How does dynein cycle its conformations and takes one step forward along the MT? Check out our exciting new results unveiling the atomic details of the conformational space of Reactive Full-length Human Dynein-1, on and off microtubules:

Based on decades of hard work and so many brilliant ideas from those outstanding scientists contributing to the dynein field, combined with our own exciting results by dynamic cryo-EM analysis, we now propose a substantially revised model of dynein mechanochemical cycle:

Dynein-1 motion in unbelievable detail: