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🧬 Introducing Longevity Vaccines. Building on experience from the Rentosertib program, Insilico’s new research initiative extends its strategy of tackling both disease and biological aging into preventive cell clearing. 🛡️ Combining AI and circular mRNA, the approach aims to equip the body’s own T cells to remove selected aging... show more

Insilico Medicine

15,427 subscribers

72,191 次观看 • 7 天前 •via X (Twitter)

新闻政治健康养生科学技术

Anya Rossi• Live Now

Private livecam show

15 条评论

Mgoes (bio/acc 🤖💉) 的头像

Mgoes (bio/acc 🤖💉)7 天前

rentosertib was a lung drug that happened to move an aging clock now there's a longevity vaccine program. the pipeline is downstream of a post-hoc analysis and everyone's cool with it

ProgressBureau 的头像

ProgressBureau7 天前

More healthy years mean more chances to learn, begin again and stay close to the people we love. If we can prevent some of the damage of aging, we give people more freedom over their own lives. That is a future worth building.

Whatever — e/acc 的头像

Whatever — e/acc7 天前

Biology is getting so cool. Literally reprogramming our meat computers.

George Frukenmiller 的头像

George Frukenmiller7 天前

🚀🚀

EyeCoin 的头像

EyeCoin7 天前

Clearing senescent immune cells could protect more than lifespan aging doesn’t spare the eyes. Strong direction.

sgurney1@bigpond.com 的头像

[email protected]7 天前

This is exciting! Fibrious in Lipedema is another market whose upside would be massive. Something like 10 % of all woman are suffering with it. There are no treatments apart from removal surgery, costing thousands $$. It'd be great to test the drugs effectiveness on this disease.

🇺🇦🇮🇱Путина нужно судить 的头像

🇺🇦🇮🇱Путина нужно судить7 天前

Please hurry 🙄

Mark 的头像

Mark7 天前

@grok чья это компания страна кто добился этого ?

Pavel Zun 的头像

Pavel Zun7 天前

Okay, yeah, when do you plan to roll it out to the clinic and how much will it cost?

KickWestra 的头像

KickWestra7 天前

Make it mainstream pls.

🇺🇦🇮🇱Путина нужно судить 的头像

🇺🇦🇮🇱Путина нужно судить7 天前

@grok please tell me me more in great detail.

PEB97 的头像

PEB977 天前

Lfg

P.D. Petro 𝕏 🎸🤠🇺🇸 的头像

P.D. Petro 𝕏 🎸🤠🇺🇸7 天前

👍🏻

Cory Kornowicz 的头像

Cory Kornowicz7 天前

So these are just CAAR-T cell therapies?

Joe Williams 的头像

Joe Williams7 天前

Oh please YES

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Aging has a language. 🧬 We’re teaching AI to read it. On the cover of Cell: compact Longevity-LLMs, jointly trained by Insilico Medicine and Liquid AI, demonstrate SOTA performance on LongevityBench. Powered by these models, Longevity Claw nominated 328 candidate gene targets for aging research. Small model. Big questions. Open source. 🧵👇 #insilicoSOTAFM

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Big Pharma spends billions on cancer drugs that may weaken our body’s natural defenses, but Dr. Soon-Shiong reveals a $10 test could hold the key to longevity—keeping your natural killer cells above 1,000 to fight cancer, infections, and more! Dr. Patrick Soon-Shiong unveils a groundbreaking perspective on human health, describing not an invention but an evolution in understanding the body’s defense system. For 450-460 million years, a single cell has enabled mammalian survival against infection, cancer, and trauma: the natural killer (NK) cell. This cell, he argues, forms the foundation of a unifying theory of longevity—a bold claim grounded in decades of research. Soon-Shiong critiques the conventional “whack-a-mole” approach to cancer treatment. He spent years chasing genomic mutations, only to realize that targeting one mutation often spawns another. Big Pharma, he notes, invests billions in mutation-specific drugs, chemotherapy, radiation, and checkpoint inhibitors—treatments that inadvertently suppress the very NK cells critical to life. Even therapies like EPOGEN and NEUPOGEN, designed to support chemotherapy, enable more aggressive treatments that further deplete these vital cells. The solution, he proposes, is startlingly simple: monitor the absolute lymphocyte count (ALC) via a $10 CBC test. NK cells, a subset of lymphocytes, must remain above 1,000 per microliter to maintain robust defense against cancer, infections, and sepsis. Radiation, however, often crashes this count, sometimes for over a year, leaving patients vulnerable to metastasis. A recent study highlights this “badscopal” effect, where radiation, while shrinking one tumor, may increase metastatic spread by wiping out NK cells—contrasting the long-touted “abscopal” benefit of systemic tumor reduction. Aging, viral infections, sepsis, and cancer all correlate with declining NK cell levels. Yet, Soon-Shiong emphasizes, these cells possess an innate ability to recognize and destroy transforming cells before they become cancerous. This insight shifts the paradigm from attacking disease to bolstering the body’s natural defenses. The challenge now is to rethink medical approaches. “Follow the science,” Soon-Shiong urges, advocating for data-driven strategies over entrenched agendas. By preserving NK cell counts, we may unlock the secret to long, healthy lives. This isn’t just a theory—it’s a call to transform how we fight disease.

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40,281 次观看 • 1 年前

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In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors E1 Ventures 🇺🇸. Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging

Ashlee Vance

63,172 次观看 • 10 个月前

Dr. Patrick Soon-Shiong on the Cancer-Fighting Immune Breakthrough: Awakening the 450 Million-Year-Old Natural Killer Cell After decades of pioneering work since discovering the natural killer cell in the 1990s—a remarkable immune cell created by God and preserved through 450 million years—Dr. Patrick Soon-Shiong reveals an extraordinary breakthrough. This cell, unknown to many until the 1970s, serves as the body's first line of defense, designed to destroy cancer cells, infections like COVID, sepsis, bacteria, and fungus. Dr. Soon-Shiong emphasizes that this is not an invention, but an enlightenment: activating the body’s own natural killer cells to combat disease naturally, shifting away from toxic chemotherapy and radiation. With a single jab, they have unlocked the secret to empowering this primal cellular protector. This is evolution’s own weapon against illness, a game-changer that taps into ancient biology to revolutionize modern medicine. This insight reframes how we think about health and cancer treatment by harnessing the immune system's innate power, moving beyond harsh treatments, and embracing nature’s original disease-fighter from within. The discovery is a call to awaken the body’s own god-given defense system for a future of empowered healing.

Dr. Patrick Soon-Shiong on the Cancer-Fighting Immune Breakthrough: Awakening the 450 Million-Year-Old Natural Killer Cell After decades of pioneering work since discovering the natural killer cell in the 1990s—a remarkable immune cell created by God and preserved through 450 million years—Dr. Patrick Soon-Shiong reveals an extraordinary breakthrough. This cell, unknown to many until the 1970s, serves as the body's first line of defense, designed to destroy cancer cells, infections like COVID, sepsis, bacteria, and fungus. Dr. Soon-Shiong emphasizes that this is not an invention, but an enlightenment: activating the body’s own natural killer cells to combat disease naturally, shifting away from toxic chemotherapy and radiation. With a single jab, they have unlocked the secret to empowering this primal cellular protector. This is evolution’s own weapon against illness, a game-changer that taps into ancient biology to revolutionize modern medicine. This insight reframes how we think about health and cancer treatment by harnessing the immune system's innate power, moving beyond harsh treatments, and embracing nature’s original disease-fighter from within. The discovery is a call to awaken the body’s own god-given defense system for a future of empowered healing.

Camus

33,407 次观看 • 10 个月前

We were told the shot stays in your arm. It doesn’t. The mRNA is wrapped in tiny fat bubbles. Those bubbles leak out of the muscle and travel through your blood. Almost every cell in your body has a fatty coating, so the bubbles get swallowed by whatever cells they bump into — heart cells, liver cells, brain cells, reproductive organs. Once inside, the cell reads the message and starts making a piece of the virus. Your immune system sees one of your own cells pumping out a foreign protein and assumes the cell is infected. So it kills it. There’s no “only go to muscle cells” instruction. Which organs get hit is mostly luck. That’s the real design problem — not just the spike protein, but a delivery system that turns random cells into targets. That’s why critics call it a flawed platform. Until they can aim these fat bubbles at the right cells and keep them there, every new version carries the same basic risk.

We were told the shot stays in your arm. It doesn’t. The mRNA is wrapped in tiny fat bubbles. Those bubbles leak out of the muscle and travel through your blood. Almost every cell in your body has a fatty coating, so the bubbles get swallowed by whatever cells they bump into — heart cells, liver cells, brain cells, reproductive organs. Once inside, the cell reads the message and starts making a piece of the virus. Your immune system sees one of your own cells pumping out a foreign protein and assumes the cell is infected. So it kills it. There’s no “only go to muscle cells” instruction. Which organs get hit is mostly luck. That’s the real design problem — not just the spike protein, but a delivery system that turns random cells into targets. That’s why critics call it a flawed platform. Until they can aim these fat bubbles at the right cells and keep them there, every new version carries the same basic risk.

Dr. Dawn Michael

51,409 次观看 • 1 天前

Scientists just figured out how to reverse aging using AI. And this is a massive breakthrough. We can now reprogram any human cell back to age 20. Heart cells, brain cells, skin cells, all reset to their biological prime. And here’s the wildest part…the technology to do this, has already existed since 2012 (it won the Nobel Prize). But the real breakthrough wasn’t possible until this year, when they supercharged it with AI. It’s a wild story. So in 2006, scientists discovered Yamanaka factors. They’re proteins that can basically convert any normal cell into a universal stem cell. Now this was a huge deal, because these stem cells are basically like magic healers. If you have torn muscle tissue, you could inject these stem cells into the area and they will turn into the youthful muscle cells you need. So Yamanaka factors were this insane breakthrough, because they allowed any human to turn any cell you already have into these magic healers. But, there was one big problem… It turns out, the original Yamanaka factors weren’t very good at this stem cell conversion. They could do it, but they just weren’t very reliable. Enter OpenAI...and this is where things get crazy. OpenAI designed a special AI model built specifically to create new proteins. Think of it like ChatGPT but for protein engineering. So they took all the Yamanaka research and asked this new AI to go ham on improving it. And get this… Their version was 50x more effective than the original. They tested it on 50 year old cells and it successfully started repairing 30% of their cells in just 7 days. This is just science fiction…it actually happened. And it sounds crazy, but in a few years, humans will be able to take a shot that will literally reverse the age of their cells.

Scientists just figured out how to reverse aging using AI. And this is a massive breakthrough. We can now reprogram any human cell back to age 20. Heart cells, brain cells, skin cells, all reset to their biological prime. And here’s the wildest part…the technology to do this, has already existed since 2012 (it won the Nobel Prize). But the real breakthrough wasn’t possible until this year, when they supercharged it with AI. It’s a wild story. So in 2006, scientists discovered Yamanaka factors. They’re proteins that can basically convert any normal cell into a universal stem cell. Now this was a huge deal, because these stem cells are basically like magic healers. If you have torn muscle tissue, you could inject these stem cells into the area and they will turn into the youthful muscle cells you need. So Yamanaka factors were this insane breakthrough, because they allowed any human to turn any cell you already have into these magic healers. But, there was one big problem… It turns out, the original Yamanaka factors weren’t very good at this stem cell conversion. They could do it, but they just weren’t very reliable. Enter OpenAI...and this is where things get crazy. OpenAI designed a special AI model built specifically to create new proteins. Think of it like ChatGPT but for protein engineering. So they took all the Yamanaka research and asked this new AI to go ham on improving it. And get this… Their version was 50x more effective than the original. They tested it on 50 year old cells and it successfully started repairing 30% of their cells in just 7 days. This is just science fiction…it actually happened. And it sounds crazy, but in a few years, humans will be able to take a shot that will literally reverse the age of their cells.

Whiplash347

68,643 次观看 • 10 个月前