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Fantastic news for genome engineers: Bridge recombinases work in human cells!!🧬 And they can make really big insertions, deletions, and inversions with impressive efficiency. From Arc Institute Patrick Hsu Nicholas Perry & team

Julia Bauman

10,467 subscribers

16,353 просмотров • 1 год назад •via X (Twitter)

Anya Rossi• Live Now

Private livecam show

Комментарии: 3

Фото профиля Julia Bauman

Julia Bauman1 год назад

The preprint: The tweetorial:

Фото профиля Julia Bauman

Julia Bauman1 год назад

The STICHR video:

Фото профиля ksminnovation

ksminnovation1 год назад

AI is transforming healthcare! A KSM-led study shows AI can detect Celiac disease 4 years earlier @TalPatalon @MedPredict

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Can AI cure disease & make science faster? Patrick Hsu Jorge Conde and Erik Torenberg discuss (00:45) The Moonshot: Virtual Cells and Human Biology (02:58) Interdisciplinary Collaboration at Arc Institute (05:11) The Role of AI in Biology (10:18) Understanding Virtual Cells (22:13) Biotech and Pharma Industry Insights (28:13) Capital Intensity and Technological Advancements (30:12) Market Impact and Industry Trends (33:19) Future Technological Breakthroughs (38:15) AI in Drug Discovery (45:50) Investment Focus and Future Prospects

Can AI cure disease & make science faster? Patrick Hsu Jorge Conde and Erik Torenberg discuss (00:45) The Moonshot: Virtual Cells and Human Biology (02:58) Interdisciplinary Collaboration at Arc Institute (05:11) The Role of AI in Biology (10:18) Understanding Virtual Cells (22:13) Biotech and Pharma Industry Insights (28:13) Capital Intensity and Technological Advancements (30:12) Market Impact and Industry Trends (33:19) Future Technological Breakthroughs (38:15) AI in Drug Discovery (45:50) Investment Focus and Future Prospects

a16z

53,540 просмотров • 10 месяцев назад

watch me realize in realtime that Greg Brockman is deadly serious about character-level tokenization and it's already working well for Patrick Hsu, Silvana Konermann, and Patrick Collison's Arc Institute 's 40B model that is the "GPT-1 of DNA" with biological language models (instead of natural language), we may finally be able to understand the causes of genetic conditions like Ehlers-Danlos syndrome, scanning the billions of base pairs of individual human DNA in a massively scaled up way only AI can do. Superintelligent healthcare may be the one thing that excites me more than superintelligent coding agents.

watch me realize in realtime that Greg Brockman is deadly serious about character-level tokenization and it's already working well for Patrick Hsu, Silvana Konermann, and Patrick Collison's Arc Institute 's 40B model that is the "GPT-1 of DNA" with biological language models (instead of natural language), we may finally be able to understand the causes of genetic conditions like Ehlers-Danlos syndrome, scanning the billions of base pairs of individual human DNA in a massively scaled up way only AI can do. Superintelligent healthcare may be the one thing that excites me more than superintelligent coding agents.

swyx

75,685 просмотров • 11 месяцев назад

Whether you punch a clock or swipe a badge, work for tips or a salary, care for a child or for an aging parent, your work has dignity. Today I’m launching the Dignity of Work Institute to create an economy where Americans’ work is valued, where they benefit from the wealth they create, and where everyone can afford a decent living. Let’s make workers the winners in our economy. Follow Dignity of Work Institute

Whether you punch a clock or swipe a badge, work for tips or a salary, care for a child or for an aging parent, your work has dignity. Today I’m launching the Dignity of Work Institute to create an economy where Americans’ work is valued, where they benefit from the wealth they create, and where everyone can afford a decent living. Let’s make workers the winners in our economy. Follow Dignity of Work Institute

Sherrod Brown

47,964 просмотров • 1 год назад

Here is an introductory lecture I gave for The School of Life about my work in human genetics 🧬 What can DNA tell us about where you came from and what kind of person you will become? It's in Dutch, but with English subtitles 🇳🇱🇬🇧

Here is an introductory lecture I gave for The School of Life about my work in human genetics 🧬 What can DNA tell us about where you came from and what kind of person you will become? It's in Dutch, but with English subtitles 🇳🇱🇬🇧

Abdel Abdellaoui

18,314 просмотров • 3 лет назад

We are hiring creative strategists. If you’re excited about AI video and ads, this role is for you. With AI you can make anything. But making something worth watching requires a human. That’s why we’re building a super-team of creative strategists. You will: - Work with the fastest growing and largest AI brands - Be paid to learn at the frontier of AI - Work with the top AI marketers, filmmakers, engineers, and creators - Ship more ads per day than others do in a month

We are hiring creative strategists. If you’re excited about AI video and ads, this role is for you. With AI you can make anything. But making something worth watching requires a human. That’s why we’re building a super-team of creative strategists. You will: - Work with the fastest growing and largest AI brands - Be paid to learn at the frontier of AI - Work with the top AI marketers, filmmakers, engineers, and creators - Ship more ads per day than others do in a month

Rahul Bhardwaj

46,223 просмотров • 2 месяцев назад

BREAKING: Jacob Kimmel on closing $130M in funding for NewLimit and how epigenetic marks work "All the cells in your body have the same DNA code. Since they have the same code base, it presents a question: how do your eyeball, kidney and tongue all do different things?" "The answer is epigenetic marks, which are chemical modifications. They are kind of like control flows in software (genome), and help express different genes from your genome to do different jobs." "Turns out as you age, all of those epigenetic marks get messed up. Your cells stop using the right genes at the right time, and then they degrade in function." "This precipitates a number of diseases and pathologies that arise with age, including things that we don't even traditionally define as disease but should remedy."

BREAKING: Jacob Kimmel on closing $130M in funding for NewLimit and how epigenetic marks work "All the cells in your body have the same DNA code. Since they have the same code base, it presents a question: how do your eyeball, kidney and tongue all do different things?" "The answer is epigenetic marks, which are chemical modifications. They are kind of like control flows in software (genome), and help express different genes from your genome to do different jobs." "Turns out as you age, all of those epigenetic marks get messed up. Your cells stop using the right genes at the right time, and then they degrade in function." "This precipitates a number of diseases and pathologies that arise with age, including things that we don't even traditionally define as disease but should remedy."

TBPN

18,231 просмотров • 1 год назад

The amazing dedicated team at CSSIFM treating our cancer patients with NK cells in clinical trials. So many requests from patients who have failed all standards of care and they are working so hard to file for FDA authorization as many single patient INDs as we can. Happy Easter and stay safe

The amazing dedicated team at CSSIFM treating our cancer patients with NK cells in clinical trials. So many requests from patients who have failed all standards of care and they are working so hard to file for FDA authorization as many single patient INDs as we can. Happy Easter and stay safe

Dr. Pat Soon-Shiong

32,877 просмотров • 4 месяцев назад

Elon Musk: - "Physics is the law and everything else is a recommendation!" - "I've seen many people break human-made laws, but I have not seen anyone break the laws of physics." As AI becomes more capable, the only law it will really have to obey is the law of physics. -- to me that's a powerful argument: AI specifications will mutate and evolve and we shouldn't really expect any fundamental constants. The only reasonable assumption we can make is that these systems, being really capable, will be able to reason from "first principles" with impressive accuracy and efficiency.

Elon Musk: - "Physics is the law and everything else is a recommendation!" - "I've seen many people break human-made laws, but I have not seen anyone break the laws of physics." As AI becomes more capable, the only law it will really have to obey is the law of physics. -- to me that's a powerful argument: AI specifications will mutate and evolve and we shouldn't really expect any fundamental constants. The only reasonable assumption we can make is that these systems, being really capable, will be able to reason from "first principles" with impressive accuracy and efficiency.

Lethal Intelligence

932,783 просмотров • 1 год назад

Wow! Super impressive work by the new Amazon FAR team (from Covariant acquisition). Mapping long sequences of human motion (>30 sec) on robots with a differing shapes or interating with objects (box, table, etc) of different size. Enabling easier in-simulation data-augmentation and zero-shoot transfer. Super impressive and huge help to reduce the need for human teleop data (which is very complex to gather for humanoids) Dataset trajectories on Hugging Face (search OmniRetarget), full code framework to come soon Project page has some pretty three.js interactive demos

Wow! Super impressive work by the new Amazon FAR team (from Covariant acquisition). Mapping long sequences of human motion (>30 sec) on robots with a differing shapes or interating with objects (box, table, etc) of different size. Enabling easier in-simulation data-augmentation and zero-shoot transfer. Super impressive and huge help to reduce the need for human teleop data (which is very complex to gather for humanoids) Dataset trajectories on Hugging Face (search OmniRetarget), full code framework to come soon Project page has some pretty three.js interactive demos

Thomas Wolf

149,734 просмотров • 10 месяцев назад

When key “housekeeper” brain cells grow in lab dishes, they spawn unusual microscopic vesicles that can move on their own and carry energy-generating organelles, a research team revealed. The biologists have dubbed their discovery zombosomes because the blobs can move like cells for a period despite lacking a nucleus, which acts as a cell's control center. The group also showed the membrane-bound messengers ferry proteins related to Parkinson’s disease, suggesting they may contribute to it and other brain disorders. Learn more: News from Science

When key “housekeeper” brain cells grow in lab dishes, they spawn unusual microscopic vesicles that can move on their own and carry energy-generating organelles, a research team revealed. The biologists have dubbed their discovery zombosomes because the blobs can move like cells for a period despite lacking a nucleus, which acts as a cell's control center. The group also showed the membrane-bound messengers ferry proteins related to Parkinson’s disease, suggesting they may contribute to it and other brain disorders. Learn more: News from Science

Science Magazine

65,806 просмотров • 6 месяцев назад

🚨ImmunityBio’s Anktiva: A New FDA-Approved Immunotherapy for certain bladder cancer. They are also developing treatments that may reduce the need for strong chemo, for blood cancer, lung cancer, brain cancer, and more. Broader approvals may take time. Someone call the President and fast-track this. Dr. Pat Soon-Shiong leads development beyond typical biotech efforts. Most cancer medicines, like chemotherapy, work by poisoning fast-growing cells to kill the cancer. This also hurts healthy cells, causing side effects like hair loss and weakness. Anktiva is different. It is an immunotherapy that wakes up your body’s own immune cells; natural killer cells and T cells to hunt and destroy cancer cells themselves. It acts like a booster shot for your immune system, using a protein called IL-15 to make these cells multiply and remember how to fight cancer long-term. ImmunityBio is different from most companies because of 3 big unique things: 1. They wake up 3 kinds of fighter cells at the same time: • NK cells (natural killers) • CD8 T cells (main attackers) • CD4 T cells (helpers) These three work together like a basketball team. This makes the body remember the cancer for a long time (maybe years). 2. They have a special cell line called NK-92. → It’s like buying frozen pizza instead of making dough from scratch every time. Doctors can just thaw it and give it to any patient. No need to take cells from the sick kid, customize them, and make them super weak with hospital chemo (that’s what normal CAR-T does). 3. Their medicine Anktiva gives a long, steady boost to the immune cells. Older drugs (like IL-2) gave a short, crazy boost that made people very sick. Anktiva is seems safer, so far. Exciting to follow the development. Interview: Chris Cuomo (NewsNation) — “Killing Cancer”

🚨ImmunityBio’s Anktiva: A New FDA-Approved Immunotherapy for certain bladder cancer. They are also developing treatments that may reduce the need for strong chemo, for blood cancer, lung cancer, brain cancer, and more. Broader approvals may take time. Someone call the President and fast-track this. Dr. Pat Soon-Shiong leads development beyond typical biotech efforts. Most cancer medicines, like chemotherapy, work by poisoning fast-growing cells to kill the cancer. This also hurts healthy cells, causing side effects like hair loss and weakness. Anktiva is different. It is an immunotherapy that wakes up your body’s own immune cells; natural killer cells and T cells to hunt and destroy cancer cells themselves. It acts like a booster shot for your immune system, using a protein called IL-15 to make these cells multiply and remember how to fight cancer long-term. ImmunityBio is different from most companies because of 3 big unique things: 1. They wake up 3 kinds of fighter cells at the same time: • NK cells (natural killers) • CD8 T cells (main attackers) • CD4 T cells (helpers) These three work together like a basketball team. This makes the body remember the cancer for a long time (maybe years). 2. They have a special cell line called NK-92. → It’s like buying frozen pizza instead of making dough from scratch every time. Doctors can just thaw it and give it to any patient. No need to take cells from the sick kid, customize them, and make them super weak with hospital chemo (that’s what normal CAR-T does). 3. Their medicine Anktiva gives a long, steady boost to the immune cells. Older drugs (like IL-2) gave a short, crazy boost that made people very sick. Anktiva is seems safer, so far. Exciting to follow the development. Interview: Chris Cuomo (NewsNation) — “Killing Cancer”

Black Panther Capital

40,249 просмотров • 6 месяцев назад

We just crossed a line we can’t uncross. The boundary between life and technology is gone. After years of work, a team of scientists created living tissue using cells from his own body They didn't clone a human, they built something completely new OSCAR is a living organism, about the size of a human hand Made from real human cells Human life is usually one closed system OSCAR is modular That's the massive difference Organs can be added, removed, or changed It’s not a finished product just a prototype but it's crazy to see what's already possible in science There might be many things like this we don't even know about

We just crossed a line we can’t uncross. The boundary between life and technology is gone. After years of work, a team of scientists created living tissue using cells from his own body They didn't clone a human, they built something completely new OSCAR is a living organism, about the size of a human hand Made from real human cells Human life is usually one closed system OSCAR is modular That's the massive difference Organs can be added, removed, or changed It’s not a finished product just a prototype but it's crazy to see what's already possible in science There might be many things like this we don't even know about

Sweep

146,180 просмотров • 6 месяцев назад

Just a reminder: Kevin McKernan participated in the original Human Genome Project, and his video is featured at the Museum of Science, where he’s already made history. No one is more knowledgeable on this subject than him. Kevin McKernan is a prominent genomic scientist and entrepreneur. He served as the R&D lead for the Human Genome Project at the MIT Whitehead Institute for Biomedical Research. He founded Medicinal Genomics in 2011, where he pioneered the sequencing of the cannabis genome, making worldwide news as the first to publicly release a cannabis genome sequence. Previously, he was involved in developing next-generation sequencing technologies and founded Agencourt Biosciences, which advanced DNA sequencing methods used in various genomic projects. McKernan holds a degree from MIT and has authored numerous publications and patents in genomics, focusing on areas like DNA sequencing, microRNAs, and personalized medicine. His contributions have solidified his reputation as a leading expert in the field. What is amazing about his discovery is that it ties in with my work finding mRNA vaccines kill the bifidobacteria and finding of loss of bifidobacteria in invasive cancer BUT it also ties in with the independent findings on Covid spike affecting p53 by Wafik S. El-Deiry, MD, PhD, FACP . Imagine 3 different scientists with 3 different pathways coming to the same conclusions. This needs to be looked at …

Just a reminder: Kevin McKernan participated in the original Human Genome Project, and his video is featured at the Museum of Science, where he’s already made history. No one is more knowledgeable on this subject than him. Kevin McKernan is a prominent genomic scientist and entrepreneur. He served as the R&D lead for the Human Genome Project at the MIT Whitehead Institute for Biomedical Research. He founded Medicinal Genomics in 2011, where he pioneered the sequencing of the cannabis genome, making worldwide news as the first to publicly release a cannabis genome sequence. Previously, he was involved in developing next-generation sequencing technologies and founded Agencourt Biosciences, which advanced DNA sequencing methods used in various genomic projects. McKernan holds a degree from MIT and has authored numerous publications and patents in genomics, focusing on areas like DNA sequencing, microRNAs, and personalized medicine. His contributions have solidified his reputation as a leading expert in the field. What is amazing about his discovery is that it ties in with my work finding mRNA vaccines kill the bifidobacteria and finding of loss of bifidobacteria in invasive cancer BUT it also ties in with the independent findings on Covid spike affecting p53 by Wafik S. El-Deiry, MD, PhD, FACP . Imagine 3 different scientists with 3 different pathways coming to the same conclusions. This needs to be looked at …

sabine hazan md

25,437 просмотров • 9 месяцев назад

"In Yabusele, they get a very talented big man, a guy who did a lot of different things for the Sixers last year" Ian Begley with more on the Knicks' addition of Guerschon Yabusele and what other moves the team can make

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Butler's Samu Adler is having a strong last 10 games for Salon Vilpas in Korisliiga play The 6-6 18 year old is averaging 18 PPG, 2.6 RPG and 3.3 APG in that stretch shooting 44.2% from the field Adler's blend of shot making, size and physicality at the guard spot is really impressive and should make for productive HM player right off the jump, needs to add a left to his game and work on the shot selection but lot's to work with. Really enjoyed his progress over his last 2 seasons.

Butler's Samu Adler is having a strong last 10 games for Salon Vilpas in Korisliiga play The 6-6 18 year old is averaging 18 PPG, 2.6 RPG and 3.3 APG in that stretch shooting 44.2% from the field Adler's blend of shot making, size and physicality at the guard spot is really impressive and should make for productive HM player right off the jump, needs to add a left to his game and work on the shot selection but lot's to work with. Really enjoyed his progress over his last 2 seasons.

Arman Jovic

22,859 просмотров • 3 месяцев назад

🇯🇵 Western mom takes her children to KidZania in Tokyo. It's a land designed to entertain and educate children and prepare them for adulthood. There are over a dozen jobs kids can choose from and undergo work simulation, and they actually get paid for work. Staff along with family members then teach the children how to save money, pay taxes, and make a living.

🇯🇵 Western mom takes her children to KidZania in Tokyo. It's a land designed to entertain and educate children and prepare them for adulthood. There are over a dozen jobs kids can choose from and undergo work simulation, and they actually get paid for work. Staff along with family members then teach the children how to save money, pay taxes, and make a living.

Asian Dawn

428,651 просмотров • 3 месяцев назад

BIG NEWS FOR THE GIOVANNI SHOW! I am proud to announce I have signed with the DreamMakers agency. They will help me build the show I want to have in Philadelphia where players can come to studio and I can ask the questions you guys really want answers to.

BIG NEWS FOR THE GIOVANNI SHOW! I am proud to announce I have signed with the DreamMakers agency. They will help me build the show I want to have in Philadelphia where players can come to studio and I can ask the questions you guys really want answers to.

The Giovanni Show Podcast

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For #IDPD, Minister for Social Security and Disability Sir Stephen Timms answered questions from listeners on BBC Radio 4's In Touch He highlighted how the DWP will work with disabled people to remove the unnecessary barriers to the valuable contribution they can make

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Department for Work and Pensions

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“With weapons they have and adding me to the puzzle, we can make a big run, a championship” More from star QB Sammy Dunn transfer to Vigor: Sammy Dunn says he’s practiced 2 days w/Wolfpack, great chemistry w/team, 5-star OL Micah”Big Ticket🎫” DeBose, 3-star RB Carlos (Greenpants) Benjamin Jr, & others

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Simone Eli

13,077 просмотров • 2 лет назад

Pen!s Pumps Can Actually Help Thinking about trying a P-E-N!S pump? Here’s the honest info most guys are missing. They’re legit for helping with reliable erections, maintaining what you’ve got, and feeling more in control in the bedroom. Studies show they work really well when used right, and the confidence shift can be surprisingly big. Just make sure you pick a safe one with a limiter and follow basic guidelines so you avoid any issues.

Pen!s Pumps Can Actually Help Thinking about trying a P-E-N!S pump? Here’s the honest info most guys are missing. They’re legit for helping with reliable erections, maintaining what you’ve got, and feeling more in control in the bedroom. Studies show they work really well when used right, and the confidence shift can be surprisingly big. Just make sure you pick a safe one with a limiter and follow basic guidelines so you avoid any issues.

Kate Shelor

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