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Introducing Latent-X — our all-atom frontier AI model for protein binder design. State-of-the-art lab performance, widely accessible via the Latent Labs Platform. Free tier: Blog: Technical report:

Simon Kohl

3,097 subscribers

57,495 görüntüleme • 1 yıl önce •via X (Twitter)

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Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Latent-X achieved breakthrough lab results: Picomolar binding affinities, directly outperforming prior methods in head-to-head validation. Leading experimental hit rates: * 91-100% for macrocycles * 10-64% for mini-binders Testing 30-100 designs per target vs millions traditionally.

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Latent-X generates novel binders from scratch, solving the geometric puzzle of binding at the all-atom level while obeying biochemical rules nature follows. I'm still mesmerized watching the model generate successful binders directly at the atom level — hydrogen bonds included!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

What excites me most: getting this into the hands of scientists through our no-code platform. Replicates our validated workflows, no AI background required. And it’s fast — up to 10x faster than prior methods!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

We’re making Latent-X available with a free tier for commercial and academic users alike. We want to get cutting-edge AI into the hands of scientists at big pharma and small labs without needing AI teams or infrastructure.

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Starting with macrocycles and mini-binders. Can't wait for your feedback! More to come! For requests beyond current platform capabilities: [email protected].

microRoc profil fotoğrafı

microRoc1 yıl önce

@razoralign Want to say a word or two about your user agreement?

Chaitanya K. Joshi profil fotoğrafı

Chaitanya K. Joshi1 yıl önce

Congrats team!!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you, Chaitanya!

Charlie Harris profil fotoğrafı

Charlie Harris1 yıl önce

Congrats Simon!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you, Charlie!

Aidan Gomez profil fotoğrafı

Aidan Gomez1 yıl önce

Congrats!!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you, Aidan!!

Kentsis Research Group profil fotoğrafı

Kentsis Research Group1 yıl önce

Great to see joint operation on sequence and structure @CalebLareau

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

@CalebLareau Thank you, looking forward to having you try the model!

Rishabh profil fotoğrafı

Rishabh1 yıl önce

Awesome stuff, Simon!! 🥳🔥

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you Rishabh! It would be great to get your feedback on the platform!

Rishabh profil fotoğrafı

Rishabh1 yıl önce

Would love to! DM’d :D

Mati Staniszewski profil fotoğrafı

Mati Staniszewski1 yıl önce

Congratulations - that’s amazing!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you Mati - it’s fantastic to have you on board!

Mattias Ordboken profil fotoğrafı

Mattias Ordboken1 yıl önce

@saakohl Awesome work and business model - congratulations. When will we see models further downstream, e.g. ADME?

Tomas Geffner profil fotoğrafı

Tomas Geffner1 yıl önce

Congrats @saakohl and team!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you Tomas and congrats for La Proteina

Ethan Fast profil fotoğrafı

Ethan Fast1 yıl önce

congrats on the launch, very exciting! just filled out your interest form, we'd love to give the model a try

Russ Wilcox profil fotoğrafı

Russ Wilcox1 yıl önce

What a massive change is coming for drug discovery

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you @Russ_Wilcox, and thanks for being onboard from the start! We can't wait to see what our partners and users are achieving with it!

Karsten Kreis profil fotoğrafı

Karsten Kreis1 yıl önce

Congrats to this strong release, Simon!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you Karsten, really appreciate it! Congrats on La Proteina as well!

Gina El Nesr profil fotoğrafı

Gina El Nesr1 yıl önce

Awesome to see!! Congrats Simon!

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thank you, Gina!

Evgenii profil fotoğrafı

Evgenii1 yıl önce

Looks neat! Why you didn't validate the structures? These binders look small enough to be tested by NMR or X-rays.

Javin Oza profil fotoğrafı

Javin Oza1 yıl önce

Does it only generate new binders or Is it possible to do 'affinity maturation' if a know binding pair is provided?

Simon Kohl profil fotoğrafı

Simon Kohl1 yıl önce

Thanks for the interest! This model generates new binders.

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