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.Jacob Trefethen runs the science program at Open Philanthropy, directing about $100m/year in philanthropic funding. For New Science, we ended up talking about academia, peer review, grant-making; and also about love, the meaning of life, and our personal histories. Enjoy! Timestamps 0:00:00 - Introduction 0:01:11 - On Open Philanthropy's...

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Alexey Guzey

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23,458 次观看 • 1 年前 •via X (Twitter)

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Alexey Guzey1 年前

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I Can Go To College1 年前

Join College Corps and transform your future! Earn up to $10K, gain hands-on experience, and make a real impact in your community. This groundbreaking program lets you pursue your education while supporting vital community needs. Don’t wait—tune in to learn more! 🎧

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@JacobTref @newscienceorg excited to watch

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@JacobTref @newscienceorg Banger

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@JacobTref @newscienceorg hell yeah

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Episode w Dylan Patel and Asianometry out! A bonanza on how the semiconductor industry actually works. & what Xi could do if he becomes scaling pilled, how we can train models with 10,000x GPT-4's compute by end of decade, & much more. This one is very fun. Enjoy! Links below. 0:00:00 – Xi’s path to AGI 0:05:05 – Liang Mong Song 0:09:10 – How semiconductors get better 0:12:01 – China can centralize compute 0:19:35 – Export controls & sanctions 0:33:45 – Huawei’s intense culture 0:39:45 – Why the semiconductor industry is so stratified 0:41:50 – N2 should not exist 0:46:47 – Taiwan invasion hypothetical 0:50:15 – Mind-boggling complexity of semiconductors 1:00:06 – Chip architecture design 1:05:29 – Architectures lead to different AI models? China vs. US 1:11:06 – Being head of compute at an AI lab 1:17:17 – Scaling costs and power demand 1:37:59 – Are we financing an AI bubble?
2:11:02

Episode w Dylan Patel and Asianometry out! A bonanza on how the semiconductor industry actually works. & what Xi could do if he becomes scaling pilled, how we can train models with 10,000x GPT-4's compute by end of decade, & much more. This one is very fun. Enjoy! Links below. 0:00:00 – Xi’s path to AGI 0:05:05 – Liang Mong Song 0:09:10 – How semiconductors get better 0:12:01 – China can centralize compute 0:19:35 – Export controls & sanctions 0:33:45 – Huawei’s intense culture 0:39:45 – Why the semiconductor industry is so stratified 0:41:50 – N2 should not exist 0:46:47 – Taiwan invasion hypothetical 0:50:15 – Mind-boggling complexity of semiconductors 1:00:06 – Chip architecture design 1:05:29 – Architectures lead to different AI models? China vs. US 1:11:06 – Being head of compute at an AI lab 1:17:17 – Scaling costs and power demand 1:37:59 – Are we financing an AI bubble?

Dwarkesh Patel

261,054 次观看 • 1 年前

Our episode with aerospace investor and York Space Systems Chairman Charles "Chuck" Beames is now live! Chuck joins us to discuss: 🚀 The Dawn of the Second Space Race 🔐 Cybersecurity and Satellites 🎯 Wargaming with AIs and Humans ➿ The Complexity of Space Procurement ♾ and MUCH more! Timestamps: 0:00:00 Intro 0:01:01 Guest introduction 0:02:15 The Second Space Race 0:07:52 The Zero Trust Approach and 'Secure By Design' 0:16:01 GPS as a Military Technology 0:20:22 The Space Force is dealing with Multiple Complex Adaptive Systems 0:28:21 New Paradigms in Satellite Design 0:31:20 What VCs and Bankers Need to know about the Space Community 0:40:17 Wargaming with AIs and Humans 0:51:11 Laser Spoofing and Adversarial AIs 1:00:10 Establishing Supply Chain Sovereignty 1:05:13 Open Organizational Cultures 1:10:59 The importance of working with your hands 1:21:22 The Job of an Executive Chairman 1:26:41 Chuck as World Emperor
1:31:36

Our episode with aerospace investor and York Space Systems Chairman Charles "Chuck" Beames is now live! Chuck joins us to discuss: 🚀 The Dawn of the Second Space Race 🔐 Cybersecurity and Satellites 🎯 Wargaming with AIs and Humans ➿ The Complexity of Space Procurement ♾ and MUCH more! Timestamps: 0:00:00 Intro 0:01:01 Guest introduction 0:02:15 The Second Space Race 0:07:52 The Zero Trust Approach and 'Secure By Design' 0:16:01 GPS as a Military Technology 0:20:22 The Space Force is dealing with Multiple Complex Adaptive Systems 0:28:21 New Paradigms in Satellite Design 0:31:20 What VCs and Bankers Need to know about the Space Community 0:40:17 Wargaming with AIs and Humans 0:51:11 Laser Spoofing and Adversarial AIs 1:00:10 Establishing Supply Chain Sovereignty 1:05:13 Open Organizational Cultures 1:10:59 The importance of working with your hands 1:21:22 The Job of an Executive Chairman 1:26:41 Chuck as World Emperor

Infinite Loops 🎙

13,374 次观看 • 1 年前

"In time a million dollars will not be enough" Episode 54 with my good friend Innerdevcrypto One of the best conversations we have recorded on the podcast We talk all things crypto, love, life, finance, self development, if happiness is real, meditation and much more Timestamps: 0:00:07 Intro 0:02:01 Before crypto 0:06:20 Nihilism 0:09:35 What are people chasing? 0:14:40 Finding purpose 0:19:17 What is love? 0:24:48 The first crypto President 0:33:03 Operating in a flow state 0:37:20 Being contempt while striving for more 0:39:37 Do you believe in happiness? 0:45:07 Running the rat race 0:54:50 Authenticity and our sense of self 0:57:11 Born with certain Karma? 1:02:09 Life is a hypothesis to be tested not an ideology to be proven
1:10:58

"In time a million dollars will not be enough" Episode 54 with my good friend Innerdevcrypto One of the best conversations we have recorded on the podcast We talk all things crypto, love, life, finance, self development, if happiness is real, meditation and much more Timestamps: 0:00:07 Intro 0:02:01 Before crypto 0:06:20 Nihilism 0:09:35 What are people chasing? 0:14:40 Finding purpose 0:19:17 What is love? 0:24:48 The first crypto President 0:33:03 Operating in a flow state 0:37:20 Being contempt while striving for more 0:39:37 Do you believe in happiness? 0:45:07 Running the rat race 0:54:50 Authenticity and our sense of self 0:57:11 Born with certain Karma? 1:02:09 Life is a hypothesis to be tested not an ideology to be proven

Andrew Forte

23,209 次观看 • 1 年前

🚨Our episode with Anne-Laure Le Cunff is now live! Anne-Laure Le Cunff is the founder of Ness Labs and author of Tiny Experiments: How to Live Freely in a Goal-Obsessed World. She's a neuroscience PhD and writes a newsletter that has 100,000+ subscribers. She's used those insights to develop a new model of success — one built around conducting “tiny experiments” that help her build a life on her own terms. She joins me to discuss how we get trapped in cognitive scripts, the hidden dangers of productivity culture, how we can experiment our way to a better life and MUCH more! Timestamps 0:00:00 Intro 0:00:48 Guest introduction 0:05:15 How do you know you are bored out? 0:17:18 People who love us the most might turn out to be our biggest blockers 0:22:20 Don't confuse activity with effectiveness 0:27:39 We will do virtually anything to gain what is really an illusion of control 0:32:16 The map is not the territory, the menu is not the meal. And yet, words are magic spells 0:39:16 The Winner’s Script and the Loser’s Script 0:47:34 "You gotta run at the top speed if you just want to stay in place.” 0:50:27 Let go of the linear and replace it with the loop- a more cyclical approach for growth 0:55:20 Can you sit alone in a room for 15 minutes? 0:58:24 Procrastination is just a signal from your brain that something is not quite working right now 1:20:38 We know nothing 1:24:26 AI is a rocket ship for the mind 1:28:20 In 100 years, nobody will remember you
1:31:29

🚨Our episode with Anne-Laure Le Cunff is now live! Anne-Laure Le Cunff is the founder of Ness Labs and author of Tiny Experiments: How to Live Freely in a Goal-Obsessed World. She's a neuroscience PhD and writes a newsletter that has 100,000+ subscribers. She's used those insights to develop a new model of success — one built around conducting “tiny experiments” that help her build a life on her own terms. She joins me to discuss how we get trapped in cognitive scripts, the hidden dangers of productivity culture, how we can experiment our way to a better life and MUCH more! Timestamps 0:00:00 Intro 0:00:48 Guest introduction 0:05:15 How do you know you are bored out? 0:17:18 People who love us the most might turn out to be our biggest blockers 0:22:20 Don't confuse activity with effectiveness 0:27:39 We will do virtually anything to gain what is really an illusion of control 0:32:16 The map is not the territory, the menu is not the meal. And yet, words are magic spells 0:39:16 The Winner’s Script and the Loser’s Script 0:47:34 "You gotta run at the top speed if you just want to stay in place.” 0:50:27 Let go of the linear and replace it with the loop- a more cyclical approach for growth 0:55:20 Can you sit alone in a room for 15 minutes? 0:58:24 Procrastination is just a signal from your brain that something is not quite working right now 1:20:38 We know nothing 1:24:26 AI is a rocket ship for the mind 1:28:20 In 100 years, nobody will remember you

Infinite Loops 🎙

22,154 次观看 • 1 年前

Episode 64 with Claynosaurz This is our dot com era. This is the future and we believe that. We have this current model that works We spoke about the past, present and future of Claynosaurz, IP tokenization, DATs It was great to have a casual sit down with the team and talk shop Timestamps: 0:01:58 Intro 0:04:38 Clayno quarterly workshop 0:05:56 Cab 🌋 new role at Claynosaurz 0:10:23 Navy seals 0:16:01 Tokenize everything 0:20:07 "Disney will buy us or we will buy them" Andrew 0:23:11 The thing we are really thinking about 0:29:20 Future of digital asset treasuries 0:34:30 GameSquare Holdings Inc. acquiring high value punks 0:37:50 Alpha 0:40:47 How is it to have DAVID HORVATH on the team 0:44:00 Assessing the Asian markets 0:48:00 Retaining top talent and the core team 0:48:50 William Liu joins the set + new position 0:56:29 Clayno's first event experience ever 1:00:10 How Plaposaur | CC 🌋 and the team went full time Clayno 1:07:34 Team member growth 1:17:02 Disney 1:20:00 Future of IP 1:30:30 "No way im saying this on air"
1:39:47

Episode 64 with Claynosaurz This is our dot com era. This is the future and we believe that. We have this current model that works We spoke about the past, present and future of Claynosaurz, IP tokenization, DATs It was great to have a casual sit down with the team and talk shop Timestamps: 0:01:58 Intro 0:04:38 Clayno quarterly workshop 0:05:56 Cab 🌋 new role at Claynosaurz 0:10:23 Navy seals 0:16:01 Tokenize everything 0:20:07 "Disney will buy us or we will buy them" Andrew 0:23:11 The thing we are really thinking about 0:29:20 Future of digital asset treasuries 0:34:30 GameSquare Holdings Inc. acquiring high value punks 0:37:50 Alpha 0:40:47 How is it to have DAVID HORVATH on the team 0:44:00 Assessing the Asian markets 0:48:00 Retaining top talent and the core team 0:48:50 William Liu joins the set + new position 0:56:29 Clayno's first event experience ever 1:00:10 How Plaposaur | CC 🌋 and the team went full time Clayno 1:07:34 Team member growth 1:17:02 Disney 1:20:00 Future of IP 1:30:30 "No way im saying this on air"

Andrew Forte

26,952 次观看 • 10 个月前

Yesterday and friends discussed how blockchains are developing and the future of web3. We also gave out lots of $SFP tokens to viewers. Recap of our October Community Call 0:00:00- Introduction 0:02:06- Veronica shares the latest crypto scams 0:07:36- supporting Sei 0:10:00- Demo on improvements to the app swap feature 0:16:33- Introducing the Halloween event 0:17:19- Veronica shares highlights at The Gateway 2024 event 0:24:07- GiftNow, a Free Tool for Web3 Community Growth 0:30:57- Sei sharing insights on SEI ecosystem 0:47:44- Venom Network shares about building L0 & L1 1:10:49- GoPlus Security 🚦 discusses on protecting transactions
1:29:52

Yesterday and friends discussed how blockchains are developing and the future of web3. We also gave out lots of $SFP tokens to viewers. Recap of our October Community Call 0:00:00- Introduction 0:02:06- Veronica shares the latest crypto scams 0:07:36- supporting Sei 0:10:00- Demo on improvements to the app swap feature 0:16:33- Introducing the Halloween event 0:17:19- Veronica shares highlights at The Gateway 2024 event 0:24:07- GiftNow, a Free Tool for Web3 Community Growth 0:30:57- Sei sharing insights on SEI ecosystem 0:47:44- Venom Network shares about building L0 & L1 1:10:49- GoPlus Security 🚦 discusses on protecting transactions

SafePal - Crypto Wallet

29,435 次观看 • 1 年前

A Quest to Formalize Intelligence ft. ludwig 0:00:00 - INTRO 0:01:06 - What is he most excited about these days 0:03:31 - All arcs are isomorphic, Dropping out in 7th grade 0:09:31 - Does skipping formal education make you naturally broader? 0:10:11 - Growing up on 4chan, Mathematics is humbling 0:14:52 - Mentors, First programming job, Internet microcultures 0:21:47 - Culture in SF, Why he won't start a company 0:25:21 - Does AI make self-teaching easier or trap you in infinite explanations? 0:29:49 - The 20% doing 80% inside a company 0:33:24 - Company culture and Building subcultures 0:35:56 - Define understanding, Compression equals Prediction 0:45:44 - Understanding vs knowing, Michael Levin, Cognitive light cones 0:54:39 - Starting a Research lab, Sheaf theory and Grothendieck 0:58:43 - Mapping Levin's biology onto proof space with MCTS and Lean4 1:02:49 - Active inference, Distributed systems and Morphogenesis 1:12:28 - Signal vs noise on X, The unit distance proof, Flanderization 1:17:39 - Community Questions 1:21:39 - Shape rotator vs wordcel, Tenstorrent, How to hire great engineers 1:28:01 - Building mental space to do things that will be left to do 1:33:42 - Advice to a 20-year-old. Be a capable thinker, you have 20k days left
1:38:06

A Quest to Formalize Intelligence ft. ludwig 0:00:00 - INTRO 0:01:06 - What is he most excited about these days 0:03:31 - All arcs are isomorphic, Dropping out in 7th grade 0:09:31 - Does skipping formal education make you naturally broader? 0:10:11 - Growing up on 4chan, Mathematics is humbling 0:14:52 - Mentors, First programming job, Internet microcultures 0:21:47 - Culture in SF, Why he won't start a company 0:25:21 - Does AI make self-teaching easier or trap you in infinite explanations? 0:29:49 - The 20% doing 80% inside a company 0:33:24 - Company culture and Building subcultures 0:35:56 - Define understanding, Compression equals Prediction 0:45:44 - Understanding vs knowing, Michael Levin, Cognitive light cones 0:54:39 - Starting a Research lab, Sheaf theory and Grothendieck 0:58:43 - Mapping Levin's biology onto proof space with MCTS and Lean4 1:02:49 - Active inference, Distributed systems and Morphogenesis 1:12:28 - Signal vs noise on X, The unit distance proof, Flanderization 1:17:39 - Community Questions 1:21:39 - Shape rotator vs wordcel, Tenstorrent, How to hire great engineers 1:28:01 - Building mental space to do things that will be left to do 1:33:42 - Advice to a 20-year-old. Be a capable thinker, you have 20k days left

himanshu

43,187 次观看 • 2 个月前

New episode Much fun chatting with Laura 🌲 ⛰️! We discuss: - personal identity, and what, exactly, we want to preserve - what a “more humane transhumanism” might look like - scientific awe - seeing inside the cell - the antimemetic qualities of reversible cryopreservation - why cryopreservation might be the most leveraged problem in longevity - and much, much more Links below. Enjoy! Timestamps: (0:00:00) - Introduction. (0:01:17) - Personal identity: what, exactly, do we want to preserve? (0:05:20) - How has Laura's emotional relation to longevity evolved? (0:10:32) - Transhumanism: what do current visions lack? (0:17:34) - The sociopolitical implications of longevity. (0:29:29) - Awe in scientific discovery. (0:37:46) - Embodied thought-experiments, & seeing inside the cell. (0:42:05) - Visualising cells to think about cryopreservation. (0:46:08) - Are some fields / types of science more amenable to embodied thinking? (0:47:13) - Scientific mentorship. (0:55:26) - Longevity drug development. (0:57:46) - Laura's current takes on theories of ageing. (1:01:17) - Key regulatory bottlenecks to longevity drugs. (1:02:40) - Patterns among The Longevity Fund's most successful investments. (1:05:18) - Laura's questions about evolution and natural selection. (1:08:57) - Why work on cryopreservation?
1:16:46

New episode Much fun chatting with Laura 🌲 ⛰️! We discuss: - personal identity, and what, exactly, we want to preserve - what a “more humane transhumanism” might look like - scientific awe - seeing inside the cell - the antimemetic qualities of reversible cryopreservation - why cryopreservation might be the most leveraged problem in longevity - and much, much more Links below. Enjoy! Timestamps: (0:00:00) - Introduction. (0:01:17) - Personal identity: what, exactly, do we want to preserve? (0:05:20) - How has Laura's emotional relation to longevity evolved? (0:10:32) - Transhumanism: what do current visions lack? (0:17:34) - The sociopolitical implications of longevity. (0:29:29) - Awe in scientific discovery. (0:37:46) - Embodied thought-experiments, & seeing inside the cell. (0:42:05) - Visualising cells to think about cryopreservation. (0:46:08) - Are some fields / types of science more amenable to embodied thinking? (0:47:13) - Scientific mentorship. (0:55:26) - Longevity drug development. (0:57:46) - Laura's current takes on theories of ageing. (1:01:17) - Key regulatory bottlenecks to longevity drugs. (1:02:40) - Patterns among The Longevity Fund's most successful investments. (1:05:18) - Laura's questions about evolution and natural selection. (1:08:57) - Why work on cryopreservation?

Joseph Noel Walker

17,580 次观看 • 1 年前

The Princeton Dictionary of Buddhism is comprised of 5,000 entries totaling over a million words, and Donald S. Lopez Jr. (along with his co-author) wrote every word of it. He’s also written over 20 books on Buddhism, including Buddhism: A Journey through History, which tylercowen calls one of the best books of 2025. Who better to explain what the West gets wrong about Buddhism? Timestamps: 0:00:00 – The Buddha’s omniscience 0:03:13 – How the Buddha looked and lived 0:08:25 – Reincarnation, hell, sacrifice, and hungry ghosts 0:11:52 – Western (mis)conceptions of Buddhism (not always peaceful!) 0:17:15 – Buddha’s child, castes, and visual portrayals of the Buddha 0:22:50 – Buddhism as an oral religion 0:26:13 – How different strands of Buddhism coexist 0:29:27 – Global waning of Buddhism 0:32:20 – On the Dalai Lama 0:37:20 – The Tibetan Book of the Dead and Theosophy 0:41:39 – Zen Buddhism and South Asian strands 0:46:00 – Why Thailand is the wealthiest amongst Buddhist countries 0:48:21 – Itinerary for a world tour of Buddhism 0:50:01 – How Lopez became a leading scholar on Buddhism
1:01:07

The Princeton Dictionary of Buddhism is comprised of 5,000 entries totaling over a million words, and Donald S. Lopez Jr. (along with his co-author) wrote every word of it. He’s also written over 20 books on Buddhism, including Buddhism: A Journey through History, which tylercowen calls one of the best books of 2025. Who better to explain what the West gets wrong about Buddhism? Timestamps: 0:00:00 – The Buddha’s omniscience 0:03:13 – How the Buddha looked and lived 0:08:25 – Reincarnation, hell, sacrifice, and hungry ghosts 0:11:52 – Western (mis)conceptions of Buddhism (not always peaceful!) 0:17:15 – Buddha’s child, castes, and visual portrayals of the Buddha 0:22:50 – Buddhism as an oral religion 0:26:13 – How different strands of Buddhism coexist 0:29:27 – Global waning of Buddhism 0:32:20 – On the Dalai Lama 0:37:20 – The Tibetan Book of the Dead and Theosophy 0:41:39 – Zen Buddhism and South Asian strands 0:46:00 – Why Thailand is the wealthiest amongst Buddhist countries 0:48:21 – Itinerary for a world tour of Buddhism 0:50:01 – How Lopez became a leading scholar on Buddhism

Conversations with Tyler

11,859 次观看 • 8 个月前

The Jeff Dean & Noam Shazeer episode. We talk about 25 years at Google, from PageRank to MapReduce to the Transformer to MoEs to AlphaChip – and soon to ASI. My favorite part was Jeff's vision for AGI as one giant MoE that is grown in bits and pieces over time like a forest, rather than trained all at once. Specialization, distillation, inference time scaling all emerge organically rather than by design. Noam bites every bullet: 100x world GDP soon; let’s get a million automated researchers running in the Google datacenter; living to see the year 3000. Links below. Enjoy! Timestamps 0:00:00 - Intro 0:03:29 - Joining Google in 1999 0:06:20 - Future of Moore's Law 0:11:04 - Future TPUs 0:13:56 - Jeff’s undergrad thesis: parallel backprop 0:15:54 - LLMs in 2007 0:25:09 - “Holy shit” moments 0:27:28 - AI fulfills Google’s original mission 0:32:00 - Doing Search in-context 0:36:12 - The internal coding model 0:37:29 - What will 2027 models do? 0:43:20 - A new architecture every day? 0:49:10 - Automated chips and intelligence explosion 0:53:07 - Future of inference scaling 1:02:38 - Already doing multi-datacenter runs 1:08:15 - Debugging at scale 1:12:41 - Fast takeoff and superalignment 1:20:51 - A million evil Jeff Deans 1:24:22 - Fun times at Google 1:27:51 - World compute demand in 2030 1:34:37 - Getting back to modularity 1:44:48 - Keeping a giga-MoE in-memory 1:49:35 - All of Google in one model 1:57:59 - What’s missing from distillation 2:03:10 - Open research, pros and cons 2:09:58 - Going the distance
2:15:30

The Jeff Dean & Noam Shazeer episode. We talk about 25 years at Google, from PageRank to MapReduce to the Transformer to MoEs to AlphaChip – and soon to ASI. My favorite part was Jeff's vision for AGI as one giant MoE that is grown in bits and pieces over time like a forest, rather than trained all at once. Specialization, distillation, inference time scaling all emerge organically rather than by design. Noam bites every bullet: 100x world GDP soon; let’s get a million automated researchers running in the Google datacenter; living to see the year 3000. Links below. Enjoy! Timestamps 0:00:00 - Intro 0:03:29 - Joining Google in 1999 0:06:20 - Future of Moore's Law 0:11:04 - Future TPUs 0:13:56 - Jeff’s undergrad thesis: parallel backprop 0:15:54 - LLMs in 2007 0:25:09 - “Holy shit” moments 0:27:28 - AI fulfills Google’s original mission 0:32:00 - Doing Search in-context 0:36:12 - The internal coding model 0:37:29 - What will 2027 models do? 0:43:20 - A new architecture every day? 0:49:10 - Automated chips and intelligence explosion 0:53:07 - Future of inference scaling 1:02:38 - Already doing multi-datacenter runs 1:08:15 - Debugging at scale 1:12:41 - Fast takeoff and superalignment 1:20:51 - A million evil Jeff Deans 1:24:22 - Fun times at Google 1:27:51 - World compute demand in 2030 1:34:37 - Getting back to modularity 1:44:48 - Keeping a giga-MoE in-memory 1:49:35 - All of Google in one model 1:57:59 - What’s missing from distillation 2:03:10 - Open research, pros and cons 2:09:58 - Going the distance

Dwarkesh Patel

544,788 次观看 • 1 年前