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Mapping how neurons connect is one of neuroscience’s biggest challenges. MouseLight (from our Janelia Research Campus) is building a dataset of fully traced neurons — available to researchers everywhere, & helping reveal how brain circuits work & what goes wrong in disease.

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20,404 просмотров • 5 месяцев назад •via X (Twitter)

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Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior & building AI-in-the-Loop — a new way of doing biology. Tiny transparent fish + 1 of neuroscience’s biggest questions? Let's go
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Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior & building AI-in-the-Loop — a new way of doing biology. Tiny transparent fish + 1 of neuroscience’s biggest questions? Let's go

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(1/2) When Janelia set out to map every neuron in the fly brain in 2008, many thought it couldn’t be done. Nearly 20 years later, a complete wiring diagram of the 166,000+ neurons of the adult male fruit fly is helping to reveal the brain’s secrets:
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(1/2) When Janelia set out to map every neuron in the fly brain in 2008, many thought it couldn’t be done. Nearly 20 years later, a complete wiring diagram of the 166,000+ neurons of the adult male fruit fly is helping to reveal the brain’s secrets:

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A tiny 1-millimeter cube of human brain tissue can contain tens of thousands of neurons & other structures. Our new animation explores Neuroglancer data from Google & allen institute, using visualization techniques to reveal the complexity packed into microscopic brain tissue 🧠
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🧠 A new wiring diagram of the 166,000+ neurons in the brain & nerve cord of a male fruit fly is a key tool in uncovering how the brain enables complex behavior—information that could ultimately help scientists understand what causes different diseases ➡️
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Dyno Therapeutics co-founder Sam Sinai on how his team cracked the blood-brain barrier well enough to reach 50% of neurons with a single injection: "For brain specifically, the brain has this extra layer of defense called the blood brain barrier. It's really put there to prevent anything to get in." "What we have done is actually in primates we can show that we can get up more than 50% of neurons, through a systemic injection." "You're just injecting in the veins, and then the virus actually makes its way into the brain." "Neurons are a primary target, but it could be in some cases glial cells, depending on the disease. Solving pan brain, meaning all of brain delivery, is a key objective there."
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Dyno Therapeutics co-founder Sam Sinai on how his team cracked the blood-brain barrier well enough to reach 50% of neurons with a single injection: "For brain specifically, the brain has this extra layer of defense called the blood brain barrier. It's really put there to prevent anything to get in." "What we have done is actually in primates we can show that we can get up more than 50% of neurons, through a systemic injection." "You're just injecting in the veins, and then the virus actually makes its way into the brain." "Neurons are a primary target, but it could be in some cases glial cells, depending on the disease. Solving pan brain, meaning all of brain delivery, is a key objective there."

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For the first time ever, a fruit fly brain has been trained to launch a memecoin. Not "AI inspired by a brain" — the real connectome. 165,122 neurons, 10,228,000 synaptic connections, every one traced from an actual male Drosophila by electron microscopy. Janelia FlyEM + Google Research, released CC-BY. How it works: Screenshots of the live launchpad go in through 892 retinotopic hex columns into L1 and L2 — the neurons sitting directly behind a fly's photoreceptors. All 165,122 integrate. The cursor comes back out of the descending neurons a fly actually walks with: DNa02's left-right asymmetry steers, DNa01 drives forward, DNp09 clicks. The wiring is never trained. Only synaptic gains — you don't get to invent connections the fly doesn't have. Proof its eye is doing real work: in light mode it filled 0 of 3 form fields. In dark mode, 2 of 3. Its retina is a luminance map, so invert the contrast and it goes blind. And the honest split: the fly types the description and the ticker. The rig does the name, the pair and the tax. CA: 0x4eb990547bce4a982432ca88cf5fae7eed1a2d35
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For the first time ever, a fruit fly brain has been trained to launch a memecoin. Not "AI inspired by a brain" — the real connectome. 165,122 neurons, 10,228,000 synaptic connections, every one traced from an actual male Drosophila by electron microscopy. Janelia FlyEM + Google Research, released CC-BY. How it works: Screenshots of the live launchpad go in through 892 retinotopic hex columns into L1 and L2 — the neurons sitting directly behind a fly's photoreceptors. All 165,122 integrate. The cursor comes back out of the descending neurons a fly actually walks with: DNa02's left-right asymmetry steers, DNa01 drives forward, DNp09 clicks. The wiring is never trained. Only synaptic gains — you don't get to invent connections the fly doesn't have. Proof its eye is doing real work: in light mode it filled 0 of 3 form fields. In dark mode, 2 of 3. Its retina is a luminance map, so invert the contrast and it goes blind. And the honest split: the fly types the description and the ticker. The rig does the name, the pair and the tax. CA: 0x4eb990547bce4a982432ca88cf5fae7eed1a2d35

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EINSTEIN’S BRAIN AND THE NEURONS THAT TAUGHT THEMSELVES PONG When Einstein died, scientists studied his brain to see what set it apart. Most of it looked ordinary, except for one thing: the folds. His brain had far more of them than average. More folds meant more surface area, and more surface area meant more neurons. The difference was concentrated in his parietal lobes, the regions tied to math and spatial reasoning. Genius left a trace, but it was subtle, hidden in structure rather than size. Decades later, another mystery arrived. In 2022, researchers at Cortical Labs grew human neurons in a Petri dish and wired them to a chip running the game Pong. There was no human player, no brain, and no mind, just cells, signals, and feedback. Yet somehow, the neurons learned. The longer they played, the better they became. That forced an uncomfortable question: how does a group of disconnected neurons know how to play a game it has never seen. The answer is still unclear. Einstein’s brain revealed how intelligence can be built. Source: Joe Rogan
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every time you have a thought, neurons connect and strengthen a path in your brain. one thought, repeated enough, becomes a structure. it's not a metaphor. your brain literally rewires itself every time you think. every thought fires neurons that physically strengthen their connection, making that same path easier to travel next time. the science backs this up: whatever you keep thinking, your brain keeps building. that's not motivation talking. that's just how neurons work. so the real question was never whether you can change. it's what you're choosing to build, on purpose, right now.
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every time you have a thought, neurons connect and strengthen a path in your brain. one thought, repeated enough, becomes a structure. it's not a metaphor. your brain literally rewires itself every time you think. every thought fires neurons that physically strengthen their connection, making that same path easier to travel next time. the science backs this up: whatever you keep thinking, your brain keeps building. that's not motivation talking. that's just how neurons work. so the real question was never whether you can change. it's what you're choosing to build, on purpose, right now.

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Researchers UC San Francisco, led by neurosurgeon Edward Chang, MD, have used #Neuropixels probes to record activity from hundreds of individual neurons while participants listened to speech. Out today in nature, this study gives us a view into how the brain analyzes the sounds in words.
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Researchers UC San Francisco, led by neurosurgeon Edward Chang, MD, have used #Neuropixels probes to record activity from hundreds of individual neurons while participants listened to speech. Out today in nature, this study gives us a view into how the brain analyzes the sounds in words.

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Finally! #PHORHUM -- our 3D human reconstruction model from a single image -- is available to the research community 🎉 PHORHUM is joint work with Mihai Zanfir & Cristian Sminchisescu. How to get access: 👇
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