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Neural population dynamics in mouse motor cortex during voluntary gait modification. Neuropixels 2.0 is really a game-changer for resolving single-trial dynamics in a freely-moving prep. Check out Eric Kirk’s poster at SfN for more details …

Britton Sauerbrei

3,451 subscribers

19,802 Aufrufe • vor 2 Jahren •via X (Twitter)

Gesundheit & Wellness Wissenschaft & Technologie

Anya Rossi• Live Now

Private livecam show

8 Kommentare

Profilbild von Jianing Yu

Jianing Yuvor 2 Jahren

Cool demo! Why does the contral-trail type drive MC eariler than the contral-lead type in PC1/2? I thought the mouse lifts contral paw first in the later contral-lead type?

Profilbild von Britton Sauerbrei

Britton Sauerbreivor 2 Jahren

Great question! The data in both conditions are aligned to swing onset for the contralateral limb. While there are certainly neurons (like this one) that fire during cFL swing over the obstacle, the dominant signal in PC 1-2 is synchronized with swing in the *leading* limb.

Profilbild von Dan Butler

Dan Butlervor 2 Jahren

Looks interesting - is there a link to read more?

Profilbild von Britton Sauerbrei

Britton Sauerbreivor 2 Jahren

Thanks! Not yet, but stay tuned …

Profilbild von GG🌱

GG🌱vor 2 Jahren

wow, it looks cool! I will let my team to visit the Eric Kirk's poster!

Profilbild von Mackenzie Mathis, PhD

Mackenzie Mathis, PhDvor 2 Jahren

DLC still? Beautiful work 🥳

Profilbild von Britton Sauerbrei

Britton Sauerbreivor 2 Jahren

Thanks, Mackenzie! Yep - DLC + Anipose are the backbone of our tracking pipeline, and they work beautifully!

Profilbild von Dr Rob Leigh

Dr Rob Leighvor 2 Jahren

@JohnRHutchinson @CathalMcCrory1

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