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High-quality experimental data fuels biological discovery. Could an AI-enabled "autonomous lab" fundamentally increase the rate at which we generate it, and accelerate our progress toward cures for disease? That's the question I sat down to explore with Jason Kelly, CEO of Ginkgo Bioworks, for a deep-dive and tour of...

11,508 просмотров • 5 месяцев назад •via X (Twitter)

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How can generative AI and Robotics help advance drug discovery? 🚀 Excited to introduce LUMI-lab! A foundation model-driven Self-Driving Lab (SDL) for autonomous ionizable lipid discovery in mRNA delivery 🤖🔍 🔬 What is LUMI-lab? LUMI-lab integrates molecular foundation models with autonomous robotic experiments to efficiently explore new LNPs (lipid nanoparticles, mRNA delivery vehicles) with minimal wet-lab data. 🔥 Key Highlights: - 🧠 Foundation model trained on 28M molecules using a three-step strategy: - Unsupervised pretraining to capture broad molecular knowledge - Continual pretraining to specialize in lipid-like molecules - Active learning fine-tuning within a closed-loop experimental system - 🤖 1,700+ new LNPs synthesized & tested across 10 iterative cycles - 🧪 Brominated lipids autonomously identified as a novel structural feature that enhances mRNA transfection—an insight previously unrecognized in LNP design - 🏆 20.3% in vivo CRISPR gene editing efficiency in lung epithelial cells—the highest reported for inhaled LNPs 🚀 Why it matters? LNPs are the backbone of mRNA therapeutics, yet discovery has been slow due to data scarcity. LUMI-lab shows that AI-powered autonomous labs can accelerate mRNA delivery innovation🚀💡 🌐 Beyond mRNA drugs, LUMI-lab exemplifies a scalable framework for AI-driven molecular discovery, pushing boundaries in material science & drug delivery. 📜 Read the preprint: 🔗 💻 Code available on GitHub: 🔗 #AI #DrugDiscovery #mRNA #LNP #SyntheticBiology 🙏 A huge team effort behind this work, with special appreciation to Bowen LI for driving the project. Kudos to Haotian Cui, @YueXu1995, Kuan Pang, Gen Li, and Bettycat567!

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Automating the lab bench is the best thing we can do for AI in biology. Most experiments are still run by hand. Every biologist's handiwork is unique and every lab is a little different. So, biology faces widespread reproducibility issues. But, AI will demand more reproducible data than we can produce, and generate more ideas than we can test. Experiments must be communicated and executed in a standardized way to generate reproducible data. So, Tetsuwan is building a lab where users specify experiments in an exact syntax. These experiments are executed by an automated platform to generate transparent, reproducible output. The user never needs physical access to a lab. This is a biology lab you can use like a computer. Our platform, built and tested with pilot labs over the past two years, lets users configure automated workflows rapidly & precisely. Later this year, we will bring our first services online, focusing on functional screens for protein design. Alex and I met at Caltech, where she was one year my senior. We're building this company because we were little kids who wanted to be biologists that grew up into adults who resented the lab bench. We want biology to be about asking questions, not the painful and frustrating manual process of asking them. For those looking to receive updates on our pilot services, looking for a meaningful job, or just to learn more about our work, see the links in the comments!

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