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Introducing ESM Cambrian. Unsupervised learning can invert biology at scale to reveal the hidden structure of the natural world. We’ve scaled up compute and data to train a new generation of protein language models. ESM C defines a new state of the art for protein representation learning.

Alex Rives

14,396 subscribers

206,827 Aufrufe • vor 1 Jahr •via X (Twitter)

Wissenschaft & Technologie Bildung Gesundheit & Wellness

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10 Kommentare

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

ESM C models establish a frontier of performance as a function of parameter scale. We see large improvements across all parameter scales over previous state of the art models. Read more:

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

Information about protein structure in ESM C representations improves predictably with increasing training compute, demonstrating linear scaling across multiple orders of magnitude. (We overtrained the 300M and 600M models past the predicted point of compute optimality).

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

ESM C comes with major performance and efficiency benefits over ESM2. The 300M parameter ESM C delivers similar performance to ESM2 650M. The 600M delivers similar performance to ESM2 3B and approaches the capabilities of the ESM2 15B, with far greater efficiency. The 6B parameter ESM C outperforms all ESM2 models by a wide margin.

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

Today we’re releasing ESM C 300M, and 600M with open weights. ESM C 6B is available immediately on EvolutionaryScale Forge for academic use, and AWS Sagemaker for commercial use. ESM C will be on NVIDIA BioNemo soon. We’re excited to see what you build with ESM!

Profilbild von Nathan Benaich

Nathan Benaichvor 1 Jahr

cool work!

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

Thanks Nathan!

Profilbild von Kevin K. Yang 楊凱筌

Kevin K. Yang 楊凱筌vor 1 Jahr

Why is it called Cambrian?

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

wouldn't want to spoil the mystery!

Profilbild von Surge Biswas

Surge Biswasvor 1 Jahr

Congrats Alex and the evoscale team! Exciting

Profilbild von Alex Rives

Alex Rivesvor 1 Jahr

Thank you Surge!

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