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Hard Fork ep 139: The Trump-Musk Fallout + A DOGE Coder Speaks + ChefGPT 00:00:51 - It's Kevin's birthday! 00:02:39 - This week on the show 00:03:05 - The Musk/Trump breakup 00:19:24 - Interview with Sahil Lavingia, former DOGE staffer 00:46:58 - NYT's Pete Wells on AI for chefs

Kevin Roose

167,289 subscribers

12,096 次观看 • 1 年前 •via X (Twitter)

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Anya Rossi• Live Now

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Stuart Meyers1 年前

@shl @pete_wells How come you fail to mention that the major issue that Elon and others have is the size of the bill and the debt spiral the US are on…

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Lark Davis1 年前

Think $BTC has topped? Think again. Past cycles show: 2012-13: Topped 367 days post-halving. 2016-17: 526 days. 2020-21: 548 days. 2024? We’re only 237 days in. There’s still a long way to go. 👉 Subscribe now and join 130K+ investors prepping for the next big move.

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Core Memory

14,718 次观看 • 1 年前

For the first episode of Development & Research, I spoke with Meri Beckwith on: • being a patient in an incompetently-run clinical trial, • how many drug trials fail b/c of bad paperwork, • who benefits when trials are expensive, • just how quickly biotech founders lose control to investors, • why no one is picking up the billion-dollar bills on the sidewalk. Timestamps: 00:01:51 - "Eroom's Law" 00:03:12 - The gap between new science and new medicine 00:04:51 - Clinical trials: the patient experience 00:08:19 - The lifecycle of a biotech startup 00:10:22 - Clinical Research Organizations 00:13:19 - 10% of trials fail b/c of clerical errors 00:17:27 - Lindus Health (Meri's Series-B startup) 00:19:03 - Recruiting more patients won't save badly-planned trials 00:23:36 - Meri's skepticism of international trials 00:27:04 - Biotech culture vs tech culture 00:32:54 - What'll it take to get biotechs to act like tech companies? 00:35:13 - *Adaptive* clinical trials 00:39:10 - "Sidebar on the FDA..." 00:43:06 - *Decentralized* trials 00:46:13 - *Who* makes clinical trials expensive? 00:48:43 - (Not) picking up the billion-dollar bills on the sidewalk 00:53:22 - What does "better" look like? 00:56:08 - "...a lot of alpha if you're willing to disregard all of this b——..." 00:58:42 - What's changing with AI? 01:00:57 - What's going on with China? 01:03:10 - What's ahead for Lindus?

For the first episode of Development & Research, I spoke with Meri Beckwith on: • being a patient in an incompetently-run clinical trial, • how many drug trials fail b/c of bad paperwork, • who benefits when trials are expensive, • just how quickly biotech founders lose control to investors, • why no one is picking up the billion-dollar bills on the sidewalk. Timestamps: 00:01:51 - "Eroom's Law" 00:03:12 - The gap between new science and new medicine 00:04:51 - Clinical trials: the patient experience 00:08:19 - The lifecycle of a biotech startup 00:10:22 - Clinical Research Organizations 00:13:19 - 10% of trials fail b/c of clerical errors 00:17:27 - Lindus Health (Meri's Series-B startup) 00:19:03 - Recruiting more patients won't save badly-planned trials 00:23:36 - Meri's skepticism of international trials 00:27:04 - Biotech culture vs tech culture 00:32:54 - What'll it take to get biotechs to act like tech companies? 00:35:13 - Adaptive clinical trials 00:39:10 - "Sidebar on the FDA..." 00:43:06 - Decentralized trials 00:46:13 - Who makes clinical trials expensive? 00:48:43 - (Not) picking up the billion-dollar bills on the sidewalk 00:53:22 - What does "better" look like? 00:56:08 - "...a lot of alpha if you're willing to disregard all of this b——..." 00:58:42 - What's changing with AI? 01:00:57 - What's going on with China? 01:03:10 - What's ahead for Lindus?

Ross Rheingans-Yoo🔸

18,066 次观看 • 1 年前

Hey Siri, why are American kids so sick? Aaron Siri on DarkHorse with Bret Weinstein : 00:00:00 Welcome Aaron Siri 00:05:22 Vaccines: Then vs. Now 00:18:04 What We Don’t Know About Childhood Vaccines 00:33:45 Financial Incentives in Vaccine Development 00:52:02 Polio Vaccine: Unintended Consequences 00:55:39 The Polio Story as a Red Pill 01:25:32 HIV Origins & Parallels to COVID 01:45:04 Rethinking the Spanish Flu 01:47:31 When Interventions Cause Harm 01:49:40 Measles Mortality Data 01:56:07 Health Before Vaccination 02:03:17 Defining “Vaccine” 02:05:01 Why Hep B Remains on the Schedule 02:11:29 Autism & Vaccines 02:20:02 The Tyranny of Vaccine Mandates 02:35:27 Scientific vs. Legal Fraud 02:53:00 Trump Administration & the Childhood Schedule 03:04:38 Think of Vaccines as a Product

Hey Siri, why are American kids so sick? Aaron Siri on DarkHorse with Bret Weinstein : 00:00:00 Welcome Aaron Siri 00:05:22 Vaccines: Then vs. Now 00:18:04 What We Don’t Know About Childhood Vaccines 00:33:45 Financial Incentives in Vaccine Development 00:52:02 Polio Vaccine: Unintended Consequences 00:55:39 The Polio Story as a Red Pill 01:25:32 HIV Origins & Parallels to COVID 01:45:04 Rethinking the Spanish Flu 01:47:31 When Interventions Cause Harm 01:49:40 Measles Mortality Data 01:56:07 Health Before Vaccination 02:03:17 Defining “Vaccine” 02:05:01 Why Hep B Remains on the Schedule 02:11:29 Autism & Vaccines 02:20:02 The Tyranny of Vaccine Mandates 02:35:27 Scientific vs. Legal Fraud 02:53:00 Trump Administration & the Childhood Schedule 03:04:38 Think of Vaccines as a Product

The DarkHorse Podcast

69,778 次观看 • 7 个月前

Core Memory podcast with Suzanne Gildert on the hunt for AI consciousness in the quantum realm. The theory being that LLMs are too constrained to really get to robots and AIs that are really like us 00:00:00 – Consciousness: The First AI Training Model? 00:02:03 – Exploring the Quantum Mind with AI 00:04:42 – Will Robots Ever Have Rights? 00:07:54 – The AI Paradox: Fear vs. Progress 00:13:20 – Can Language Models Teach Robots? 00:17:29 – Why Today’s AI Feels Like a Zombie 00:23:47 – Quantum Computing Meets Artificial Consciousness 00:29:50 – Free Will, Entanglement, and Decision Making 00:38:21 – Teaching a Robot to Think, Not Just React 00:52:51 – Will Conscious AI Power Space Exploration?

Core Memory podcast with Suzanne Gildert on the hunt for AI consciousness in the quantum realm. The theory being that LLMs are too constrained to really get to robots and AIs that are really like us 00:00:00 – Consciousness: The First AI Training Model? 00:02:03 – Exploring the Quantum Mind with AI 00:04:42 – Will Robots Ever Have Rights? 00:07:54 – The AI Paradox: Fear vs. Progress 00:13:20 – Can Language Models Teach Robots? 00:17:29 – Why Today’s AI Feels Like a Zombie 00:23:47 – Quantum Computing Meets Artificial Consciousness 00:29:50 – Free Will, Entanglement, and Decision Making 00:38:21 – Teaching a Robot to Think, Not Just React 00:52:51 – Will Conscious AI Power Space Exploration?

Ashlee Vance

17,189 次观看 • 1 年前

The Caitlyn Jenner Interview 02:30 Downfall Of America 04:00 Why Crypto Matters 07:20 CBDCs 10:13 Crypto And The Elections 13:58 Trump Being Charged 22:00 What Happens If Trump Loses 26:00 Hunter Biden?? 29:15 Was Covid Man Made? 35:00 Why Ownership Matters 39:30 The $jenner Story 41:00 The truth about Sahil 52:00 What Does Hollywood Think Of Crypto? 56:40 Andrew Tate In Crypto 1:02 Elon Buying Twitter 1:09 Caitlyn Jenner AI Test 1:16 ChatGPT x Apple 1:19 Deepfakes In 2024 1:23 Future Of Jenner Coin 1:35 Wrap

The Caitlyn Jenner Interview 02:30 Downfall Of America 04:00 Why Crypto Matters 07:20 CBDCs 10:13 Crypto And The Elections 13:58 Trump Being Charged 22:00 What Happens If Trump Loses 26:00 Hunter Biden?? 29:15 Was Covid Man Made? 35:00 Why Ownership Matters 39:30 The $jenner Story 41:00 The truth about Sahil 52:00 What Does Hollywood Think Of Crypto? 56:40 Andrew Tate In Crypto 1:02 Elon Buying Twitter 1:09 Caitlyn Jenner AI Test 1:16 ChatGPT x Apple 1:19 Deepfakes In 2024 1:23 Future Of Jenner Coin 1:35 Wrap

Mika

245,099 次观看 • 2 年前

Sat down with Scott Kupor, Director of OPM and former a16z managing partner, about why he left a comfy VC job to work in Gov and what he's building with US Tech Force. (00:00) His wife's reaction to leaving a16z (04:00) How this Trump admin is different for tech (09:00) What is OPM and the federal talent gap (16:00) Where DOGE stands now (18:00) $250B on employees vs $750B on contractors (22:00) The 1981 hiring law nobody touched for 44 years (28:00) What is US Tech Force (36:00) AI in government today (44:30) His pitch on why engineers should work for government

Sat down with Scott Kupor, Director of OPM and former a16z managing partner, about why he left a comfy VC job to work in Gov and what he's building with US Tech Force. (00:00) His wife's reaction to leaving a16z (04:00) How this Trump admin is different for tech (09:00) What is OPM and the federal talent gap (16:00) Where DOGE stands now (18:00) $250B on employees vs $750B on contractors (22:00) The 1981 hiring law nobody touched for 44 years (28:00) What is US Tech Force (36:00) AI in government today (44:30) His pitch on why engineers should work for government

Nathan Lands

41,285 次观看 • 5 个月前

Taking a Waymo is one of the most delightful new product experiences of the past few years, and they're now ramping to considerable scale (500,000 rides/week). I was excited to host co-CEO Dmitri Dolgov on Cheeky Pint. He’s been working on self-driving since the very beginning, and I got to ask all my questions about how Waymo works underneath the hood. 00:00:22 Russia 00:02:51 Waymo architecture 00:09:59 Why now? 00:19:46 Driving nuance 00:29:37 Stripe Agentic Commerce Suite 00:30:17 Hardware 00:40:20 Emergent behavior 00:46:36 Scaling 00:57:56 Google

Taking a Waymo is one of the most delightful new product experiences of the past few years, and they're now ramping to considerable scale (500,000 rides/week). I was excited to host co-CEO Dmitri Dolgov on Cheeky Pint. He’s been working on self-driving since the very beginning, and I got to ask all my questions about how Waymo works underneath the hood. 00:00:22 Russia 00:02:51 Waymo architecture 00:09:59 Why now? 00:19:46 Driving nuance 00:29:37 Stripe Agentic Commerce Suite 00:30:17 Hardware 00:40:20 Emergent behavior 00:46:36 Scaling 00:57:56 Google

John Collison

703,195 次观看 • 4 个月前

Is God More Than a Story? Jonathan Pageau with Jordan Hall on Bret Weinstein's DarkHorse Inside Rail Bret Weinstein debates Jonathan Pageau with Jordan Hall on whether science or religion can save humanity from itself. 00:00:00 Welcoming Pageau & Jordan Hall 00:02:00 Science, Faith & Materialism's Limits 00:08:08 Sponsor: Fresh-Pressed Olive Oil Club 00:10:42 Why Science Can't Provide Values 00:16:42 COVID & the Collapse of Shared Values 00:19:55 AI & the Missing Ethical Framework 00:21:06 Cults, Religions & the Test of Time 00:27:46 Ideology vs. Faith: What Corrupts 00:42:55 Martyrdom, Lineage & Christianity 00:49:15 Group Selection & Game Theory 00:57:40 The Religion of Religions 00:58:08 Judaism, Islam & Ceasefire 01:07:50 Love as the Principle of Principles 01:16:00 Human Dignity & the Game Theory Problem 01:23:32 Moloch vs. the Heavenly Jerusalem 01:29:41 Which Churches Survive? 01:39:57 Humility & the Unfinished Story

Is God More Than a Story? Jonathan Pageau with Jordan Hall on Bret Weinstein's DarkHorse Inside Rail Bret Weinstein debates Jonathan Pageau with Jordan Hall on whether science or religion can save humanity from itself. 00:00:00 Welcoming Pageau & Jordan Hall 00:02:00 Science, Faith & Materialism's Limits 00:08:08 Sponsor: Fresh-Pressed Olive Oil Club 00:10:42 Why Science Can't Provide Values 00:16:42 COVID & the Collapse of Shared Values 00:19:55 AI & the Missing Ethical Framework 00:21:06 Cults, Religions & the Test of Time 00:27:46 Ideology vs. Faith: What Corrupts 00:42:55 Martyrdom, Lineage & Christianity 00:49:15 Group Selection & Game Theory 00:57:40 The Religion of Religions 00:58:08 Judaism, Islam & Ceasefire 01:07:50 Love as the Principle of Principles 01:16:00 Human Dignity & the Game Theory Problem 01:23:32 Moloch vs. the Heavenly Jerusalem 01:29:41 Which Churches Survive? 01:39:57 Humility & the Unfinished Story

The DarkHorse Podcast

110,302 次观看 • 3 个月前