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Let’s take a closer look at this protein structure determined using AlphaFold2. This protein structure is part of a huge molecular structure in the human body. More than a thousand proteins form a pore through the membrane surrounding the cell nucleus. Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciences #NobelPrize

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The Nobel Prize

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57,895 görüntüleme • 1 yıl önce •via X (Twitter)

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This is a bacterial flagellar motor … one of nature’s most sophisticated molecular machines - a rotary motor embedded in the cell membrane consisting of ~25-30 protein types totaling 20,000-50,000 atoms in a multi-part structure of rotor, stator, drive shaft, and propeller. Operating at 100-300 Hz (6,000-18,000 RPM) with some species reaching 1,700 Hz (~100,000 RPM) at nearly 100% efficiency, this nanoscale engine features rotor proteins FliG/FliM/FliN forming the C-ring, MotA/MotB stator complexes, FlgG rod protein drive shaft, FliC flagellin propeller filament, and FlgE hook proteins acting as a universal joint, all powered by proton or sodium flow across the membrane generating torque through conformational changes in the stator complexes.
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