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Most people are using Retatrutide wrong. Here is the masterclass. 00:00 Intro and why I'm doing these masterclasses 04:04 The two users: weight loss vs longevity 05:30 What Retatrutide actually does 07:54 Weight loss trial data (1mg to 12mg) 10:50 The longevity data most people ignore 13:50 The titration... show more

Hunter Williams

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59,932 просмотров • 4 месяцев назад •via X (Twitter)

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Retatrutide just posted Phase 3 numbers that are hard to ignore. ~30% average body weight loss. ~70 pounds lost. Even the lowest dose outperformed what used to be considered best-in-class. But the most interesting part of the story isn't the weight loss. It's the thousands of people already using grey-market Retatrutide before there's an approved pharmacy version available. What did the trials actually do? What dose produced the best balance of results and tolerability? And why might the biggest risk have nothing to do with the drug itself?

Retatrutide just posted Phase 3 numbers that are hard to ignore. ~30% average body weight loss. ~70 pounds lost. Even the lowest dose outperformed what used to be considered best-in-class. But the most interesting part of the story isn't the weight loss. It's the thousands of people already using grey-market Retatrutide before there's an approved pharmacy version available. What did the trials actually do? What dose produced the best balance of results and tolerability? And why might the biggest risk have nothing to do with the drug itself?

Dr. Alex Tatem

232,738 просмотров • 3 месяцев назад

RETA Is More Powerful... But Is It Better Than Tirzepatide? 00:00 RETA vs Tirzepatide: Which Is Actually Better? 01:52 Why RETA Was Created 02:32 Why RETA Causes More Weight Loss 03:38 The Biggest Downside of RETA 04:27 RETA vs Tirzepatide for Muscle Retention 05:48 Why Tirzepatide Is the Goldilocks Option 06:48 Who Should Actually Use RETA? 07:21 When RETA Might Be Better For You 08:02 My Final Recommendation 09:20 How to Get Started With Tirzepatide

RETA Is More Powerful... But Is It Better Than Tirzepatide? 00:00 RETA vs Tirzepatide: Which Is Actually Better? 01:52 Why RETA Was Created 02:32 Why RETA Causes More Weight Loss 03:38 The Biggest Downside of RETA 04:27 RETA vs Tirzepatide for Muscle Retention 05:48 Why Tirzepatide Is the Goldilocks Option 06:48 Who Should Actually Use RETA? 07:21 When RETA Might Be Better For You 08:02 My Final Recommendation 09:20 How to Get Started With Tirzepatide

Greg O'Gallagher

21,723 просмотров • 3 месяцев назад

Retatrutide Explained : ) 0:00:00 Intro 0:00:44 How It Works: The Molecule 0:04:01 Sponsor 0:04:37 How It Works: The Three Targets 0:22:44 Lab and Animal Studies 0:28:38 First Human Trials 0:32:34 Diabetes: The First Big Trial 0:42:13 Obesity: The First Big Trial 0:51:25 Liver Fat 0:55:25 Fat Loss vs Muscle Loss 1:00:05 Diabetes: The Phase 3 Trial 1:07:02 Obesity: The Phase 3 Trial 1:12:33 Knee Osteoarthritis 1:13:16 Sleep Apnea 1:14:10 Two-Year Results 1:17:49 Diabetes and Obesity Together 1:21:59 Heart Disease 1:26:13 Knee Osteoarthritis: The Dedicated Trial 1:28:35 Why You Cannot Just Compare Percentages 1:30:07 Side Effects and Risks

Retatrutide Explained : ) 0:00:00 Intro 0:00:44 How It Works: The Molecule 0:04:01 Sponsor 0:04:37 How It Works: The Three Targets 0:22:44 Lab and Animal Studies 0:28:38 First Human Trials 0:32:34 Diabetes: The First Big Trial 0:42:13 Obesity: The First Big Trial 0:51:25 Liver Fat 0:55:25 Fat Loss vs Muscle Loss 1:00:05 Diabetes: The Phase 3 Trial 1:07:02 Obesity: The Phase 3 Trial 1:12:33 Knee Osteoarthritis 1:13:16 Sleep Apnea 1:14:10 Two-Year Results 1:17:49 Diabetes and Obesity Together 1:21:59 Heart Disease 1:26:13 Knee Osteoarthritis: The Dedicated Trial 1:28:35 Why You Cannot Just Compare Percentages 1:30:07 Side Effects and Risks

Bioavailable

95,853 просмотров • 1 месяц назад

Andrew Huberman just broke down the next wave of weight-loss drugs on Gwyneth Paltrow’s goop podcast. He says the new triple agonist Retatrutide (currently in trials) is a big step up from Ozempic and Mounjaro. It hits three pathways (GLP-1 + glucagon + GIP) more gently, leading to significant weight loss with potentially less muscle loss and fewer side effects. People are already hunting for gray/black market versions. Early trial data on Retatrutide showed participants losing up to 24% of their body weight over 48 weeks, with notably better muscle preservation compared to earlier GLP-1 drugs when combined with resistance training. These next-generation drugs are becoming more targeted, but access, safety, and proper use remain key issues. This conversation made the rapid evolution of these drugs feel very real. It’s wild how fast this space is moving. What’s your take on the new generation of GLP drugs like Retatrutide?

Andrew Huberman just broke down the next wave of weight-loss drugs on Gwyneth Paltrow’s goop podcast. He says the new triple agonist Retatrutide (currently in trials) is a big step up from Ozempic and Mounjaro. It hits three pathways (GLP-1 + glucagon + GIP) more gently, leading to significant weight loss with potentially less muscle loss and fewer side effects. People are already hunting for gray/black market versions. Early trial data on Retatrutide showed participants losing up to 24% of their body weight over 48 weeks, with notably better muscle preservation compared to earlier GLP-1 drugs when combined with resistance training. These next-generation drugs are becoming more targeted, but access, safety, and proper use remain key issues. This conversation made the rapid evolution of these drugs feel very real. It’s wild how fast this space is moving. What’s your take on the new generation of GLP drugs like Retatrutide?

Camus

360,949 просмотров • 4 месяцев назад

He just quit. He was a primary editor for Diary of a CEO. So I asked him to tell all of his secrets for how he helps the Diary of a CEO be the number 1 podcast on YouTube. 00:00:00 Why Trailers Are Essential for Podcast Growth 00:03:30 Why Most People Are Doing Trailers Wrong 00:06:36 From Film and TV to Diary of a CEO 00:11:48 Retention Rates and What They Actually Mean 00:14:52 What Actually Makes a Podcast Good 00:17:00 Why the Guest Is 50% of Everything 00:22:59 What Makes a Great Podcast Host 00:26:31 Red Flags in Podcast Trailers 00:30:33 The Jefferson Fisher Hook Breakdown 00:34:16 The Louis Tomlinson Hook Breakdown 00:42:35 The 15 Point Checklist for the Perfect Trailer 00:45:28 The Oz Pearlman Hook (41 Second Rule) 00:48:06 The Laughter Track Hack 00:54:11 Sound Design and Visual Details 00:57:04 How to Choose Music Like a Film Director 01:00:02 Disney Imagineering Lesson 01:02:46 The Vanessa Van Edwards Hook Breakdown 01:07:02 The Kevin Hart Narrative Arc Breakdown 01:16:40 The A-B-C Storytelling Framework 01:20:13 The Easiest Win You Can Implement Right Now 01:22:36 How Diary of a CEO Uses AI

He just quit. He was a primary editor for Diary of a CEO. So I asked him to tell all of his secrets for how he helps the Diary of a CEO be the number 1 podcast on YouTube. 00:00:00 Why Trailers Are Essential for Podcast Growth 00:03:30 Why Most People Are Doing Trailers Wrong 00:06:36 From Film and TV to Diary of a CEO 00:11:48 Retention Rates and What They Actually Mean 00:14:52 What Actually Makes a Podcast Good 00:17:00 Why the Guest Is 50% of Everything 00:22:59 What Makes a Great Podcast Host 00:26:31 Red Flags in Podcast Trailers 00:30:33 The Jefferson Fisher Hook Breakdown 00:34:16 The Louis Tomlinson Hook Breakdown 00:42:35 The 15 Point Checklist for the Perfect Trailer 00:45:28 The Oz Pearlman Hook (41 Second Rule) 00:48:06 The Laughter Track Hack 00:54:11 Sound Design and Visual Details 00:57:04 How to Choose Music Like a Film Director 01:00:02 Disney Imagineering Lesson 01:02:46 The Vanessa Van Edwards Hook Breakdown 01:07:02 The Kevin Hart Narrative Arc Breakdown 01:16:40 The A-B-C Storytelling Framework 01:20:13 The Easiest Win You Can Implement Right Now 01:22:36 How Diary of a CEO Uses AI

Grant

206,702 просмотров • 1 месяц назад

Anthropic engineer: "Most people are using 10% of what Claude can do. The other 90% is Loops and Graphs." In 30 minutes he explains how Anthropic uses Claude, and why most people never get there. The missing piece most people skip: Claude isn't hard to use, loops and graphs are how you use it well. Watch it, then read what Claude is actually capable of below.

Anthropic engineer: "Most people are using 10% of what Claude can do. The other 90% is Loops and Graphs." In 30 minutes he explains how Anthropic uses Claude, and why most people never get there. The missing piece most people skip: Claude isn't hard to use, loops and graphs are how you use it well. Watch it, then read what Claude is actually capable of below.

Mahax

67,758 просмотров • 1 месяц назад

Join my conversation with Elon Musk on AGI timelines, energy, robots, and why abundance is the most likely outcome for humanity's future, alongside my Moonshot Mate NOTDAVID! (00:00) - Navigating the Future of AI and Robotics (04:54) - The Promise of Abundance and Optimism (10:02) - Energy: The Key to a Sustainable Future (15:00) - The Role of Education in a Changing World (41:07) - Health, Longevity, and the Future of Humanity (50:51) - AI's Impact on Labor and Employment (55:05) - Universal High Income: A New Economic Paradigm (57:58) - Navigating the Singularity and AI's Acceleration (01:02:30) - The Role of AI in Healthcare and Surgery (01:08:22) - Ethics and AI: Programming Values into Machines (01:14:18) - The Future of Space Exploration and AI's Role (01:33:30) - The Chip Shortage Crisis (01:42:46) - Simulation Theory and Consciousness (01:48:18) - The Search for Extraterrestrial Life (01:58:28) - The Future of Robotics and AI Integration

Join my conversation with Elon Musk on AGI timelines, energy, robots, and why abundance is the most likely outcome for humanity's future, alongside my Moonshot Mate NOTDAVID! (00:00) - Navigating the Future of AI and Robotics (04:54) - The Promise of Abundance and Optimism (10:02) - Energy: The Key to a Sustainable Future (15:00) - The Role of Education in a Changing World (41:07) - Health, Longevity, and the Future of Humanity (50:51) - AI's Impact on Labor and Employment (55:05) - Universal High Income: A New Economic Paradigm (57:58) - Navigating the Singularity and AI's Acceleration (01:02:30) - The Role of AI in Healthcare and Surgery (01:08:22) - Ethics and AI: Programming Values into Machines (01:14:18) - The Future of Space Exploration and AI's Role (01:33:30) - The Chip Shortage Crisis (01:42:46) - Simulation Theory and Consciousness (01:48:18) - The Search for Extraterrestrial Life (01:58:28) - The Future of Robotics and AI Integration

Peter H. Diamandis, MD

6,237,059 просмотров • 8 месяцев назад

I debated a Bitcoin skeptic (who's also a CFA charter holder!) about Bitcoin's future TIME STAMPS: 00:00 Intro 02:06 Is Bitcoin better than fiat? 09:17 Bitcoin speculation 12:50 How many people are speculating on Bitcoin? 14:40 The benefits of Fiat 18:50 Most people are hurt by fiat today 25:25 Who should control the money? 38:00 The US Dollar benefits America the most 44:00 The majority of people will never understand Bitcoin 46:20 What's the end goal with Bitcoin? 55:15 Nobody can be certain of Bitcoin's future 01:00:21 Is Bitcoin transparent? 01:04:19 The majority of people don't study Bitcoin Special thanks to @JLarge53 for having this conversation and Maurizio Pedrazzoli Grazioli for moderating!

I debated a Bitcoin skeptic (who's also a CFA charter holder!) about Bitcoin's future TIME STAMPS: 00:00 Intro 02:06 Is Bitcoin better than fiat? 09:17 Bitcoin speculation 12:50 How many people are speculating on Bitcoin? 14:40 The benefits of Fiat 18:50 Most people are hurt by fiat today 25:25 Who should control the money? 38:00 The US Dollar benefits America the most 44:00 The majority of people will never understand Bitcoin 46:20 What's the end goal with Bitcoin? 55:15 Nobody can be certain of Bitcoin's future 01:00:21 Is Bitcoin transparent? 01:04:19 The majority of people don't study Bitcoin Special thanks to @JLarge53 for having this conversation and Maurizio Pedrazzoli Grazioli for moderating!

Rajat Soni, CFA

80,427 просмотров • 1 год назад

My conversation with OpenAI co-founder Greg Brockman This is the most detailed first-person account of the 72 hours after Sam Altman was fired. We also go deep on what comes next: the global race to AGI, why ChatGPT stopped showing reasoning, how much of OpenAI's own code is now written by AI ("it's hard to know what percent is not"), and the untold story of how OpenAI actually started in 2015. 00:00:00 Introduction 00:00:49 Meeting Sam Altman and Starting OpenAI 00:02:40 Building the Founding Team 00:04:25 DeepMind's Lead Over OpenAI 00:04:54 Changing OpenAI to a For-Profit Model 00:06:05 Breakthrough Moments at OpenAI 00:08:22 What Dota 2 Meant for OpenAI 00:10:04 Reasoning Versus Prediction 00:11:59 Tensions Grow at OpenAI 00:15:44 Sam Altman's Firing 00:17:49 Greg Quits OpenAI 00:19:56 Sam Explores Deal with Microsoft's Satya 00:20:28 Petition for Altman's Return 00:23:43 Ilya Sutskever Leaves OpenAI 00:24:59 Lessons Learned after Sam Ousting 00:28:22 The Thing Ilya Said that Greg Can't Forget 00:32:22 Is AI Going Parabolic? 00:33:24 How Much of OpenAI's Code is Written by AI? 00:36:21 Do AI Chatbots Tell Us What We Want to Hear? 00:38:06 The Global AI Race to Reach AGI 00:38:40 What Happens if US Doesn't Reach AGI First? 00:39:49 Are Countries Stealing AI Advancements? 00:40:38 Why ChatGPT No Longer Shows Reasoning 00:41:47 The Finite Constraints of Compute 00:43:38 On Investing Early in Data Centers 00:46:31 The Future of Data Center Specialization 00:47:52 How to Decide Whose Queries to Serve 00:49:08 OpenAI on Consumer vs Enterprise Models 00:53:05 Data Centers in Space? 01:00:56 What Should AI Regulation Look Like? 01:04:33 The Future of AI-Powered Entrepreneurship 01:04:44 AI and Job Loss 01:07:15 The Skills Young People Should Invest In 01:11:30 What Does Success Look Like For You? Full episode on X below. Also find it on: • YouTube: • Spotify: • Apple:

My conversation with OpenAI co-founder Greg Brockman This is the most detailed first-person account of the 72 hours after Sam Altman was fired. We also go deep on what comes next: the global race to AGI, why ChatGPT stopped showing reasoning, how much of OpenAI's own code is now written by AI ("it's hard to know what percent is not"), and the untold story of how OpenAI actually started in 2015. 00:00:00 Introduction 00:00:49 Meeting Sam Altman and Starting OpenAI 00:02:40 Building the Founding Team 00:04:25 DeepMind's Lead Over OpenAI 00:04:54 Changing OpenAI to a For-Profit Model 00:06:05 Breakthrough Moments at OpenAI 00:08:22 What Dota 2 Meant for OpenAI 00:10:04 Reasoning Versus Prediction 00:11:59 Tensions Grow at OpenAI 00:15:44 Sam Altman's Firing 00:17:49 Greg Quits OpenAI 00:19:56 Sam Explores Deal with Microsoft's Satya 00:20:28 Petition for Altman's Return 00:23:43 Ilya Sutskever Leaves OpenAI 00:24:59 Lessons Learned after Sam Ousting 00:28:22 The Thing Ilya Said that Greg Can't Forget 00:32:22 Is AI Going Parabolic? 00:33:24 How Much of OpenAI's Code is Written by AI? 00:36:21 Do AI Chatbots Tell Us What We Want to Hear? 00:38:06 The Global AI Race to Reach AGI 00:38:40 What Happens if US Doesn't Reach AGI First? 00:39:49 Are Countries Stealing AI Advancements? 00:40:38 Why ChatGPT No Longer Shows Reasoning 00:41:47 The Finite Constraints of Compute 00:43:38 On Investing Early in Data Centers 00:46:31 The Future of Data Center Specialization 00:47:52 How to Decide Whose Queries to Serve 00:49:08 OpenAI on Consumer vs Enterprise Models 00:53:05 Data Centers in Space? 01:00:56 What Should AI Regulation Look Like? 01:04:33 The Future of AI-Powered Entrepreneurship 01:04:44 AI and Job Loss 01:07:15 The Skills Young People Should Invest In 01:11:30 What Does Success Look Like For You? Full episode on X below. Also find it on: • YouTube: • Spotify: • Apple:

Shane Parrish

450,952 просмотров • 5 месяцев назад

E162: CoinGecko: How CoinGecko became crypto's most trusted data layer Bobby Ong is the co-founder and CEO of CoinGecko - the data backbone of the crypto industry, bootstrapped with $200 and now rumoured to be worth $500M. We get into the CoinMarketCap vs CoinGecko debate, a failed NFT acquisition, and the sale rumour he can't fully deny. Timestamps: 0:00 Intro 5:10 What is CoinGecko? 13:35 Partnerships: Jupiter KAST Sumsub 23:58 What’s the deal with Pudgy Penguins? 30:25 Partnerships: Trezor @BitwiseInvest Sui 34:00 Don’t Chase Fast Cash 40:41 The Most Painful Moment of CoinGecko 50:20 Explain CoinGecko To Your Mom 1:08:08 What’s The Playbook To Survive the Cycle 1:16:01 Why Stay in Malaysia? 1:24:00 Is being #2 Frustrating or Motivating? 1:27:17 CoinMarketCap vs CoinGecko 1:30:00 Why Your Big Bet Didn’t Work Out 1:35:00 Red Flags in Acquisitions 1:38:00 CoinGecko Being Sold For $500M Rumor 1:39:00 When Is The Right Moment to Sell?

E162: CoinGecko: How CoinGecko became crypto's most trusted data layer Bobby Ong is the co-founder and CEO of CoinGecko - the data backbone of the crypto industry, bootstrapped with $200 and now rumoured to be worth $500M. We get into the CoinMarketCap vs CoinGecko debate, a failed NFT acquisition, and the sale rumour he can't fully deny. Timestamps: 0:00 Intro 5:10 What is CoinGecko? 13:35 Partnerships: Jupiter KAST Sumsub 23:58 What’s the deal with Pudgy Penguins? 30:25 Partnerships: Trezor @BitwiseInvest Sui 34:00 Don’t Chase Fast Cash 40:41 The Most Painful Moment of CoinGecko 50:20 Explain CoinGecko To Your Mom 1:08:08 What’s The Playbook To Survive the Cycle 1:16:01 Why Stay in Malaysia? 1:24:00 Is being #2 Frustrating or Motivating? 1:27:17 CoinMarketCap vs CoinGecko 1:30:00 Why Your Big Bet Didn’t Work Out 1:35:00 Red Flags in Acquisitions 1:38:00 CoinGecko Being Sold For $500M Rumor 1:39:00 When Is The Right Moment to Sell?

MR SHIFT 🦁

135,967 просмотров • 6 месяцев назад

. OpenLedger x : The full episode Our core contributor Ram sat down with Sreeram Kannan (founder ) to discuss verifiable AI, crypto's app problem, AI's trust problem and much more Check out the video below to learn more Timestamps: 00:00 Sreeram's introduction 00:29 How to build verification for AI systems 01:27 The Crypto and AI problem 03:10 Unstoppable AGI 05:08 What is Verifiable AI 06:05 The Verifiability Problem with Centralized AI 07:15 The current state of AI and its future 08:48 How humans are getting better at intelligence extraction 10:31 What is OpenLedger doing 11:50 Where LLMs fall short and how co-ordination helps 12:50 SLMs are already there 13:29 Crypto as an incentivisation mechanism 15:38 Apps with commitments, achieving product market fit 16:50 Existing examples of commitments in society 18:24 Investable AI 19:00 Data contributors as co-owner 21:30 The solution for the incentivisation problem 22:25 Explaining explainable AI 23:58 Trusting the trustless way 25:07 Data is the new oil 25:40 The idea of openledger is very crypto native 26:50 David v Goliath (in the data perspective) 28:03 What Eigen is working on 29:06 Making unstoppable verifiable AI practically possible 32:20 What Sreeram uses for productivity 33:30 Make Eigen Labs agentic 34:16 (community question) How Sreeram frames his prompts 36:08 (community question) What's the momentum driver for blockchain apps and what is Sreeram most excited about? (ZkTLS) 38:54 (community question) Where is attribution and verification really needed in AI?

. OpenLedger x : The full episode Our core contributor Ram sat down with Sreeram Kannan (founder ) to discuss verifiable AI, crypto's app problem, AI's trust problem and much more Check out the video below to learn more Timestamps: 00:00 Sreeram's introduction 00:29 How to build verification for AI systems 01:27 The Crypto and AI problem 03:10 Unstoppable AGI 05:08 What is Verifiable AI 06:05 The Verifiability Problem with Centralized AI 07:15 The current state of AI and its future 08:48 How humans are getting better at intelligence extraction 10:31 What is OpenLedger doing 11:50 Where LLMs fall short and how co-ordination helps 12:50 SLMs are already there 13:29 Crypto as an incentivisation mechanism 15:38 Apps with commitments, achieving product market fit 16:50 Existing examples of commitments in society 18:24 Investable AI 19:00 Data contributors as co-owner 21:30 The solution for the incentivisation problem 22:25 Explaining explainable AI 23:58 Trusting the trustless way 25:07 Data is the new oil 25:40 The idea of openledger is very crypto native 26:50 David v Goliath (in the data perspective) 28:03 What Eigen is working on 29:06 Making unstoppable verifiable AI practically possible 32:20 What Sreeram uses for productivity 33:30 Make Eigen Labs agentic 34:16 (community question) How Sreeram frames his prompts 36:08 (community question) What's the momentum driver for blockchain apps and what is Sreeram most excited about? (ZkTLS) 38:54 (community question) Where is attribution and verification really needed in AI?

OpenLedger

274,844 просмотров • 1 год назад

E182: Jordi Visser - Why Aging is a disease, Why Bitcoin is a hedge against abundance and why you shouldn't buy a house! Jordi Visser spent three decades on Wall Street, from a Morgan Stanley trading desk to CIO at Weiss Multi-Strategy. These days he studies AI, macro, and longevity full time. We cover why he thinks aging is optional, why Bitcoin is the only asset he'd bet on for the next decade, and why money never actually made him happy. 00:00 Intro 02:10 Jordi's Weekend Recap 03:49 The Blueprint For Living To 100 04:31 Why Longevity Became An Obsession 05:44 What Kills A Healthy Habit 07:20 Supplements & Meds: Worth It? 09:51 Partnerships: Variational Bitwise 10:44 The First Step Into Longevity 12:17 Wealth's Hidden Effect On Longevity 14:03 Peptides & Hormones: Jordi's Take 17:47 What Is Heart-Rate Variability? 21:21 How To Track Your HRV 23:17 Average vs. Great HRV 25:12 Lessons From The Finance World 29:10 Learning What Money Really Means 31:58 Partnership: KAST 32:47 Why Make More Money At All 35:20 "AI Will Make Everything Abundant" 38:20 Does Abundance Mean Cheaper? 38:54 Why We'll Still Need Wealth 41:22 How Jordi Fell Into Bitcoin 47:44 Jordi's Bitcoin Thesis, Simplified 50:10 How Much Bitcoin Is In His Portfolio 50:48 Would Jordi Ever Sell? 51:52 Partnerships: Jupiter Ethena 52:38 How Big Can Bitcoin Get 54:00 On "Bitcoin Is Too Expensive" 55:28 Why A Crypto Channel, Not Just Bitcoin 56:25 Does Jordi Own Other Crypto 57:24 Other Scarce Assets He's Bought 58:41 Should 20-Somethings Buy A House 01:02:00 Routine vs. Unique 01:03:57 Why Allergies Aren't Real 01:07:02 Closing Thoughts

E182: Jordi Visser - Why Aging is a disease, Why Bitcoin is a hedge against abundance and why you shouldn't buy a house! Jordi Visser spent three decades on Wall Street, from a Morgan Stanley trading desk to CIO at Weiss Multi-Strategy. These days he studies AI, macro, and longevity full time. We cover why he thinks aging is optional, why Bitcoin is the only asset he'd bet on for the next decade, and why money never actually made him happy. 00:00 Intro 02:10 Jordi's Weekend Recap 03:49 The Blueprint For Living To 100 04:31 Why Longevity Became An Obsession 05:44 What Kills A Healthy Habit 07:20 Supplements & Meds: Worth It? 09:51 Partnerships: Variational Bitwise 10:44 The First Step Into Longevity 12:17 Wealth's Hidden Effect On Longevity 14:03 Peptides & Hormones: Jordi's Take 17:47 What Is Heart-Rate Variability? 21:21 How To Track Your HRV 23:17 Average vs. Great HRV 25:12 Lessons From The Finance World 29:10 Learning What Money Really Means 31:58 Partnership: KAST 32:47 Why Make More Money At All 35:20 "AI Will Make Everything Abundant" 38:20 Does Abundance Mean Cheaper? 38:54 Why We'll Still Need Wealth 41:22 How Jordi Fell Into Bitcoin 47:44 Jordi's Bitcoin Thesis, Simplified 50:10 How Much Bitcoin Is In His Portfolio 50:48 Would Jordi Ever Sell? 51:52 Partnerships: Jupiter Ethena 52:38 How Big Can Bitcoin Get 54:00 On "Bitcoin Is Too Expensive" 55:28 Why A Crypto Channel, Not Just Bitcoin 56:25 Does Jordi Own Other Crypto 57:24 Other Scarce Assets He's Bought 58:41 Should 20-Somethings Buy A House 01:02:00 Routine vs. Unique 01:03:57 Why Allergies Aren't Real 01:07:02 Closing Thoughts

MR SHIFT 🦁

148,873 просмотров • 1 месяц назад

Yafah Edelmen and David Owen of Epoch AI reveal why AI could solve the Riemann hypothesis in 5 years, and what 30% GDP growth actually looks like. They explain why "energy bottlenecks" are just companies complaining about paying 2x for power instead of getting it cheap and the most data-driven take on whether we're racing toward superintelligence or headed for history's biggest bubble. Timestamps 00:00 - Introduction 02:51 - Pre-training plateaus vs post-training innovations 05:10 - Why software-only singularity seems unlikely 11:16 - Evaluating Dario's bold predictions on AI capabilities 16:12 - AI's labor market impact over the next decade 24:27 - Computer use breakthroughs and real-world utility 28:06 - GDP growth forecasts: from 1% to 30% scenarios 35:00 - What comes after current benchmarks are solved 37:16 - Timeline for AI solving major math problems 46:54 - Robotics as primarily a hardware problem 50:06 - Data center infrastructure reality vs hype Yafah Edelman @everysum Marco Mascorro Erik Torenberg

Yafah Edelmen and David Owen of Epoch AI reveal why AI could solve the Riemann hypothesis in 5 years, and what 30% GDP growth actually looks like. They explain why "energy bottlenecks" are just companies complaining about paying 2x for power instead of getting it cheap and the most data-driven take on whether we're racing toward superintelligence or headed for history's biggest bubble. Timestamps 00:00 - Introduction 02:51 - Pre-training plateaus vs post-training innovations 05:10 - Why software-only singularity seems unlikely 11:16 - Evaluating Dario's bold predictions on AI capabilities 16:12 - AI's labor market impact over the next decade 24:27 - Computer use breakthroughs and real-world utility 28:06 - GDP growth forecasts: from 1% to 30% scenarios 35:00 - What comes after current benchmarks are solved 37:16 - Timeline for AI solving major math problems 46:54 - Robotics as primarily a hardware problem 50:06 - Data center infrastructure reality vs hype Yafah Edelman @everysum Marco Mascorro Erik Torenberg

a16z

25,833 просмотров • 10 месяцев назад

Full interview with the founder and CEO of Propr Lou sits down with me to discuss Hyperliquid and the future of prop trading Timestamps: 00:00:00 Intro 00:00:16 Meet Louis: from TradFi to crypto 00:01:52 How the crypto market has changed 00:03:49 Why build on Hyperliquid 00:06:52 How propr got started 00:08:40 Scaling a lean team (and the grind) 00:12:24 What a prop firm actually is 00:15:33 Agents, bots, and the future of trading 00:18:32 What Louis is most proud of 00:21:02 Thinking about the token and TGE 00:24:14 Where propr goes in 5 years 00:25:57 Best and worst trades 00:27:50 Life outside crypto + shoutouts

Full interview with the founder and CEO of Propr Lou sits down with me to discuss Hyperliquid and the future of prop trading Timestamps: 00:00:00 Intro 00:00:16 Meet Louis: from TradFi to crypto 00:01:52 How the crypto market has changed 00:03:49 Why build on Hyperliquid 00:06:52 How propr got started 00:08:40 Scaling a lean team (and the grind) 00:12:24 What a prop firm actually is 00:15:33 Agents, bots, and the future of trading 00:18:32 What Louis is most proud of 00:21:02 Thinking about the token and TGE 00:24:14 Where propr goes in 5 years 00:25:57 Best and worst trades 00:27:50 Life outside crypto + shoutouts

ryandcrypto

43,284 просмотров • 3 месяцев назад

BG2 Guest Interview. AI Enterprise - Databricks & Glean 💥Why AIs Fail and Where Real Value Emerges Bg2 Pod Apoorv Agrawal Ali Ghodsi Arvind Jain --- (00:00) Intro (01:00) Consumer AI vs. Enterprise Reality (02:15) Why 95% of AI Projects Fail (04:15) RBC, Merck, and 7-Eleven Use Cases (06:45) What Actually Makes AI Work (07:00) LLMs Are Commodities—Data Is the Moat (08:45) Failed AI Bets at Databricks & Glean (11:00) RPA vs. Generative AI (14:15) Advice for CIOs Planning AI Budgets (16:00) AI CapEx and the Revenue Math (18:00) The Three Camps of AI (21:00) Making AI Useful Inside Enterprises (24:30) Why Apps Capture the Value (30:00) The Future of UI, Voice, and Data Entry (37:30) Rapid Fire: Winners, Bubbles, Long/Short

BG2 Guest Interview. AI Enterprise - Databricks & Glean 💥Why AIs Fail and Where Real Value Emerges Bg2 Pod Apoorv Agrawal Ali Ghodsi Arvind Jain --- (00:00) Intro (01:00) Consumer AI vs. Enterprise Reality (02:15) Why 95% of AI Projects Fail (04:15) RBC, Merck, and 7-Eleven Use Cases (06:45) What Actually Makes AI Work (07:00) LLMs Are Commodities—Data Is the Moat (08:45) Failed AI Bets at Databricks & Glean (11:00) RPA vs. Generative AI (14:15) Advice for CIOs Planning AI Budgets (16:00) AI CapEx and the Revenue Math (18:00) The Three Camps of AI (21:00) Making AI Useful Inside Enterprises (24:30) Why Apps Capture the Value (30:00) The Future of UI, Voice, and Data Entry (37:30) Rapid Fire: Winners, Bubbles, Long/Short

Bg2 Pod

35,410 просмотров • 9 месяцев назад

Why build games on Avalanche? Coop⏱️ shares the playbook & insights on why Avalanche🔺 is attracting the likes of Off the Grid and MapleStory. Which 🔺 games are you most excited for? 01:05 Introduction 02:32 Coop's Journey Into Web3 06:31 Why Build Games on Avalanche? 10:30 What Is a "Successful" Web3 Game 15:48 Avalanche's Marketing Strategy 19:50 Why Avalanche9000? 22:40 Trading Up In Gaming 26:00 Challenges of "Betting on Winners" 28:48 Why So Many Avax Shooters? 30:25 Exciting Updates 34:41 Avalanche Regional Focus 39:12 Future Focus and Success Metrics 42:30 Why Rebrand Subnets to L1s 44:38 Final Thoughts and Hidden Gems

Why build games on Avalanche? Coop⏱️ shares the playbook & insights on why Avalanche🔺 is attracting the likes of Off the Grid and MapleStory. Which 🔺 games are you most excited for? 01:05 Introduction 02:32 Coop's Journey Into Web3 06:31 Why Build Games on Avalanche? 10:30 What Is a "Successful" Web3 Game 15:48 Avalanche's Marketing Strategy 19:50 Why Avalanche9000? 22:40 Trading Up In Gaming 26:00 Challenges of "Betting on Winners" 28:48 Why So Many Avax Shooters? 30:25 Exciting Updates 34:41 Avalanche Regional Focus 39:12 Future Focus and Success Metrics 42:30 Why Rebrand Subnets to L1s 44:38 Final Thoughts and Hidden Gems

GAMES.GG

411,789 просмотров • 1 год назад

Ownership S1 E10: Ranga (Solomon Labs) "Building the productive dollar" 00:00 Intro 00:32 From BlackBerry to Bitcoin to building a better dollar 05:54 Why the old VC playbook is dead 09:59 The raise: Polymarket FUD and the Cloudflare outage 17:47 Inside the most-traded decision market in MetaDAO history 26:50 Ownership coins, cap tables, founder vs investor friendly 32:33 What Solomon is: USDv, productive dollars, YaaS 34:50 What backs USDv, and the history of private money 45:57 YaaS: programmable monetary policy on chain 01:05:37 Stablecoins and the future of money Hosted by 8bitpenis.sol Produced by Blockformer Powered by MetaDAO & Umbra Privacy

Ownership S1 E10: Ranga (Solomon Labs) "Building the productive dollar" 00:00 Intro 00:32 From BlackBerry to Bitcoin to building a better dollar 05:54 Why the old VC playbook is dead 09:59 The raise: Polymarket FUD and the Cloudflare outage 17:47 Inside the most-traded decision market in MetaDAO history 26:50 Ownership coins, cap tables, founder vs investor friendly 32:33 What Solomon is: USDv, productive dollars, YaaS 34:50 What backs USDv, and the history of private money 45:57 YaaS: programmable monetary policy on chain 01:05:37 Stablecoins and the future of money Hosted by 8bitpenis.sol Produced by Blockformer Powered by MetaDAO & Umbra Privacy

Ownership

20,568 просмотров • 2 месяцев назад

Running Through Ethereum with hamdi (Ep. 1) I started craic overflow because I had questions about where Ethereum is headed, and I wanted to ask them to the people shaping it. I decided to interview Hamdi while jogging because as a software engineer, I honestly spend way too much time sitting on my ass. Never been more bullish on the future of Ethereum. 00:00 - Intro 00:08 - Hamdi 00:40 - What's The Craic? 01:59 - How did Hamdi get into crypto? 02:40 - Why not plasma? 03:24 - Working at OP Labs/Optimism 04:06 - Shipping L2 Interoperability 05:12 - Building on the Superchain 05:30 - Asynchronicity in Solidity 07:00 - Predications for Ethereum 08:46 - What are the hurdles for Ethereum? 09:47 - Stablecoins 10:22 - Application specific chains 11:53 - Wallet UX 13:18 - Quick breather 13:30 - Why are you in crypto? 14:20 - How do you find balance? 16:20 - Hot take on ETH the asset 17:39 - The chains security 18:53 - Market talk 19:45 - Data availability 21:01 - Onchain L2 configs 21:22 - Outro

Running Through Ethereum with hamdi (Ep. 1) I started craic overflow because I had questions about where Ethereum is headed, and I wanted to ask them to the people shaping it. I decided to interview Hamdi while jogging because as a software engineer, I honestly spend way too much time sitting on my ass. Never been more bullish on the future of Ethereum. 00:00 - Intro 00:08 - Hamdi 00:40 - What's The Craic? 01:59 - How did Hamdi get into crypto? 02:40 - Why not plasma? 03:24 - Working at OP Labs/Optimism 04:06 - Shipping L2 Interoperability 05:12 - Building on the Superchain 05:30 - Asynchronicity in Solidity 07:00 - Predications for Ethereum 08:46 - What are the hurdles for Ethereum? 09:47 - Stablecoins 10:22 - Application specific chains 11:53 - Wallet UX 13:18 - Quick breather 13:30 - Why are you in crypto? 14:20 - How do you find balance? 16:20 - Hot take on ETH the asset 17:39 - The chains security 18:53 - Market talk 19:45 - Data availability 21:01 - Onchain L2 configs 21:22 - Outro

malone

11,924 просмотров • 1 год назад

Why The State SUCKS (at everything) Saifedean Ammous gives a 10 minute masterclass on Austrian Economics, Anarchy, Socialist/Communist failures, and the Market vs the State in security/defense. ⚡️THE Bitcoin Podcast CHAPTERS 00:00 The Failures of Socialism and Communism 02:40 Contributions of the Austrian School 03:20 The Reality of Anarchy 03:50 Why Does the State Suck? 04:20 The #Bitcoin Rabbit Hole 05:00 Defense & Security as Economic Goods 07:15 The Market vs The State 08:45 The Potential Benefits of Monarchy

Why The State SUCKS (at everything) Saifedean Ammous gives a 10 minute masterclass on Austrian Economics, Anarchy, Socialist/Communist failures, and the Market vs the State in security/defense. ⚡️THE Bitcoin Podcast CHAPTERS 00:00 The Failures of Socialism and Communism 02:40 Contributions of the Austrian School 03:20 The Reality of Anarchy 03:50 Why Does the State Suck? 04:20 The #Bitcoin Rabbit Hole 05:00 Defense & Security as Economic Goods 07:15 The Market vs The State 08:45 The Potential Benefits of Monarchy

Walker⚡️

16,025 просмотров • 2 лет назад

How can you be broke when you can just do this? The agency model is one of the fastest ways to build real income online. (0:00) Why agencies are the fastest path to wealth (02:15) Why most people fail at starting a business (04:40) The two types of agencies dominating right now (07:10) Email marketing: The goldmine nobody’s talking about (09:25) Virtual assistant agencies and why they’re scaling fast (12:00) The #1 mistake new agency owners make (14:30) How to start with zero experience today

How can you be broke when you can just do this? The agency model is one of the fastest ways to build real income online. (0:00) Why agencies are the fastest path to wealth (02:15) Why most people fail at starting a business (04:40) The two types of agencies dominating right now (07:10) Email marketing: The goldmine nobody’s talking about (09:25) Virtual assistant agencies and why they’re scaling fast (12:00) The #1 mistake new agency owners make (14:30) How to start with zero experience today

Tai Lopez

771,242 просмотров • 1 год назад