to blame on bias. DCVax-L fits on every count, and it was the first medicine ever to receive the MHRA's Promising Innovative Medicine designation, which asks essentially the same questions. The newly diagnosed case carries the decision on its own evidence, and regulators weigh that evidence against the disease it treats: in a cancer this lethal, with nothing better on offer, the question is whether the benefit is large, clear, and consistent enough to act on, and a benefit of this size, pointing the same way from every direction, is. 📜 𝗧𝗵𝗶𝘀 𝗵𝗮𝘀 𝗯𝗲𝗲𝗻 𝗱𝗼𝗻𝗲 𝗯𝗲𝗳𝗼𝗿𝗲, 𝗮𝗻𝗱 𝗮𝗽𝗽𝗿𝗼𝘃𝗲𝗱 External controls are not a novelty invented for this drug. Over the past two decades they have factored into roughly forty-five drug approvals by the United States regulator, each granted under the conditions that apply here: a serious or rare disease, a placebo that would be unethical, and high unmet need. Regulators do not grant this lightly. They grant it when the disease is serious, its course is predictable and objectively measured, and the effect is large. Glioblastoma meets all three. The named cases cover every part of this disease's profile. Defibrotide, for a life-threatening transplant complication, was approved on a propensity-score comparison to a historical control, the same kind of method used here. Blinatumomab, for an aggressive relapsed leukemia, is the precedent for a fast-killing cancer, cleared by both the United States and European regulators. Cerliponase alfa is the precedent for a fatal brain disease, cleared by both agencies on treated patients versus a matched natural-history group. Glioblastoma is both at once, a fast-killing cancer of the brain, read by the same method, so no part of its profile lacks a close approved precedent. And on the one axis that governs how far an external-control result can be trusted, DCVax-L goes beyond all three. Each of those drugs was tested in a single-arm trial, with no randomization at all. DCVax-L began as a randomized trial and became an external-control comparison only when ethics consumed its placebo group. It sits in that tradition, and at the top of it. 🎯 𝗧𝗵𝗲 𝗯𝗼𝘁𝘁𝗼𝗺 𝗹𝗶𝗻𝗲 This began as a randomized trial. Medical ethics forced it into an external-control comparison. Every independent way of checking it, on different data and different math, points the same direction, and the biology predicted that direction in advance. The first analysis did not overstate the vaccine's effect. Read with the right tools, it understated it.

Andrew Caravello, DO

10,959 次观看 • 1 个月前