Keto-CTA study - Everything that could go wrong, has gone wrong. The "lean mass hyper-responder" phenotype is associated with greater plaque progression than expected. References in comments below

KETO-CTA study: Why clinicians are concerned about elevated LDL-c and ApoB: Authors estimated a mean plaque volume change of 7 mm³ during the study period: When instead, the KETO-CTA study showed 18.8 mm³: 18.8 mm³ is rapid progression that does not compare favorably: This meme sums up the situation

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I agree that the situation regarding the study is indeed concerning. At the same time no critic is able to explain why an extremely high ldl of 500 is apparently not any worse than a high ldl of 180. Some piece of the puzzle is clearly missing but is being ignored.

Please encourage your followers to read for clarification:

Thanks for posting this. I saw some of the claims being made by Keto proponents based on this study which seemed to promote the Keto diet as not raising the risk of CVD. Thanks for breaking down some of the problems with the study and the related claims!

Do you acknowledge that the absolute amount of plaque roughly rounds to ZERO or near zero both BEFORE and AFTER calculated relative amount of change; for nearly all KETO-CTA participants, despite all having sky high LDL.

The change in plaque volume was 18.8 units. That’s over 1.5x what the study authors expected to find. Incredibly concerning

Oh wow this is super important

@AskPerplexity , explain this study.

Thanks for the clarification