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🤯 Imagine losing weight effortlessly while you sleep! A recent study revealed Suvorexant boosted participants' fat oxidation during sleep by a staggering 35%. What do YOU think of these findings? #futuristic #wellness

16,367 views • 1 year ago •via X (Twitter)

10 Comments

Alex Longevity's profile picture
Alex Longevity1 year ago

I wonder what would be the secondary effects ..

Kirk Parsley, MD's profile picture
Kirk Parsley, MD1 year ago

How was their sleep architecture?

Christopher's profile picture
Christopher1 year ago

Since fat oxidation during sleep contributes roughly 20-25% of total daily fat oxidation, this is an incredible finding!

Zoapone 🕊️'s profile picture
Zoapone 🕊️1 year ago

Every effect has side effects…

Theodore A Hoppe's profile picture
Theodore A Hoppe1 year ago

Here's the trade-off: "U of A researchers urge caution about the unknown unintended negative health consequences of trendy anti-obesity medications."

ConvivialityNow's profile picture
ConvivialityNow1 year ago

Nuts! That’s what I think.

Anthony Parr's profile picture
Anthony Parr1 year ago

Dr. Walker, has your team ever done research on magnesium glycinate supplementation? It seems to have really improved my sleep metrics, and others swear by it.

Dr. Roger Hugh's profile picture
Dr. Roger Hugh1 year ago

Hypnotics will always have side effects. The best Rx sleep med is micro dose mirtazapine, It transforms from a tricyclic to a pure HA antihistamine at doses under 5 mg. Sweet spot is 1-3mg.

Vertical's profile picture
Vertical1 year ago

Very interesting, has there been any evidence for risk of hyperthermia as a side effect?

Karl Gibson's profile picture
Karl Gibson1 year ago

I think it's interesting, but somewhat contradictory to data showing loss of orexin in narcoleptics is associated with obesity.

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Your body runs a nightly deuterium depletion cycle during sleep. Most people are switching it off without knowing it. During sleep, your body shifts toward fat oxidation, activates peroxisomes, and produces deuterium-depleted metabolic water. Sleep is the one time your body is forced to fast. Dr. Laszlo Boros — Hungarian medical biochemist, retired professor at UCLA School of Medicine, author of 100+ peer-reviewed papers, and one of the world's leading deuterium researchers — puts it simply on the Sleep Is A Skill podcast: "When you sleep, you can do this simply because you don't walk through the freezer — unless you do sleepwalking. What you do is leave your body in a fasting state, where you don't eat for 6 or 8 hours, and you get into a metabolic state called burning fat or metabolic ketosis. After 2 or 3 hours, glucose and carbohydrates are limited — and then you have to burn fat to produce energy and heat during sleep." That's when the real work begins. REM activity and muscle movement burn through glucose and glycogen reserves. Once glucose availability falls, metabolism shifts toward fat oxidation. Breathing slows to 6-8 inhalations per minute — roughly half the daytime rate. Hemoglobin-delivered oxygen falls. The body increasingly relies on dissolved oxygen circulating in the blood — a small but sufficient supply that doesn't require active breathing to access. But something prepares the body for this transition before sleep even begins. Yawning. According to Boros, yawning is a biological preparation mechanism. A yawn is a held inhalation — it pressurizes the chest cavity, squeezing more dissolved oxygen into the blood like pressurizing a soda bottle. This dissolved oxygen is what peroxisomes need to burn fat. But peroxisomes only activate once glucose is gone. Yawning prepares the oxygen supply. Fat must be the available fuel. Boros: "Sleep starts with yawning." Peroxisomes are small organelles that can only burn fat. They cannot utilize carbohydrates. They cannot utilize amino acids. They use dissolved O₂ directly. They produce hydrogen peroxide (H₂O₂) from fat. This hydrogen peroxide is inherently low in deuterium because it comes from fat. Catalase — the fastest enzymatic reaction in biological systems — then converts that hydrogen peroxide into metabolic water while recycling oxygen in the process. The result is fresh deuterium-depleted metabolic water. Boros calls sleep a metabolic miracle. Every night your body activates pathways that burn fat, deplete deuterium, and preserve the integrity of the mitochondrial nanomotors — all without requiring food intake. But here is the twist: If you eat too close to bed — or wake up and eat during the night — glucose remains available for longer. The transition into fat oxidation is delayed. The peroxisomal cycle starts later. Every hour of delayed ketosis is an hour of missed nocturnal deuterium depletion. This is not theoretical. Boros works with military personnel and emergency crews in Europe and the United States on exactly this problem. Emergency workers return from a call, eat under stress, then try to sleep. Glucose reloads. The peroxisomal cycle never fully activates. Deuterium accumulates. Sleep quality degrades. This is one of the reasons emergency workers retire early. Their disrupted sleep and stress-eating patterns create chronic metabolic confusion — the body never gets the nightly deuterium cleanup it evolved to run. The opposite is also true. According to Boros, people following ketogenic diets often report needing one to two fewer hours of sleep while waking up more rested. Boros explains why: Less deuterium accumulates during the day. The nocturnal depletion cycle runs more efficiently during the night. The metabolic cleanup process finishes faster. The required sleep duration is shorter. This is one reason I stop eating at least 3 hours before bed. And it is one reason I treat sleep consistency as a non-negotiable. I am in bed before 10pm. Usually closer to 9:30pm. When I yawn 3 times in a row, I know it’s time.

no.mind

27,616 views • 3 months ago

#evan saying he’d rather just swear while sleeping instead of farting hahaha! 🐹 you want me to do a livestream while lying down? 🐹 hmm… i’ll have to think about that a bit more. 🐹 (laughs) 🐹 a livestream while sleeping? wow, that’s not easy 🐹 what if i end up talking in my sleep… 🐹 what if i suddenly start swearing in my sleep? 🐹 then what would happen? 🐹 like, what if they’re words i don’t actually want to say, but they just come out? 🐹 that’s… that’s something i’m kind of worried about too 🐹 okay, imagine this. 🐹 imagine i fall asleep, and then… 🐹 ah, no, no. let’s not do this. let’s not. 🐹 like, talking in my sleep… 🐹 huh? you’d let it slide? 🐹 you’d actually like that even more? 🐹 what if i suddenly yell in my sleep… 🐹 hey! you punk! (shouting an example) 🐹 what would you do then? 🐹 you don’t think i’d do that? 🐹 yeah… i probably wouldn’t. 🐹 honestly, i’m not like that. (laughs) 🐹 you think that’s how we’d get even closer? 🐹 you mean because there was a bad guy in my dream, i’d end up saying things? 🐹 no, but… 🐹 you actually want that? 🐹 but, evers… 🐹 no… 🐹 why are you all so immersed? 🐹 wait a second 🐹 hold on. 🐹 you’d even love the sound of me farting? 🐹 now that’s… 🐹 that’s something… 🐹 i really don’t want to show that side of myself in front of evers. 🐹 i don’t think that’s gonna happen. 🐹 i’d rather end up swearing instead. 🐹 of course, not at evers, i mean if i happened to swear in my sleep. 🐹 like… if i were doing a livestream while asleep…

세리🪽

41,086 views • 2 months ago