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23,164 次观看 • 2 年前 •via X (Twitter)

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Superbowl Sunday at Stanford’s Experimental Therapeutics Hub 1) Making our hands twitch: A demo of SAINT – the rapid TMS protocol, personalized by prior fMRI analysis, making it much more rapid and efficacious than previous generations of Transcranial Magnetic Stimulation (TMS). They are FDA-approved and seeing 90% remission rates from treatment-resistant depression after an average of 2.6 days of treatment. More: 2) The brain scan on the screen guides the focal point of the magnetically induced activation, and the three retroreflectors on forehead and instrument provide registration, like the virtual filming rig we saw on the Avatar set: 3) “Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain” — the next study. They have used focused Ultrasound (tFUS) to unlock an engineered molecular cage carrying a small-molecule drug so that the drug is only released in a precise region of the brain (to millimeter-scale). This can verify the mechanism of action in that particular brain region while avoiding systemic exposure and its side effects. They have shown this to work in animal models, delivering higher doses than systemic ketamine administration, and just to the targeted brain region. 4) Self-Hypnosis: We are most hypnotizable at the age of 6-10 years old (a developmental critical period). As adults, about 20% of us are highly hypnotizable and 20% are resistant. We had a similar distribution in Dr. Spiegal’s impromptu test of our crew (the outdoor photo). While we have genetic markers for hypnotizability, there are few correlates with other measurable traits — other than the subjective ability to be imaginative and disassociate from distraction. Hypnosis therapy has been effective for many disorders from anxiety to addiction (e.g., 20% cessation of smoking). You can take the 3-minute self-test here: They have shown that they can increase responsiveness to hypnosis treatments with the SAINT TMS. And I suspect the same will be found in an upcoming study of psilocybin, given its potential to reopen critical periods (ref. Gül Dölen’s work:

Steve Jurvetson

12,934 次观看 • 2 年前