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🚨Exposing Separate state controversy -I exposed BJP IT cell hypocrisy in this video. -Also, if you agree with General category demands, please RT & share it with everyone.🙏 -Let's spread awareness. Timestamps: 0:35 - BJP talks of separate state 0:40- BJP leaders demand separate state 0:48 - RSS talks...

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Satyajeet Mishra

7,832 subscribers

12,044 次观看 • 5 个月前 •via X (Twitter)

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Kerala Sir, 100% Literacy Sir. Epic Reply to the Makers of KERALA STORY 2 with A AI Video. Beef is Openly Available in the BJP Ruled state Of GOA INDIA Ranks third in Beef Export But Propaganda is to be Spread Only Against Kerala by making fake films. But This Time People are Raising their voice against this Propaganda. 90% of the people there, be it from BJP RSS, Hindu, Muslim or Christian, all eat beef, mutton and pork. Is it patriotism to defame a state by making a propaganda film? Watch the video and must Answer
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Kerala Sir, 100% Literacy Sir. Epic Reply to the Makers of KERALA STORY 2 with A AI Video. Beef is Openly Available in the BJP Ruled state Of GOA INDIA Ranks third in Beef Export But Propaganda is to be Spread Only Against Kerala by making fake films. But This Time People are Raising their voice against this Propaganda. 90% of the people there, be it from BJP RSS, Hindu, Muslim or Christian, all eat beef, mutton and pork. Is it patriotism to defame a state by making a propaganda film? Watch the video and must Answer

BITTU SHARMA- ‏بٹو شرما

142,502 次观看 • 4 个月前

🚨 GET RID OF A-LOT OF INPUT DELAY 🚨 (tips on my profile) PLEASE Like, RT, and REPLY. Will also help SOME with, hit reg and packet burst. Come back and QUOTE+reply if this video later on if it helped you Also do this BEFORE you buy my Opti if your in line it can stack w/it
8:27

🚨 GET RID OF A-LOT OF INPUT DELAY 🚨 (tips on my profile) PLEASE Like, RT, and REPLY. Will also help SOME with, hit reg and packet burst. Come back and QUOTE+reply if this video later on if it helped you Also do this BEFORE you buy my Opti if your in line it can stack w/it

AllSkillNoTalk| PC & Internet Tweaker/Optimizer

445,097 次观看 • 2 年前

BREAKING NEWS Dhruv Rathee has released another video to counter WhatsApp University and lies in PM Modi's speech He has exposed hypocrisy of BJP leaders on Aurangzeb to polarize election🔥 In just 26 minutes, Dhruv torn apart world's largest IT Cell like a piece of toy. He never stopped after that video in which he proved Dictator rule. Share and spread maximum to reach with this exclusive video to everyone. This should hit 2.5 million views till morning on YT. #DhruvRathee #Dhruv_Rathee #Mission100Crore #LokSabhaElection2024
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BREAKING NEWS Dhruv Rathee has released another video to counter WhatsApp University and lies in PM Modi's speech He has exposed hypocrisy of BJP leaders on Aurangzeb to polarize election🔥 In just 26 minutes, Dhruv torn apart world's largest IT Cell like a piece of toy. He never stopped after that video in which he proved Dictator rule. Share and spread maximum to reach with this exclusive video to everyone. This should hit 2.5 million views till morning on YT. #DhruvRathee #Dhruv_Rathee #Mission100Crore #LokSabhaElection2024

Amock_

141,847 次观看 • 2 年前

This video is from Thiruvananthapuram. Kerala Police is giving the treatment to SFI "activists" for protesting against a fee hike in some colleges. I've no issue with the police, SFI deserves the worst. But doesn't this expose the hypocrisy of Pappu & Co.? Imagine if a BJP-ruled state increased fees and protesters were treated like this for opposing it...
3:25

This video is from Thiruvananthapuram. Kerala Police is giving the treatment to SFI "activists" for protesting against a fee hike in some colleges. I've no issue with the police, SFI deserves the worst. But doesn't this expose the hypocrisy of Pappu & Co.? Imagine if a BJP-ruled state increased fees and protesters were treated like this for opposing it...

Mr Sinha

128,359 次观看 • 24 天前

#WATCH | #DelhiElection2025 | In a video message, AAP National Convenor Arvind Kejriwal addresses BJP supporters, he says, "A few days back I met a 'kattar' BJP supporter, he asked Arvind ji, what if you lose? I also smiled and asked, what will happen to you if I'll lose? I asked where your children go to study to which he replied - in a govt school as schools are better now and the teachers are also good there. Then I asked in which BJP-ruled state, schools are better than us and he replied - none... I said if I lose this election, free electricity, free water, free healthcare free buses for women and good education - all these things would stop and it will cost you around 25,000. I asked him to forget about politics, and BJP and think about family. He said - I'll vote for you in this election but will not leave the BJP... I appeal to all the BJP supporters that if the BJP govt comes, all our schemes will be stopped. It will cost you around Rs 25,000; do you have this much money? Can you bear this loss? I don't think so. Being your brother - I appeal to you to vote for AAP in this election - it's your choice to leave BJP or not, but vote for us in this election." (Source - AAP)
3:07

#WATCH | #DelhiElection2025 | In a video message, AAP National Convenor Arvind Kejriwal addresses BJP supporters, he says, "A few days back I met a 'kattar' BJP supporter, he asked Arvind ji, what if you lose? I also smiled and asked, what will happen to you if I'll lose? I asked where your children go to study to which he replied - in a govt school as schools are better now and the teachers are also good there. Then I asked in which BJP-ruled state, schools are better than us and he replied - none... I said if I lose this election, free electricity, free water, free healthcare free buses for women and good education - all these things would stop and it will cost you around 25,000. I asked him to forget about politics, and BJP and think about family. He said - I'll vote for you in this election but will not leave the BJP... I appeal to all the BJP supporters that if the BJP govt comes, all our schemes will be stopped. It will cost you around Rs 25,000; do you have this much money? Can you bear this loss? I don't think so. Being your brother - I appeal to you to vote for AAP in this election - it's your choice to leave BJP or not, but vote for us in this election." (Source - AAP)

ANI

577,671 次观看 • 1 年前

You know why i don’t trust wahid para or his party Listen to this video, how when they were in Coalition with BJP he is supporting and justifying what BJP has now, how he is claiming that it is MR MODI who will take us out of this mess. “The question is why are we passing the resolution, what was need, who took it ask these questions to yourself the answer you will get is “Coalition of PDP with BJP” the power hungry morons were in awe of BJP at that time and now are doing this shit show of being our messiah, Has their leader been sorry for “tofee remark” answer is NO! We know what you did, we remember what you did, stop this nonsense, we know when in power how you took jobs from students and whole JK bank is filled with PDP backdoor entries there is separate group in JKbank “ yechu PDP woul” Just let government do job .
1:58

You know why i don’t trust wahid para or his party Listen to this video, how when they were in Coalition with BJP he is supporting and justifying what BJP has now, how he is claiming that it is MR MODI who will take us out of this mess. “The question is why are we passing the resolution, what was need, who took it ask these questions to yourself the answer you will get is “Coalition of PDP with BJP” the power hungry morons were in awe of BJP at that time and now are doing this shit show of being our messiah, Has their leader been sorry for “tofee remark” answer is NO! We know what you did, we remember what you did, stop this nonsense, we know when in power how you took jobs from students and whole JK bank is filled with PDP backdoor entries there is separate group in JKbank “ yechu PDP woul” Just let government do job .

Sherlock Ohms

15,028 次观看 • 1 年前

I started from $0 and am taking it to $10,000 to prove anyone can do it in a month. This video is of me and Keyflow doordashing to get enough to buy a prop firm account. This is a preview I made of some funny clips from the vid Hope you all follow along the journey.
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I started from $0 and am taking it to $10,000 to prove anyone can do it in a month. This video is of me and Keyflow doordashing to get enough to buy a prop firm account. This is a preview I made of some funny clips from the vid Hope you all follow along the journey.

Shinobi

26,792 次观看 • 1 年前

How to grow your SaaS from $0 to $1M ARR (1+ hour FREE course) I just released a free course where I break down everything we learned going from $0 to $1M ARR. The exact strategies that actually moved the needle. It’s all inside this video and you can watch it right now. I also recorded a 10-minute bonus explaining how one viral post generated $20k in new MRR. RT + comment "BONUS" and I’ll send it.
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How to grow your SaaS from $0 to $1M ARR (1+ hour FREE course) I just released a free course where I break down everything we learned going from $0 to $1M ARR. The exact strategies that actually moved the needle. It’s all inside this video and you can watch it right now. I also recorded a 10-minute bonus explaining how one viral post generated $20k in new MRR. RT + comment "BONUS" and I’ll send it.

Romàn

16,804 次观看 • 4 个月前

. BJP Karnataka’s fake news factory is working overtime, they are desperately trying to emulate Joseph Goebbels. Please play the video entirely and people will know the context. Also, BJP IT & social media coolies, this speech was done when your Government was in power. Why didn’t you book a case against me? Why didn’t you throw me in jail? Why are you disowning your BJP candidate of Chittapur against whom this speech was directed? BTW, BJP President Vijayendra Yediyurappa and LoP Chalavadi Narayanaswamy, please listen to the conversation where your MLA candidate who had stated that he would murder my family. I filed a complaint during your regime, but you rewarded him with a ticket. FYI, he was in jail for a couple months this year. Maybe I should follow your suggestion and make Kalaburgi a BJP Free Republic. Do your homework better next time or your Delhi bosses will get mad at you. For the last time, I might be a Minister for whatever reason, please tell me how Sri. Vijendra qualified for the BJP State Chief and how many RSS shakas he has attended since he was a child. I have offered free DNA testing for BJP members, but you never seem to take it up. Are you people afraid that you might find out something you don’t want to know?
0:50

. BJP Karnataka’s fake news factory is working overtime, they are desperately trying to emulate Joseph Goebbels. Please play the video entirely and people will know the context. Also, BJP IT & social media coolies, this speech was done when your Government was in power. Why didn’t you book a case against me? Why didn’t you throw me in jail? Why are you disowning your BJP candidate of Chittapur against whom this speech was directed? BTW, BJP President Vijayendra Yediyurappa and LoP Chalavadi Narayanaswamy, please listen to the conversation where your MLA candidate who had stated that he would murder my family. I filed a complaint during your regime, but you rewarded him with a ticket. FYI, he was in jail for a couple months this year. Maybe I should follow your suggestion and make Kalaburgi a BJP Free Republic. Do your homework better next time or your Delhi bosses will get mad at you. For the last time, I might be a Minister for whatever reason, please tell me how Sri. Vijendra qualified for the BJP State Chief and how many RSS shakas he has attended since he was a child. I have offered free DNA testing for BJP members, but you never seem to take it up. Are you people afraid that you might find out something you don’t want to know?

Priyank Kharge / ಪ್ರಿಯಾಂಕ್ ಖರ್ಗೆ

25,760 次观看 • 1 年前

Today I will show you the importance of your vote. Yes, the very same Right which you ignore while taking your family out on a holiday or to the movies on voting day. This video is from WB. Observe the Mahadev sticker on the car and how it is being vandalised by a certain community. Imagine the state of the family and kids inside. Imagine if it was YOU with your daughter and wife inside. This can be executed with impunity in WB because this state votes for TMC. Try this in UP, Assam, MH, Rajasthan, Delhi and see the consequences. Next time your girl group or friends suggest going for a picnic on voting day, recall this video. VOTE !!🙏🙏🙏
0:31

Today I will show you the importance of your vote. Yes, the very same Right which you ignore while taking your family out on a holiday or to the movies on voting day. This video is from WB. Observe the Mahadev sticker on the car and how it is being vandalised by a certain community. Imagine the state of the family and kids inside. Imagine if it was YOU with your daughter and wife inside. This can be executed with impunity in WB because this state votes for TMC. Try this in UP, Assam, MH, Rajasthan, Delhi and see the consequences. Next time your girl group or friends suggest going for a picnic on voting day, recall this video. VOTE !!🙏🙏🙏

Dr Poornima 🇮🇳

256,944 次观看 • 9 个月前

It has come to light by members of the RSS who are on record -- a gentleman by the name of Shantanu Sinha related to Rahul Sinha, an office bearer of the BJP in Bengal has alleged that Mr Amit Malviya, the head of BJP IT Cell has indulged in nefarious activities, he has indulged in sexual exploitation of women not only in 5-star hotels but also in BJP offices in Bengal. We seek from the BJP justice for women in Bengal; whether it is Hathras, Lakhimpur, our most decorated athletes, or Bilkis Bano, the Prime Minister has consistently given political patronage to the perpetrators of crime. It is high time you stand with women. It is high time you stand with the daughter of India and unless and until you do not answer their plight, you have no business to be in power. Less than 24 hours after the PM has been sworn in, serious charges of sexual allegations have been levelled against a prominent office-bearer of the BJP. But is it to anybody’s surprise? If you remember the IIT-BHU gangrape and the three people involved --- Saksham Patel, Kunal Pander, and Anand Chauhan --- are all extremely close to the senior leaders of the BJP including PM Modi. This is a pattern, whether it is Kuldeep Singh Sengar, Chinmyanand, Brij Bhushan, or Ankita Bhandari’s murderers, they are all BJP leaders protected by Narendra Modi. : Supriya Shrinate ji
2:16

It has come to light by members of the RSS who are on record -- a gentleman by the name of Shantanu Sinha related to Rahul Sinha, an office bearer of the BJP in Bengal has alleged that Mr Amit Malviya, the head of BJP IT Cell has indulged in nefarious activities, he has indulged in sexual exploitation of women not only in 5-star hotels but also in BJP offices in Bengal. We seek from the BJP justice for women in Bengal; whether it is Hathras, Lakhimpur, our most decorated athletes, or Bilkis Bano, the Prime Minister has consistently given political patronage to the perpetrators of crime. It is high time you stand with women. It is high time you stand with the daughter of India and unless and until you do not answer their plight, you have no business to be in power. Less than 24 hours after the PM has been sworn in, serious charges of sexual allegations have been levelled against a prominent office-bearer of the BJP. But is it to anybody’s surprise? If you remember the IIT-BHU gangrape and the three people involved --- Saksham Patel, Kunal Pander, and Anand Chauhan --- are all extremely close to the senior leaders of the BJP including PM Modi. This is a pattern, whether it is Kuldeep Singh Sengar, Chinmyanand, Brij Bhushan, or Ankita Bhandari’s murderers, they are all BJP leaders protected by Narendra Modi. : Supriya Shrinate ji

Congress

123,300 次观看 • 2 年前

Claude Opus 4.5 is the most powerful AI model ever released It allows you to build apps with 0 technical knowledge needed You MUST try it In this video I go over how to get the most out of Opus and how to build incredible apps with it, even if you've never coded before:
13:49

Claude Opus 4.5 is the most powerful AI model ever released It allows you to build apps with 0 technical knowledge needed You MUST try it In this video I go over how to get the most out of Opus and how to build incredible apps with it, even if you've never coded before:

Alex Finn

32,627 次观看 • 7 个月前

This is VERY BAD for Ruben Gallego If you have a moment, I need your help. Can you share this video with EVERY voter you know in Arizona? Even if they have already voted, they may know other people that need to see it. I will be posting it on EVERY social media platform. Retweet, share, message and spread this video to everyone in Arizona. (Even if you’re not from Arizona, you can send it to your friends here!) If you or anyone else needs info on where/how to vote, go to Thank you so much! -Kari ♥️
0:27

This is VERY BAD for Ruben Gallego If you have a moment, I need your help. Can you share this video with EVERY voter you know in Arizona? Even if they have already voted, they may know other people that need to see it. I will be posting it on EVERY social media platform. Retweet, share, message and spread this video to everyone in Arizona. (Even if you’re not from Arizona, you can send it to your friends here!) If you or anyone else needs info on where/how to vote, go to Thank you so much! -Kari ♥️

Kari Lake

117,392 次观看 • 1 年前

🚨 THE "TWO-STATE SOLUTION" IS A LIE. 40 YEARS OF OSLO = 0% FREEDOM 🚨 When people say they support a "Two-State Solution," George Galloway asks: ➠ "Where is this two state solution?" ▫️ OSLO ACCORDS (1993): 40+ years later → not 1cm of Palestine is free. Excluded MILLIONS of refugees worldwide: • "Lucky" in US/Canada → forever displaced. • 3rd/4th generations in camps (Lebanon/Jordan/Syria) → born into despair + poverty. ▫️ OSLO PROMISED PEACE. IT DELIVERED: ✖️ Occupation ✖️ Apartheid ✖️ Permanent exile THE "SOLUTION" IS A MYTH: A slogan masking 40 years of colonisation and ethnic cleansing. #OneStatePalestine #FreePalestine #EndTheOccupation #RightOfReturn #OsloFailed #PalestinianRefugees #Justice 🔁 RT if you demand TRUTH + RIGHTS for ALL Palestinians.
1:03

🚨 THE "TWO-STATE SOLUTION" IS A LIE. 40 YEARS OF OSLO = 0% FREEDOM 🚨 When people say they support a "Two-State Solution," George Galloway asks: ➠ "Where is this two state solution?" ▫️ OSLO ACCORDS (1993): 40+ years later → not 1cm of Palestine is free. Excluded MILLIONS of refugees worldwide: • "Lucky" in US/Canada → forever displaced. • 3rd/4th generations in camps (Lebanon/Jordan/Syria) → born into despair + poverty. ▫️ OSLO PROMISED PEACE. IT DELIVERED: ✖️ Occupation ✖️ Apartheid ✖️ Permanent exile THE "SOLUTION" IS A MYTH: A slogan masking 40 years of colonisation and ethnic cleansing. #OneStatePalestine #FreePalestine #EndTheOccupation #RightOfReturn #OsloFailed #PalestinianRefugees #Justice 🔁 RT if you demand TRUTH + RIGHTS for ALL Palestinians.

OneStatePalestine

24,799 次观看 • 11 个月前

Not all abuse starts with violence. Sometimes it begins with control. With isolation. With subtle manipulation disguised as “love” or “concern.” In this video, we break down common traits often associated with abusive behavior. Understanding these patterns can help individuals identify unhealthy dynamics early and make informed decisions. Awareness is protection and recognizing the signs could save someone from long-term harm. Watch, share, and continue the conversation. If you or someone you know needs support: 📞 Hotline: 0-8000-333-333 📧 USSD: *6820# (MTN subscribers only) 🌐 #LagosDSVA #RealConversationsWithDSVA #SGBVItConcernsUsAll #SGBVNotInMyLagos #LASG The Lagos State Govt
1:36

Not all abuse starts with violence. Sometimes it begins with control. With isolation. With subtle manipulation disguised as “love” or “concern.” In this video, we break down common traits often associated with abusive behavior. Understanding these patterns can help individuals identify unhealthy dynamics early and make informed decisions. Awareness is protection and recognizing the signs could save someone from long-term harm. Watch, share, and continue the conversation. If you or someone you know needs support: 📞 Hotline: 0-8000-333-333 📧 USSD: *6820# (MTN subscribers only) 🌐 #LagosDSVA #RealConversationsWithDSVA #SGBVItConcernsUsAll #SGBVNotInMyLagos #LASG The Lagos State Govt

Lagos DSVA

53,887 次观看 • 4 个月前

Venus Aerospace is building a detonation ramjet engine. It's a unique design: one engine to go from Mach 0 to Mach 6, with a rotating-detonation rocket engine upstream and a ramjet downstream. The rocket starts the flight, and the ramjet brings the specific impulse you need for commercial air travel. I invited Venus CTO Andrew Duggleby to the Astranis office to talk about how it works, what he's already demonstrated (a lot!), and what is left between Venus Aerospace and hypersonic flight. Timestamps: 0:00:00 — Introducing the detonation ramjet 0:04:27 — How rockets can be more efficient than turbofans 0:09:10 — Riding up the ISP curve with a ramjet 0:13:07 — What has Venus built so far? 0:22:40 — The driving constraint: heat 0:25:17 — Is this too hard to model with CFD tools? 0:30:52 — How did you prove to yourself this could work? 0:33:09 — How does this approach differ from other super/hypersonic jets? 0:38:30 — How is the government supporting hypersonic development? 0:40:36 — Was a Twitter commenter correct to roast my earlier video on ramjets? 0:45:20 — Why not just use normal rockets for point-to-point transportation? 0:47:50 — How does this engine work for takeoff and landing? 0:51:15 — "If I could add a new regulation..." 0:55:30 — "Hypersonics is the speed at which heat kicks your ass" 0:58:31 — What's the next big technical demo?
1:00:30

Venus Aerospace is building a detonation ramjet engine. It's a unique design: one engine to go from Mach 0 to Mach 6, with a rotating-detonation rocket engine upstream and a ramjet downstream. The rocket starts the flight, and the ramjet brings the specific impulse you need for commercial air travel. I invited Venus CTO Andrew Duggleby to the Astranis office to talk about how it works, what he's already demonstrated (a lot!), and what is left between Venus Aerospace and hypersonic flight. Timestamps: 0:00:00 — Introducing the detonation ramjet 0:04:27 — How rockets can be more efficient than turbofans 0:09:10 — Riding up the ISP curve with a ramjet 0:13:07 — What has Venus built so far? 0:22:40 — The driving constraint: heat 0:25:17 — Is this too hard to model with CFD tools? 0:30:52 — How did you prove to yourself this could work? 0:33:09 — How does this approach differ from other super/hypersonic jets? 0:38:30 — How is the government supporting hypersonic development? 0:40:36 — Was a Twitter commenter correct to roast my earlier video on ramjets? 0:45:20 — Why not just use normal rockets for point-to-point transportation? 0:47:50 — How does this engine work for takeoff and landing? 0:51:15 — "If I could add a new regulation..." 0:55:30 — "Hypersonics is the speed at which heat kicks your ass" 0:58:31 — What's the next big technical demo?

Christian Keil

36,178 次观看 • 1 年前

Favor is 23. A sickle cell warrior and currently at the risk of amputation of both forearms if she doesn’t get the properly treatment. The wound requires daily dressing in preparation for surgery. She would also need blood transfusion as her blood level is too low. I have been footing her bills since last year and i can no longer do it alone. If you can please donate via 6060313332 Heal for africa initiative Fidelity bank (Warning: graphic pictures/video. Please share this post 🙏🙏
0:13

Favor is 23. A sickle cell warrior and currently at the risk of amputation of both forearms if she doesn’t get the properly treatment. The wound requires daily dressing in preparation for surgery. She would also need blood transfusion as her blood level is too low. I have been footing her bills since last year and i can no longer do it alone. If you can please donate via 6060313332 Heal for africa initiative Fidelity bank (Warning: graphic pictures/video. Please share this post 🙏🙏

Dr Kelechi Okoro | Ebonyi Babe

647,404 次观看 • 2 年前

Today: a 1.5 hour interview with the co-founders of Coherence Neuro: Ben Woodington and Elise Jenkins They are, as far as i can tell, the only (neurotechnology x oncology) startup that exists today. 'Neurotechnology? For cancer?' you may ask. Yes! As it turns out, tumors interact with the nervous system a fair bit, and you can use the very same neuromodulation toolbox that exists for neuropsychiatric conditions, for monitoring and treating cancer. Coherence has built an invasive device to place at the site of a tumor to do exactly this. Their first indication is a form of brain cancer called glioblastoma; one of the most fatal subtypes of cancer to exist today. The standard of care (with one exception that we discuss) has not changed in 25 years. If Coherence works out, and there is a very real chance they will, that may change. Most interesting of all is that Coherence believes that the bioelectric properties of cancer are not just worth poking at for brain cancers, but for all cancers. And maybe even for diseases outside of it! This conversation covers how Coherence’s first neurotech device (SOMA) works, the molecular reasons behind why neuromodulation affects cancer at all, what the biomarker readouts look like, the obvious Michael Levin comparison, and a lot more. Also: shout to Nicole for setting up the connection here in the first place! Crazy to think that a meeting in mid-2025 ended up leading to this Youtube/Spotify/Apple Podcasts links in replies 0:00:00 - Introduction 0:01:42 - How is SOMA different from Novocure’s Optune? 0:08:57 - Why does neuromodulation affect cancer at all? 0:13:28 - How was cancer-nervous system crosstalk first discovered? 0:15:42 - Anti-epileptics and beta blockers as accidental cancer drugs 0:17:38 - What is molecularly happening when you block cancer-neuron crosstalk? 0:19:50 - What is SOMA actually reading out as a biomarker? 0:20:44 - What does it mean that cancer is “very electric”? 0:22:02 - Can you derive universal biomarkers across patients? 0:23:09 - How is the device placed? 0:24:45 - How does the blocking stimulation regime work? 0:26:43 - Is it fair to say this is closed loop? 0:29:05 - Why not just spam the tumor with constant stimulation? 0:32:31 - Why MRI safety is non-negotiable for oncology devices 0:33:35 - Walk us through the patient journey from diagnosis to implantation 0:36:13 - The Michael Levin question: can you reprogram cancer back to normal? 0:42:29 - Efficacy, hospice settings, and the utility of the neuromodulation literature 0:45:52 - Why start with glioblastoma instead of an easier cancer? 0:48:57 - Regulatory strategy and the reimbursement threat 0:55:37 - How well does mouse-to-human translation work for neuromodulation? 0:55:57 - What do in silico models of neuromodulation look like? 0:58:09 - Why didn’t this exist 10 years ago? 1:01:48 - The founding story 1:06:38 - Why build your own device instead of using off-the-shelf arrays? 1:08:35 - Speaking with glioblastoma patients 1:12:04 - What was it like to raise money for this? 1:13:56 - Beyond cancer: TBI, lung disease, and the pan-disease argument 1:17:40 - Hiring at Coherence + what is the hardest type of talent to find 1:23:17 - What would you do with $100M equity-free? 1:27:15 - Are you a neurotech company or a cancer company?
1:33:20

Today: a 1.5 hour interview with the co-founders of Coherence Neuro: Ben Woodington and Elise Jenkins They are, as far as i can tell, the only (neurotechnology x oncology) startup that exists today. 'Neurotechnology? For cancer?' you may ask. Yes! As it turns out, tumors interact with the nervous system a fair bit, and you can use the very same neuromodulation toolbox that exists for neuropsychiatric conditions, for monitoring and treating cancer. Coherence has built an invasive device to place at the site of a tumor to do exactly this. Their first indication is a form of brain cancer called glioblastoma; one of the most fatal subtypes of cancer to exist today. The standard of care (with one exception that we discuss) has not changed in 25 years. If Coherence works out, and there is a very real chance they will, that may change. Most interesting of all is that Coherence believes that the bioelectric properties of cancer are not just worth poking at for brain cancers, but for all cancers. And maybe even for diseases outside of it! This conversation covers how Coherence’s first neurotech device (SOMA) works, the molecular reasons behind why neuromodulation affects cancer at all, what the biomarker readouts look like, the obvious Michael Levin comparison, and a lot more. Also: shout to Nicole for setting up the connection here in the first place! Crazy to think that a meeting in mid-2025 ended up leading to this Youtube/Spotify/Apple Podcasts links in replies 0:00:00 - Introduction 0:01:42 - How is SOMA different from Novocure’s Optune? 0:08:57 - Why does neuromodulation affect cancer at all? 0:13:28 - How was cancer-nervous system crosstalk first discovered? 0:15:42 - Anti-epileptics and beta blockers as accidental cancer drugs 0:17:38 - What is molecularly happening when you block cancer-neuron crosstalk? 0:19:50 - What is SOMA actually reading out as a biomarker? 0:20:44 - What does it mean that cancer is “very electric”? 0:22:02 - Can you derive universal biomarkers across patients? 0:23:09 - How is the device placed? 0:24:45 - How does the blocking stimulation regime work? 0:26:43 - Is it fair to say this is closed loop? 0:29:05 - Why not just spam the tumor with constant stimulation? 0:32:31 - Why MRI safety is non-negotiable for oncology devices 0:33:35 - Walk us through the patient journey from diagnosis to implantation 0:36:13 - The Michael Levin question: can you reprogram cancer back to normal? 0:42:29 - Efficacy, hospice settings, and the utility of the neuromodulation literature 0:45:52 - Why start with glioblastoma instead of an easier cancer? 0:48:57 - Regulatory strategy and the reimbursement threat 0:55:37 - How well does mouse-to-human translation work for neuromodulation? 0:55:57 - What do in silico models of neuromodulation look like? 0:58:09 - Why didn’t this exist 10 years ago? 1:01:48 - The founding story 1:06:38 - Why build your own device instead of using off-the-shelf arrays? 1:08:35 - Speaking with glioblastoma patients 1:12:04 - What was it like to raise money for this? 1:13:56 - Beyond cancer: TBI, lung disease, and the pan-disease argument 1:17:40 - Hiring at Coherence + what is the hardest type of talent to find 1:23:17 - What would you do with $100M equity-free? 1:27:15 - Are you a neurotech company or a cancer company?

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37,299 次观看 • 4 个月前