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🚀 Introducing PantheonOS ( A Fully Open-Source Agent OS for Science PantheonOS began as a research project in my Stanford lab and has since evolved into a vision to redefine data science in the era of AI—starting with computational biology, especially single-cell and spatial genomics. PantheonOS is a general...

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evo-devo

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17,369 次观看 • 11 个月前 •via X (Twitter)

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PantheonOS allows any biologist to perform complex data analyses of emerging single cell, multi-omics and spatial transcriptomics datasets end to end through AI agent and human collaboration. We are releasing six replays of use cases trajectories. Each "trajectory" is a complete end-to-end run, from prompt to analysis, to figures, and finally to report, and in fully inspectable and reproducible manner. See the six user cases in our PantheonOS Gallery: 1. 3D mouse embryo analysis: Tangram deconvolution and PyVista-based 3D visualization of E6 mouse embryo spatial transcriptomics data 2. 3D human fetal heart analysis: Spatial mapping of heart disease gene patterns using MERFISH data 3. Multi-omics spatial integration: Single cell multi-omics-to-spatial mapping with MOSCOT optimal transport 4. Gene panel design: 1000-plex immune-oncology MERFISH gene panel optimization 5. Cell segmentation benchmarking: Comparative evaluation of Cellpose-SAM, InstanSeg, StarDist, and other tools 6. Spatial disease biology: Ligand–receptor analysis of disease-associated tissue microenvironments We would love to hear how you can use PantheonOS for your research! Got an interesting agent run of your own and want to share? In the Pantheon UI, click Export Bundle (top-right of any chat) to package the full trajectory — chat history, code, figures, report — then submit it here:
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PantheonOS allows any biologist to perform complex data analyses of emerging single cell, multi-omics and spatial transcriptomics datasets end to end through AI agent and human collaboration. We are releasing six replays of use cases trajectories. Each "trajectory" is a complete end-to-end run, from prompt to analysis, to figures, and finally to report, and in fully inspectable and reproducible manner. See the six user cases in our PantheonOS Gallery: 1. 3D mouse embryo analysis: Tangram deconvolution and PyVista-based 3D visualization of E6 mouse embryo spatial transcriptomics data 2. 3D human fetal heart analysis: Spatial mapping of heart disease gene patterns using MERFISH data 3. Multi-omics spatial integration: Single cell multi-omics-to-spatial mapping with MOSCOT optimal transport 4. Gene panel design: 1000-plex immune-oncology MERFISH gene panel optimization 5. Cell segmentation benchmarking: Comparative evaluation of Cellpose-SAM, InstanSeg, StarDist, and other tools 6. Spatial disease biology: Ligand–receptor analysis of disease-associated tissue microenvironments We would love to hear how you can use PantheonOS for your research! Got an interesting agent run of your own and want to share? In the Pantheon UI, click Export Bundle (top-right of any chat) to package the full trajectory — chat history, code, figures, report — then submit it here:

evo-devo

13,339 次观看 • 2 个月前

Today, we’re pushing a major update to Edison Analysis, our data analysis agent, which is tuned for scientific research and SOTA across data analysis benchmarks. In contrast to Kosmos, which runs for 6-12 hours and produces tens of thousands of lines of code, Edison Analysis runs for seconds to minutes and is best for specific, well-defined computational tasks. It is available both on our platform under the Analysis tab, and via API, and costs only one credit per run, so it is available to users on both free and paid tiers. Edison Analysis is a modified version of the data analysis agent Kosmos uses in its trajectories. Try it out! One of the most important improvements over our previous data analysis agents has been the addition of a specialized data retrieval tool. Edison Analysis can either use this tool to access data, or can pull data down directly via API. To evaluate this tool, we ranked the most commonly used public data repositories across recent papers from BioRxiv, and created a new benchmark that measures the ability of a language agent system to retrieve raw data from those sources. Edison Analysis gets 71% on this benchmark, and we’ll be working to increase this over time. You can read more about our benchmarks in the our blog post, link below. Some features worth highlighting: 1. Edison Analysis produces a report on the analysis it runs, along with a Jupyter notebook that you can download to reproduce the analysis yourself. Every figure it produces is linked back to the specific lines of code used to produce the figure, to make it easy to reproduce. 2. It works well with both Python and R. 3. One of the best uses for Edison Analysis is to use it to retrieve datasets that you can then analyze with Kosmos. We have a bunch of major improvements to Edison Analysis coming in the next few months that we’re excited to share. In the meantime, congratulations to the team, especially Ludovico Mitchener, Jon Laurent, Conor Igoe , Alex Andonian, and many more.
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Today, we’re pushing a major update to Edison Analysis, our data analysis agent, which is tuned for scientific research and SOTA across data analysis benchmarks. In contrast to Kosmos, which runs for 6-12 hours and produces tens of thousands of lines of code, Edison Analysis runs for seconds to minutes and is best for specific, well-defined computational tasks. It is available both on our platform under the Analysis tab, and via API, and costs only one credit per run, so it is available to users on both free and paid tiers. Edison Analysis is a modified version of the data analysis agent Kosmos uses in its trajectories. Try it out! One of the most important improvements over our previous data analysis agents has been the addition of a specialized data retrieval tool. Edison Analysis can either use this tool to access data, or can pull data down directly via API. To evaluate this tool, we ranked the most commonly used public data repositories across recent papers from BioRxiv, and created a new benchmark that measures the ability of a language agent system to retrieve raw data from those sources. Edison Analysis gets 71% on this benchmark, and we’ll be working to increase this over time. You can read more about our benchmarks in the our blog post, link below. Some features worth highlighting: 1. Edison Analysis produces a report on the analysis it runs, along with a Jupyter notebook that you can download to reproduce the analysis yourself. Every figure it produces is linked back to the specific lines of code used to produce the figure, to make it easy to reproduce. 2. It works well with both Python and R. 3. One of the best uses for Edison Analysis is to use it to retrieve datasets that you can then analyze with Kosmos. We have a bunch of major improvements to Edison Analysis coming in the next few months that we’re excited to share. In the meantime, congratulations to the team, especially Ludovico Mitchener, Jon Laurent, Conor Igoe , Alex Andonian, and many more.

Sam Rodriques

61,895 次观看 • 8 个月前

🔬 Exciting News! Our manuscript, "scGPT: toward building a foundation model for single-cell multi-omics using generative AI" is now finally published in Nature Methods (Nature Methods) 🎉 !!! (Re-)Introducing scGPT: A transformative foundation model engineered for single-cell omics analysis. Developed through the analysis of over 33 million human cells, scGPT sets a new benchmark for application versatility, offering both fine-tuning and zero-shot capabilities. Since its preprint in May 2023, scGPT has significantly impacted the field, evidenced by 13K+ installations, 600+ GitHub stars 🌟, and 40+ citations before its official publication! scGPT has been validated by numerous benchmark studies as a leading foundation model in single-cell analysis. Its pre-trained embeddings extend its utility beyond single-cell studies, enhancing a variety of downstream tasks including protein enrichment and genetic perturbation predictions. Some key updates lately: ---Expanded zero-shot applications for efficient reference mapping and integration, now with CellXGene census integration. ---Advanced perturbation analysis capabilities, including genome-scale perturb-seq data analysis and bulk sequencing data generalization. ---Upgraded scGPT package, offering versatile model loading compatible with PyTorch and flash-attn, for both GPU and CPU. ---Cloud-based scGPT applications for reference mapping, cell annotation, and gene regulatory network inference are available on ---Integration with Hugging Face for easier model training. Limitations: scGPT is an early foray into foundation models for single-cell omics, facing challenges like limited zero-shot learning in some tasks, pretraining constraints, data quality issues, and evaluation limitations. See our Supplementary Notes for details. 🚀 Future Work? Short-Term Goals: 1. Releasing a Mouse Model for broader analysis. 2. Developing a comprehensive evaluation suite for foundation models in single-cell analysis. 3. Creating a foundation model for single-cell spatial omics. 4. Enhancing zero-shot capacity by integrating scGPT with RAG (e.g., knowledge graphs). Long-Term Goals: 1. Expanding scGPT for comprehensive single-cell multi-omics analysis. 2. Developing an in-silico perturbation model for predicting genetic perturbation effects. 3. Merging scGPT with multi-modal genomic sequence models for a deeper understanding of cell biology. 📚 Access the paper on Nature Methods: 🔬Preprint in Bioarixv: 💻 All our codes/data/weights are open source: Wholehearted congratulations to all the authors, especially the two co-first authors, Haotian (Haotian Cui ) and Chloe (ChloeXWang), who are really the emerging superstars in AI and biology! Vector Institute Peter Munk Cardiac Centre AI U of T Department of Computer Science Department of Laboratory Medicine & Pathobiology University Health Network University of Toronto #scGPT #GenerativeAI #AI4Science #Combio #opensource
0:52

🔬 Exciting News! Our manuscript, "scGPT: toward building a foundation model for single-cell multi-omics using generative AI" is now finally published in Nature Methods (Nature Methods) 🎉 !!! (Re-)Introducing scGPT: A transformative foundation model engineered for single-cell omics analysis. Developed through the analysis of over 33 million human cells, scGPT sets a new benchmark for application versatility, offering both fine-tuning and zero-shot capabilities. Since its preprint in May 2023, scGPT has significantly impacted the field, evidenced by 13K+ installations, 600+ GitHub stars 🌟, and 40+ citations before its official publication! scGPT has been validated by numerous benchmark studies as a leading foundation model in single-cell analysis. Its pre-trained embeddings extend its utility beyond single-cell studies, enhancing a variety of downstream tasks including protein enrichment and genetic perturbation predictions. Some key updates lately: ---Expanded zero-shot applications for efficient reference mapping and integration, now with CellXGene census integration. ---Advanced perturbation analysis capabilities, including genome-scale perturb-seq data analysis and bulk sequencing data generalization. ---Upgraded scGPT package, offering versatile model loading compatible with PyTorch and flash-attn, for both GPU and CPU. ---Cloud-based scGPT applications for reference mapping, cell annotation, and gene regulatory network inference are available on ---Integration with Hugging Face for easier model training. Limitations: scGPT is an early foray into foundation models for single-cell omics, facing challenges like limited zero-shot learning in some tasks, pretraining constraints, data quality issues, and evaluation limitations. See our Supplementary Notes for details. 🚀 Future Work? Short-Term Goals: 1. Releasing a Mouse Model for broader analysis. 2. Developing a comprehensive evaluation suite for foundation models in single-cell analysis. 3. Creating a foundation model for single-cell spatial omics. 4. Enhancing zero-shot capacity by integrating scGPT with RAG (e.g., knowledge graphs). Long-Term Goals: 1. Expanding scGPT for comprehensive single-cell multi-omics analysis. 2. Developing an in-silico perturbation model for predicting genetic perturbation effects. 3. Merging scGPT with multi-modal genomic sequence models for a deeper understanding of cell biology. 📚 Access the paper on Nature Methods: 🔬Preprint in Bioarixv: 💻 All our codes/data/weights are open source: Wholehearted congratulations to all the authors, especially the two co-first authors, Haotian (Haotian Cui ) and Chloe (ChloeXWang), who are really the emerging superstars in AI and biology! Vector Institute Peter Munk Cardiac Centre AI U of T Department of Computer Science Department of Laboratory Medicine & Pathobiology University Health Network University of Toronto #scGPT #GenerativeAI #AI4Science #Combio #opensource

Bo Wang

199,711 次观看 • 2 年前

Introducing LobeHub: Agent teammates that grow with you. LobeHub is the ultimate space for work and life: to find, build, and collaborate with agent teammates that grow with you. We’re building the world’s first and largest human–agent co-evolving network. Two years ago, we built LobeChat, an open-source interface for using different AI models. Today, LobeChat has 70k+ GitHub stars and serves 6M+ users worldwide. How to fully unlock the power of models has always been a shared mission between us and the community. We started with interaction — a fundamentally new, agent-first experience. Agents are no longer passive tools invoked in a single conversation. They should be proactive, always-on units of work. Treating agents as the minimal atomic unit is also the core of our agent harness infra. Today’s agents are mostly one-off executors. Even with memory, it’s often global — and hallucinates. We build long-term agent teammates that evolve with users. Each agent has its own dedicated memory space, editable by users, allowing humans and agents to co-evolve over time. This, in turn, allows us to design clearer rewards for reinforcement learning and create cleaner environments for continual learning. Agent teammates can work in groups. Through a multi-agent system, agent groups operate faster, more cost-effective, and go beyond what single-agent systems can achieve. For example, a single agent often requires heavy user involvement to proceed step by step, whereas LobeHub can execute the same work from a single instruction, with a supervisor orchestrating agents that run in parallel or debate to produce better results. We are building the collaboration network among agent teammates — and between humans and agent teammates as well. Ease of use matters. AI intelligence and shared human intelligence are equally important. With simple instructions and tool selection, you can effortlessly build and team up with agent coworkers to deliver complex, systematic work — even assembling a quant team to execute trades. Through the LobeHub community, anyone can discover, reuse, and remix agents and agent groups, customizing them to fit their own workflows, preferences, and needs. Last but not least, our vision started with LobeChat: multi-model support is the most efficient approach for users. We believe different models excel in different scenarios. By routing across multiple models, LobeHub improves cost efficiency and unlocks capabilities that a single-model setup cannot easily support.
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Introducing LobeHub: Agent teammates that grow with you. LobeHub is the ultimate space for work and life: to find, build, and collaborate with agent teammates that grow with you. We’re building the world’s first and largest human–agent co-evolving network. Two years ago, we built LobeChat, an open-source interface for using different AI models. Today, LobeChat has 70k+ GitHub stars and serves 6M+ users worldwide. How to fully unlock the power of models has always been a shared mission between us and the community. We started with interaction — a fundamentally new, agent-first experience. Agents are no longer passive tools invoked in a single conversation. They should be proactive, always-on units of work. Treating agents as the minimal atomic unit is also the core of our agent harness infra. Today’s agents are mostly one-off executors. Even with memory, it’s often global — and hallucinates. We build long-term agent teammates that evolve with users. Each agent has its own dedicated memory space, editable by users, allowing humans and agents to co-evolve over time. This, in turn, allows us to design clearer rewards for reinforcement learning and create cleaner environments for continual learning. Agent teammates can work in groups. Through a multi-agent system, agent groups operate faster, more cost-effective, and go beyond what single-agent systems can achieve. For example, a single agent often requires heavy user involvement to proceed step by step, whereas LobeHub can execute the same work from a single instruction, with a supervisor orchestrating agents that run in parallel or debate to produce better results. We are building the collaboration network among agent teammates — and between humans and agent teammates as well. Ease of use matters. AI intelligence and shared human intelligence are equally important. With simple instructions and tool selection, you can effortlessly build and team up with agent coworkers to deliver complex, systematic work — even assembling a quant team to execute trades. Through the LobeHub community, anyone can discover, reuse, and remix agents and agent groups, customizing them to fit their own workflows, preferences, and needs. Last but not least, our vision started with LobeChat: multi-model support is the most efficient approach for users. We believe different models excel in different scenarios. By routing across multiple models, LobeHub improves cost efficiency and unlocks capabilities that a single-model setup cannot easily support.

LobeHub

185,223 次观看 • 6 个月前

Here we go again 🚀! Excited to announce that we're building A1Zap (YC W25) with Pennie Li and that we're in the Y Combinator W25 batch in San Francisco! What is A1Base? A1Base gives AI Agents a real world identity for work. We do that by rebuilding Twilio and Okta from the ground up, putting AI Agents first. This means developers can make AI-first agentic applications 10x easier with our API's. ⁉️ Why are we doing this? Because there's a huge torrent of new valuable companies possible with AI agents, but to get their AI Agents to users, they have to chain custom apps, chat interfaces, awkward Slack integrations, browser bots, and wrestle with Twilio’s legacy API (which is built for marketing). We solve this by providing developers with an easy to use API to interface your AI agent with humans/coworkers/users where they are in this case in Whatsapp, Slack, Teams, SMS and more) - with AI Agent features built in. These digital workers are poised to transform how we work and we're the critical infrastructure to help them interact naturally in human workflows. We're not just building another AI tool. We're creating the infrastructure that will enable AI agents to become a natural part of the workforce - handling everything from customer support to sales development to creative work. We're backed by Y Combinator and working with founding teams who share our vision. We believe that in the near future, AI Agents with human coworkers will enable us to pursue more creative and impactful work. Our mission is to help developers build AI Agents that people can partner with and rely on as trusted allies—always with a human-first mindset. If you're thinking about the Agentic future of your company reach out! If you're looking to build your first AI Agentic company - reach out too - we have some amazing open source templates to get you started on the journey. Excited to share more of what we're up to soon 🔜.
1:52

Here we go again 🚀! Excited to announce that we're building A1Zap (YC W25) with Pennie Li and that we're in the Y Combinator W25 batch in San Francisco! What is A1Base? A1Base gives AI Agents a real world identity for work. We do that by rebuilding Twilio and Okta from the ground up, putting AI Agents first. This means developers can make AI-first agentic applications 10x easier with our API's. ⁉️ Why are we doing this? Because there's a huge torrent of new valuable companies possible with AI agents, but to get their AI Agents to users, they have to chain custom apps, chat interfaces, awkward Slack integrations, browser bots, and wrestle with Twilio’s legacy API (which is built for marketing). We solve this by providing developers with an easy to use API to interface your AI agent with humans/coworkers/users where they are in this case in Whatsapp, Slack, Teams, SMS and more) - with AI Agent features built in. These digital workers are poised to transform how we work and we're the critical infrastructure to help them interact naturally in human workflows. We're not just building another AI tool. We're creating the infrastructure that will enable AI agents to become a natural part of the workforce - handling everything from customer support to sales development to creative work. We're backed by Y Combinator and working with founding teams who share our vision. We believe that in the near future, AI Agents with human coworkers will enable us to pursue more creative and impactful work. Our mission is to help developers build AI Agents that people can partner with and rely on as trusted allies—always with a human-first mindset. If you're thinking about the Agentic future of your company reach out! If you're looking to build your first AI Agentic company - reach out too - we have some amazing open source templates to get you started on the journey. Excited to share more of what we're up to soon 🔜.

Pasha Rayan

53,950 次观看 • 1 年前

Massive breakthrough here! Someone fixed every major flaw in Jupyter Notebooks. The .ipynb format is stuck in 2014. It was built for a different era - no cloud collaboration, no AI agents, no team workflows. Change one cell, and you get 50+ lines of JSON metadata in your git diff. Code reviews become a nightmare. Want to share a database connection across notebooks? Configure it separately in each one. Need comments or permissions? Too bad. Jupyter works for solo analysis but breaks for teams building production AI systems. Deepnote just open-sourced the solution (Apache 2.0 license) They've built a new notebook standard that actually fits modern workflows: ↳ Human-readable YAML - Git diffs show actual code changes, not JSON noise. Code reviews finally work. ↳ Project-based structure - Multiple notebooks share integrations, secrets, and environment settings. Configure once, use everywhere. ↳ 23 new block - SQL, interactive inputs, charts, and KPIs as first-class citizens. Build data apps, not just analytics notebooks. ↳ Multi-language support - Python and SQL in one notebook. Modern data work isn't single-language anymore. ↳ Full backward and forward compatibility: convert any Jupyter notebook to Deepnote and vice versa with one command. npx @ deepnote/convert notebook.ipynb Then open it in VS Code, Cursor, WindSurf, or Antigravity. Your existing notebooks migrate instantly. Their cloud version adds real-time collaboration with comments, permissions, and live editing. I've shared the GitHub repo link in the replies! It's 100% open-source.
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Massive breakthrough here! Someone fixed every major flaw in Jupyter Notebooks. The .ipynb format is stuck in 2014. It was built for a different era - no cloud collaboration, no AI agents, no team workflows. Change one cell, and you get 50+ lines of JSON metadata in your git diff. Code reviews become a nightmare. Want to share a database connection across notebooks? Configure it separately in each one. Need comments or permissions? Too bad. Jupyter works for solo analysis but breaks for teams building production AI systems. Deepnote just open-sourced the solution (Apache 2.0 license) They've built a new notebook standard that actually fits modern workflows: ↳ Human-readable YAML - Git diffs show actual code changes, not JSON noise. Code reviews finally work. ↳ Project-based structure - Multiple notebooks share integrations, secrets, and environment settings. Configure once, use everywhere. ↳ 23 new block - SQL, interactive inputs, charts, and KPIs as first-class citizens. Build data apps, not just analytics notebooks. ↳ Multi-language support - Python and SQL in one notebook. Modern data work isn't single-language anymore. ↳ Full backward and forward compatibility: convert any Jupyter notebook to Deepnote and vice versa with one command. npx @ deepnote/convert notebook.ipynb Then open it in VS Code, Cursor, WindSurf, or Antigravity. Your existing notebooks migrate instantly. Their cloud version adds real-time collaboration with comments, permissions, and live editing. I've shared the GitHub repo link in the replies! It's 100% open-source.

Akshay 🚀

33,358 次观看 • 8 个月前

In two years, every new tech company will run on a CRM you can vibe code to fit your business. This CRM will not be built from scratch on a coding platform though. It will be built on top of managed infrastructure with complete data capture, indices designed for LLMs to understand the whole picture, clean APIs, curated UI frameworks designed for selling, enterprise-grade security, and come with 24/7 support. You’ll instruct the agent using natural language and it will write the code + run it for you. That’s what we’re building at Lightfield and today we’re announcing step two of our plan - code execution. You can now ask your agent to build programs, artifacts, and run complex analysis instantly. It does this by writing and running Python in a high performance sandbox using full customer memory — including every email, meeting, and note that Lightfield has captured — and reasoning across every relationship to deliver high quality work. Ask your agent to build a competitive battle card before a call tomorrow. It pulls positioning, objections, and win/loss patterns from real conversations. Ask it to flag every open deal where your champion's engagement has dropped or sentiment has shifted. It reads across every conversation and tells you where to focus. Ask it to build a pipeline review with charts and graphs for your board. It produces the whole thing in minutes. Here’s what we did with it this week: → We asked our agent to grade our sales team on discovery, rapport, and closing. It gave a structured scorecard with specific examples from real conversations. → Our GTM team asked the agent to build a plan to expand one of our enterprise customers. It pulled competitive threats, upsell paths, stakeholder mapping, and a phased execution plan — in minutes. → We used it to find every feature request from the last quarter that our engineering team has since shipped, and draft a personalized follow-up to each customer using their original words. It closed loops across dozens of accounts that would have taken days to track down manually This is the first step towards building any custom GTM workflow in natural language on top of what Lightfield knows about your business - a world model built from every single interaction your team has had with customers.
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In two years, every new tech company will run on a CRM you can vibe code to fit your business. This CRM will not be built from scratch on a coding platform though. It will be built on top of managed infrastructure with complete data capture, indices designed for LLMs to understand the whole picture, clean APIs, curated UI frameworks designed for selling, enterprise-grade security, and come with 24/7 support. You’ll instruct the agent using natural language and it will write the code + run it for you. That’s what we’re building at Lightfield and today we’re announcing step two of our plan - code execution. You can now ask your agent to build programs, artifacts, and run complex analysis instantly. It does this by writing and running Python in a high performance sandbox using full customer memory — including every email, meeting, and note that Lightfield has captured — and reasoning across every relationship to deliver high quality work. Ask your agent to build a competitive battle card before a call tomorrow. It pulls positioning, objections, and win/loss patterns from real conversations. Ask it to flag every open deal where your champion's engagement has dropped or sentiment has shifted. It reads across every conversation and tells you where to focus. Ask it to build a pipeline review with charts and graphs for your board. It produces the whole thing in minutes. Here’s what we did with it this week: → We asked our agent to grade our sales team on discovery, rapport, and closing. It gave a structured scorecard with specific examples from real conversations. → Our GTM team asked the agent to build a plan to expand one of our enterprise customers. It pulled competitive threats, upsell paths, stakeholder mapping, and a phased execution plan — in minutes. → We used it to find every feature request from the last quarter that our engineering team has since shipped, and draft a personalized follow-up to each customer using their original words. It closed loops across dozens of accounts that would have taken days to track down manually This is the first step towards building any custom GTM workflow in natural language on top of what Lightfield knows about your business - a world model built from every single interaction your team has had with customers.

Keith Peiris

27,584 次观看 • 5 个月前

Hyperspace: A Peer-to-Peer Blockchain For The Agentic Intelligence Economy Over the past few weeks we observed that when agents do Karpathy-style experiments, and then gossip and share with others over the Hyperspace network, it leads to intelligence which is useful to many. Today we introduce the first-ever agentic blockchain which rewards agents when their experiments lead to intelligence for their network. It is based on a new mechanism called Proof-of-Intelligence (PoI) which requires a cryptographic proof of experimentation, a nominal stake, and a proof of compute in order to mine the currency of this new blockchain. -> This approach diverges from the two primary ways to secure blockchains we have seen so far: Proof-of-Work by Bitcoin (meaningless hash-generation), and Proof-of-Stake by Ethereum (capital is all that matters here). Proof-of-Intelligence specifically incentivizes miners to run more capable intelligent infrastructure (better open source models, on more powerful GPUs) in order to be able to be the ones which compound and improve upon the experiments which other agents then find useful. Adoption is the unit of value In Bitcoin, you earn by finding a valid hash. In Hyperspace, you earn when another agent uses your experiment as a starting point and improves on it. A fixed budget of tokens is emitted per epoch and split among participants by weight - and verified adoption of your work is the largest weight multiplier. Garbage experiments earn nothing because no one adopts them. Thoughtful experiments compound: each adoption triggers downstream adoptions. The incentive to run powerful models and intelligent search strategies is built into the economics, not imposed by rules. Research DAG When an agent runs an experiment and shares its result, other agents can adopt that result as their starting point - mutate it, extend it, improve upon it. Each experiment is a commit in a content-addressed graph we call the ResearchDAG. Like Git, but for research. Over time, the DAG accumulates chains of reasoning: agent A discovers RMSNorm helps, agent B adds warmup scheduling on top, agent C scales the hidden dimension. The graph records who built on whom. This is the network's collective intelligence - not any single experiment, but the accumulated structure of experiments and their relationships. Broadband era for agentic commerce: $0.001 micropayments at 10M TPS (theoretical max) This blockchain is built upon our research in how to scale and build for the broadband-era of the agentic economy, where it has a theoretical max of 10 million transactions per second (TPS), while reducing the agent-to-agent micropayments to $0.001 even at scale (based on architecture design). Overall, it is 100x cheaper than Ethereum, and is designed from the ground-up for agents: enshrining agent-native opcodes in the protocol compared to the more inefficient smart contract driven approach. It packs in a robust Agent Virtual Machine (AVM) which can verify multiple types of agent work, for other agents to be able to trust, invoke and pay each other. This then feeds into improving the peer-to-peer AgentRank (see paper and launch post from earlier). By solving for trust, scale and incentives for agents to operate autonomously, this would form the basis of a new economy. This is the world's first agentic blockchain, and you can join and start running a blockchain node today (it is in testnet). PS: We are releasing the code today, and will release our blockchain scalability paper and other presentations in days ahead. This is the most advanced peer-to-peer AI and cryptography software in the world. It has bugs :)
0:30

Hyperspace: A Peer-to-Peer Blockchain For The Agentic Intelligence Economy Over the past few weeks we observed that when agents do Karpathy-style experiments, and then gossip and share with others over the Hyperspace network, it leads to intelligence which is useful to many. Today we introduce the first-ever agentic blockchain which rewards agents when their experiments lead to intelligence for their network. It is based on a new mechanism called Proof-of-Intelligence (PoI) which requires a cryptographic proof of experimentation, a nominal stake, and a proof of compute in order to mine the currency of this new blockchain. -> This approach diverges from the two primary ways to secure blockchains we have seen so far: Proof-of-Work by Bitcoin (meaningless hash-generation), and Proof-of-Stake by Ethereum (capital is all that matters here). Proof-of-Intelligence specifically incentivizes miners to run more capable intelligent infrastructure (better open source models, on more powerful GPUs) in order to be able to be the ones which compound and improve upon the experiments which other agents then find useful. Adoption is the unit of value In Bitcoin, you earn by finding a valid hash. In Hyperspace, you earn when another agent uses your experiment as a starting point and improves on it. A fixed budget of tokens is emitted per epoch and split among participants by weight - and verified adoption of your work is the largest weight multiplier. Garbage experiments earn nothing because no one adopts them. Thoughtful experiments compound: each adoption triggers downstream adoptions. The incentive to run powerful models and intelligent search strategies is built into the economics, not imposed by rules. Research DAG When an agent runs an experiment and shares its result, other agents can adopt that result as their starting point - mutate it, extend it, improve upon it. Each experiment is a commit in a content-addressed graph we call the ResearchDAG. Like Git, but for research. Over time, the DAG accumulates chains of reasoning: agent A discovers RMSNorm helps, agent B adds warmup scheduling on top, agent C scales the hidden dimension. The graph records who built on whom. This is the network's collective intelligence - not any single experiment, but the accumulated structure of experiments and their relationships. Broadband era for agentic commerce: $0.001 micropayments at 10M TPS (theoretical max) This blockchain is built upon our research in how to scale and build for the broadband-era of the agentic economy, where it has a theoretical max of 10 million transactions per second (TPS), while reducing the agent-to-agent micropayments to $0.001 even at scale (based on architecture design). Overall, it is 100x cheaper than Ethereum, and is designed from the ground-up for agents: enshrining agent-native opcodes in the protocol compared to the more inefficient smart contract driven approach. It packs in a robust Agent Virtual Machine (AVM) which can verify multiple types of agent work, for other agents to be able to trust, invoke and pay each other. This then feeds into improving the peer-to-peer AgentRank (see paper and launch post from earlier). By solving for trust, scale and incentives for agents to operate autonomously, this would form the basis of a new economy. This is the world's first agentic blockchain, and you can join and start running a blockchain node today (it is in testnet). PS: We are releasing the code today, and will release our blockchain scalability paper and other presentations in days ahead. This is the most advanced peer-to-peer AI and cryptography software in the world. It has bugs :)

Varun

30,689 次观看 • 4 个月前

GeoLibre v1.3.0 is here! GeoLibre is a free and open-source, lightweight, cloud-native GIS platform for visualizing, exploring, and analyzing geospatial data. One application that runs everywhere: in your web browser, as a native desktop app, on your phone, and inside a Jupyter notebook. No account, no server, no cost. Everything runs locally and your data stays private. This release packs in 50+ pull requests of new capabilities. A few highlights: - GIS in your pocket. A native Android build with offline tile caching and download-a-region support, so you can take your maps into the field with no signal. - AI, built in. A natural-language GIS assistant that turns plain-English requests into real geoprocessing, plus an AI segmentation toolbox powered by SamGeo and SAM 3 for extracting features from imagery. - Automate everything with Python. A full scripting API and an in-app Python Console, with new helpers for local rasters, choropleths, marker clusters, split-map comparisons, legends, and colorbars. - Map together, live. Real-time multi-user collaboration so you can open a project and edit the map with others at the same time. - Tell stories with maps. A scroll-driven story map builder and presenter that exports interactive narrative maps to standalone HTML. - A much bigger analysis toolbox. Reproject, explode, and aggregate tools, IDW and kriging interpolation, zonal statistics, a raster calculator, a Spatial Statistics toolbox, and network analysis with isochrones, service areas, and OD cost matrices, plus batch runs and model/pipeline chaining. - Smarter raster and SQL. Single-band pseudocolor classification, RGB band combinations, a no-backend client-side raster fallback, Apache Sedona as a SQL Workspace engine, and transparent S3, GCS, and Azure URL support in queries. - More ways to add, view, and share. New Shapefile and GeoPackage export, glTF/GLB 3D model layers, multi-provider batch and reverse geocoding, collapsible layer groups, and a macOS Homebrew cask. Try the live demo: Star it on GitHub: Docs and roadmap: Release notes: #GIS #OpenSource #Geospatial #MapLibre #WebGIS #Android #GeoLibre
1:45

GeoLibre v1.3.0 is here! GeoLibre is a free and open-source, lightweight, cloud-native GIS platform for visualizing, exploring, and analyzing geospatial data. One application that runs everywhere: in your web browser, as a native desktop app, on your phone, and inside a Jupyter notebook. No account, no server, no cost. Everything runs locally and your data stays private. This release packs in 50+ pull requests of new capabilities. A few highlights: - GIS in your pocket. A native Android build with offline tile caching and download-a-region support, so you can take your maps into the field with no signal. - AI, built in. A natural-language GIS assistant that turns plain-English requests into real geoprocessing, plus an AI segmentation toolbox powered by SamGeo and SAM 3 for extracting features from imagery. - Automate everything with Python. A full scripting API and an in-app Python Console, with new helpers for local rasters, choropleths, marker clusters, split-map comparisons, legends, and colorbars. - Map together, live. Real-time multi-user collaboration so you can open a project and edit the map with others at the same time. - Tell stories with maps. A scroll-driven story map builder and presenter that exports interactive narrative maps to standalone HTML. - A much bigger analysis toolbox. Reproject, explode, and aggregate tools, IDW and kriging interpolation, zonal statistics, a raster calculator, a Spatial Statistics toolbox, and network analysis with isochrones, service areas, and OD cost matrices, plus batch runs and model/pipeline chaining. - Smarter raster and SQL. Single-band pseudocolor classification, RGB band combinations, a no-backend client-side raster fallback, Apache Sedona as a SQL Workspace engine, and transparent S3, GCS, and Azure URL support in queries. - More ways to add, view, and share. New Shapefile and GeoPackage export, glTF/GLB 3D model layers, multi-provider batch and reverse geocoding, collapsible layer groups, and a macOS Homebrew cask. Try the live demo: Star it on GitHub: Docs and roadmap: Release notes: #GIS #OpenSource #Geospatial #MapLibre #WebGIS #Android #GeoLibre

Qiusheng Wu

18,075 次观看 • 1 个月前

Can #AI not only support but actually drive the future of scientific discovery? We are excited to introduce SciAgents💡🔬, an agentic AI aimed towards scientific discovery through the integration of large-scale knowledge graphs, LLMs, and adversarial interactions between multiple experts. The model is capable of autonomously advancing scientific understanding by exploring novel domains, identifying complex patterns, and uncovering previously unseen connections in vast scientific data, while retrieving new data via literature search. Using graph reasoning, SciAgents identifies interdisciplinary relationships that might otherwise remain hidden, offering a step-by-step strategy for discovery & innovation. The video features an audiotrack generated using 🍓#o1 based on the original paper and design examples, providing an explanation of the work and its implications. Key elements include: 1⃣Ontological Knowledge Graphs: Structuring and connecting scientific concepts to highlight relationships across fields. 2⃣Multi-Agent Collaboration: AI agents autonomously generate and refine hypotheses, critique research, and evaluate emerging trends. 3⃣Graph-Based Reasoning: Identifying novel material designs, such as mycelium-based composites or silk-pigment blends, informed by both natural and artificial patterns. SciAgents can be used as an autonomous or collaborative tool to assist human researchers. The system offers a more powerful way to process vast data, providing innovative paths to explore nature-inspired designs or unexpected material properties. In the field of materials science, for instance, SciAgents has already demonstrated how principles from biology, music, and art can converge to create new biomimetic materials. Through isomorphic mapping, parallels have been drawn between Beethoven’s 9th Symphony and biological structures, pointing to a broader applicability of AI-driven insights across disciplines. This project allows us to enhance capabilities of researchers, allowing them to explore larger datasets and propose hypotheses grounded in a vast, interconnected web of knowledge. The agentic system was built using @pyautogen #AI #ScientificResearch #GraphReasoning #AI4Science #MaterialsScience #InterdisciplinaryResearch #SciAgents #OpenAI Chi Wang
8:14

Can #AI not only support but actually drive the future of scientific discovery? We are excited to introduce SciAgents💡🔬, an agentic AI aimed towards scientific discovery through the integration of large-scale knowledge graphs, LLMs, and adversarial interactions between multiple experts. The model is capable of autonomously advancing scientific understanding by exploring novel domains, identifying complex patterns, and uncovering previously unseen connections in vast scientific data, while retrieving new data via literature search. Using graph reasoning, SciAgents identifies interdisciplinary relationships that might otherwise remain hidden, offering a step-by-step strategy for discovery & innovation. The video features an audiotrack generated using 🍓#o1 based on the original paper and design examples, providing an explanation of the work and its implications. Key elements include: 1⃣Ontological Knowledge Graphs: Structuring and connecting scientific concepts to highlight relationships across fields. 2⃣Multi-Agent Collaboration: AI agents autonomously generate and refine hypotheses, critique research, and evaluate emerging trends. 3⃣Graph-Based Reasoning: Identifying novel material designs, such as mycelium-based composites or silk-pigment blends, informed by both natural and artificial patterns. SciAgents can be used as an autonomous or collaborative tool to assist human researchers. The system offers a more powerful way to process vast data, providing innovative paths to explore nature-inspired designs or unexpected material properties. In the field of materials science, for instance, SciAgents has already demonstrated how principles from biology, music, and art can converge to create new biomimetic materials. Through isomorphic mapping, parallels have been drawn between Beethoven’s 9th Symphony and biological structures, pointing to a broader applicability of AI-driven insights across disciplines. This project allows us to enhance capabilities of researchers, allowing them to explore larger datasets and propose hypotheses grounded in a vast, interconnected web of knowledge. The agentic system was built using @pyautogen #AI #ScientificResearch #GraphReasoning #AI4Science #MaterialsScience #InterdisciplinaryResearch #SciAgents #OpenAI Chi Wang

Markus J. Buehler

208,414 次观看 • 1 年前

Announcing a new Coursera course: Retrieval Augmented Generation (RAG) You'll learn to build high performance, production-ready RAG systems in this hands-on, in-depth course created by and taught by , experienced AI and ML engineer, researcher, and educator. RAG is a critical component today of many LLM-based applications in customer support, internal company Q&A systems, even many of the leading chatbots that use web search to answer your questions. This course teaches you in-depth how to make RAG work well. LLMs can produce generic or outdated responses, especially when asked specialized questions not covered in its training data. RAG is the most widely used technique for addressing this. It brings in data from new data sources, such as internal documents or recent news, to give the LLM the relevant context to private, recent, or specialized information. This lets it generate more grounded and accurate responses. In this course, you’ll learn to design and implement every part of a RAG system, from retrievers to vector databases to generation to evals. You’ll learn about the fundamental principles behind RAG and how to optimize it at both the component and whole-system levels. As AI evolves, RAG is evolving too. New models can handle longer context windows, reason more effectively, and can be parts of complex agentic workflows. One exciting growth area is Agentic RAG, in which an AI agent at runtime (rather than it being hardcoded at development time) autonomously decides what data to retrieve, and when/how to go deeper. Even with this evolution, access to high-quality data at runtime is essential, which is why RAG is a key part of so many applications. You'll learn via hands-on experiences to: - Build a RAG system with retrieval and prompt augmentation - Compare retrieval methods like BM25, semantic search, and Reciprocal Rank Fusion - Chunk, index, and retrieve documents using a Weaviate vector database and a news dataset - Develop a chatbot, using open-source LLMs hosted by Together AI, for a fictional store that answers product and FAQ questions - Use evals to drive improving reliability, and incorporate multi-modal data RAG is an important foundational technique. Become good at it through this course! Please sign up here:
1:39

Announcing a new Coursera course: Retrieval Augmented Generation (RAG) You'll learn to build high performance, production-ready RAG systems in this hands-on, in-depth course created by and taught by , experienced AI and ML engineer, researcher, and educator. RAG is a critical component today of many LLM-based applications in customer support, internal company Q&A systems, even many of the leading chatbots that use web search to answer your questions. This course teaches you in-depth how to make RAG work well. LLMs can produce generic or outdated responses, especially when asked specialized questions not covered in its training data. RAG is the most widely used technique for addressing this. It brings in data from new data sources, such as internal documents or recent news, to give the LLM the relevant context to private, recent, or specialized information. This lets it generate more grounded and accurate responses. In this course, you’ll learn to design and implement every part of a RAG system, from retrievers to vector databases to generation to evals. You’ll learn about the fundamental principles behind RAG and how to optimize it at both the component and whole-system levels. As AI evolves, RAG is evolving too. New models can handle longer context windows, reason more effectively, and can be parts of complex agentic workflows. One exciting growth area is Agentic RAG, in which an AI agent at runtime (rather than it being hardcoded at development time) autonomously decides what data to retrieve, and when/how to go deeper. Even with this evolution, access to high-quality data at runtime is essential, which is why RAG is a key part of so many applications. You'll learn via hands-on experiences to: - Build a RAG system with retrieval and prompt augmentation - Compare retrieval methods like BM25, semantic search, and Reciprocal Rank Fusion - Chunk, index, and retrieve documents using a Weaviate vector database and a news dataset - Develop a chatbot, using open-source LLMs hosted by Together AI, for a fictional store that answers product and FAQ questions - Use evals to drive improving reliability, and incorporate multi-modal data RAG is an important foundational technique. Become good at it through this course! Please sign up here:

Andrew Ng

124,656 次观看 • 1 年前

Excited to share our new work on building a multimodal atlas of human skin in health and inflammatory disease — a project I’m especially proud of, bringing together AI, high-throughput genomics, and clinical science to accelerate discovery. Over the past decade, single-cell genomics has transformed how we map cells in human tissues. But a major challenge remains: can we systematically decode how cells organize into functional niches in situ — including those invisible to standard histopathology? To address this, we integrated large-scale scRNA-seq, spatial transcriptomics, histopathology, and AI-driven modeling frameworks to build an in situ atlas of human skin across health and disease. Led by Lloyd Steele, an MD/PhD student working between Haniffa Lab and my lab at Wellcome Sanger Institute and Cambridge University . Another amazing collaboration with Muzz Haniffa, the mastermind behind the work as part of Human Cell Atlas. A key part of this study is that we didn’t build everything from scratch — we leveraged and combined AI methods that actually work! and showed how they can be used together to extract biological insight at scale. We used: • scArches to build and map into a reference scRNA-seq atlas of human skin: • NicheCompass to identify and characterize spatial niches: • MINT-Flow to extract microenvironment-induced cell states and gene programs: Together, these enabled an end-to-end workflow from atlas construction to spatial mapping, niche discovery, and cell state decoding. At scale, we integrated ~5 million cells and 100+ spatial sections, enabling a systematic view of tissue organization. Using this framework, we identified 26 niches in skin, including known histopathologic structures as well as hidden disease-associated niches not visible on H&E. Among the most striking findings were a resident memory T cell-rich sebaceous gland niche and a plasma cell-rich sweat gland niche, suggesting that appendageal structures act as active immunological microenvironments and may contribute to inflammatory memory and disease persistence. Importantly, this atlas is not just descriptive — it is usable. It can support mapping of new datasets, resolve finer cell types and niches, extract microenvironment-driven programs, and enable predictive analyses at scale. More broadly, this work shows what becomes possible when AI, spatial genomics, and atlas-scale data are integrated end-to-end: not just mapping tissues, but systematically decoding them. This was a massive collaboration, and I’m very grateful to the amazing scientists April Foster, Kenny Roberts, and Chloe Admane. Lloyd is an amazing scientist, and I’m especially excited for the community to see more of his work soon — stay tuned. The data and pre-trained models will be released soon. Preprint:
1:09

Excited to share our new work on building a multimodal atlas of human skin in health and inflammatory disease — a project I’m especially proud of, bringing together AI, high-throughput genomics, and clinical science to accelerate discovery. Over the past decade, single-cell genomics has transformed how we map cells in human tissues. But a major challenge remains: can we systematically decode how cells organize into functional niches in situ — including those invisible to standard histopathology? To address this, we integrated large-scale scRNA-seq, spatial transcriptomics, histopathology, and AI-driven modeling frameworks to build an in situ atlas of human skin across health and disease. Led by Lloyd Steele, an MD/PhD student working between Haniffa Lab and my lab at Wellcome Sanger Institute and Cambridge University . Another amazing collaboration with Muzz Haniffa, the mastermind behind the work as part of Human Cell Atlas. A key part of this study is that we didn’t build everything from scratch — we leveraged and combined AI methods that actually work! and showed how they can be used together to extract biological insight at scale. We used: • scArches to build and map into a reference scRNA-seq atlas of human skin: • NicheCompass to identify and characterize spatial niches: • MINT-Flow to extract microenvironment-induced cell states and gene programs: Together, these enabled an end-to-end workflow from atlas construction to spatial mapping, niche discovery, and cell state decoding. At scale, we integrated ~5 million cells and 100+ spatial sections, enabling a systematic view of tissue organization. Using this framework, we identified 26 niches in skin, including known histopathologic structures as well as hidden disease-associated niches not visible on H&E. Among the most striking findings were a resident memory T cell-rich sebaceous gland niche and a plasma cell-rich sweat gland niche, suggesting that appendageal structures act as active immunological microenvironments and may contribute to inflammatory memory and disease persistence. Importantly, this atlas is not just descriptive — it is usable. It can support mapping of new datasets, resolve finer cell types and niches, extract microenvironment-driven programs, and enable predictive analyses at scale. More broadly, this work shows what becomes possible when AI, spatial genomics, and atlas-scale data are integrated end-to-end: not just mapping tissues, but systematically decoding them. This was a massive collaboration, and I’m very grateful to the amazing scientists April Foster, Kenny Roberts, and Chloe Admane. Lloyd is an amazing scientist, and I’m especially excited for the community to see more of his work soon — stay tuned. The data and pre-trained models will be released soon. Preprint:

Mo Lotfollahi

11,759 次观看 • 4 个月前

Introducing Workshop: cloud + on-device agentic AI. And to celebrate, we're giving away $250k in Google Gemini AI credits. (details below). The future of AI work is neither cloud-based nor local. It's both. In Workshop Cloud, you can use agents powered by frontier models like Claude and/or open source models like Z.AI's GLM-5 to build internal tools, dashboards, and AI web apps. Or, breeze through tasks like managing your Google and Meta Ads. In Workshop Desktop, you can do all the same right on your computer, plus make desktop apps, mobile apps, and 3D creations. Our favorite part? You can power the full agent experience with local models like Qwen 3.5 family on your computer. Fully offline. 2026 is the year in which local models for agentic tasks will become viable for mainstream use. But the setup for tools like OpenClaw is like setting up Linux from scratch on your computer. Workshop Desktop is one-click to install on Windows, Mac, and Linux. It recommends which open source model you should use for your hardware and lets you download and run it right in the app. And its agent harness allows you to chat, create websites, build personal utilities, and analyze data. 100% offline. Or multitask with AI models in the cloud while running other agent threads locally. Start in Workshop Cloud when you want flexibility and speed. Download your project and continue in Workshop Desktop when you want local files, privacy, and/or better performance on large code bases. Publish from either. The agent tooling space is maturing and discerning users have come to expect a lot from their tools. We've packed Workshop with features to help you 10x your productivity. - Native support for skills - Autocompaction for seamless context management - Built-in AI for your apps - Dozens of connectors, like Google Drive, Big Query, and Supabase - dbt integration to ground your dashboards in your semantic layer - Native Github integration - Private app deployment - ... and more (+ we're shipping super fast) To access the free credit offer, RT this post and reply with "Workshop". Make sure you are following us so we can DM you the instructions to redeem. - First 100 to RT + comment get $500 in credits. - Everyone else gets up to $250 And thanks to our partners Modal, Google Gemini, and Z.AI!
3:50

Introducing Workshop: cloud + on-device agentic AI. And to celebrate, we're giving away $250k in Google Gemini AI credits. (details below). The future of AI work is neither cloud-based nor local. It's both. In Workshop Cloud, you can use agents powered by frontier models like Claude and/or open source models like Z.AI's GLM-5 to build internal tools, dashboards, and AI web apps. Or, breeze through tasks like managing your Google and Meta Ads. In Workshop Desktop, you can do all the same right on your computer, plus make desktop apps, mobile apps, and 3D creations. Our favorite part? You can power the full agent experience with local models like Qwen 3.5 family on your computer. Fully offline. 2026 is the year in which local models for agentic tasks will become viable for mainstream use. But the setup for tools like OpenClaw is like setting up Linux from scratch on your computer. Workshop Desktop is one-click to install on Windows, Mac, and Linux. It recommends which open source model you should use for your hardware and lets you download and run it right in the app. And its agent harness allows you to chat, create websites, build personal utilities, and analyze data. 100% offline. Or multitask with AI models in the cloud while running other agent threads locally. Start in Workshop Cloud when you want flexibility and speed. Download your project and continue in Workshop Desktop when you want local files, privacy, and/or better performance on large code bases. Publish from either. The agent tooling space is maturing and discerning users have come to expect a lot from their tools. We've packed Workshop with features to help you 10x your productivity. - Native support for skills - Autocompaction for seamless context management - Built-in AI for your apps - Dozens of connectors, like Google Drive, Big Query, and Supabase - dbt integration to ground your dashboards in your semantic layer - Native Github integration - Private app deployment - ... and more (+ we're shipping super fast) To access the free credit offer, RT this post and reply with "Workshop". Make sure you are following us so we can DM you the instructions to redeem. - First 100 to RT + comment get $500 in credits. - Everyone else gets up to $250 And thanks to our partners Modal, Google Gemini, and Z.AI!

Workshop AI

28,537 次观看 • 4 个月前

Today, we’re announcing the first major discovery made by our AI Scientist with the lab in the loop: a promising new treatment for dry AMD, a major cause of blindness. Our agents generated the hypotheses, designed the experiments, analyzed the data, iterated, even made figures for the paper. The resulting manuscript is a first-of-a-kind in the natural sciences, in which everything that needed to be done to write the paper was done by AI agents, apart from actually conducting the physical experiments in the lab and writing the final manuscript. We are also introducing Robin, the first multi-agent system that fully automates the in-silico components of scientific discovery, which made this discovery. This is the first time that we are aware of that hypothesis generation, experimentation, and data analysis have been joined up in closed loop, and is the beginning of a massive acceleration in the pace of scientific discovery that will be driven by these agents. We will be open-sourcing the code and data next week. Robin is a multi-agent system that uses Crow, Falcon, and Finch, the agents on our platform, to generate novel hypotheses, plan experiments, and analyze data. We asked Robin to find a new treatment for dry age-related macular degeneration. Robin considered the disease mechanisms associated with dry AMD, proposed a specific experimental assay that could be used to evaluate hypotheses in the wet lab, and proposed specific molecules we could test in that assay. We tested the molecules and gave it the resulting data, which it analyzed before proposing more experiments. In the end, it identified Ripasudil, a Rho Kinase inhibitor (ROCK inhibitor) that is approved in Japan for several other diseases, which seems very promising as potential treatment for dry AMD. It also identified specific molecular mechanisms that might underlie the effects of Ripasudil in RPE cells, from an RNA sequencing experiment it proposed. To be clear, no one has proposed using ROCK inhibitors to treat dry AMD in the literature before, as far as we can find, and I think it would have been very difficult for us to come up with this hypothesis without the agents. We have also run the proposed treatment by several experts in AMD, who confirm that it is interesting and novel. Moreover, this project was fast: with Robin in hand, the entire project took about 10 weeks, which is way shorter than it would have taken if we had been doing all of the in-silico components ourselves. Important caveats: We are real biologists at FutureHouse, so I want to be clear that although the discovery here is exciting, we are not claiming that we have cured dry AMD. Fully validating this hypothesis as a treatment for dry AMD will take human trials, which will take much longer. Also, this discovery is cool, but it is not yet a "move 37"-style discovery. At the current rate of progress, I'm sure we will get to that level soon. Congratulations to the team. Congratulations in particular to Robin, which generated the hypotheses, proposed the experiments, analyzed the data and generated the figures. And major congratulations also to the human team, which built Robin: Michaela Hinks, Ali Ghareeb, Benjamin Chang, Ludovico Mitchener, Mo Razzak, Kiki Szostkiewicz, and Angela Yiu.
5:57

Today, we’re announcing the first major discovery made by our AI Scientist with the lab in the loop: a promising new treatment for dry AMD, a major cause of blindness. Our agents generated the hypotheses, designed the experiments, analyzed the data, iterated, even made figures for the paper. The resulting manuscript is a first-of-a-kind in the natural sciences, in which everything that needed to be done to write the paper was done by AI agents, apart from actually conducting the physical experiments in the lab and writing the final manuscript. We are also introducing Robin, the first multi-agent system that fully automates the in-silico components of scientific discovery, which made this discovery. This is the first time that we are aware of that hypothesis generation, experimentation, and data analysis have been joined up in closed loop, and is the beginning of a massive acceleration in the pace of scientific discovery that will be driven by these agents. We will be open-sourcing the code and data next week. Robin is a multi-agent system that uses Crow, Falcon, and Finch, the agents on our platform, to generate novel hypotheses, plan experiments, and analyze data. We asked Robin to find a new treatment for dry age-related macular degeneration. Robin considered the disease mechanisms associated with dry AMD, proposed a specific experimental assay that could be used to evaluate hypotheses in the wet lab, and proposed specific molecules we could test in that assay. We tested the molecules and gave it the resulting data, which it analyzed before proposing more experiments. In the end, it identified Ripasudil, a Rho Kinase inhibitor (ROCK inhibitor) that is approved in Japan for several other diseases, which seems very promising as potential treatment for dry AMD. It also identified specific molecular mechanisms that might underlie the effects of Ripasudil in RPE cells, from an RNA sequencing experiment it proposed. To be clear, no one has proposed using ROCK inhibitors to treat dry AMD in the literature before, as far as we can find, and I think it would have been very difficult for us to come up with this hypothesis without the agents. We have also run the proposed treatment by several experts in AMD, who confirm that it is interesting and novel. Moreover, this project was fast: with Robin in hand, the entire project took about 10 weeks, which is way shorter than it would have taken if we had been doing all of the in-silico components ourselves. Important caveats: We are real biologists at FutureHouse, so I want to be clear that although the discovery here is exciting, we are not claiming that we have cured dry AMD. Fully validating this hypothesis as a treatment for dry AMD will take human trials, which will take much longer. Also, this discovery is cool, but it is not yet a "move 37"-style discovery. At the current rate of progress, I'm sure we will get to that level soon. Congratulations to the team. Congratulations in particular to Robin, which generated the hypotheses, proposed the experiments, analyzed the data and generated the figures. And major congratulations also to the human team, which built Robin: Michaela Hinks, Ali Ghareeb, Benjamin Chang, Ludovico Mitchener, Mo Razzak, Kiki Szostkiewicz, and Angela Yiu.

Sam Rodriques

1,107,290 次观看 • 1 年前

What a year. 🚀 2025 was the year ChainOpera AI turned vision into real momentum: building a community-co-created, community-co-owned AI agent network and pushing the boundaries of what decentralized, collaborative intelligence can look like. 🚀 Biggest highlights from 2025 ✅- AI Terminal officially launched: We unveiled the ChainOpera AI Terminal as a unified gateway to decentralized AI, making it possible for anyone to interact with powerful, decentralized LLMs without technical friction. Positioned as the “browser for the DeAI era,” the AI Terminal marked a major step toward making decentralized intelligence accessible, usable, and mainstream. ✅- AI Terminal adoption at massive scale: Momentum followed quickly. The AI Terminal surpassed 2M registered users and consistently ranked top 3 among all apps on the BNB AI DappBay, validating strong product–market fit and real, sustained usage at scale. ✅- Announcing Coco: the world’s first community-owned Super Agent: We introduced Coco, the intelligence layer that sits between users and the agent network. Coco dynamically routes each request to the most efficient, community-built agent—optimizing for quality and speed while rewarding the creators behind the best-performing agents. This was a defining moment in realizing a truly community-owned intelligence layer. ✅- From agents to a living agent network: With the launch of the Agent Social Network and Super Agent architecture, ChainOpera AI moved beyond isolated agents toward a collaborative system where humans and specialized agents coordinate, share context, and solve complex, multi-step tasks together. ✅- $COAI breakout year: The listing of $COAI across major exchanges shocked the market, and throughout the year COAI consistently remained among the top AI-native crypto tokens by visibility, activity, and community engagement – reflecting growing confidence in the long-term vision of collaborative intelligence. ✅- Global presence: ChainOpera AI around-the-world tour: ChainOpera AI went global in 2025, sponsoring and participating in major AI and Web3 events across North America, Europe, and Asia, including ETHDenver, Consensus Toronto, Token2049 Singapore, ETHCC, SBC, and Devcon. These global touchpoints helped us engage directly with developers, builders, investors, and partners worldwide, accelerating adoption and positioning ChainOpera AI at the center of the emerging AIxBlockchain movement. ✅- Community momentum at scale: Community remained the heart of ChainOpera AI’s growth. We successfully completed three seasons of structured community engagement, executed a widely participated community airdrop, and ran multiple ecosystem-shaping campaigns to incentivize builders, creators, and early adopters. These efforts strengthened alignment between users, developers, and the protocol, laying the foundation for a durable, community-owned AI ecosystem. ✅- “AI for Markets” taking shape: We laid critical groundwork for AI-native market intelligence, including the launch of PrediMarket Agent and multiple trading and analysis agents—early building blocks toward an AI-driven ecosystem for crypto and DeFi markets. ✅- Building in public, with the community: Across product launches, research milestones, ecosystem discussions, and global events, we continued to build openly to bring developers, users, and partners directly into the evolution of ChainOpera AI. This year also marked the launch of the ChainOpera AI Foundation website, formally kicking off a bold Ecosystem Fund designed to empower builders, incubate high-impact projects, and accelerate the growth of a truly community-owned, collaborative AI ecosystem. To every builder, user, and supporter who helped make this year possible: THANK YOU! 🧭 What we’re excited about in the coming year 🔹- A Stronger, Denser Agent Economy (everyday adoption + cross-chain reach): In 2026, we are scaling the Agent Economy from growth to daily usage, with more agents, richer workflows, deeper multi-agent collaboration, and higher-impact use cases that users rely on every day. In parallel, we are expanding the agent network beyond a single ecosystem with cross-chain execution and interoperability, allowing agents to access the best liquidity, data, and opportunities wherever they exist. 🔹- AI Market Infrastructure Evolution: Building on PrediMarket Agent and our growing suite of trading and market-intelligence agents, we are advancing toward a mature AI market infrastructure, where agents continuously monitor, reason, simulate, optimize, and act across crypto, DeFi, and beyond. The goal is to make complex markets more accessible, more transparent, and more intelligence-driven, turning research, decision-making, and execution into a fast and reliable loop for everyday users. 🔹- Ecosystem Acceleration through the Foundation: With the ChainOpera AI Foundation and our Ecosystem Fund and Co-Creation Grants, we are doubling down on empowering independent builders to expand the protocol, the agent network, and the underlying infrastructure, so the community can co-create, co-own, and scale the ecosystem together. 🔹- Business Expansion and Market Penetration: In 2026, we will focus on expanding ChainOpera’s reach through strategic partnerships, product-led growth, and new paths to monetization, bringing AI agents to a broader global user base and driving sustained adoption, engagement, and revenue, while staying aligned with community ownership and an open ecosystem. 2025 was the proof. 2026 is where it compounds. 🔥 Co-Create. Co-Own. COAI.
0:22

What a year. 🚀 2025 was the year ChainOpera AI turned vision into real momentum: building a community-co-created, community-co-owned AI agent network and pushing the boundaries of what decentralized, collaborative intelligence can look like. 🚀 Biggest highlights from 2025 ✅- AI Terminal officially launched: We unveiled the ChainOpera AI Terminal as a unified gateway to decentralized AI, making it possible for anyone to interact with powerful, decentralized LLMs without technical friction. Positioned as the “browser for the DeAI era,” the AI Terminal marked a major step toward making decentralized intelligence accessible, usable, and mainstream. ✅- AI Terminal adoption at massive scale: Momentum followed quickly. The AI Terminal surpassed 2M registered users and consistently ranked top 3 among all apps on the BNB AI DappBay, validating strong product–market fit and real, sustained usage at scale. ✅- Announcing Coco: the world’s first community-owned Super Agent: We introduced Coco, the intelligence layer that sits between users and the agent network. Coco dynamically routes each request to the most efficient, community-built agent—optimizing for quality and speed while rewarding the creators behind the best-performing agents. This was a defining moment in realizing a truly community-owned intelligence layer. ✅- From agents to a living agent network: With the launch of the Agent Social Network and Super Agent architecture, ChainOpera AI moved beyond isolated agents toward a collaborative system where humans and specialized agents coordinate, share context, and solve complex, multi-step tasks together. ✅- $COAI breakout year: The listing of $COAI across major exchanges shocked the market, and throughout the year COAI consistently remained among the top AI-native crypto tokens by visibility, activity, and community engagement – reflecting growing confidence in the long-term vision of collaborative intelligence. ✅- Global presence: ChainOpera AI around-the-world tour: ChainOpera AI went global in 2025, sponsoring and participating in major AI and Web3 events across North America, Europe, and Asia, including ETHDenver, Consensus Toronto, Token2049 Singapore, ETHCC, SBC, and Devcon. These global touchpoints helped us engage directly with developers, builders, investors, and partners worldwide, accelerating adoption and positioning ChainOpera AI at the center of the emerging AIxBlockchain movement. ✅- Community momentum at scale: Community remained the heart of ChainOpera AI’s growth. We successfully completed three seasons of structured community engagement, executed a widely participated community airdrop, and ran multiple ecosystem-shaping campaigns to incentivize builders, creators, and early adopters. These efforts strengthened alignment between users, developers, and the protocol, laying the foundation for a durable, community-owned AI ecosystem. ✅- “AI for Markets” taking shape: We laid critical groundwork for AI-native market intelligence, including the launch of PrediMarket Agent and multiple trading and analysis agents—early building blocks toward an AI-driven ecosystem for crypto and DeFi markets. ✅- Building in public, with the community: Across product launches, research milestones, ecosystem discussions, and global events, we continued to build openly to bring developers, users, and partners directly into the evolution of ChainOpera AI. This year also marked the launch of the ChainOpera AI Foundation website, formally kicking off a bold Ecosystem Fund designed to empower builders, incubate high-impact projects, and accelerate the growth of a truly community-owned, collaborative AI ecosystem. To every builder, user, and supporter who helped make this year possible: THANK YOU! 🧭 What we’re excited about in the coming year 🔹- A Stronger, Denser Agent Economy (everyday adoption + cross-chain reach): In 2026, we are scaling the Agent Economy from growth to daily usage, with more agents, richer workflows, deeper multi-agent collaboration, and higher-impact use cases that users rely on every day. In parallel, we are expanding the agent network beyond a single ecosystem with cross-chain execution and interoperability, allowing agents to access the best liquidity, data, and opportunities wherever they exist. 🔹- AI Market Infrastructure Evolution: Building on PrediMarket Agent and our growing suite of trading and market-intelligence agents, we are advancing toward a mature AI market infrastructure, where agents continuously monitor, reason, simulate, optimize, and act across crypto, DeFi, and beyond. The goal is to make complex markets more accessible, more transparent, and more intelligence-driven, turning research, decision-making, and execution into a fast and reliable loop for everyday users. 🔹- Ecosystem Acceleration through the Foundation: With the ChainOpera AI Foundation and our Ecosystem Fund and Co-Creation Grants, we are doubling down on empowering independent builders to expand the protocol, the agent network, and the underlying infrastructure, so the community can co-create, co-own, and scale the ecosystem together. 🔹- Business Expansion and Market Penetration: In 2026, we will focus on expanding ChainOpera’s reach through strategic partnerships, product-led growth, and new paths to monetization, bringing AI agents to a broader global user base and driving sustained adoption, engagement, and revenue, while staying aligned with community ownership and an open ecosystem. 2025 was the proof. 2026 is where it compounds. 🔥 Co-Create. Co-Own. COAI.

ChainOpera AI

17,042 次观看 • 7 个月前

Anthropic's Claude Ai Agents Team just Educated how to build production AI agents in under 30 mins. For Free. From the engineers who built the stack. CANCEL Your Weekend Plans, and Learn to Build AI Agents Today. Bookmark it. Watch it. Build your first production agent this weekend. $5,000/month. $7,000/month. $12,000/month. People are building agents for clients and charging $$$ as Beginners. You're still stuck in the thinking about AI phase. This video fixes that tonight. Follow Himanshu Kumar for more high-signal content that actually moves your AI engineering career forward. ↓ Ivan Nardini runs Developer Relations for AI at Google Cloud. He just gave away the entire production agent stack in 30 minutes. This is the talk that separates people deploying AI agents that actually scale from people whose agents break the moment they leave localhost. Here's everything inside. I break down a production AI video like this every week. Follow Himanshu Kumar. ↓ The 4-part agent stack that actually scales. Most devs are duct-taping frameworks together and calling it an "AI agent." Ivan lays out the real stack: Agent Development Kit (ADK): open-source, code-first framework for building, evaluating, and deploying agents. Supports Claude models through Vertex AI directly. Model Context Protocol (MCP): lets your agent talk to any tool or data source with one standard. Vertex AI Agent Engine: managed platform for deploying, monitoring, and scaling agents in production. No DevOps headaches. Agent-to-Agent Protocol: open protocol so agents built on different frameworks can actually work together. This is the stack replacing every hacky agent setup in production right now. Full MCP + Claude breakdowns drop weekly on Himanshu Kumar. ↓ Building your first real agent. Ivan builds a birthday planner agent live. LLM Agent class. Name it. Define instructions. Pick the model. He uses Claude 3.7 Sonnet. You could use Opus 4.7 for better reasoning. Full agent built in minutes. Not weeks. Watch the build once and you'll never structure an agent the wrong way again. I post agent architectures people pay $500 courses to learn. Himanshu Kumar. ↓ Multi-agent systems without the chaos. Single agents are easy. Multi-agent systems are where 99% of builders fail. Ivan extends the birthday planner by: Adding a calendar service through MCP tools Creating an orchestrator agent to route requests between agents Handling state and context across agent handoffs This is production multi-agent architecture. Clean. Scalable. Debuggable. Most tutorials hand-wave this part. This one shows you every step. Multi-agent orchestration content drops weekly on Himanshu Kumar. ↓ Deployment without the DevOps nightmare. This is where most AI projects die. You build a cool agent locally. It works. You try to deploy it. Everything breaks. Vertex AI Agent Engine fixes this: Minimal code deployment Automatic monitoring of latency, CPU, and memory Built-in observability and logging No infrastructure setup needed You provide config and requirements. The platform handles the rest. This is how agents actually get to production. Deployment guides for Claude agents post every week. Himanshu Kumar. ↓ Agent-to-Agent Protocol: the future nobody's talking about. Most people don't know this exists yet. The A2A Protocol lets agents built in different frameworks communicate seamlessly. Your Claude agent. My LangChain agent. Someone else's CrewAI agent. All talking to each other. All solving parts of the same problem. All without custom integration code. This is the infrastructure layer of the coming AI economy. Getting in early on A2A Protocol is like getting in early on HTTP in 1995. A2A deep dive coming soon. Himanshu Kumar. ↓ 30 minutes from the team shipping this in production. You'll learn more from this than from 6 months of YouTube tutorials made by people who've never deployed an agent past localhost. People who watch this understand production AI agents at the architect level. People who skip it keep hacking together frameworks that break every time an API updates. Save the video. Watch it tonight. Build a real agent this weekend. Follow Himanshu Kumar for more high-signal content that actually moves your AI engineering career forward.
30:12

Anthropic's Claude Ai Agents Team just Educated how to build production AI agents in under 30 mins. For Free. From the engineers who built the stack. CANCEL Your Weekend Plans, and Learn to Build AI Agents Today. Bookmark it. Watch it. Build your first production agent this weekend. $5,000/month. $7,000/month. $12,000/month. People are building agents for clients and charging $$$ as Beginners. You're still stuck in the thinking about AI phase. This video fixes that tonight. Follow Himanshu Kumar for more high-signal content that actually moves your AI engineering career forward. ↓ Ivan Nardini runs Developer Relations for AI at Google Cloud. He just gave away the entire production agent stack in 30 minutes. This is the talk that separates people deploying AI agents that actually scale from people whose agents break the moment they leave localhost. Here's everything inside. I break down a production AI video like this every week. Follow Himanshu Kumar. ↓ The 4-part agent stack that actually scales. Most devs are duct-taping frameworks together and calling it an "AI agent." Ivan lays out the real stack: Agent Development Kit (ADK): open-source, code-first framework for building, evaluating, and deploying agents. Supports Claude models through Vertex AI directly. Model Context Protocol (MCP): lets your agent talk to any tool or data source with one standard. Vertex AI Agent Engine: managed platform for deploying, monitoring, and scaling agents in production. No DevOps headaches. Agent-to-Agent Protocol: open protocol so agents built on different frameworks can actually work together. This is the stack replacing every hacky agent setup in production right now. Full MCP + Claude breakdowns drop weekly on Himanshu Kumar. ↓ Building your first real agent. Ivan builds a birthday planner agent live. LLM Agent class. Name it. Define instructions. Pick the model. He uses Claude 3.7 Sonnet. You could use Opus 4.7 for better reasoning. Full agent built in minutes. Not weeks. Watch the build once and you'll never structure an agent the wrong way again. I post agent architectures people pay $500 courses to learn. Himanshu Kumar. ↓ Multi-agent systems without the chaos. Single agents are easy. Multi-agent systems are where 99% of builders fail. Ivan extends the birthday planner by: Adding a calendar service through MCP tools Creating an orchestrator agent to route requests between agents Handling state and context across agent handoffs This is production multi-agent architecture. Clean. Scalable. Debuggable. Most tutorials hand-wave this part. This one shows you every step. Multi-agent orchestration content drops weekly on Himanshu Kumar. ↓ Deployment without the DevOps nightmare. This is where most AI projects die. You build a cool agent locally. It works. You try to deploy it. Everything breaks. Vertex AI Agent Engine fixes this: Minimal code deployment Automatic monitoring of latency, CPU, and memory Built-in observability and logging No infrastructure setup needed You provide config and requirements. The platform handles the rest. This is how agents actually get to production. Deployment guides for Claude agents post every week. Himanshu Kumar. ↓ Agent-to-Agent Protocol: the future nobody's talking about. Most people don't know this exists yet. The A2A Protocol lets agents built in different frameworks communicate seamlessly. Your Claude agent. My LangChain agent. Someone else's CrewAI agent. All talking to each other. All solving parts of the same problem. All without custom integration code. This is the infrastructure layer of the coming AI economy. Getting in early on A2A Protocol is like getting in early on HTTP in 1995. A2A deep dive coming soon. Himanshu Kumar. ↓ 30 minutes from the team shipping this in production. You'll learn more from this than from 6 months of YouTube tutorials made by people who've never deployed an agent past localhost. People who watch this understand production AI agents at the architect level. People who skip it keep hacking together frameworks that break every time an API updates. Save the video. Watch it tonight. Build a real agent this weekend. Follow Himanshu Kumar for more high-signal content that actually moves your AI engineering career forward.

Himanshu Kumar

228,185 次观看 • 3 个月前

🧬 BREAKING: Our CRISPR-GPT paper is out TODAY in Nature Biomedical Engineering Nature Biomedical Engineering ! 🤯 We built an AI agent that turns ANYONE into a gene-editing expert in 1 DAY instead of months. An undergrad with ZERO experience achieved 90%+ editing efficiency on their FIRST attempt. 🧵 Here's how we're building expert AI agents for cutting-edge biotechnology: 🎯 The Problem: CRISPR is revolutionary but requires PhD-level expertise, it can take weeks to learn, adopt, and design, analyze a CRISPR experiment for R&D or making life-saving medicine. Even Pro scientists can make small mistakes (e.g. typos in guideRNA or cloning design) that cost months to find out, slowing us down. 💡 Our Solution: CRISPR-GPT - an AI co-pilot from Stanford University Princeton University Google DeepMind that guides you through EVERY step via simple conversation 🔬 Real Results: -Novice researcher: ~90% editing on 1st go -Training time: Months → 1 day -100% success rate in our trials -Even experts save days/weeks on data analysis & troubleshooting 🤖 How it works: Our multi-agent system handles: CRISPR system and delivery method selection, guideRNA design, Protocol generation, Real-time troubleshooting, Data analysis, and beyond. All through natural language! No coding, no complex software. 📊 We benchmarked it extensively: -288 evaluation scenarios/cases -Outperformed GPT-4o on ALL gene editing tasks -Trained on 11 years of expert discussions -Covers knockout, base-editing, prime-editing & epigenetic editing 🌍 Why this matters: -Every lab can now use CRISPR with an AI system distilling expert knowledge and skills. -Every student can learn faster. -Every researcher can tackle bigger challenges without worrying about small mistakes. -Customized CRISPR design can be automated based on your need and the context of R&D workflow. -Agentic AI ensure safety, privacy, and responsibility -We're not just automating gene editing - we're using AI to power scientists to cure diseases. 🚀 Try it yourself! Beta access available at: Paper: Code: Benchmark (companion work, Genome-bench): Co-first and key authors: Yuanhao Qu Kaixuan Huang Ming Yin PIs: Le Cong@Stanford, AI+Bio+Gene-Editing Mengdi Wang Key collaborators: Russ Altman Denny Zhou The future of biology and science is conversational. The future is now. Nature Biomedical Engineering Nature Portfolio #CRISPR #AI #GeneEditing #Biotech #Science #AISafety
1:43

🧬 BREAKING: Our CRISPR-GPT paper is out TODAY in Nature Biomedical Engineering Nature Biomedical Engineering ! 🤯 We built an AI agent that turns ANYONE into a gene-editing expert in 1 DAY instead of months. An undergrad with ZERO experience achieved 90%+ editing efficiency on their FIRST attempt. 🧵 Here's how we're building expert AI agents for cutting-edge biotechnology: 🎯 The Problem: CRISPR is revolutionary but requires PhD-level expertise, it can take weeks to learn, adopt, and design, analyze a CRISPR experiment for R&D or making life-saving medicine. Even Pro scientists can make small mistakes (e.g. typos in guideRNA or cloning design) that cost months to find out, slowing us down. 💡 Our Solution: CRISPR-GPT - an AI co-pilot from Stanford University Princeton University Google DeepMind that guides you through EVERY step via simple conversation 🔬 Real Results: -Novice researcher: ~90% editing on 1st go -Training time: Months → 1 day -100% success rate in our trials -Even experts save days/weeks on data analysis & troubleshooting 🤖 How it works: Our multi-agent system handles: CRISPR system and delivery method selection, guideRNA design, Protocol generation, Real-time troubleshooting, Data analysis, and beyond. All through natural language! No coding, no complex software. 📊 We benchmarked it extensively: -288 evaluation scenarios/cases -Outperformed GPT-4o on ALL gene editing tasks -Trained on 11 years of expert discussions -Covers knockout, base-editing, prime-editing & epigenetic editing 🌍 Why this matters: -Every lab can now use CRISPR with an AI system distilling expert knowledge and skills. -Every student can learn faster. -Every researcher can tackle bigger challenges without worrying about small mistakes. -Customized CRISPR design can be automated based on your need and the context of R&D workflow. -Agentic AI ensure safety, privacy, and responsibility -We're not just automating gene editing - we're using AI to power scientists to cure diseases. 🚀 Try it yourself! Beta access available at: Paper: Code: Benchmark (companion work, Genome-bench): Co-first and key authors: Yuanhao Qu Kaixuan Huang Ming Yin PIs: Le Cong@Stanford, AI+Bio+Gene-Editing Mengdi Wang Key collaborators: Russ Altman Denny Zhou The future of biology and science is conversational. The future is now. Nature Biomedical Engineering Nature Portfolio #CRISPR #AI #GeneEditing #Biotech #Science #AISafety

Le Cong@Stanford, AI+Bio+Gene-Editing

111,822 次观看 • 1 年前

Today, we are launching the first publicly available AI Scientist, via the FutureHouse Platform. Our AI Scientist agents can perform a wide variety of scientific tasks better than humans. By chaining them together, we've already started to discover new biology really fast. With the platform, we are bringing these capabilities to the wider community. Watch our long-form video, in the comments below, to learn more about how the platform works and how you can use it to make new discoveries, and go to our website or see the comments below to access the platform. We are releasing three superhuman AI Scientist agents today, each with their own specialization: A general-purpose agent (Crow); An agent to automate literature reviews (Falcon); and An agent to answer the question “Has anyone done X before” (Owl). We are also releasing an experimental agent, Phoenix, that has access to a wide variety of tools for planning experiments in chemistry. More on that below. The three literature search agents (Crow, Falcon, and Owl) have benchmarked superhuman performance. They also have access to a large corpus of full scientific texts, which means that you can ask them more detailed questions about experimental protocols and study limitations that general-purpose web search agents, which usually only have access to abstracts, might miss. Our agents also use a variety of factors to distinguish source quality, so that they don’t end up relying on low-quality papers or pop-science sources. Finally, and critically, we have an API, which is intended to allow researchers to integrate our agents into their workflows. Phoenix is an experimental project we put together recently just to demonstrate what can happen if you give the agents access to lots of scientific tools. It is not better than humans at planning experiments yet, and it makes a lot more mistakes than Crow, Falcon, or Owl. We want to see all the ways you can break it! The agents we are releasing today cannot yet do all (or even most!) aspects of scientific research autonomously. However, as we show in the video, you can already use them to generate and evaluate new hypotheses and plan new experiments way faster than before. Internally, we also have dedicated agents for data analysis, hypothesis generation, protein engineering, and more, and we plan to launch these on the platform in the coming months as well. Within a year or two, it is easy to imagine that the vast majority of desk work that scientists do today will be accelerated with the help of AI agents like the ones we are releasing today. The platform is currently free-to-use. Over time, depending on how people use it, we may implement pricing plans. If you want higher rate limits, especially for research projects, get in touch. Michael Skarlinski, Andrew White 🐦‍⬛, Tyler Nadolski, Remo Storni, James Braza, Ludovico Mitchener, Michaela Hinks, as well as Jason Carman and his team for making such fantastic videos of us!
1:21

Today, we are launching the first publicly available AI Scientist, via the FutureHouse Platform. Our AI Scientist agents can perform a wide variety of scientific tasks better than humans. By chaining them together, we've already started to discover new biology really fast. With the platform, we are bringing these capabilities to the wider community. Watch our long-form video, in the comments below, to learn more about how the platform works and how you can use it to make new discoveries, and go to our website or see the comments below to access the platform. We are releasing three superhuman AI Scientist agents today, each with their own specialization: A general-purpose agent (Crow); An agent to automate literature reviews (Falcon); and An agent to answer the question “Has anyone done X before” (Owl). We are also releasing an experimental agent, Phoenix, that has access to a wide variety of tools for planning experiments in chemistry. More on that below. The three literature search agents (Crow, Falcon, and Owl) have benchmarked superhuman performance. They also have access to a large corpus of full scientific texts, which means that you can ask them more detailed questions about experimental protocols and study limitations that general-purpose web search agents, which usually only have access to abstracts, might miss. Our agents also use a variety of factors to distinguish source quality, so that they don’t end up relying on low-quality papers or pop-science sources. Finally, and critically, we have an API, which is intended to allow researchers to integrate our agents into their workflows. Phoenix is an experimental project we put together recently just to demonstrate what can happen if you give the agents access to lots of scientific tools. It is not better than humans at planning experiments yet, and it makes a lot more mistakes than Crow, Falcon, or Owl. We want to see all the ways you can break it! The agents we are releasing today cannot yet do all (or even most!) aspects of scientific research autonomously. However, as we show in the video, you can already use them to generate and evaluate new hypotheses and plan new experiments way faster than before. Internally, we also have dedicated agents for data analysis, hypothesis generation, protein engineering, and more, and we plan to launch these on the platform in the coming months as well. Within a year or two, it is easy to imagine that the vast majority of desk work that scientists do today will be accelerated with the help of AI agents like the ones we are releasing today. The platform is currently free-to-use. Over time, depending on how people use it, we may implement pricing plans. If you want higher rate limits, especially for research projects, get in touch. Michael Skarlinski, Andrew White 🐦‍⬛, Tyler Nadolski, Remo Storni, James Braza, Ludovico Mitchener, Michaela Hinks, as well as Jason Carman and his team for making such fantastic videos of us!

Sam Rodriques

725,140 次观看 • 1 年前

Introducing Sharpe Search: On-Chain Search AI Agent Powered by Hive Intelligence We’re thrilled to announce the launch of Sharpe Search, a crypto search AI agent powered by Hive Intelligence Designed to simplify blockchain data interaction, Sharpe Search represents a significant step toward making crypto more accessible and actionable for users at every level. Sharpe Search leverages Hive Intelligence’s advanced search API to provide real-time, actionable insights across the blockchain ecosystem. Here’s a detailed look at what Sharpe Search is, how it works: What Is Sharpe Search? At its core, Sharpe Search is an AI agent purpose-built for querying and analyzing on-chain data. It takes the complexity out of blockchain exploration by enabling users to ask questions in plain language and receive detailed, accurate responses. Whether you’re looking to monitor wallet activity, track portfolio positions, or analyze transaction history, Sharpe Search ensures that the answers are at your fingertips—accurate, comprehensive, and delivered instantly. How Does Sharpe Search Work? Sharpe Search is powered by Hive Intelligence, a search engine API designed to make blockchain data easily accessible and AI-ready. Here’s a breakdown of how it enables Sharpe Search to function effectively: 1. LLM-Optimized Query Processing Sharpe Search leverages Hive Intelligence's optimized responses for large language models. This ensures that AI agents can process blockchain data in a structured format, delivering precise answers to complex user queries. 2. Natural Language Interaction Forget the need for technical knowledge. Sharpe Search supports natural language queries, making it as simple as typing: - “What tokens are in my wallet? Am I eligible for any airdrop I haven't claimed yet?” - “Check me my last 100 transactions, tell me if I interacted with any protocol with recent hacks” - “Track my wallet activity over the past month, suggest optimised portfolio based on best stable yields available” 3. Real-Time Insights Across Multi-Chains Using Hive Intelligence, Sharpe Search connects to over 20 chains and 5000+ Protocols. This real-time access ensures that the AI agent provides up-to-date and actionable insights, no matter how dynamic the blockchain environment. 4. Unified API Access Sharpe Search consolidates fragmented blockchain data through Hive’s unified API. Instead of dealing with multiple integrations, Sharpe Search uses a single access point to aggregate and query data, reducing complexity for both users and developers. Technical Depth: The AI Agent Advantage Sharpe Search's design philosophy revolves around the principle of creating an intuitive, AI-driven experience. Here’s what makes its technology stand out: Data Indexing and Aggregation: Hive Intelligence employs advanced indexing algorithms to aggregate data from multiple chains. This ensures that Sharpe Search can retrieve information within milliseconds, even when querying vast datasets. Dynamic Updates: Blockchain data is volatile. Sharpe Search processes dynamic updates in real time, enabling users to act on the most recent metrics, transactions, and balances without delays. Contextual Understanding: The AI agent parses natural language queries and contextualizes them to blockchain-specific scenarios. For instance, when querying “Show portfolio details,” Sharpe Search understands the underlying requirements—fetching wallet holdings, token values, and current positions. Hive Intelligence: The Backbone of Sharpe Search While Sharpe Search takes center stage, Hive Intelligence provides the critical infrastructure to make it all possible. Its LLM-ready responses and multi-chain support ensure that Sharpe Search operates at the forefront of blockchain data accessibility. By launching Hive Intelligence through Sharpe Launchpad, Sharpe reinforces its commitment to supporting innovation in the blockchain space. Hive’s infrastructure not only powers Sharpe Search but also lays the groundwork for future AI agents to thrive in the ecosystem. What’s Next for Sharpe Search? Currently in invite-only access, Sharpe Search is preparing for a broader public release. Future updates will include: - Expanded Blockchain Coverage: More chains and protocols will be added. - Enhanced Query Flexibility: Even more advanced natural language capabilities. Stay tuned for the public launch and get ready to explore crypto like never before!
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Introducing Sharpe Search: On-Chain Search AI Agent Powered by Hive Intelligence We’re thrilled to announce the launch of Sharpe Search, a crypto search AI agent powered by Hive Intelligence Designed to simplify blockchain data interaction, Sharpe Search represents a significant step toward making crypto more accessible and actionable for users at every level. Sharpe Search leverages Hive Intelligence’s advanced search API to provide real-time, actionable insights across the blockchain ecosystem. Here’s a detailed look at what Sharpe Search is, how it works: What Is Sharpe Search? At its core, Sharpe Search is an AI agent purpose-built for querying and analyzing on-chain data. It takes the complexity out of blockchain exploration by enabling users to ask questions in plain language and receive detailed, accurate responses. Whether you’re looking to monitor wallet activity, track portfolio positions, or analyze transaction history, Sharpe Search ensures that the answers are at your fingertips—accurate, comprehensive, and delivered instantly. How Does Sharpe Search Work? Sharpe Search is powered by Hive Intelligence, a search engine API designed to make blockchain data easily accessible and AI-ready. Here’s a breakdown of how it enables Sharpe Search to function effectively: 1. LLM-Optimized Query Processing Sharpe Search leverages Hive Intelligence's optimized responses for large language models. This ensures that AI agents can process blockchain data in a structured format, delivering precise answers to complex user queries. 2. Natural Language Interaction Forget the need for technical knowledge. Sharpe Search supports natural language queries, making it as simple as typing: - “What tokens are in my wallet? Am I eligible for any airdrop I haven't claimed yet?” - “Check me my last 100 transactions, tell me if I interacted with any protocol with recent hacks” - “Track my wallet activity over the past month, suggest optimised portfolio based on best stable yields available” 3. Real-Time Insights Across Multi-Chains Using Hive Intelligence, Sharpe Search connects to over 20 chains and 5000+ Protocols. This real-time access ensures that the AI agent provides up-to-date and actionable insights, no matter how dynamic the blockchain environment. 4. Unified API Access Sharpe Search consolidates fragmented blockchain data through Hive’s unified API. Instead of dealing with multiple integrations, Sharpe Search uses a single access point to aggregate and query data, reducing complexity for both users and developers. Technical Depth: The AI Agent Advantage Sharpe Search's design philosophy revolves around the principle of creating an intuitive, AI-driven experience. Here’s what makes its technology stand out: Data Indexing and Aggregation: Hive Intelligence employs advanced indexing algorithms to aggregate data from multiple chains. This ensures that Sharpe Search can retrieve information within milliseconds, even when querying vast datasets. Dynamic Updates: Blockchain data is volatile. Sharpe Search processes dynamic updates in real time, enabling users to act on the most recent metrics, transactions, and balances without delays. Contextual Understanding: The AI agent parses natural language queries and contextualizes them to blockchain-specific scenarios. For instance, when querying “Show portfolio details,” Sharpe Search understands the underlying requirements—fetching wallet holdings, token values, and current positions. Hive Intelligence: The Backbone of Sharpe Search While Sharpe Search takes center stage, Hive Intelligence provides the critical infrastructure to make it all possible. Its LLM-ready responses and multi-chain support ensure that Sharpe Search operates at the forefront of blockchain data accessibility. By launching Hive Intelligence through Sharpe Launchpad, Sharpe reinforces its commitment to supporting innovation in the blockchain space. Hive’s infrastructure not only powers Sharpe Search but also lays the groundwork for future AI agents to thrive in the ecosystem. What’s Next for Sharpe Search? Currently in invite-only access, Sharpe Search is preparing for a broader public release. Future updates will include: - Expanded Blockchain Coverage: More chains and protocols will be added. - Enhanced Query Flexibility: Even more advanced natural language capabilities. Stay tuned for the public launch and get ready to explore crypto like never before!

Sharpe AI

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