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I got Meng To to break down how to create AI designs with Codex that aren't slop: 0:00 - The line that scares everyone 2:44 - Why Meng dropped Cursor 4:05 - Codex setup + the AI browser 8:43 - His real project folders 13:27 - AI avatars +... show more

Aakash Gupta

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155,039 次观看 • 2 个月前 •via X (Twitter)

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Billions are pouring into AI drug discovery. Zero approved drugs. But that's about to change. Retro Bio Head of Applied AI rico meinl explains it all. 00:00 - Zero AI Drugs Approved 05:05 - Retro’s 50x 09:38 - The AlphaFold Moment 13:47 - Black Box Data 21:23 - The Ladder: Proteins to Cells 25:02 - Are Virtual Cells Overhyped? 32:53 - Hitting the Clinical Wall 35:58 - AWS for Biotech 46:16 - The Real Inflection Point 49:30 - The Anti-Scaling Law 54:25 - AI Co-Scientists 1:03:32 - Real vs hype

Billions are pouring into AI drug discovery. Zero approved drugs. But that's about to change. Retro Bio Head of Applied AI rico meinl explains it all. 00:00 - Zero AI Drugs Approved 05:05 - Retro’s 50x 09:38 - The AlphaFold Moment 13:47 - Black Box Data 21:23 - The Ladder: Proteins to Cells 25:02 - Are Virtual Cells Overhyped? 32:53 - Hitting the Clinical Wall 35:58 - AWS for Biotech 46:16 - The Real Inflection Point 49:30 - The Anti-Scaling Law 54:25 - AI Co-Scientists 1:03:32 - Real vs hype

Mgoes (bio/acc 🤖💉)

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I recently sat down with João Filipe and revealed my exact plan to build a $100M AI company. This is more than I've ever revealed publicly before. 0:00 Trailer 2:34 Credentials 5:56 Running multiple companies at once 11:45 Why I love content 13:33 My background 20:11 Don't quit your job *yet* 25:24 Opportunity cost 31:39 Self-reflection 36:07 Owning your AI memory 39:02 Using AI for content 52:22 Audit your life 55:39 The one AI system everyone should build 58:07 Traits > Skills 58:47 Founding AI Edge 1:01:00 How to spot trends early 1:14:00 Reinvesting in AI Edge 1:20:01 Spending $100k +/mo on AI 1:32:02 𝕏 vs. YouTube 1:49:32 My take on "AI influencers" 1:50:29 Biggest takeaway from the podcast 1:53:49 Health is the best investment

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Miles Deutscher

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Being early to SEO helped Dharmesh Shah build HubSpot into a $30B company. Now he's obsessed with something new: AI ranking. It's how to show up when people ask ChatGPT for recommendations instead of Googling. I sat down with him to break down the entire playbook: 0:00 Intro 0:53 The AI ranking opportunity (AEO) 6:14 How to rank in AI chatbots 8:11 Using AI to adapt content for AEO 12:24 Training teams on "AI Intuition" 19:45 Content moats in the AI-slop era 21:57 Dharmesh's new AI agent startup 30:33 AI agent monetization strategy 39:38 The bottlenecks to autonomous agents 45:15 Building teams: humans vs agents 52:49 Why Dharmesh still codes as a billionaire

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Rowan Cheung

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Riley Brown

20,154 次观看 • 4 个月前

Here's my conversation with DHH. He is back for round 2! It was an epic fun 5 hour conversation about the future of programming, AI, Linux, and human civilization. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Episode highlight 1:27 - Introduction 2:56 - Programming with AI agents 18:14 - How software will change 27:30 - AI impact on open source 37:21 - Building Omarchy Linux distro 47:05 - Vibe coding vs agentic engineering 1:00:06 - The end of manual programming 1:10:24 - Advice for programmers 1:22:30 - Surviving Internet Hate 1:31:46 - Programming setup for AI Agents 1:44:11 - Obsessing about speed 2:07:06 - Voice prompting vs typing 2:21:05 - Best AI coding models 2:37:55 - Best AI coding harnesses 2:50:57 - AI video generation and filmmaking 3:10:28 - Fatherhood 3:38:35 - Linux will win the desktop 3:49:51 - PewDiePie 3:59:24 - Future of programming 4:22:17 - Politics and immigration 4:53:54 - Longevity, over-optimization, and fear of death 5:05:38 - Eternal recurrence and future of human civization

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Matthew Berman

49,153 次观看 • 1 年前

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Chong-U

14,908 次观看 • 4 个月前

This guy literally broke down everything to build a 21 agent dev team in Claude Code: 0:00 - Why one prompt = AI slop 1:55 - Claude Code as your full startup 2:43 - The 21-agent team 4:57 - Inside the system analyst agent 5:52 - Live demo: 0 → TestFlight 8:42 - Define a "good" system analyst first 11:53 - The system analyst workflow 12:17 - Why Confluence + Jira + MCPs matter 15:30 - Classic PM skills > vibe coding 19:15 - The scaffolding that kills spaghetti code 22:10 - Setting up agents inside Claude Code 26:19 - The longest dictation prompt this podcast has seen 35:29 - Why dictation beats typing for AI specs 47:30 - Brand guidelines in Figma Make 55:59 - Idea → prompt → design → app 1:06:27 - Claude Code builds the Figma screens 1:23:59 - Frontend tickets appear in Jira (with Figma links) 1:48:49 - The hockey rules AI app goes live 1:53:56 - Full recap: Claude, Confluence, Figma, Jira, Simulator, TestFlight 2:03:17 - Should PMs get AI PM certificates? 2:08:15 - How to build a PM portfolio that lands FAANG offers 2:13:25 - How to get started this week

Aakash Gupta

178,026 次观看 • 4 个月前

The end of coding? *Epic* conversation with Guillermo Rauch of Vercel on vibe coding, MCP, agents and building products in the AI era. (00:00) - Intro: Guillermo's Story (02:08) - What is v0 and Why Did It Take Off So Fast? (04:10) - Building a hit product with < people (07:51) - Cursor, Replit, etc: v0 vs Other AI Coding Tools (10:35) - Everyone can cook - What is Vibe Coding? (17:05) - Is v0 Just Frontend? Moving Toward Full Stack 19:40 - How to Become a Great Vibe Coder (23:35) - A GUI for AI: The Future of Interfaces (29:46) - Developer Love vs Agent Love (33:41) - The Importance of Taste in the AI Era (39:10) - MCP: The Protocol for AI-to-AI Communication (43:11) - Security and the Risks of Agentic Web (45:25) - Are Enterprises Ready for the Agentic Future? (49:42) - Building a Data Flywheel (56:06) - The Vercel AI Cloud: From Pixels to Tokens (1:10:14) - Adapting to a Non-Developer Persona (1:13:47) - Retention, Margins, and the Business of AI (1:16:51) - The Secret Behind Vercel Last Year Growth (1:24:15) - The importance of Online Presence (1:30:49) - Everything, Everywhere, All at Once: Keeping your Sanity as a CEO (1:34:59) - Guillermo's Advice to Younger Self

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Matt Turck

86,153 次观看 • 1 年前

In the first episode of our new series Full Stack, Conductor CEO and co-founder Charlie Holtz takes us into the details of how he sets up his workflow for coding and managing AI agents. 00:00 – Building Conductor With Conductor 01:05 – Managing a Team of Coding Agents 02:39 – Do You Still Write Code? 04:17 – Charlie's AI Stack and Setup 05:48 – “Slop-free” Zones 07:25 – Don’t Let the AI Be Your Architect 09:15 – The Future of Cloud Workspaces 10:40 – Claude vs Codex 12:01 – Tokenmaxxing 14:17 – The Future of Human–AI Collaboration 15:07 – "Code Is Becoming Sawdust"

In the first episode of our new series Full Stack, Conductor CEO and co-founder Charlie Holtz takes us into the details of how he sets up his workflow for coding and managing AI agents. 00:00 – Building Conductor With Conductor 01:05 – Managing a Team of Coding Agents 02:39 – Do You Still Write Code? 04:17 – Charlie's AI Stack and Setup 05:48 – “Slop-free” Zones 07:25 – Don’t Let the AI Be Your Architect 09:15 – The Future of Cloud Workspaces 10:40 – Claude vs Codex 12:01 – Tokenmaxxing 14:17 – The Future of Human–AI Collaboration 15:07 – "Code Is Becoming Sawdust"

Y Combinator

157,443 次观看 • 3 个月前

Sam Altman on OpenAI’s next model and the AI backlash I recently sat down with Sam for a two-part conversation. We covered a lot of ground: the need to slow down frontier research, alignment concerns, OpenAI's next big model, Astra, competition with Anthropic, his thoughts on an IPO, reaching AGI, consumer hardware, and a lot more. Timestamps: 00:00 Why OpenAI Slowed Training 08:37 What Alignment Means 15:22 Keeping Humans in Control 24:39 AGI vs. Superintelligence 30:04 OpenAI’s Next Compute Bet 31:47 AI Backlash, Jobs, and Creators 41:31 OpenAI’s Missteps and Refocus 45:47 Astra and Computer-Using Agents 47:42 Regulation and the AI Race 51:24 Merging ChatGPT and Codex 54:22 The AI Compute Bubble 57:07 Recursive Self-Improvement and IPO 58:22 Humanoid Robots and Consumer Devices 1:05:47 Life After Superintelligence This episode was produced in partnership with TIME. Thanks to the show's premier sponsors: Atlassian, Granola, and Mercury.

Sam Altman on OpenAI’s next model and the AI backlash I recently sat down with Sam for a two-part conversation. We covered a lot of ground: the need to slow down frontier research, alignment concerns, OpenAI's next big model, Astra, competition with Anthropic, his thoughts on an IPO, reaching AGI, consumer hardware, and a lot more. Timestamps: 00:00 Why OpenAI Slowed Training 08:37 What Alignment Means 15:22 Keeping Humans in Control 24:39 AGI vs. Superintelligence 30:04 OpenAI’s Next Compute Bet 31:47 AI Backlash, Jobs, and Creators 41:31 OpenAI’s Missteps and Refocus 45:47 Astra and Computer-Using Agents 47:42 Regulation and the AI Race 51:24 Merging ChatGPT and Codex 54:22 The AI Compute Bubble 57:07 Recursive Self-Improvement and IPO 58:22 Humanoid Robots and Consumer Devices 1:05:47 Life After Superintelligence This episode was produced in partnership with TIME. Thanks to the show's premier sponsors: Atlassian, Granola, and Mercury.

Alex Heath

546,982 次观看 • 23 天前

When AI builds AI: my conversation with Richard Socher about RSI and scientific progress. 00:00 Intro: AI That Improves Itself 00:55 Why Scientific Progress Is Slowing 03:08 The Labyrinth of Human Knowledge 05:59 Can AI Put Science Back Together? 07:57 How LLMs Learn Biology and Proteins 10:56 Next-Token Prediction as a World Model 16:44 Can AI Generate Truly Original Ideas? 17:32 Simulations, Verifiers and Superhuman AI 22:18 The Path to Recursive Self-Improvement 24:49 Why AI Hallucinations Can Drive Discovery 27:42 From Reading Biology to Writing It 31:31 Can AI Accelerate Drug Discovery? 33:31 Will AI Help Cure Cancer? 38:03 AI Breakthroughs in Biology, Energy and Materials 40:19 Will Some Societies Reject AI? 45:07 Building the AI Economist 52:22 The Scientific Data Bottleneck 53:41 The Four Pillars of the Eureka Machine 55:01 Teaching AI the Rules of Reality 57:44 Simulations and Virtual Cells 1:00:40 Self-Driving Robotic Laboratories 1:02:51 Agent Swarms and Open-Ended Discovery 1:04:30 The Compute Bottleneck 1:05:44 Inside Recursive 1:07:33 What Recursive Will Build First 1:10:10 How Do We Define Intelligence? 1:11:32 How Far Can Intelligence Go?

When AI builds AI: my conversation with Richard Socher about RSI and scientific progress. 00:00 Intro: AI That Improves Itself 00:55 Why Scientific Progress Is Slowing 03:08 The Labyrinth of Human Knowledge 05:59 Can AI Put Science Back Together? 07:57 How LLMs Learn Biology and Proteins 10:56 Next-Token Prediction as a World Model 16:44 Can AI Generate Truly Original Ideas? 17:32 Simulations, Verifiers and Superhuman AI 22:18 The Path to Recursive Self-Improvement 24:49 Why AI Hallucinations Can Drive Discovery 27:42 From Reading Biology to Writing It 31:31 Can AI Accelerate Drug Discovery? 33:31 Will AI Help Cure Cancer? 38:03 AI Breakthroughs in Biology, Energy and Materials 40:19 Will Some Societies Reject AI? 45:07 Building the AI Economist 52:22 The Scientific Data Bottleneck 53:41 The Four Pillars of the Eureka Machine 55:01 Teaching AI the Rules of Reality 57:44 Simulations and Virtual Cells 1:00:40 Self-Driving Robotic Laboratories 1:02:51 Agent Swarms and Open-Ended Discovery 1:04:30 The Compute Bottleneck 1:05:44 Inside Recursive 1:07:33 What Recursive Will Build First 1:10:10 How Do We Define Intelligence? 1:11:32 How Far Can Intelligence Go?

Matt Turck

10,849 次观看 • 15 天前

$INTERVIEW: AI, Surveillance, & the Fight for Digital Sovereignty | Near's Illia Polosukhin What happens when powerful AI requires an ID, governments can restrict access by country, and your most private data flows through centralized systems? NEAR Protocol co-founder Illia (root.near) (🇺🇦, ⋈) joins David Hoffman to explain why AI export controls could fracture the internet, how nationalized AI could become a surveillance layer, and why decentralized, user-owned AI may be the only real alternative. They also unpack Ironclaw, confidential inference, private agents, and NEAR’s push to make AI and assets fully sovereign. [TIMESTAMPS] 0:00 Intro 3:47 Pandora’s Box Opens 6:03 AI Meets Government 7:16 Decentralizing the Stack 8:51 Why Ban Fable? 11:18 Internet Balkanization 13:57 KYC for AI? 18:43 Nationalized Models 21:07 Building Private AI 26:30 Agent Marketplace 30:26 User-Owned Alignment 35:28 Winning Against Giants 40:19 Regulation Fuels Crypto 42:24 Global AI Adoption 45:05 Compute Is the Bottleneck 49:00 Enterprise Use Cases 51:39 Confidential TVL Explained 55:25 Full Sovereign Mode$

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Bankless

59,588 次观看 • 3 个月前

How to Maximize Your Cognitive & Physical Energy w/ Noah Ryan 00:00 Why is everyone talking about fruit till noon? 05:23 Biological Security & Abundance 09:24 Why does Fruit Till Noon work? 20:12 Honing Health Intuition 31:57 Seasonal Eating Considerations 43:04 Energymaxxing 50:49 Supplementation 58:26 Circadian Health 1:05:50 Flow States 1:17:29 Adding Novelty to Life 1:24:41 Domestication vs Wildness 1:30:54 The Overintrospection Problem 1:37:56 Escaping the Overthinking Cycle

How to Maximize Your Cognitive & Physical Energy w/ Noah Ryan 00:00 Why is everyone talking about fruit till noon? 05:23 Biological Security & Abundance 09:24 Why does Fruit Till Noon work? 20:12 Honing Health Intuition 31:57 Seasonal Eating Considerations 43:04 Energymaxxing 50:49 Supplementation 58:26 Circadian Health 1:05:50 Flow States 1:17:29 Adding Novelty to Life 1:24:41 Domestication vs Wildness 1:30:54 The Overintrospection Problem 1:37:56 Escaping the Overthinking Cycle

Sam Matla

61,541 次观看 • 1 年前

GPT-6 Astra is by far the best inside Codex. & this is THE Complete Beginners Guide to Codex. The 28 things you need to know about Codex and GPT-6 to start using it for knowledge work and coding work. My goal with this video: give you one guide you can send to anyone on your team so they can get comfortable with Codex, understand what’s possible, and start finding ways to use AI in your business. 00:00 Intro 01:15 The Codex Platform 02:02 Downloading Codex (ChatGPT Desktop) 03:25 1. Codex Is the App, GPT-6 Is the Model 06:10 2. Build Any App 10:32 3. Host Sites with GPT Sites 18:12 4A. Building Desktop App 21:33 4B. Building an iOS app 24:09 5. Built-In Web Browser 32:27 6. Create Any Document 35:00 7. Annotation Mode 38:41 8. Production-Ready Apps 44:29 9. Chats & Projects 48:54 10. Multitasking 50:09 10B Side Chat 51:13 11. Sections 54:27 12. Connect Every App (Plugins) 01:03:17 13. Ask Codex What to Work On 01:05:39 14. Blender & 3D Assets 01:08:25 15. Video Games 01:09:24 16. Interactive Learning Websites 01:13:12 17. Scheduled Tasks 01:16:19 18. Email & iMessage 01:18:56 19. Skills 01:22:54 20. Record and Replay 01:26:45 21. External APIs in Skills 01:30:00 22. Video Understanding Skill 01:35:51 23. Inline Charts 01:38:03 24. Control Codex from Your Phone 01:42:49 25. Generate & Edit Images 01:45:17 26. Sub-Agents 01:48:09 27. Computer Use 01:49:35 28. Whatever You Want

GPT-6 Astra is by far the best inside Codex. & this is THE Complete Beginners Guide to Codex. The 28 things you need to know about Codex and GPT-6 to start using it for knowledge work and coding work. My goal with this video: give you one guide you can send to anyone on your team so they can get comfortable with Codex, understand what’s possible, and start finding ways to use AI in your business. 00:00 Intro 01:15 The Codex Platform 02:02 Downloading Codex (ChatGPT Desktop) 03:25 1. Codex Is the App, GPT-6 Is the Model 06:10 2. Build Any App 10:32 3. Host Sites with GPT Sites 18:12 4A. Building Desktop App 21:33 4B. Building an iOS app 24:09 5. Built-In Web Browser 32:27 6. Create Any Document 35:00 7. Annotation Mode 38:41 8. Production-Ready Apps 44:29 9. Chats & Projects 48:54 10. Multitasking 50:09 10B Side Chat 51:13 11. Sections 54:27 12. Connect Every App (Plugins) 01:03:17 13. Ask Codex What to Work On 01:05:39 14. Blender & 3D Assets 01:08:25 15. Video Games 01:09:24 16. Interactive Learning Websites 01:13:12 17. Scheduled Tasks 01:16:19 18. Email & iMessage 01:18:56 19. Skills 01:22:54 20. Record and Replay 01:26:45 21. External APIs in Skills 01:30:00 22. Video Understanding Skill 01:35:51 23. Inline Charts 01:38:03 24. Control Codex from Your Phone 01:42:49 25. Generate & Edit Images 01:45:17 26. Sub-Agents 01:48:09 27. Computer Use 01:49:35 28. Whatever You Want

Riley Brown

172,297 次观看 • 10 天前

NEW POD | EP 73 AI & Robotics Stealing Crypto's Thunder? Timestamps: 0:47 The Only Narrative in Crypto Right Now 1:41 Competitive Landscape in Crypto 4:50 Robinhood's Future Plans 11:42 Future of Crypto Innovation 12:00 Noise ( 13:15 Circle IPO 16:51 USDC vs USDT 18:00 Predictions for Circle's Future 18:49 Circle & CCTP 20:07 Kraken Acquiring NinjaTrader 21:19 Where Are We in The Market? 25:55 China, US and Global Markets 32:13 Manus vs. Gemini 34:12 Sesame AI 35:07 Will Google Have The Best AI? 37:51 AI Investment and Valuation 39:35 AI Coding 43:54 AI in Startup Development and Innovation 44:15 46:24 Niche Apps and Micro Unicorns 49:01 Young Founders & Education 50:15 "Google/Harvard doesn't give you status" - Nikita Bier 52:04 Alpha School - AI-Powered Private School 55:19 AI Doctors 1:00:39 AI Replacing Jr. Jobs 1:02:19 Parenting and Teaching Agency 1:05:46 Tailoring Education to Children's Interests Link ↓

NEW POD | EP 73 AI & Robotics Stealing Crypto's Thunder? Timestamps: 0:47 The Only Narrative in Crypto Right Now 1:41 Competitive Landscape in Crypto 4:50 Robinhood's Future Plans 11:42 Future of Crypto Innovation 12:00 Noise ( 13:15 Circle IPO 16:51 USDC vs USDT 18:00 Predictions for Circle's Future 18:49 Circle & CCTP 20:07 Kraken Acquiring NinjaTrader 21:19 Where Are We in The Market? 25:55 China, US and Global Markets 32:13 Manus vs. Gemini 34:12 Sesame AI 35:07 Will Google Have The Best AI? 37:51 AI Investment and Valuation 39:35 AI Coding 43:54 AI in Startup Development and Innovation 44:15 46:24 Niche Apps and Micro Unicorns 49:01 Young Founders & Education 50:15 "Google/Harvard doesn't give you status" - Nikita Bier 52:04 Alpha School - AI-Powered Private School 55:19 AI Doctors 1:00:39 AI Replacing Jr. Jobs 1:02:19 Parenting and Teaching Agency 1:05:46 Tailoring Education to Children's Interests Link ↓

Good Game

11,576 次观看 • 1 年前

ICP United | DFINITY On CVE List, Events, & AI Agents Dive into the world of AI on $ICP with the latest ICP United show! Segments: 0:18 - Welcome Back! 0:47 - DFINITY Makes CVE List 1:16 - New Motoko Plushies 1:46 - Chain Chapter Events 2:05 - Organizing The FAM 2:47 - Texas Blockchain Workshop 3:01 - Pursue Typescript Course 3:22 - Cheers To The Builders 3:44 - Building Connections 4:20 - Interview With Lucid 4:38 - The Early Days 5:00 - Why Build on ICP? 5:42 - Early AI Agents 7:25 - Outpost Metaverse 8:13 - Building With AI 9:30 - What Is Chain Fusion? 11:32 - Bitcoin Las Vegas 12:20 - Discount Code: THESWOP 12:30 - Google A2A Protocol 12:45 - IC Panda Watch 13:27 - Google Firebase Launch 13:44 - Dom Talks Caffeine AI 14:31 - Javier On The Edge 14:53 - Piggycell Seed Funding

ICP United | DFINITY On CVE List, Events, & AI Agents Dive into the world of AI on $ICP with the latest ICP United show! Segments: 0:18 - Welcome Back! 0:47 - DFINITY Makes CVE List 1:16 - New Motoko Plushies 1:46 - Chain Chapter Events 2:05 - Organizing The FAM 2:47 - Texas Blockchain Workshop 3:01 - Pursue Typescript Course 3:22 - Cheers To The Builders 3:44 - Building Connections 4:20 - Interview With Lucid 4:38 - The Early Days 5:00 - Why Build on ICP? 5:42 - Early AI Agents 7:25 - Outpost Metaverse 8:13 - Building With AI 9:30 - What Is Chain Fusion? 11:32 - Bitcoin Las Vegas 12:20 - Discount Code: THESWOP 12:30 - Google A2A Protocol 12:45 - IC Panda Watch 13:27 - Google Firebase Launch 13:44 - Dom Talks Caffeine AI 14:31 - Javier On The Edge 14:53 - Piggycell Seed Funding

ICP WIRE

34,612 次观看 • 1 年前