Video wird geladen...

Video konnte nicht geladen werden

Beim Laden dieses Videos ist ein Problem aufgetreten. Dies könnte an einem vorübergehenden Netzwerkproblem liegen oder das Video ist möglicherweise nicht verfügbar.

Introducing Latent-X — our all-atom frontier AI model for protein binder design. State-of-the-art lab performance, widely accessible via the Latent Labs Platform. Free tier: Blog: Technical report:

Simon Kohl

3,097 subscribers

57,495 Aufrufe • vor 1 Jahr •via X (Twitter)

Gesundheit & Wellness Wissenschaft & Technologie Bildung

Anya Rossi• Live Now

Private livecam show

32 Kommentare

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Latent-X achieved breakthrough lab results: Picomolar binding affinities, directly outperforming prior methods in head-to-head validation. Leading experimental hit rates: * 91-100% for macrocycles * 10-64% for mini-binders Testing 30-100 designs per target vs millions traditionally.

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Latent-X generates novel binders from scratch, solving the geometric puzzle of binding at the all-atom level while obeying biochemical rules nature follows. I'm still mesmerized watching the model generate successful binders directly at the atom level — hydrogen bonds included!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

What excites me most: getting this into the hands of scientists through our no-code platform. Replicates our validated workflows, no AI background required. And it’s fast — up to 10x faster than prior methods!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

We’re making Latent-X available with a free tier for commercial and academic users alike. We want to get cutting-edge AI into the hands of scientists at big pharma and small labs without needing AI teams or infrastructure.

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Starting with macrocycles and mini-binders. Can't wait for your feedback! More to come! For requests beyond current platform capabilities: [email protected].

Profilbild von microRoc

microRocvor 1 Jahr

@razoralign Want to say a word or two about your user agreement?

Profilbild von Chaitanya K. Joshi

Chaitanya K. Joshivor 1 Jahr

Congrats team!!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you, Chaitanya!

Profilbild von Charlie Harris

Charlie Harrisvor 1 Jahr

Congrats Simon!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you, Charlie!

Profilbild von Aidan Gomez

Aidan Gomezvor 1 Jahr

Congrats!!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you, Aidan!!

Profilbild von Kentsis Research Group

Kentsis Research Groupvor 1 Jahr

Great to see joint operation on sequence and structure @CalebLareau

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

@CalebLareau Thank you, looking forward to having you try the model!

Profilbild von Rishabh

Rishabhvor 1 Jahr

Awesome stuff, Simon!! 🥳🔥

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you Rishabh! It would be great to get your feedback on the platform!

Profilbild von Rishabh

Rishabhvor 1 Jahr

Would love to! DM’d :D

Profilbild von Mati Staniszewski

Mati Staniszewskivor 1 Jahr

Congratulations - that’s amazing!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you Mati - it’s fantastic to have you on board!

Profilbild von Mattias Ordboken

Mattias Ordbokenvor 1 Jahr

@saakohl Awesome work and business model - congratulations. When will we see models further downstream, e.g. ADME?

Profilbild von Tomas Geffner

Tomas Geffnervor 1 Jahr

Congrats @saakohl and team!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you Tomas and congrats for La Proteina

Profilbild von Ethan Fast

Ethan Fastvor 1 Jahr

congrats on the launch, very exciting! just filled out your interest form, we'd love to give the model a try

Profilbild von Russ Wilcox

Russ Wilcoxvor 1 Jahr

What a massive change is coming for drug discovery

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you @Russ_Wilcox, and thanks for being onboard from the start! We can't wait to see what our partners and users are achieving with it!

Profilbild von Karsten Kreis

Karsten Kreisvor 1 Jahr

Congrats to this strong release, Simon!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you Karsten, really appreciate it! Congrats on La Proteina as well!

Profilbild von Gina El Nesr

Gina El Nesrvor 1 Jahr

Awesome to see!! Congrats Simon!

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thank you, Gina!

Profilbild von Evgenii

Evgeniivor 1 Jahr

Looks neat! Why you didn't validate the structures? These binders look small enough to be tested by NMR or X-rays.

Profilbild von Javin Oza

Javin Ozavor 1 Jahr

Does it only generate new binders or Is it possible to do 'affinity maturation' if a know binding pair is provided?

Profilbild von Simon Kohl

Simon Kohlvor 1 Jahr

Thanks for the interest! This model generates new binders.

Ähnliche Videos

Today we're launching Latent-Y: the world's first autonomous agent for drug design, lab-validated end to end. Give it a research goal. Latent-Y reasons, designs, iterates, and delivers lab-ready antibodies, autonomously or collaboratively, with the biological reasoning of a PhD protein design expert. Technical report: Blog post: Apply for access:

Today we're launching Latent-Y: the world's first autonomous agent for drug design, lab-validated end to end. Give it a research goal. Latent-Y reasons, designs, iterates, and delivers lab-ready antibodies, autonomously or collaboratively, with the biological reasoning of a PhD protein design expert. Technical report: Blog post: Apply for access:

Simon Kohl

121,575 Aufrufe • vor 6 Monaten

Introducing EmbeddingGemma: our new open, state-of-the-art embedding model designed for on-device AI 📱

Introducing EmbeddingGemma: our new open, state-of-the-art embedding model designed for on-device AI 📱

Google AI Developers

154,169 Aufrufe • vor 1 Jahr

We connected our autonomous lab to OpenAI's GPT-5 and let it run 36,000 experiments. The result was a new state-of-the-art for Cell-Free Protein Synthesis that cut costs by 40% per gram of protein. You can now order the beta version for your own lab: You can read the full preprint and read OpenAI’s blog post about our work here: See the full press release here:

We connected our autonomous lab to OpenAI's GPT-5 and let it run 36,000 experiments. The result was a new state-of-the-art for Cell-Free Protein Synthesis that cut costs by 40% per gram of protein. You can now order the beta version for your own lab: You can read the full preprint and read OpenAI’s blog post about our work here: See the full press release here:

Ginkgo Bioworks

80,608 Aufrufe • vor 8 Monaten

AI has solved software. Biology is the next frontier. We're hiring across every team at Adaptyv. We’ve built the best automated lab for protein designers to experimentally test their AI-designed proteins. Today, the most advanced protein design companies run their wet-lab work on Adaptyv, from the biggest biopharmas to frontier AI labs to dozens of virtual biotech startups. Demand has grown faster than we have, so we’re hiring across the board: • Bio: Research associates, scientists and lab technicians to develop and run new assays at scale. • Lab automation: Engineers and interns to onboard new lab instruments and scale our automation infrastructure. • Software: Product and backend engineers to scale LabOS, our internal lab orchestration platform, our API for agents and the data pipelines that turn messy physical-world data into clean results. • Partnerships, customer success and operations: Building partnerships with AI & pharma labs, making sure customers understand their data and can run more campaigns, making sure the company operations run smoothly

AI has solved software. Biology is the next frontier. We're hiring across every team at Adaptyv. We’ve built the best automated lab for protein designers to experimentally test their AI-designed proteins. Today, the most advanced protein design companies run their wet-lab work on Adaptyv, from the biggest biopharmas to frontier AI labs to dozens of virtual biotech startups. Demand has grown faster than we have, so we’re hiring across the board: • Bio: Research associates, scientists and lab technicians to develop and run new assays at scale. • Lab automation: Engineers and interns to onboard new lab instruments and scale our automation infrastructure. • Software: Product and backend engineers to scale LabOS, our internal lab orchestration platform, our API for agents and the data pipelines that turn messy physical-world data into clean results. • Partnerships, customer success and operations: Building partnerships with AI & pharma labs, making sure customers understand their data and can run more campaigns, making sure the company operations run smoothly

Adaptyv Bio

15,109 Aufrufe • vor 4 Monaten

Really fun No Priors with Walter Goodwin founder of Fractile topics: - how to win the ai chip market, structurally - ai for chip design, what’s compressible - the need to be a frontier lab to serve frontier labs - solving memory bandwidth - new hardware scaling laws

Really fun No Priors with Walter Goodwin founder of Fractile topics: - how to win the ai chip market, structurally - ai for chip design, what’s compressible - the need to be a frontier lab to serve frontier labs - solving memory bandwidth - new hardware scaling laws

sarah guo

30,285 Aufrufe • vor 4 Tagen

We recently released a technical report highlighting how Isomorphic Labs’ drug design engine is achieving a step change in how we model complex biological mechanisms, consistently outperforming industry benchmarks. Read our blog to discover how we’re bridging the gap between structure prediction and rational drug design. You can find the link in the comments.

We recently released a technical report highlighting how Isomorphic Labs’ drug design engine is achieving a step change in how we model complex biological mechanisms, consistently outperforming industry benchmarks. Read our blog to discover how we’re bridging the gap between structure prediction and rational drug design. You can find the link in the comments.

Isomorphic Labs

125,474 Aufrufe • vor 7 Monaten

Wave 9 is here: a frontier model built for software engineering. Introducing our new family of models: SWE-1, SWE-1-lite, and SWE-1-mini. Based on internal evals, it has performance nearing that of frontier models from the foundation labs. Available now, only in Windsurf!

Wave 9 is here: a frontier model built for software engineering. Introducing our new family of models: SWE-1, SWE-1-lite, and SWE-1-mini. Based on internal evals, it has performance nearing that of frontier models from the foundation labs. Available now, only in Windsurf!

Devin Desktop

743,273 Aufrufe • vor 1 Jahr

Introducing Magnific Precision, now on the Freepik AI Suite Upscale your images while keeping the original intact. The lastest state of the art model by Magnific.ai Available for all plans

Introducing Magnific Precision, now on the Freepik AI Suite Upscale your images while keeping the original intact. The lastest state of the art model by Magnific.ai Available for all plans

Magnific

51,831 Aufrufe • vor 1 Jahr

lab·o·ra·to·ry A place equipped for experimental study in a science or for testing and analysis. Introducing our state-of-the-art, in-stadium Maven Baseball Lab player development lab! #GoHoos

lab·o·ra·to·ry A place equipped for experimental study in a science or for testing and analysis. Introducing our state-of-the-art, in-stadium Maven Baseball Lab player development lab! #GoHoos

Virginia Baseball

35,289 Aufrufe • vor 10 Monaten

Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models turn the publicly available, state-of-the-art text-to-image LDM Stable Diffusion into an efficient and expressive text-to-video model with resolution up to 1280 x 2048 abs: project page:

Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models turn the publicly available, state-of-the-art text-to-image LDM Stable Diffusion into an efficient and expressive text-to-video model with resolution up to 1280 x 2048 abs: project page:

AK

718,760 Aufrufe • vor 3 Jahren

Thesis (Thesis (YC F25)) is an applied research lab accelerating AI R&D. What if every researcher, anywhere, could discover the next Transformer or invent the next AlphaFold? Thesis' mission is to make state-of-the-art AI discovery 10x faster and 10x cheaper, putting frontier research within reach of every lab. With 1 month and $10k, they've achieved state-of-the-art performance on OpenAI’s MLE-bench.

Thesis (Thesis (YC F25)) is an applied research lab accelerating AI R&D. What if every researcher, anywhere, could discover the next Transformer or invent the next AlphaFold? Thesis' mission is to make state-of-the-art AI discovery 10x faster and 10x cheaper, putting frontier research within reach of every lab. With 1 month and $10k, they've achieved state-of-the-art performance on OpenAI’s MLE-bench.

Y Combinator

16,337 Aufrufe • vor 10 Monaten

Introducing the 𝗚𝗲𝗺𝗶𝗻𝗶 𝗮𝗱𝘃𝗮𝗻𝘁𝗮𝗴𝗲 in Google Marketing Platform. Our best AI for your best ROI Experience unified inventory, accelerated performance, and ease of use. All in one place.

Introducing the 𝗚𝗲𝗺𝗶𝗻𝗶 𝗮𝗱𝘃𝗮𝗻𝘁𝗮𝗴𝗲 in Google Marketing Platform. Our best AI for your best ROI Experience unified inventory, accelerated performance, and ease of use. All in one place.

Google Marketing Platform

111,542 Aufrufe • vor 6 Monaten

The most effective AI systems don't rely on a single model. Frontier models provide state-of-the-art performance for complex tasks, while routers automatically select lightweight, open-source models for simpler jobs to optimize accuracy, latency, and cost. Learn more:

The most effective AI systems don't rely on a single model. Frontier models provide state-of-the-art performance for complex tasks, while routers automatically select lightweight, open-source models for simpler jobs to optimize accuracy, latency, and cost. Learn more:

NVIDIA AI

12,152 Aufrufe • vor 6 Monaten

The possibilities for AI-powered protein design are endless! In this case study we show how we used BindCraft to engineer a programmable maltose biosensor from scratch, including wet lab validation at Adaptyv of course. We envision a future where every biologist can make their own bespoke protein tools to investigate environmental samples, cell behaviour or create therapeutics. AI-based protein design can enable that future if powered by rapid wet lab validation. Once the cycle from design → test → application shrinks to weeks, the frontier explodes.

The possibilities for AI-powered protein design are endless! In this case study we show how we used BindCraft to engineer a programmable maltose biosensor from scratch, including wet lab validation at Adaptyv of course. We envision a future where every biologist can make their own bespoke protein tools to investigate environmental samples, cell behaviour or create therapeutics. AI-based protein design can enable that future if powered by rapid wet lab validation. Once the cycle from design → test → application shrinks to weeks, the frontier explodes.

Adaptyv Bio

52,197 Aufrufe • vor 1 Jahr

Announcing FastVideo V1, a unified framework for accelerating video generation. FastVideo V1 offers: - A simple, consistent Python API - State of the art model performance optimizations - Optimized implementations of popular models Blog:

Announcing FastVideo V1, a unified framework for accelerating video generation. FastVideo V1 offers: - A simple, consistent Python API - State of the art model performance optimizations - Optimized implementations of popular models Blog:

Hao AI Lab

15,071 Aufrufe • vor 1 Jahr

Introducing Handshake AI—the most ambitious chapter in our story. We leverage the scale of the largest early career network to source, train, and manage domain experts who test and challenge frontier models to failure for the top AI labs.

Introducing Handshake AI—the most ambitious chapter in our story. We leverage the scale of the largest early career network to source, train, and manage domain experts who test and challenge frontier models to failure for the top AI labs.

Handshake

357,761 Aufrufe • vor 1 Jahr

Introducing our new frontier video model, Runway Gen-4.5. Previously known as Whisper Thunder (aka) David. Gen-4.5 is state-of-the-art and sets a new standard for video generation motion quality, prompt adherence and visual fidelity. Learn more below.

Introducing our new frontier video model, Runway Gen-4.5. Previously known as Whisper Thunder (aka) David. Gen-4.5 is state-of-the-art and sets a new standard for video generation motion quality, prompt adherence and visual fidelity. Learn more below.

Runway

854,925 Aufrufe • vor 10 Monaten

Introducing Saaras V4 Multi-speaker Our best-in-class speech recognition model that accurately captures overlapping conversations and multi-speaker interactions, while delivering state-of-the-art performance in English across accents.

Introducing Saaras V4 Multi-speaker Our best-in-class speech recognition model that accurately captures overlapping conversations and multi-speaker interactions, while delivering state-of-the-art performance in English across accents.

Sarvam

31,433 Aufrufe • vor 2 Monaten

High-quality experimental data fuels biological discovery. Could an AI-enabled "autonomous lab" fundamentally increase the rate at which we generate it, and accelerate our progress toward cures for disease? That's the question I sat down to explore with Jason Kelly, CEO of Ginkgo Bioworks, for a deep-dive and tour of their 52-RAC lab in Boston's Seaport District. In our conversation we covered: → Ginkgo's recent collaboration with OpenAI on cell-free protein synthesis → U.S. Department of Energy's POTUS-backed Genesis Mission to accelerate AI for science → The evolution from cloud labs to truly autonomous labs → An on-the-floor look at Ginkgo's lab, including early challenges and creative workarounds If you're curious about frontier AI models meet the lab bench, check out the latest episode of the Discovery Engines Podcast. Watch or listen: 👀 YouTube: 🎧 Spotify: 🎧 Apple:

High-quality experimental data fuels biological discovery. Could an AI-enabled "autonomous lab" fundamentally increase the rate at which we generate it, and accelerate our progress toward cures for disease? That's the question I sat down to explore with Jason Kelly, CEO of Ginkgo Bioworks, for a deep-dive and tour of their 52-RAC lab in Boston's Seaport District. In our conversation we covered: → Ginkgo's recent collaboration with OpenAI on cell-free protein synthesis → U.S. Department of Energy's POTUS-backed Genesis Mission to accelerate AI for science → The evolution from cloud labs to truly autonomous labs → An on-the-floor look at Ginkgo's lab, including early challenges and creative workarounds If you're curious about frontier AI models meet the lab bench, check out the latest episode of the Discovery Engines Podcast. Watch or listen: 👀 YouTube: 🎧 Spotify: 🎧 Apple:

Nabil Laoudji

11,508 Aufrufe • vor 6 Monaten

Our bodies’ molecules aren’t static so why do many AI models treat them that way? Without considering the physical movement of molecules, many AI tools fail to robustly capture what makes drug candidates promising. AquaGen is a generative AI framework built to close that gap: an all-atom, explicit-solvent model that runs an order of magnitude faster than traditional MD methods. We’re excited about the implications of this work on early-stage drug discovery. Technical report and blog below.

Our bodies’ molecules aren’t static so why do many AI models treat them that way? Without considering the physical movement of molecules, many AI tools fail to robustly capture what makes drug candidates promising. AquaGen is a generative AI framework built to close that gap: an all-atom, explicit-solvent model that runs an order of magnitude faster than traditional MD methods. We’re excited about the implications of this work on early-stage drug discovery. Technical report and blog below.

Valence Labs

10,379 Aufrufe • vor 3 Monaten